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STK323534 (CID 9586790) - Compound BioActivity Data
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BioActivity Outcomes:
Active(84)
 
 
Inactive(482)
 
 
Inconclusive(22)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
7TM GPCR Srsx(15)
 
 
 
 
Firefly Luc l..(10)
 
 
 
Peptidase C48(8)
 
 
 
Alpha TIF(6)
 
 
 
BioAssay Types:
Screening(388)
 
 
 
Confirmatory(188)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(130)
 
 
 
 
 
IC50(37)
 
 
 
EC50(9)
 
 
 
AC50(8)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 544    Data Row: 589   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID47204086]
Potency 0.0046FLuc inhibitory activity for the follow-up compounds in a biochemical assay with Km concentrations of substrate and 500microM CoASH [AID602358, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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2
[SID47204086]
Potency 0.0046FLuc inhibitory activity for the follow-up compounds in a biochemical assay with 1mM ATP [AID602364, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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3
[SID47204086]
Potency 0.0146FLuc inhibitory activity for the follow-up compounds in a biochemical assay with Km concentrations of substrate [AID602357, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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4
[SID47204086]
Potency 0.019qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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5
[SID47204086]
Potency 0.0252FLuc inhibitory activity for the follow-up compounds in a biochemical assay with a commercial detection reagent - BriteliteTM Plus (PerkinElmer) [AID602474, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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6
[SID47204086]
Potency 0.0318FLuc inhibitory activity for the follow-up compounds in a cell-based assay to assess the activity of miR-21 [AID602477, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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7
[SID47204086]
Potency 0.0619FLuc inhibitory activity for the follow-up compounds in a biochemical assay with an in-house formulation of detection reagent [AID602475, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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8
[SID47204086]
Potency 0.0919FLuc inhibitory activity for the follow-up compounds in a biochemical assay with 1mM D-luciferin [AID602365, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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9
[SID47204086]
Potency 0.7079qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]ras-related protein Rab-9A [Homo sapiens] [gi:4759012]
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10
[SID47204086]
Potency 0.7079qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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11
[SID47204086]
EC50 0.782Luminescence Biochemical Dose Response HTS to Identify Inhibitors of Luciferase [AID1891, Type: confirmatory]
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12
[SID47204086]
IC50_Mean 0.86Dose Response selectivity of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a 697B cell line using a luminescence assay [AID489033, Type: confirmatory]
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13
[SID47204086]
IC50_Mean 1.11Dose response confirmation of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a Jurkat cell line using a luminescence assay [AID489035, Type: confirmatory]
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14
[SID49728452]
Potency 1.122qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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15
[SID47204086]
EC50 1.203Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Platelet Dense Granule Release [AID1889, Type: confirmatory]
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16
[SID47204086]
Potency 1.2648FLuc inhibitory activity for the follow-up compounds in a cell-based translational read-through assay (72 hour incubation) [AID602478, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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17
[SID47204086]
IC50_Mean 2.61Dose response counterscreen of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a HEK-293T cell line using a luminescence assay [AID489041, Type: confirmatory]
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18
[SID47204086]
IC50 2.803Luminescence-based dose response cell-based high throughput screening assay for inhibitors of kruppel-like factor 5 (KLF5). [AID1973, Type: confirmatory]Kruppel-like factor 5 [Homo sapiens] [gi:124263658]
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19
[SID47204086]
Potency 2.8184VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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20
[SID49728452]
AC50_uM 3.44HIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_Dose_CherryPick_Activity [AID652057, Type: confirmatory]
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21
[SID49728452]
AC50_uM 6.87HIV-1 Cell Fusion assay for clade B Env AD8 Measured in Cell-Based System Using Plate Reader - 7013-04_Inhibitor_Dose_CherryPick_Activity [AID652062, Type: confirmatory]
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22
[SID49728452]
AC50_uM 9.61Control Cell Fusion Counterscreen Assay Measured in Cell-Based System Using Plate Reader - 7013-02_Inhibitor_Dose_CherryPick_Activity [AID652040, Type: confirmatory]
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23
[SID49728452]
Potency 12.5893qHTS Assay for Inhibitors of the HIV-1 protein Vpr [AID651644, Type: confirmatory]Vpr [Human immunodeficiency virus 1] [gi:28872817]
