SMR000273021 (CID 9595043) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(46)
 
 
Inactive(395)
 
 
Inconclusive(22)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
Bcl-2 like(9)
 
 
 
7TM GPCR Srsx(8)
 
 
PTPc(7)
 
 
alkPPc(6)
 
 
BioAssay Types:
Screening(270)
 
 
 
 
Confirmatory(178)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(127)
 
 
 
 
 
IC50(38)
 
 
 
EC50(9)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 464    Data Row: 464   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24786790]
IC50 1.10118Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors [AID1417, Type: confirmatory]Mcl-1 [Homo sapiens] [gi:7582271]
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2
[SID24786790]
IC50 1.10118Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors [AID1417, Type: confirmatory]Mcl-1 [Homo sapiens] [gi:7582271]
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3
[SID24786790]
IC50 1.10118Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors [AID1417, Type: confirmatory]Mcl-1 [Homo sapiens] [gi:7582271]
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4
[SID24786790]
Potency 1.4125qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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5
[SID24786790]
Potency 2.8184qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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6
[SID24786790]
Potency 2.8184qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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7
[SID24786790]
Potency 2.8184qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]RAB9A gene product [Homo sapiens] [gi:4759012]
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8
[SID24786790]
Potency 3.1623qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]NPC1 gene product [Homo sapiens] [gi:255652944]
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9
[SID24786790]
Potency 3.1623qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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10
[SID24786790]
IC50 3.928Dose Response confirmation of HTS hits from an HePTP Fluorescent Assay using OMFP substrate - Set 2 [AID435032, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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11
[SID24786790]
IC50 3.928Dose Response confirmation of HTS hits from an HePTP Fluorescent Assay using OMFP substrate - Set 2 [AID435032, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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12
[SID24786790]
IC50 3.928Dose Response confirmation of HTS hits from an HePTP Fluorescent Assay using OMFP substrate - Set 2 [AID435032, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
View
13
[SID24786790]
IC50 4.683Dose Response confirmation of uHTS hits from a small molecule inhibitors of LYP via a fluorescence intensity assay - Set 2 [AID435024, Type: confirmatory]PTPN22 gene product [Homo sapiens] [gi:224586929]
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14
[SID24786790]
IC50 4.683Dose Response confirmation of uHTS hits from a small molecule inhibitors of LYP via a fluorescence intensity assay - Set 2 [AID435024, Type: confirmatory]PTPN22 gene product [Homo sapiens] [gi:224586929]
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15
[SID24786790]
IC50 4.683Dose Response confirmation of uHTS hits from a small molecule inhibitors of LYP via a fluorescence intensity assay - Set 2 [AID435024, Type: confirmatory]PTPN22 gene product [Homo sapiens] [gi:224586929]
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16
[SID24786790]
IC50 4.82917LYP1 Fluorescent Assay using OMFP substrate for In Vitro dose response studies. [AID2126, Type: confirmatory]PTPN22 gene product [Homo sapiens] [gi:224586929]
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17
[SID24786790]
IC50 4.82917LYP1 Fluorescent Assay using OMFP substrate for In Vitro dose response studies. [AID2126, Type: confirmatory]PTPN22 gene product [Homo sapiens] [gi:224586929]
View
18
[SID24786790]
IC50 4.82917LYP1 Fluorescent Assay using OMFP substrate for In Vitro dose response studies. [AID2126, Type: confirmatory]PTPN22 gene product [Homo sapiens] [gi:224586929]
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19
[SID24786790]
Potency 5.0119qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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20
[SID24786790]
Potency 5.0119qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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21
[SID24786790]
IC50 5.119HTS HePTP Fluorescent Assay using OMFP substrate for In Vitro dose response studies [AID2134, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
View
22
[SID24786790]
IC50 5.119HTS HePTP Fluorescent Assay using OMFP substrate for In Vitro dose response studies [AID2134, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
View
23
[SID24786790]
