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SMR000273648 (CID 9595032) - Compound BioActivity Data
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BioActivity Outcomes:
Active(87)
 
 
Inactive(467)
 
 
Inconclusive(27)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(20)
 
 
PTPc(20)
 
 
 
7TM GPCR Srsx(17)
 
 
Tryp SPc(8)
 
 
G-alpha(8)
 
 
 
BioAssay Types:
Screening(342)
 
 
 
 
Confirmatory(220)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(145)
 
 
 
 
 
IC50(63)
 
 
 
EC50(7)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 519    Data Row: 582   Total Pages: 30   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85176749]
IC50_Mean 0.113SAR LYP1 Fluorescent Assay using pCAP substrate for In Vitro dose response studies [AID2135, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 22 isoform 1 [Homo sapiens] [gi:224586929]
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2
[SID85176749]
IC50_Mean 0.193SAR analysis of compounds that inhibit HePTP - Set 2 [AID449736, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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3
[SID99380902]
IC50_Mean 0.195SAR analysis of compounds that inhibit HePTP - Set 3 [AID488889, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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4
[SID85176749]
IC50_Mean 0.249SAR LYP1 Fluorescent Assay using pCAP substrate for In Vitro dose response studies - Set 2 [AID2682, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 22 isoform 1 [Homo sapiens] [gi:224586929]
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5
[SID99380902]
IC50_Mean 0.325SAR Selectivity Analysis of small molecule inhibitors of PEST using pCAP in a fluorescence assay [AID488884, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 12 isoform 2 [Homo sapiens] [gi:196114967]
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6
[SID85176749]
IC50_Mean 0.334SAR Selectivity Analysis of small molecule inhibitors of PEST using pCAP in a fluorescence assay [AID488884, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 12 isoform 2 [Homo sapiens] [gi:196114967]
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7
[SID85176749]
IC50_Mean 0.369SAR LYP1 Fluorescent Assay using pCAP substrate for In Vitro dose response studies - Set 3 [AID449727, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 22 isoform 1 [Homo sapiens] [gi:224586929]
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8
[SID99380902]
IC50_Mean 0.527SAR LYP1 Fluorescent Assay using pCAP substrate for In Vitro dose response studies - Set 4 [AID488871, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 22 isoform 1 [Homo sapiens] [gi:224586929]
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9
[SID85176749]
IC50_Mean 0.626SAR LYP1 Fluorescent Assay using OMFP substrate for In Vitro dose response studies - Set 3 [AID449726, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 22 isoform 1 [Homo sapiens] [gi:224586929]
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10
[SID24822520]
Potency 0.8568qHTS for Inhibitors of WRN Helicase: BLM Helicase Counterscreen for WRN Inhibitors [AID720503, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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11
[SID24822520]
IC50 0.88638Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors [AID1417, Type: confirmatory]Mcl-1 [Homo sapiens] [gi:7582271]
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12
[SID85176749]
IC50_Mean 0.924Fluorescent secondary assay for dose-response confirmation of chemical inhibitors of HePTP [AID1077, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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13
[SID24822520]
IC50 1.24Dose Response confirmation of HTS hits from an HePTP Fluorescent Assay using OMFP substrate - Set 2 [AID435032, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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14
[SID85176749]
IC50_Mean 1.24SAR LYP1 Fluorescent Assay using OMFP substrate for In Vitro dose response studies - Set 2 [AID2686, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 22 isoform 1 [Homo sapiens] [gi:224586929]
View
15
[SID24822520]
IC50_1 1.24Dose Response confirmation of uHTS hits from a small molecule inhibitors of LYP via a fluorescence intensity assay - Set 2 [AID435024, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 22 isoform 1 [Homo sapiens] [gi:224586929]
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16
[SID24822520]
IC50_1 1.24Dose Response confirmation of uHTS hits from a small molecule inhibitors of LYP via a fluorescence intensity assay using pCAP substrate [AID435027, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 22 isoform 1 [Homo sapiens] [gi:224586929]
View
17
[SID24822520]
IC50 1.3Fluorescent assay for identification of compounds that inhibit VHR1 [AID1878, Type: confirmatory]dual specificity protein phosphatase 3 [Homo sapiens] [gi:4758208]
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18
[SID24822520]
Absolute IC50 1.43Dose Response Confirmation for Mcl-1/Bid Interaction Inhibitors [AID1418, Type: confirmatory]Mcl-1 [Homo sapiens] [gi:7582271]
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19
[SID99380902]
IC50_Mean 1.47SAR LYP1 Fluorescent Assay using OMFP substrate for In Vitro dose response studies - Set 4 [AID488869, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 22 isoform 1 [Homo sapiens] [gi:224586929]
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20
[SID24822520]
Potency 1.6944Tb PFK orthogonal confirmatory assay using ATP depletion (Kinase-Glo Plus) as an alternative measure of Tb PFK activity: Hit Validation [AID504636, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:72386991]
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