STK582630 (CID 9613210) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(52)
 
 
Inactive(550)
 
 
Inconclusive(38)
 
 
Unspecified(3)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
Bcl-2 like(10)
 
 
alkPPc(10)
 
 
7TM GPCR Srsx(9)
 
 
Peptidase C48(8)
 
 
 
BioAssay Types:
Screening(438)
 
 
 
 
 
Confirmatory(190)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(137)
 
 
 
 
 
IC50(34)
 
 
 
EC50(14)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 643    Data Row: 643   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17505306]
Potency 0.5012qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]RAB9A gene product [Homo sapiens] [gi:4759012]
View
2
[SID17505306]
Potency 0.5858Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
View
3
[SID17505306]
Potency 0.7079qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]NPC1 gene product [Homo sapiens] [gi:255652944]
View
4
[SID17505306]
Potency 0.7308qHTS assay for re-activators of p53 using a Luc reporter: Hit Validation [AID624305, Type: confirmatory]P53 [Homo sapiens] [gi:23491729]
View
5
[SID17505306]
Potency 0.7308qHTS assay for re-activators of p53 using a Luc reporter: Hit Validation [AID624305, Type: confirmatory]P53 [Homo sapiens] [gi:23491729]
View
6
[SID17505306]
Potency 0.7308qHTS assay for re-activators of p53 using a Luc reporter: Hit Validation [AID624305, Type: confirmatory]P53 [Homo sapiens] [gi:23491729]
View
7
[SID17505306]
Potency 0.7308qHTS assay for re-activators of p53 using a Luc reporter: Hit Validation [AID624305, Type: confirmatory]P53 [Homo sapiens] [gi:23491729]
View
8
[SID17505306]
Potency 0.8492qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
View
9
[SID17505306]
EC50 2.155Luminescence Cell-Based/Microorganism Dose Confirmation HTS to Identify Inhibitors of T.Cruzi Replication. [AID2044, Type: confirmatory]
View
10
[SID17505306]
Potency 3.1623qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
View
11
[SID17505306]
Potency 3.1623qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
View
12
[SID17505306]
Potency 5.1735qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504466, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
View
13
[SID17505306]
EC50 7.892Luminescence Microorganism-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to SK(-)GAS Group A Streptococcus [AID1900, Type: confirmatory]
View
14
[SID17505306]
EC50 9.714Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity [AID1902, Type: confirmatory]streptokinase A precursor [Streptococcus pyogenes M1 GAS] [gi:15675770]
View
15
[SID17505306]
Potency 10Counterscreen for Luciferase (Kinase-Glo TM) Inhibition [AID1379, Type: confirmatory]luciferase [Photuris pennsylvanica] [gi:1669525]
View
16
[SID17505306]
Potency 12.5893qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
View
17
[SID17505306]
Potency 14.1254qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Giardia lamblia growth inhibition [AID2785, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-Biphosphate Aldolase In Complex With Phosphoglycolohydrox [gi:122920737]
View
18
[SID17505306]
Potency 18.3564qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
View
19
[SID17505306]
Potency 18.3564qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
20
[SID17505306]
Potency 18.3564qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
21
[SID17505306]
Potency 18.3564qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
22
[SID17505306]
Potency 19.9054qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-Biphosphate Aldolase In Complex With Phosphoglycolohydrox [gi:122920737]
View
23
[SID17505306]
Potency 23.1093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
24
[SID17505306]
Potency 23.1093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
25
[SID17505306]
Potency 23.1093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
26
[SID17505306]
Potency 25.1189qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent) [AID1476, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
View
27
[SID17505306]
Potency 25.1189qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Mammalian cellular toxicity [AID2786, Type: confirmatory]
View
28
[SID17505306]
Potency 56.2341qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
View
29
[SID17505306]
 Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
View
30
[SID17505306]
 A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
View
31
[SID17505306]
 Counterscreen for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): Luminescence-based cell-based high throughput assay for nonselective inhibitors/assay artifacts using AP2 mutant SF-1 (NR5A1) Transactivation Assay [AID652136, Type: screening]
View
32
[SID17505306]
 Heat Shock Factor-1 (HSF-1) Measured in Cell-Based System Using Plate Reader - 2038-01_Activator_SinglePoint_HTS_Activity [AID504408, Type: screening]
View
33
[SID17505306]
 Luminescence Cell-Based/Microorganism Primary HTS to Identify Inhibitors of T.Cruzi Replication [AID1885, Type: screening]
View
34
[SID17505306]
 Counter Screen for Luciferase-based Primary Inhibition Assays [AID1006, Type: screening]
View
35
[SID17505306]
 Leishmania major promastigote HTS [AID1063, Type: screening]
View
36
[SID17505306]
 Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) [AID2796, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
View
37
[SID17505306]
 Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) [AID2796, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
View
38
[SID17505306]
 Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) [AID2796, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
View
39
[SID17505306]
 Primary screen for compounds that activate Alzheimer's amyloid precursor [AID1276, Type: screening]amyloid precursor protein; APP [Homo sapiens] [gi:257380]
View
40
[SID17505306]
 Primary screen for compounds that activate Alzheimer's amyloid precursor [AID1276, Type: screening]amyloid precursor protein; APP [Homo sapiens] [gi:257380]
View
41
[SID17505306]
 Primary screen for compounds that activate Alzheimer's amyloid precursor [AID1276, Type: screening]amyloid precursor protein; APP [Homo sapiens] [gi:257380]
View
42
[SID17505306]
 Single concentration confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay [AID488918, Type: screening]CASP3 gene product [Homo sapiens] [gi:14790119]
View
43
[SID17505306]
 Single concentration confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay [AID488918, Type: screening]CASP3 gene product [Homo sapiens] [gi:14790119]
View
44
[SID17505306]
 Single concentration confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay [AID488918, Type: screening]CASP3 gene product [Homo sapiens] [gi:14790119]
View
45
[SID17505306]
 Single concentration confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay [AID488918, Type: screening]CASP3 gene product [Homo sapiens] [gi:14790119]
View
46
[SID17505306]
 Luminescence-based cell-based primary high throughput screening assay for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): repression of SF-1 (NR5A1) activated StAR promoter by full-length DAX-1 [AID652010, Type: screening]NR0B1 gene product [Homo sapiens] [gi:5016090]
View
47
[SID17505306]
 Luminescence-based cell-based primary high throughput confirmation assay for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): repression of SF-1 (NR5A1) activated StAR promoter by full-length DAX-1 [AID652134, Type: screening]NR0B1 gene product [Homo sapiens] [gi:5016090]
View
48
[SID17505306]
 Confirmation cell-based high throughput screening assay to measure STAT1 activation [AID1262, Type: screening]signal transducer and activator of transcription 1-alpha/beta isoform alpha [Homo sapiens] [gi:6274552]
View
49
[SID17505306]
 Confirmation cell-based high throughput screening assay to measure STAT1 activation [AID1262, Type: screening]signal transducer and activator of transcription 1-alpha/beta isoform alpha [Homo sapiens] [gi:6274552]
View
50
[SID17505306]
 Primary screen for compounds that inhibit Insulin promoter activity in TRM-6 cells [AID1273, Type: screening]proinsulin [Homo sapiens] [gi:59036749]
View