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24
[SID47204086]
Potency 14.1254qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase [AID1634, Type: confirmatory]pyruvate kinase PKM isoform a [Homo sapiens] [gi:33286418]
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25
[SID49728452]
Potency 14.1254qHTS of Trypanosoma Brucei Inhibitors [AID624173, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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26
[SID49728452]
Potency 15.8489qHTS of Trypanosoma Brucei Inhibitors: Confirmatory Assay for Cherry-picked Compounds [AID720569, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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27
[SID49728452]
Potency 16.3601qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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28
[SID49728452]
AC50_uM 17.34CEM21 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7013-03_Inhibitor_Dose_CherryPick_Activity [AID652042, Type: confirmatory]
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29
[SID49728452]
Potency 18.3374qHTS for inhibitors of Phosphogylcerate Kinase: Hit Validation Screen [AID686980, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei] [gi:115503961]
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30
[SID49728452]
AC50_uM 21.392Development of CDK5 inhibitors Measured in Biochemical System Using Plate Reader - 2083-01_Inhibitor_Dose_CherryPick_Activity_Set2 [AID504545, Type: confirmatory]CDK5 [Homo sapiens] [gi:48146199]
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31
[SID49728452]
AC50_uM 21.392Development of CDK5 inhibitors Measured in Biochemical System Using Plate Reader - 2083-01_Inhibitor_Dose_CherryPick_Activity_Set2 [AID504545, Type: confirmatory]Cyclin-dependent kinase 5, regulatory subunit 1 (p35) [Homo sapiens] [gi:20072248]
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32
[SID49728452]
AC50_uM 21.84Cell fusion assay for clade C HIV-1ZM109 Env Measured in Cell-Based System Using Plate Reader - 7013-05_Inhibitor_Dose_CherryPick_Activity [AID652058, Type: confirmatory]
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33
[SID47204086]
EC50_uM 26.22Luminescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of Glycogen Synthase Kinase-3 beta Activity [AID434954, Type: confirmatory]glycogen synthase kinase-3 beta isoform 1 [Homo sapiens] [gi:21361340]
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34
[SID47204086]
EC50_uM 26.57Luminescence Cell-Free Homogeneous Counter Screen to Identify Inhibitors of ADP-glo Reagents [AID434947, Type: confirmatory]
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35
[SID47204086]
EC50_uM 32.16Luminescence Cell-Free Homogenous Dose Retest to Identify Inhibitors of Serine/Threonine Kinase 33 Activity [AID2821, Type: confirmatory]serine/threonine-protein kinase 33 isoform a [Homo sapiens] [gi:23943882]
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36
[SID49728452]
AC50_uM 92.892Development of CDK5 inhibitors, reagent counter screen Measured in Cell-Based System Using Plate Reader - 2083-03_Inhibitor_Dose_CherryPick_Activity_Set2 [AID504546, Type: confirmatory]
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37
[SID49728452]
Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_Dose_CherryPick_Activity_Set2 [AID504539, Type: confirmatory]
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38
[SID49728452]
Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_SinglePoint_HTS_Activity [AID488862, Type: screening]
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39
[SID47204086]
uHTS luminescence assay for the identification of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435003, Type: screening]
View
40
[SID47204086]
Single concentration confirmation of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435020, Type: screening]
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41
[SID49728452]
HIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_SinglePoint_HTS_Activity [AID651610, Type: screening]
View
42
[SID49728452]
Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_SinglePoint_HTS_Activity [AID651661, Type: screening]
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43
[SID49728452]
7011-01_Antagonist_SinglePoint_HTS_Activity [AID720647, Type: screening]
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44
[SID47204086]
MLPCN Platelet Activation -Dense Granule Release [AID1663, Type: screening]
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45
[SID47204086]
MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - inhibitors [AID1813, Type: screening]
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46
[SID47204086]
Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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47
[SID47204086]
Luminescence-based counterscreen assay for HSP90 inhibitors: biochemical high throughput screening assay to identify inhibitors of native luciferase. [AID1847, Type: screening]
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48
[SID49728452]
uHTS determination of small molecule cytotoxicity in a fluorescence assay to identify cystic fibrosis induced NFkb Inhibitors [AID602141, Type: screening]
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49
[SID49728452]
Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_SinglePoint_CherryPick_Activity [AID504592, Type: confirmatory]
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50
[SID173334176]
Confirmed inhibitors of Serine Threonine Kinase 33, STK33 [AID743321, Type: other]serine/threonine-protein kinase 33 isoform a [Homo sapiens] [gi:23943882]
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