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MLS000563358 (CID 9594345) - Compound BioActivity Data
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BioActivity Outcomes:
Active(31)
 
 
Inactive(690)
 
 
Inconclusive(14)
 
 
Unspecified(3)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
7TM GPCR Srsx(19)
 
 
 
alkPPc(12)
 
 
Bcl-2 like(11)
 
 
G-alpha(8)
 
 
 
BioAssay Types:
Screening(506)
 
 
 
 
 
Confirmatory(214)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(149)
 
 
 
 
 
IC50(42)
 
 
 
EC50(13)
 
 
 
AC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 678    Data Row: 738   Total Pages: 15   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17407957]
Potency 0.3162qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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2
[SID17407957]
EC50_MICROM 1.479Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically CIT2 based on MLPCN hits [AID2744, Type: confirmatory]citrate synthase 2, partial [Saccharomyces cerevisiae] [gi:171229]
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3
[SID17407957]
AC50_uM 3.591HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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4
[SID17407957]
EC50_MICROM 4.476Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits [AID2745, Type: confirmatory]LAP4 [Saccharomyces cerevisiae] [gi:486173]
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5
[SID17407957]
AC50_uM 6.39Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity [AID540268, Type: confirmatory]HSP90 [Plasmodium falciparum 3D7] [gi:124809506]
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6
[SID17407957]
Potency 12.5893qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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7
[SID17407957]
EC50_MICROM 12.94Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically RPL19A based on MLPCN hits [AID2740, Type: confirmatory]RPL19A [Saccharomyces cerevisiae] [gi:536029]
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8
[SID17407957]
Potency 17.7828qHTS Assay for Inhibitors of the HIV-1 protein Vpr [AID651644, Type: confirmatory]Vpr [Human immunodeficiency virus 1] [gi:28872817]
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9
[SID17407957]
A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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10
[SID17407957]
A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
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11
[SID17407957]
Primary cell-based high-throughput screening for identification of compounds that antagonize MrgX1 receptor signaling [AID588676, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
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12
[SID17407957]
Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically CIT2 Second Cherry Pick Compounds [AID2624, Type: screening]citrate synthase 2, partial [Saccharomyces cerevisiae] [gi:171229]
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13
[SID17407957]
Single concentration confirmation of uHTS for the identification of inhibitors of NALP1 in yeast using a luminescent assay [AID488841, Type: screening]NACHT, LRR and PYD domains-containing protein 1 isoform 1 [Homo sapiens] [gi:14719829]
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14
[SID17407957]
Single concentration confirmation of inhibitors of NALP1 in yeast using a Caspase-1-ASC counter screen. [AID488857, Type: screening]caspase-1 isoform alpha precursor [Homo sapiens] [gi:15431328]
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15
[SID17407957]
CYP2C19 Assay [AID778, Type: screening]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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16
[SID17407957]
Beta-Arrestin HTS for Positive Allosteric Modulators of the Human D2 Dopamine Receptor: Antagonists [AID624463, Type: other]D(2) dopamine receptor isoform long [Homo sapiens] [gi:4503385]
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17
[SID17407957]
Beta-Arrestin HTS for Positive Allosteric Modulators of the Human D2 Dopamine Receptor: Potentiators [AID624464, Type: other]D(2) dopamine receptor isoform long [Homo sapiens] [gi:4503385]
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18
[SID17407957]
Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of human platelet activating factor acetylhydrolase 2 (PAFAH2) [AID493030, Type: screening]platelet-activating factor acetylhydrolase 2, cytoplasmic [Homo sapiens] [gi:4758878]
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19
[SID17407957]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of human platelet activating factor acetylhydrolase 2 (PAFAH2) [AID492956, Type: screening]platelet-activating factor acetylhydrolase 2, cytoplasmic [Homo sapiens] [gi:4758878]
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20
[SID17407957]
Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ LAP4_MLPCN. [AID2023, Type: screening]LAP4 [Saccharomyces cerevisiae] [gi:486173]
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21
[SID17407957]
Screening for Modulators of Post-Golgi Transport, Control Strain [AID738, Type: screening]
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22
[SID17407957]
Screen for Chemicals that Shorten Yeast Lifespan, Dose response [AID849, Type: confirmatory]
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23
[SID17407957]
Screen for Chemicals that Shorten Yeast Lifespan, Dose Response Permissive Growth Control [AID850, Type: confirmatory]
