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N-(4-Fluoro-benzylidene)-N'-(6-methoxy-2-methyl-quinolin-4-yl)-hydrazine (CID 9594974) - Compound BioActivity Data
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BioActivity Outcomes:
Active(97)
 
 
Inactive(478)
 
 
Inconclusive(24)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(34)
 
 
 
STKc MAP4K3 l..(6)
 
 
 
UBCc(6)
 
 
 
TRP 2(5)
 
 
Esterase lipa..(5)
 
 
BioAssay Types:
Screening(391)
 
 
 
 
Confirmatory(192)
 
 
 
 
 
Literature(11)
 
 
 
BioActivity Types:
Potency(121)
 
 
 
 
 
IC50(40)
 
 
 
 
EC50(18)
 
 
 
 
AC50(8)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 547    Data Row: 600   Total Pages: 30   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID47204727]
EC50_uM 0.317Fluorescence Cell-Based Dose Response to Characterize Compounds Cytotoxic to RAS-Dependent BJ-TERT-LT-ST Fibroblast [AID2631, Type: confirmatory]
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2
[SID47204727]
EC50 0.37742Luminescence-based cell-based high throughput dose response assay for activators of the Aryl Hydrocarbon Receptor (AHR) [AID463088, Type: confirmatory]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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3
[SID47204727]
CC50 0.57A Cell Based Secondary Assay to Explore Cytotoxicity in Vero E6 Cells of Compounds that Modulate Non-Replicating, Drug-tolerant Mycobacterium tuberculosis [AID492998, Type: confirmatory]
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4
[SID47204727]
Potency 0.92qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID47204727]
Potency 1.0323qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID47204727]
Potency 1.1554qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation. [AID588397, Type: confirmatory]
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7
[SID47204727]
CC50 1.661A Cell Based Secondary Assay to Explore Cytotoxicity in THP-1 Cells of Compounds that Modulate Non-Replicating, Drug-tolerant Mycobacterium tuberculosis [AID489025, Type: confirmatory]
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8
[SID47204727]
IC50_Mean 2.08Dose Response selectivity of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a 697B cell line using a luminescence assay [AID489033, Type: confirmatory]
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9
[SID47204727]
IC50 2.129Counterscreen for inhibitors of TLR9-MyD88 binding: fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA) [AID588341, Type: confirmatory]Beta lactamase [Pseudomonas aeruginosa] [gi:114881106]
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10
[SID47204727]
Potency 2.3281qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation in HepG2 cytotox [AID588382, Type: confirmatory]
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11
[SID47204727]
IC50_Mean 2.35Dose response confirmation of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a Jurkat cell line using a luminescence assay [AID489035, Type: confirmatory]
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12
[SID47204727]
AC50_uM 2.65CEM21 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7013-03_Inhibitor_Dose_CherryPick_Activity [AID652042, Type: confirmatory]
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13
[SID47204727]
Potency 2.9093qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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14
[SID47204727]
IC50 3.12A Cell Based Secondary Assay to Explore Compounds that Modulate Non-Replicating, Drug-tolerant Compounds in Replicating H37Rv TB of Mycobacterium tuberculosis [AID492952, Type: confirmatory]
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15
[SID47204727]
Potency 3.9811qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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16
[SID47204727]
Potency 3.9811qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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17
[SID47204727]
Potency 4.6109qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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18
[SID47204727]
EC50 4.921Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to DRD Non-Viral Oncogenic Fibroblast [AID1934, Type: confirmatory]
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19
[SID47204727]
Potency 5.0119qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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20
[SID47204727]
Potency 5.0119VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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