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MLS000548877 (CID 9549757) - Compound BioActivity Data
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BioActivity Outcomes:
Active(76)
 
 
Inactive(497)
 
 
Inconclusive(15)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srsx(17)
 
 
 
7TM GPCR Srx(16)
 
 
Troponin(8)
 
 
 
KCNQ channel(8)
 
 
 
FReD(6)
 
 
 
BioAssay Types:
Screening(451)
 
 
 
 
Confirmatory(115)
 
 
 
 
 
Literature(9)
 
 
BioActivity Types:
Potency(75)
 
 
 
 
 
IC50(19)
 
 
 
 
EC50(14)
 
 
 
AC50(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 531    Data Row: 589   Total Pages: 30   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID14728463]
EC50_uM 0.3248Fluorescence Polarization Cell-Free Homogeneous Dose Retest to Confirm Inhibitors of the LANA Histone H2A/H2B Interaction [AID435023, Type: confirmatory]LANA [Human herpesvirus 8] [gi:139472804]
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2
[SID14728463]
EC50 1.209Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504698, Type: confirmatory]troponin I, cardiac muscle [Homo sapiens] [gi:151101270]
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3
[SID14728463]
EC50 1.209Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504698, Type: confirmatory]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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4
[SID14728463]
EC50 1.209Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504698, Type: confirmatory]troponin C, slow skeletal and cardiac muscles [Homo sapiens] [gi:4507615]
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5
[SID14728463]
EC50 1.209Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504698, Type: confirmatory]troponin T, cardiac muscle isoform 3 [Homo sapiens] [gi:48255881]
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6
[SID14728463]
AC50_uM 1.415C-LANA Counter Screen: DNA intercalators Measured in Biochemical System Using Plate Reader - 2117-02_Inhibitor_Dose_CherryPick_Activity_Set2 [AID504727, Type: confirmatory]LANA [Human herpesvirus 8] [gi:312275222]
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7
[SID14728463]
AC50_uM 1.605C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_Dose_CherryPick_Activity [AID504725, Type: confirmatory]LANA [Human herpesvirus 8] [gi:312275222]
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8
[SID14728463]
EC50 2.455Counterscreen for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF): Fluorescence-based biochemical high throughput dose response assay to identify fluorescence artifacts [AID504697, Type: confirmatory]
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9
[SID14728463]
AC50_uM 3.84Inhibitors of Mycobacterium tuberculosis UDP-galactopyranose mutase (UGM) enzyme Measured in Biochemical System Using Plate Reader - 2105-02_Inhibitor_Dose_CherryPick_Activity [AID540359, Type: confirmatory]UDP-galactopyranose mutase [Mycobacterium tuberculosis H37Rv] [gi:15610945]
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10
[SID14728463]
Potency 4.1052qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101: Hit Validation [AID651600, Type: confirmatory]tumor susceptibility gene 101 protein [Homo sapiens] [gi:5454140]
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11
[SID14728463]
Potency 4.7444qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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12
[SID14728463]
IC50 9.255Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn7) to the fibrin proteolytic product D-Dimer and fragment E complex [DD(E )] [AID720730, Type: confirmatory]Chain E, Fragment Double-D From Human Fibrin [gi:28373962]
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13
[SID14728463]
Potency 28.1838Inhibitors of USP1/UAF1: Primary Screen [AID743255, Type: confirmatory]USP1 protein, partial [Homo sapiens] [gi:118600387]
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14
[SID14728463]
Potency 89.1251qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen [AID720707, Type: confirmatory]Rap guanine nucleotide exchange factor 3 [gi:317373593]
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15
[SID14728463]
Potency 100qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2): primary screen [AID720711, Type: confirmatory]Rap guanine nucleotide exchange factor 4 [gi:32171491]
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16
[SID14728463]
Epi-absorbance-based confirmation assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. [AID2189, Type: screening]metallo-beta-lactamase IMP-1 [Pseudomonas aeruginosa] [gi:27368096]
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17
[SID14728463]
Epi-absorbance primary biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase [AID1556, Type: screening]metallo-beta-lactamase IMP-1 [Pseudomonas aeruginosa] [gi:27368096]
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18
[SID14728463]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of GLD-1 protein - TGE RNA interaction. [AID2280, Type: screening]Protein GLD-1 [Caenorhabditis elegans] [gi:17507875]
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19
[SID14728463]
Fluorescence-based cell-based primary high throughput confirmation assay to identify agonists of the human trace amine associated receptor 1 (TAAR1) [AID651783, Type: screening]trace amine-associated receptor 1 [Homo sapiens] [gi:21264324]
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20
[SID14728463]
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human trace amine associated receptor 1 (TAAR1) [AID624467, Type: screening]trace amine-associated receptor 1 [Homo sapiens] [gi:21264324]
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