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24
[SID17407957]
Screen for Chemicals that Shorten Yeast Lifespan [AID804, Type: screening]
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25
[SID17407957]
Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically MEP2 Second Cherry Pick Compounds [AID2622, Type: screening]MEP2 [Saccharomyces cerevisiae] [gi:1302091]
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26
[SID17407957]
Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 Second Cherry Pick Compounds [AID2621, Type: screening]LAP4 [Saccharomyces cerevisiae] [gi:486173]
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27
[SID17407957]
Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID504621, Type: screening]HSP90 [Plasmodium falciparum 3D7] [gi:124809506]
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28
[SID17407957]
uHTS identification of small molecule inhibitors of tim10-1 yeast via a luminescent assay [AID463190, Type: screening]TPA: Tim10p [Saccharomyces cerevisiae S288c] [gi:285809906]
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29
[SID17407957]
Single concentration confirmation of small molecule inhibitors of tim10-1 yeast via a luminescent assay [AID463213, Type: screening]TPA: Tim10p [Saccharomyces cerevisiae S288c] [gi:285809906]
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30
[SID17407957]
Single concentration confirmation of small molecule inhibitors of tim10 yeast via a luminescent assay [AID463215, Type: screening]TPA: Tim10p [Saccharomyces cerevisiae S288c] [gi:285809906]
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31
[SID17407957]
uHTS identification of small molecule inhibitors of tim10 yeast via a luminescent assay [AID463195, Type: screening]TPA: Tim10p [Saccharomyces cerevisiae S288c] [gi:285809906]
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32
[SID17407957]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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33
[SID17407957]
Potency Activators of T cell receptors: qHTS campaign [AID504894, Type: confirmatory]T cell receptor [Homo sapiens] [gi:553160]
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34
[SID17407957]
Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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35
[SID17407957]
Potency 1.122qHTS of alpha-syn Inhibitors [AID652106, Type: confirmatory]Alpha-synuclein [gi:586067]
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36
[SID17407957]
Potency 1.7783qHTS Assay for Inhibitors of Influenza NS1 Protein Function [AID2326, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/WSN/1933(H1N1))] [gi:194352380]
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37
[SID17407957]
Potency 14.7157Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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38
[SID17407957]
Potency 31.6228qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium [AID1457, Type: confirmatory]Inositol monophosphatase 1 [gi:44888968]
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39
[SID17407957]
Potency 35.4813qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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40
[SID17407957]
Potency 89.1251qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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41
[SID17407957]
Potency 89.1251HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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42
[SID17407957]
Potency qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter [AID463254, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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43
[SID17407957]
Identification and characterization of compounds for addressing human bone marrow failure [AID817, Type: other]unnamed protein product [Saccharomyces cerevisiae] [gi:1360328]
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44
[SID17407957]
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-W. [AID952, Type: screening]Bcl-w [Homo sapiens] [gi:1572493]
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45
[SID17407957]
Primary cell-based high-throughput screening for identification of compounds that activate MrgX1 receptor signaling [AID588627, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
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46
[SID17407957]
Primary cell-based high-throughput screening for identification of compounds that allosterically activate MrgX1 receptor signaling [AID588675, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
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47
[SID17407957]
Potency qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1469, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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48
[SID17407957]
Potency Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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49
[SID17407957]
Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of TLR9-MyD88 binding. [AID504734, Type: screening]toll-like receptor 9 [Homo sapiens] [gi:194068499]
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50
[SID17407957]
uHTS identification of small molecule inhibitors of tim23-1 yeast via a luminescent assay [AID463212, Type: screening]TPA: Tim23p [Saccharomyces cerevisiae S288c] [gi:285814664]
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