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BioActivity Data for Compound naloxonazine (CID 9576413)

BioActivity Outcomes:
Active(5)
 
 
Inactive(4)
 
 
Unspecified(130)
 
 
Top Targets:
7tm 4(31)
 
 
 
p450(8)
 
 
prostaglandin..(2)
 
 
Tryp SPc(2)
 
 
STKc ERK1 2 l..(2)
 
 
BioAssay Types:
Confirmatory(116)
 
 
 
Literature(3)
 
 
 
BioAssay Categories:
In vitro(132)
 
 
 
Biochemical(132)
 
 
 
Toxicity(1)
 
 
ADME(1)
 
 
Cell-based(84)
 
 
 
BioActivity Types:
IC50(116)
 
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 139    Data Row: 139   Total Pages: 7   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID124960987]
IC50 0.0072DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625163, Type: confirmatory]Mu-type opioid receptor [gi:2851402]
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2
[SID124960987]
IC50 0.085DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625162, Type: confirmatory]Kappa-type opioid receptor [gi:116242691]
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3
[SID124960987]
IC50 0.136DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) [AID625161, Type: confirmatory]Delta-type opioid receptor [gi:311033488]
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4
[SID124960987]
EC50 16Cytotoxicity against BESM cells after 88 hrs by HTS assay [AID547621, Type: Literature]
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5
[SID124960987]
EC50 17Antitrypanosomal activity against Trypanosoma cruzi amastigotes infected in BESM cells measured after 88 hrs postinfection by HTS assay [AID547622, Type: Literature]
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6
[SID124960987]
IC50 DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP) [AID625167, Type: confirmatory]cGMP-specific 3',5'-cyclic phosphodiesterase [gi:317373261]
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7
[SID124960987]
IC50 DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: confirmatory]Prostaglandin G/H synthase 1 [gi:317373262]
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8
[SID124960987]
DRUGMATRIX: Protein Serine/Threonine Kinase PKCalpha enzyme inhibition (substrate: Histone) [AID625179, Type: other]Protein kinase C alpha type [gi:317373571]
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9
[SID124960987]
IC50 DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH) [AID625147, Type: confirmatory]Melanocortin receptor 3 [gi:395398606]
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10
[SID124960987]
DRUGMATRIX: Calcitonin radioligand binding (ligand: [125I] Calcitonin (salmon)) [AID625214, Type: other]Calcitonin receptor [gi:550544247]
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11
[SID124960987]
IC50 DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) [AID625202, Type: confirmatory]Alpha-2B adrenergic receptor [gi:613504690]
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12
[SID124960987]
IC50 DRUGMATRIX: Vascular Endothelial Growth Factor (VEGF) radioligand binding (ligand: [125I] VEGF) [AID625231, Type: confirmatory]Vascular endothelial growth factor receptor 1 [gi:143811474]
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13
[SID124960987]
IC50 DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968) [AID625227, Type: confirmatory]Substance-K receptor [gi:229462950]
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14
[SID124960987]
IC50 DRUGMATRIX: Leukotriene LTC4 Synthase enzyme inhibition (substrate: LTA4) [AID625144, Type: confirmatory]Leukotriene C4 synthase [gi:239977155]
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15
[SID124960987]
IC50 DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) [AID625229, Type: confirmatory]Thromboxane-A synthase [gi:254763392]
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16
[SID124960987]
IC50 DRUGMATRIX: Protease, Matrix Metalloprotease-9 (MMP-9) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) [AID625178, Type: confirmatory]Matrix metalloproteinase-9 [gi:269849668]
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17
[SID124960987]
IC50 DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) [AID625205, Type: confirmatory]Beta-2 adrenergic receptor [gi:296439450]
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18
[SID124960987]
DRUGMATRIX: CYP450, 2A6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625246, Type: other]Cytochrome P450 2A6 [gi:308153612]
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19
[SID124960987]
IC50 DRUGMATRIX: Cysteinyl leukotriene receptor 1 radioligand binding (ligand: [3H]LTD4) [AID625145, Type: confirmatory]Cysteinyl leukotriene receptor 1 [gi:20138087]
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20
[SID124960987]
IC50 DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) [AID625203, Type: confirmatory]Alpha-2C adrenergic receptor [gi:20141211]
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