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T5225245 (CID 9552043) - Compound BioActivity Data
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BioActivity Outcomes:
Active(57)
 
 
Inactive(677)
 
 
Inconclusive(24)
 
 
Unspecified(4)
 
 
Top Targets:
7TM GPCR Srx(22)
 
 
7TM GPCR Srsx(19)
 
 
alkPPc(12)
 
 
Bcl-2 like(11)
 
 
G-alpha(8)
 
 
 
BioAssay Types:
Screening(525)
 
 
 
 
 
Confirmatory(221)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(147)
 
 
 
 
 
IC50(49)
 
 
 
EC50(14)
 
 
 
AC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 700    Data Row: 762   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID14747000]
AC50_uM 0.435HSF-1 induced GFP reporter and Doxycycline induced RFP reporter Measured in Cell-Based System Using Plate Reader - 2038-03_Inhibitor_DoseNoFile_CherryPick_Internal-Standard_Set3 [AID493085, Type: confirmatory]Hsf1 protein [Mus musculus] [gi:62740231]
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2
[SID14747000]
EC50 1.218Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) [AID2382, Type: confirmatory]Hsf1 protein [Mus musculus] [gi:62740231]
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3
[SID14747000]
IC50_Mean 1.82Dose response counterscreen of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a HEK-293T cell line using a luminescence assay [AID489041, Type: confirmatory]
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4
[SID14747000]
Potency 1.8356qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID14747000]
Potency 2.0596qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID14747000]
Potency 2.8184qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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7
[SID14747000]
IC50_Mean 3.1Dose response confirmation of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a Jurkat cell line using a luminescence assay [AID489035, Type: confirmatory]
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8
[SID14747000]
Potency 3.1623qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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9
[SID14747000]
Potency 3.1623qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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10
[SID14747000]
AC50_uM 3.967Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Cancer Stem Cells [AID449748, Type: confirmatory]
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11
[SID14747000]
Potency 5.1735qHTS for Inhibitors of TGF-b: Cytotox Counterscreen for Cherry Picks [AID720535, Type: confirmatory]
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12
[SID14747000]
AC50_uM 5.221Dose Response HTS Screen to Identify Cytotoxic Compounds of HMLE_sh_eGFP [AID463074, Type: confirmatory]
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13
[SID14747000]
IC50_Mean 5.3Dose Response selectivity of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a 697B cell line using a luminescence assay [AID489033, Type: confirmatory]
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14
[SID14747000]
Potency 5.6234qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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15
[SID14747000]
Potency 7.9433qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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16
[SID14747000]
Potency 8.1995qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks [AID720534, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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17
[SID14747000]
EC50 8.419Luminescence Cell-Based Dose Response HTS to Identify Activators of Luciferase Translation or Activity in H4 Neuroglioblastoma Cells [AID2002, Type: confirmatory]
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18
[SID14747000]
Potency 8.9125qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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19
[SID14747000]
Potency 9.2qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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20
[SID14747000]
Potency 10qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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21
[SID14747000]
Potency 28.1838qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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22
[SID14747000]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD1 [AID1578, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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23
[SID14747000]
Primary cell-based high throughput screening assay to measure STAT1 activation [AID932, Type: screening]signal transducer and activator of transcription 1-alpha/beta isoform alpha [Homo sapiens] [gi:6274552]
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24
[SID14747000]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]Breast cancer type 1 susceptibility protein [gi:728984]
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25
[SID14747000]
CYP2C19 Assay [AID778, Type: screening]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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26
[SID14747000]
Human H69AR Lung Tumor Cell Growth Inhibition Assay - 86K Screen [AID598, Type: screening]
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27
[SID14747000]
Human Endothelial Cell Proliferation Assay in 384-well format [AID648, Type: screening]
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28
[SID14747000]
High Throughput Screen to Identify Compounds that Suppress the Growth of Human Colon Tumor Cells Lacking Oncogenic Beta Catenin Expression [AID818, Type: screening]
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29
[SID14747000]
Counterscreen for inhibitors of mutant JAK2V617F: Cell-based high throughput screening assay for inhibitors of parental Ba/F3 cell viability. [AID1520, Type: screening]
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30
[SID14747000]
MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators [AID1814, Type: screening]
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31
[SID14747000]
Counterscreen of compound fluorescence effects on High-throughput multiplex microsphere screening for inhibitors of toxin protease [AID624483, Type: screening]
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32
[SID14747000]
Human Lung Fibroblast Proliferation Assay [AID719, Type: screening]
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33
[SID14747000]
High Throughput Screen to Identify Compounds that Suppress the Growth of Cells with a Deletion of the PTEN Tumor Suppressor [AID827, Type: screening]
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34
[SID14747000]
uHTS identification of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID449763, Type: screening]
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35
[SID14747000]
uHTS luminescence assay for the identification of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435003, Type: screening]
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36
[SID14747000]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Cancer Stem Cells [AID2717, Type: screening]
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37
[SID14747000]
Single concentration confirmation of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435020, Type: screening]
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38
[SID14747000]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Full-Length Luciferase Counterscreen assay [AID504607, Type: screening]
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39
[SID14747000]
Small molecule inhibitors of miR122 Measured in Cell-Based System Using Plate Reader - 2144-01_Inhibitor_SinglePoint_HTS_Activity [AID602342, Type: screening]
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40
[SID14747000]
Primary cell-based high throughput assay for inhibitors of the Janus kinase 2 mutant JAK2V617F [AID1446, Type: screening]Janus kinase 2 (a protein tyrosine kinase) [Homo sapiens] [gi:119579178]
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41
[SID14747000]
Confirmation cell-based high throughput screening assay for inhibitors of the Janus kinase 2 mutant JAK2V617F [AID1521, Type: screening]Janus kinase 2 (a protein tyrosine kinase) [Homo sapiens] [gi:119579178]
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42
[SID14747000]
HTS Assay for Peg3 Promoter Inhibitors [AID588405, Type: screening]protein phosphatase 1 regulatory subunit 15A [Rattus norvegicus] [gi:78486550]
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43
[SID14747000]
Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format - Set 2 [AID504601, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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44
[SID14747000]
Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID489028, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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45
[SID14747000]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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46
[SID14747000]
HTS identification of compounds inhibiting the binding of CD11b/CD18 to fibrinogen via a luminescence assay. [AID1497, Type: screening]integrin alpha-M isoform 2 precursor [Homo sapiens] [gi:88501734]
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47
[SID14747000]
HTS identification of compounds inhibiting the binding of CD11b/CD18 to fibrinogen via a luminescence assay. [AID1497, Type: screening]integrin beta-2 precursor [Homo sapiens] [gi:89191865]
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48
[SID14747000]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
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49
[SID14747000]
Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID489028, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
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50
[SID14747000]
Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format - Set 2 [AID504601, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
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