IC50 5.119HTS HePTP Fluorescent Assay using OMFP substrate for In Vitro dose response studies [AID2134, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
View
24
[SID24786790]
IC50 6.628Dose Response confirmation of uHTS hits from a small molecule inhibitors of LYP via a fluorescence intensity assay using pCAP substrate [AID435027, Type: confirmatory]PTPN22 gene product [Homo sapiens] [gi:224586929]
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25
[SID24786790]
IC50 6.628Dose Response confirmation of uHTS hits from a small molecule inhibitors of LYP via a fluorescence intensity assay using pCAP substrate [AID435027, Type: confirmatory]PTPN22 gene product [Homo sapiens] [gi:224586929]
View
26
[SID24786790]
IC50 6.628Dose Response confirmation of uHTS hits from a small molecule inhibitors of LYP via a fluorescence intensity assay using pCAP substrate [AID435027, Type: confirmatory]PTPN22 gene product [Homo sapiens] [gi:224586929]
View
27
[SID24786790]
IC50 7.29uHTS fluorescence assay for the identification of Human Immunodeficiency Virus Fusion Inhibitors. [AID1986, Type: confirmatory]envelope glycoprotein [Human immunodeficiency virus 1] [gi:45357394]
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28
[SID24786790]
IC50 8.70755uHTS identification of small molecule inhibitors of LYP via a fluorescence intensity assay [AID1779, Type: confirmatory]PTPN22 gene product [Homo sapiens] [gi:224586929]
View
29
[SID24786790]
IC50 8.70755uHTS identification of small molecule inhibitors of LYP via a fluorescence intensity assay [AID1779, Type: confirmatory]PTPN22 gene product [Homo sapiens] [gi:224586929]
View
30
[SID24786790]
IC50 8.70755uHTS identification of small molecule inhibitors of LYP via a fluorescence intensity assay [AID1779, Type: confirmatory]PTPN22 gene product [Homo sapiens] [gi:224586929]
View
31
[SID24786790]
Potency 8.9125qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
View
32
[SID24786790]
Potency 8.9125qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
View
33
[SID24786790]
IC50 11.1Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay [AID2073, Type: confirmatory]Mint1 [Rattus norvegicus] [gi:2625023]
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34
[SID24786790]
Potency 11.5701qHTS for inhibitors of Phosphogylcerate Kinase: Hit Validation Screen [AID686980, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei] [gi:115503961]
View
35
[SID24786790]
Potency 12.5893qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase [AID602233, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei] [gi:115503961]
View
36
[SID24786790]
Potency 12.5893qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
View
37
[SID24786790]
Potency 12.5893qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
View
38
[SID24786790]
IC50 14.81Dose Response Confirmation for Small Molecule Inhibitors of Epstein-Barr Virus [AID1419, Type: confirmatory]BZLF2 [Human herpesvirus 4 type 2] [gi:139424501]
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39
[SID24786790]
Potency 15.8489Confirmation Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID489007, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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40
[SID24786790]
Potency 15.8489qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein [Homo sapiens] [gi:4557365]
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41
[SID24786790]
Potency 17.7828qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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42
[SID24786790]
Potency 17.7828qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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43
[SID24786790]
Potency 22.3872qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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44
[SID24786790]
Potency 25.1189qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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45
[SID24786790]
Potency 31.6228qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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46
[SID24786790]
Potency 31.6228qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
View
47
[SID24786790]
Potency 32.3857qHTS Confirmation Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2585, Type: confirmatory]Bloom syndrome protein [Homo sapiens] [gi:4557365]
View
48
[SID24786790]
Potency 44.6684qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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49
[SID24786790]
IC50 49.1uHTS Homogeneous Terbium Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay [AID2091, Type: confirmatory]Mint1 [Rattus norvegicus] [gi:2625023]
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50
[SID24786790]
Potency 50.1187qHTS for Inhibitors of WRN Helicase [AID651768, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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