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SMR000116777 (CID 9593837) - Compound BioActivity Data
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BioActivity Outcomes:
Active(44)
 
 
Inactive(676)
 
 
Inconclusive(32)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
7TM GPCR Srsx(16)
 
 
 
Bcl-2 like(11)
 
 
alkPPc(10)
 
 
G-alpha(8)
 
 
 
BioAssay Types:
Screening(515)
 
 
 
 
 
Confirmatory(224)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(158)
 
 
 
 
 
IC50(39)
 
 
 
EC50(13)
 
 
 
AC50(7)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 692    Data Row: 754   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID14724794]
EC50 0.202Luminescence Cell-Based/Microorganism Dose Confirmation HTS to Identify Inhibitors of T.Cruzi Replication. [AID2044, Type: confirmatory]
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2
[SID14724794]
EC50 0.241Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity [AID1902, Type: confirmatory]streptokinase A [Streptococcus pyogenes M1 GAS] [gi:15675770]
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3
[SID14724794]
EC50 0.442Luminescence Microorganism-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to SK(-)GAS Group A Streptococcus [AID1900, Type: confirmatory]
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4
[SID85304848]
Potency 1.2995qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID14724794]
Potency 1.4125VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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6
[SID14724794]
Potency 1.5849qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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7
[SID85304848]
Potency 1.636qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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8
[SID14724794]
Potency 1.6511Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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9
[SID14724794]
EC50 2.384Luminescence Cell-Based Dose Response HTS Screen to Identify Cytotoxic Compounds of NIH3T3 cells. [AID2010, Type: confirmatory]
View
10
[SID85304848]
Potency 2.8184qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
View
11
[SID85304848]
Potency 2.9093Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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12
[SID85304848]
Potency 3.1623qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
View
13
[SID85304848]
Potency 3.5481qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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14
[SID85304848]
Potency 5.1714qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
View
15
[SID85304848]
Potency 5.8048Nrf2 qHTS screen for inhibitors: Nrf2 A549 ARE-Fluc Confirmation Assay for Hit Validation [AID720524, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
View
16
[SID14724794]
AC50_uM 8.411Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
View
17
[SID14724794]
EC50 8.451Luminescence Microorganism-Based Dose Response HTS to Identify Compounds Cytotoxic to Streptococcus [AID1915, Type: confirmatory]
View
18
[SID85304848]
Potency 17.7828qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
View
19
[SID14724794]
AC50_uM 21.418Viability counterscreen of potential LMP-1 inhibitors in HEK293 cell background Measured in Cell-Based System Using Plate Reader - 2122-02_Inhibitor_Dose_CherryPick_Activity [AID504861, Type: confirmatory]LMP1 [Human herpesvirus 4] [gi:23893668]
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20
[SID14724794]
AC50_uM 22.27Inhibitors of Epstein-Barr LMP1 inducible NF-kappaB luciferase reporter Measured in Cell-Based System Using Plate Reader - 2122-01_Inhibitor_Dose_CherryPick_Activity [AID588343, Type: confirmatory]
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21
[SID14724794]
AC50_uM 32.34TES1 - eGFP vs TES2 -dsRED Pathway Differentiation Measured in Cell-Based System Using Imaging - 2122-04_Inhibitor_Dose_CherryPick_Activity [AID588398, Type: confirmatory]LMP1 [Human herpesvirus 4] [gi:23893668]
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22
[SID14724794]
AC50_uM 43.78ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
View
23
[SID85304848]
Potency 50.1187qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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24
[SID14724794]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
View
25
[SID14724794]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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26
[SID14724794]
MLPCN Streptokinase Expression Inhibition [AID1662, Type: screening]streptokinase A [Streptococcus pyogenes M1 GAS] [gi:15675770]
View
27
[SID85304848]
Single concentration confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay [AID602428, Type: screening]Gli1 [Mus musculus] [gi:6009644]
View
28
[SID85304848]
uHTS identification of Gli-Sufu Antagonists in a luminescence reporter assay [AID588413, Type: screening]Gli1 [Mus musculus] [gi:6009644]
View
29
[SID14724794]
HTS using DiI-HDL to assay lipid transfer in ldlA[SR-BI] cells Measured in Cell-Based System Using Plate Reader - 2085-01_Inhibitor_SinglePoint_HTS_Activity [AID488896, Type: screening]scavenger receptor class B member 1 isoform 1 [Mus musculus] [gi:14389423]
View
30
[SID14724794]
Inhibitors of Epstein-Barr LMP1 inducible NF-kappaB luciferase reporter Measured in Cell-Based System Using Plate Reader - 2122-01_Inhibitor_SinglePoint_HTS_Activity [AID504558, Type: screening]LMP1 [Human herpesvirus 4] [gi:23893668]
View
31
[SID14724794]
Luminescence Cell-Based Primary HTS to Identify Transcriptional Activators of Hypoxia-Inducible Factor Pathway [AID1910, Type: screening]
View
32
[SID14724794]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Cancer Stem Cells [AID2717, Type: screening]
View
33
[SID14724794]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis. [AID435005, Type: screening]
View
34
[SID14724794]
Human H69AR Lung Tumor Cell Growth Inhibition Assay - 86K Screen [AID598, Type: screening]
View
35
[SID14724794]
Human Endothelial Cell Proliferation Assay in 384-well format [AID648, Type: screening]
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36
[SID14724794]
Primary HTS assay for chemical inhibitors of TNF alpha stimulated VCAM1 expression [AID802, Type: screening]
View
37
[SID14724794]
MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - inhibitors [AID1813, Type: screening]
View
38
[SID14724794]
Human Lung Fibroblast Proliferation Assay [AID719, Type: screening]
View
39
[SID14724794]
Luminescence Cell-Based/Microorganism Primary HTS to Identify Inhibitors of T.Cruzi Replication [AID1885, Type: screening]
View
40
[SID14724794]
Leishmania major promastigote HTS [AID1063, Type: screening]
View
41
[SID14724794]
Chemical Genetic Screen to Identify Inhibitors of Mitochondrial Fusion - Primary Screen [AID1362, Type: screening]
View
42
[SID14724794]
ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_SinglePoint_HTS_Activity [AID623870, Type: screening]aryl hydrocarbon receptor nuclear translocator [Homo sapiens] [gi:2702319]
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43
[SID14724794]
ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_SinglePoint_HTS_Activity [AID623870, Type: screening]transforming acidic coiled-coil-containing protein 3 [Homo sapiens] [gi:5454102]
View
44
[SID85304848]
Single concentration confirmation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay [AID651995, Type: screening]Gli1 [Mus musculus] [gi:6009644]
View
45
[SID14724794]
Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
View
46
[SID85304848]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
View
47
[SID85304848]
Potency 0.7519qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Primary Screen [AID720542, Type: confirmatory]apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7] [gi:23496270]
View
48
[SID85304848]
Potency 1.7783qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy [AID624291, Type: confirmatory]Glycoprotein hormones alpha chain [gi:121312]
View
49
[SID14724794]
Potency 2.8184qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
View
50
[SID14724794]
Potency 3.1623qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]Niemann-Pick C1 protein precursor [Homo sapiens] [gi:255652944]
View