mezerein (CID 9549167) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(35)
 
 
Inactive(311)
 
 
Inconclusive(16)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(9)
 
 
 
KCNQ channel(8)
 
 
TRP 2(5)
 
 
 
Peptidase C48(4)
 
 
alkPPc(4)
 
 
BioAssay Types:
Screening(269)
 
 
 
 
Confirmatory(86)
 
 
 
 
 
Literature(3)
 
 
BioActivity Types:
Potency(55)
 
 
 
 
 
IC50(17)
 
 
 
 
EC50(8)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 363    Data Row: 363   Total Pages: 8   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID14719309]
AbsAC26_uM 0.0012Luciferase Reporter Cell Based HTS to identify inhibitors of N-linked Glycosylation Measured in Cell-Based System Using Plate Reader - 2146-01_Inhibitor_Dose_CherryPick_Activity [AID624491, Type: confirmatory]
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2
[SID14719309]
Potency 0.002Activators of T cell receptors: Hit Validation [AID624298, Type: confirmatory]T cell receptor [Homo sapiens] [gi:553160]
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3
[SID14719309]
EC50 0.004Luminescence Cell-Based/Microorganism Primary HTS to Identify Inhibitors of T.Cruzi Infection [AID2294, Type: confirmatory]
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4
[SID14719309]
Potency 0.0052Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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5
[SID14719309]
Potency 0.0052Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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6
[SID14719309]
Potency 0.0052Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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7
[SID14719309]
Potency 0.0052Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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8
[SID14719309]
EC50 0.1Luminescence Cell-Based/Microorganism Dose Confirmation HTS to Identify Inhibitors of T.Cruzi Replication. [AID2044, Type: confirmatory]
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9
[SID14719309]
EC50 0.156Dose response confirmation of uHTS hits that enhance the survival of human induced pluripotent stem cells when cultured as single cells in a luminescent assay [AID623861, Type: confirmatory]
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10
[SID14719309]
IC50 0.16Dose response counterscreen of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a HEK-293T cell line using a luminescence assay [AID489041, Type: confirmatory]
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11
[SID14719309]
Potency 2.8184qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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12
[SID14719309]
Potency 2.8184qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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13
[SID14719309]
Potency 3.2643qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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14
[SID14719309]
Potency 3.2643qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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15
[SID14719309]
Potency 3.2643qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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16
[SID14719309]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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17
[SID14719309]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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18
[SID14719309]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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19
[SID14719309]
CC50 25Vero 76 Cytoxicity Assay for VEEV Compounds [AID588719, Type: confirmatory]
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20
[SID14719309]
CC50 100A Cell Based Secondary Assay To Explore Cytotoxicity of West Nile Virus Anti-Viral Hit Compounds [AID1650, Type: confirmatory]
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21
[SID14719309]
 Luminescence Cell-Based/Microorganism Primary HTS to Identify Inhibitors of T.Cruzi Replication [AID1885, Type: screening]
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22
[SID14719309]
 uHTS identification of small molecule activators of the adaptive arm of the Unfolded Protein response via a luminescent-based reporter assay [AID463104, Type: screening]
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23
[SID14719309]
 Single concentration confirmation of small molecule activators of the adaptive arm of the Unfolded Protein response via a luminescent-based reporter assay [AID485299, Type: screening]
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24
[SID14719309]
 uHTS luminescence assay for the identification of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435003, Type: screening]
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25
[SID14719309]
 uHTS determination of small molecule cytotoxicity in a fluorescence assay to identify cystic fibrosis induced NFkb Inhibitors [AID602141, Type: screening]
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26
[SID14719309]
 uHTS luminescent assay for identification of compounds that enhance the survival of human induced pluripotent stem cells when cultured as single cells [AID602274, Type: screening]
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27
[SID14719309]
 Luciferase Reporter Cell Based HTS to identify inhibitors of N-linked Glycosylation Measured in Cell-Based System Using Plate Reader - 2146-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588692, Type: screening]
View
28
[SID14719309]
 HTS for Beta-2AR agonists via FAP method [AID504454, Type: screening]ADRB2 gene product [Homo sapiens] [gi:4501969]
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29
[SID14719309]
 HTS for Beta-2AR agonists via FAP method [AID504454, Type: screening]ADRB2 gene product [Homo sapiens] [gi:4501969]
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30
[SID14719309]
 HTS for Beta-2AR agonists via FAP method [AID504454, Type: screening]ADRB2 gene product [Homo sapiens] [gi:4501969]
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31
[SID14719309]
 HTS for Beta-2AR agonists via FAP method [AID504454, Type: screening]ADRB2 gene product [Homo sapiens] [gi:4501969]
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32
[SID14719309]
 uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID588850, Type: screening]CFTR gene product [Homo sapiens] [gi:90421313]
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33
[SID14719309]
 uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID588850, Type: screening]CFTR gene product [Homo sapiens] [gi:90421313]
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34
[SID14719309]
 qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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35
[SID14719309]
 qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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36
[SID14719309]
 qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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37
[SID14719309]
 qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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38
[SID14719309]
 uHTS identification of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a fluorescence intensity assay [AID602261, Type: screening]FASN gene product [Homo sapiens] [gi:41872631]
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39
[SID14719309]
 uHTS identification of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a fluorescence intensity assay [AID602261, Type: screening]FASN gene product [Homo sapiens] [gi:41872631]
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40
[SID14719309]
 uHTS identification of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a fluorescence intensity assay [AID602261, Type: screening]FASN gene product [Homo sapiens] [gi:41872631]
View
41
[SID14719309]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]CHRM1 gene product [Homo sapiens] [gi:37622910]
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42
[SID14719309]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]CHRM1 gene product [Homo sapiens] [gi:37622910]
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43
[SID14719309]
 uHTS identification of antagonists of the CRF-binding protein and CRF-R2 receptor complex [AID588475, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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44
[SID14719309]
 uHTS identification of antagonists of the CRF-binding protein and CRF-R2 receptor complex [AID588475, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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45
[SID14719309]
 Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504692, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
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46
[SID14719309]
 Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504692, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
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47
[SID14719309]
 Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504692, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
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48
[SID14719309]
 Primary cell-based screen for identification of compounds that inhibit transient receptor potential cation channel C4 (TRPC4). [AID2247, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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49
[SID14719309]
 uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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50
[SID14719309]
 uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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