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naloxonazine (CID 9576413) - Compound BioActivity Data
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BioActivity Outcomes:
Active(5)
 
 
Inactive(4)
 
 
Unspecified(130)
 
 
Top Targets:
7tm 4(31)
 
 
 
p450(8)
 
 
NR LBD ER(2)
 
 
7tm 2(2)
 
 
prostaglandin..(2)
 
 
BioAssay Types:
Confirmatory(116)
 
 
 
Literature(3)
 
 
 
BioActivity Types:
IC50(116)
 
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 139    Data Row: 139   Total Pages: 7   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID124960987]
IC50 0.0072DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625163, Type: confirmatory]Mu-type opioid receptor [gi:2851402]
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2
[SID124960987]
IC50 0.085DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625162, Type: confirmatory]Kappa-type opioid receptor [gi:116242691]
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3
[SID124960987]
IC50 0.136DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) [AID625161, Type: confirmatory]Delta-type opioid receptor [gi:311033488]
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4
[SID124960987]
EC50 16Cytotoxicity against BESM cells after 88 hrs by HTS assay [AID547621, Type: Literature]
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5
[SID124960987]
EC50 17Antitrypanosomal activity against Trypanosoma cruzi amastigotes infected in BESM cells measured after 88 hrs postinfection by HTS assay [AID547622, Type: Literature]
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6
[SID124960987]
Selectivity window, ratio of EC50 for BESM cells to EC50 for Trypanosoma cruzi amastigotes infected in BESM cells [AID547804, Type: Literature]
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7
[SID124960987]
IC50 DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein) [AID625182, Type: confirmatory]Mitogen-activated protein kinase 14 [gi:2499600]
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8
[SID124960987]
IC50 DRUGMATRIX: Bradykinin B2 radioligand binding (ligand: [3H] Bradykinin) [AID625213, Type: confirmatory]B2 bradykinin receptor [gi:2506481]
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9
[SID124960987]
IC50 DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) [AID625184, Type: confirmatory]Epidermal growth factor receptor [gi:2811086]
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10
[SID124960987]
IC50 DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) [AID625173, Type: confirmatory]Angiotensin-converting enzyme [gi:2822103]
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11
[SID124960987]
IC50 DRUGMATRIX: Cysteinyl leukotriene receptor 1 radioligand binding (ligand: [3H]LTD4) [AID625145, Type: confirmatory]Cysteinyl leukotriene receptor 1 [gi:20138087]
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12
[SID124960987]
IC50 DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) [AID625203, Type: confirmatory]Alpha-2C adrenergic receptor [gi:20141211]
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13
[SID124960987]
IC50 DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625154, Type: confirmatory]Muscarinic acetylcholine receptor M4 [gi:23503039]
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14
[SID124960987]
DRUGMATRIX: Protein Tyrosine Phosphatase, PTPRC (CD45) enzyme inhibition (substrate: DiFMUP) [AID625188, Type: other]Receptor-type tyrosine-protein phosphatase C [gi:33112650]
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15
[SID124960987]
IC50 DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) [AID625204, Type: confirmatory]Beta-1 adrenergic receptor [gi:48429211]
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16
[SID124960987]
IC50 DRUGMATRIX: Melanocortin MC4 radioligand binding (ligand: [125I] NDP-alpha-MSH) [AID625148, Type: confirmatory]Melanocortin receptor 4 [gi:60392672]
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17
[SID124960987]
IC50 DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625247, Type: confirmatory]Cytochrome P450 2C19 [gi:60416369]
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18
[SID124960987]
IC50 DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) [AID625223, Type: confirmatory]Sigma non-opioid intracellular receptor 1 [gi:74752153]
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19
[SID124960987]
IC50 DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) [AID625172, Type: confirmatory]Progesterone receptor [gi:75071465]
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20
[SID124960987]
IC50 DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625249, Type: confirmatory]Cytochrome P450 2D6 [gi:84028191]
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