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SMR000273021 (CID 9595043) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(54)
 
 
Inactive(468)
 
 
Inconclusive(29)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
7TM GPCR Srsx(15)
 
 
Bcl-2 like(9)
 
 
 
G-alpha(8)
 
 
 
Tryp SPc(8)
 
 
BioAssay Types:
Screening(321)
 
 
 
 
Confirmatory(208)
 
 
 
 
 
Literature(6)
 
 
 
BioActivity Types:
Potency(151)
 
 
 
 
 
IC50(44)
 
 
 
EC50(9)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 505    Data Row: 552   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24786790]
IC50 1.10118Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors [AID1417, Type: confirmatory]Mcl-1 [Homo sapiens] [gi:7582271]
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2
[SID24786790]
Potency 1.4125qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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3
[SID24786790]
Potency 2.8184qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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4
[SID24786790]
Potency 2.8184qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]ras-related protein Rab-9A [Homo sapiens] [gi:4759012]
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5
[SID24786790]
Potency 3.1623qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]Niemann-Pick C1 protein precursor [Homo sapiens] [gi:255652944]
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6
[SID24786790]
IC50 3.928Dose Response confirmation of HTS hits from an HePTP Fluorescent Assay using OMFP substrate - Set 2 [AID435032, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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7
[SID24786790]
IC50_1 4.683Dose Response confirmation of uHTS hits from a small molecule inhibitors of LYP via a fluorescence intensity assay - Set 2 [AID435024, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 22 isoform 1 [Homo sapiens] [gi:224586929]
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8
[SID24786790]
IC50 4.82917LYP1 Fluorescent Assay using OMFP substrate for In Vitro dose response studies. [AID2126, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 22 isoform 1 [Homo sapiens] [gi:224586929]
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9
[SID24786790]
Potency 5.0119qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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10
[SID24786790]
IC50 5.119HTS HePTP Fluorescent Assay using OMFP substrate for In Vitro dose response studies [AID2134, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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11
[SID24786790]
IC50_1 6.628Dose Response confirmation of uHTS hits from a small molecule inhibitors of LYP via a fluorescence intensity assay using pCAP substrate [AID435027, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 22 isoform 1 [Homo sapiens] [gi:224586929]
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12
[SID24786790]
IC50 7.29uHTS fluorescence assay for the identification of Human Immunodeficiency Virus Fusion Inhibitors. [AID1986, Type: confirmatory]envelope glycoprotein [Human immunodeficiency virus 1] [gi:45357394]
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13
[SID24786790]
IC50 8.70755uHTS identification of small molecule inhibitors of LYP via a fluorescence intensity assay [AID1779, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 22 isoform 1 [Homo sapiens] [gi:224586929]
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14
[SID24786790]
Potency 8.9125qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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15
[SID24786790]
IC50 11.1Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay [AID2073, Type: confirmatory]voltage-dependent N-type calcium channel subunit alpha-1B isoform 1 [Homo sapiens] [gi:4502523]
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16
[SID24786790]
IC50 11.1Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay [AID2073, Type: confirmatory]Mint1 [Rattus norvegicus] [gi:2625023]
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17
[SID24786790]
Potency 11.5701qHTS for inhibitors of Phosphogylcerate Kinase: Hit Validation Screen [AID686980, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei] [gi:115503961]
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18
[SID24786790]
Potency 12.5893qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase [AID602233, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei] [gi:115503961]
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19
[SID24786790]
Potency 12.5893qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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20
[SID24786790]
Absolute IC50 14.81Dose Response Confirmation for Small Molecule Inhibitors of Epstein-Barr Virus [AID1419, Type: confirmatory]BZLF2 [Human herpesvirus 4 type 2] [gi:139424501]
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21
[SID24786790]
Potency 15.8489Confirmation Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID489007, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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22
[SID24786790]
Potency 15.8489qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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23
[SID24786790]
Potency 17.7828qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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24
[SID24786790]
Potency 18.8876qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds [AID720501, Type: Literature]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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25
[SID24786790]
Potency 22.3872qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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26
[SID24786790]
Potency 25.1189qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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27
[SID24786790]
Potency 29.9349qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds [AID720496, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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28
[SID24786790]
Potency 31.6228qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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29
[SID24786790]
Potency 32.3857qHTS Confirmation Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2585, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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30
[SID24786790]
Potency 39.8107qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen [AID720709, Type: confirmatory]Rap guanine nucleotide exchange factor 3 [gi:317373593]
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31
[SID24786790]
Potency 44.6684qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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32
[SID24786790]
IC50 49.1uHTS Homogeneous Terbium Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay [AID2091, Type: confirmatory]voltage-dependent N-type calcium channel subunit alpha-1B isoform 1 [Homo sapiens] [gi:4502523]
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33
[SID24786790]
IC50 49.1uHTS Homogeneous Terbium Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay [AID2091, Type: confirmatory]Mint1 [Rattus norvegicus] [gi:2625023]
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34
[SID24786790]
Potency 50.1187qHTS for Inhibitors of WRN Helicase [AID651768, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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35
[SID24786790]
Potency 50.1187qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). [AID588795, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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36
[SID24786790]
Potency 53.5818qHTS Assay for the Inhibitors of FEN1: Confirmatory Assay for Cherry-picked Compounds [AID720498, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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37
[SID24786790]
Potency 75.6863qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds [AID720502, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
View
38
[SID24786790]
uHTS Colorimetric assay for identification of inhibitors of Scp-1 [AID493091, Type: screening]carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1 [Homo sapiens] [gi:10864009]
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39
[SID24786790]
uHTS of Mcl-1/Noxa interaction inhibitors [AID1022, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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40
[SID24786790]
Single concentration validation of Csn-Mediated Deneddylation of Cullin-Ring Ligase Hits Using a MMP-2 Fluorescence Assay [AID720655, Type: other]72 kDa type IV collagenase isoform a preproprotein [Homo sapiens] [gi:11342666]
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41
[SID87337507]
VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID686996, Type: screening]Caspase 6, apoptosis-related cysteine peptidase [Homo sapiens] [gi:13325293]
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42
[SID24786790]
IC50 Fluorescent assay for identification of compounds that inhibit VHR1 [AID1878, Type: confirmatory]dual specificity protein phosphatase 3 [Homo sapiens] [gi:4758208]
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43
[SID24786790]
uHTS identification of inhibitors of NadD in a Colorimetric assay [AID602399, Type: screening]hypothetical protein SA1422 [Staphylococcus aureus subsp. aureus N315] [gi:15927174]
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44
[SID24786790]
uHTS for 14-3-3/Bad interaction inhibitors [AID781, Type: screening]14-3-3 protein zeta/delta [Bos taurus] [gi:27807367]
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45
[SID24786790]
uHTS identification of DNMT1 inhibitors in a Fluorescent Molecular Beacon assay [AID588458, Type: screening]DNA (cytosine-5)-methyltransferase 1 isoform b [Homo sapiens] [gi:4503351]
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46
[SID24786790]
uHTS identification of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assay [AID651560, Type: screening]Low molecular weight phosphotyrosine protein phosphatase [gi:1709543]
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47
[SID24786790]
Screen for Chemicals that Inhibit the RAM Network [AID868, Type: screening]
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48
[SID24786790]
384-well Z-Lyte format Hck-Nef inhibitor HTS run at the PMLSC [AID463187, Type: screening]
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49
[SID24786790]
High throughput discovery of novel modulators of ROMK K+ channel activity: Primary Screen [AID1918, Type: screening]Potassium inwardly-rectifying channel, subfamily J, member 1 [Homo sapiens] [gi:223460826]
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50
[SID24786790]
uHTS for Small Molecule Inhibitors of Eukaryotic Translation Initiation [AID782, Type: screening]eukaryotic translation initiation factor 4 gamma 1 isoform 4 [Homo sapiens] [gi:302699239]
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