ZINC00544706 (CID 946201) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(36)
 
 
Inactive(671)
 
 
Inconclusive(30)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
 
alkPPc(14)
 
 
7TM GPCR Srsx(11)
 
 
 
Bcl-2 like(11)
 
 
Tryp SPc(10)
 
 
 
BioAssay Types:
Screening(516)
 
 
 
 
 
Confirmatory(196)
 
 
 
 
 
Literature(6)
 
 
 
BioActivity Types:
Potency(131)
 
 
 
 
 
IC50(42)
 
 
 
EC50(12)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 739    Data Row: 739   Total Pages: 15   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID7971145]
Potency 2.5929A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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2
[SID7971145]
Potency 2.9093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID7971145]
Potency 2.9093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID7971145]
Potency 2.9093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID7971145]
Potency 10.3225A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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6
[SID7971145]
 High throughput fluorescence polarization-based assay to screen for small molecule inhibitors of the Polo box domain (PBD) of Plk1. [AID693, Type: screening]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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7
[SID7971145]
 High throughput fluorescence polarization-based assay to screen for small molecule inhibitors of the Polo box domain (PBD) of Plk1. [AID693, Type: screening]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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8
[SID7971145]
 HCS assay for microtubule stabilizers [AID2205, Type: screening]tubulin, beta [Homo sapiens] [gi:29788785]
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9
[SID7971145]
 HCS assay for microtubule stabilizers [AID2205, Type: screening]tubulin, beta [Homo sapiens] [gi:29788785]
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10
[SID7971145]
 Primary cell-based high throughput assay for inhibitors of the Janus kinase 2 mutant JAK2V617F [AID1446, Type: screening]Janus kinase 2 (a protein tyrosine kinase) [Homo sapiens] [gi:119579178]
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11
[SID7971145]
 Primary cell-based high throughput assay for inhibitors of the Janus kinase 2 mutant JAK2V617F [AID1446, Type: screening]Janus kinase 2 (a protein tyrosine kinase) [Homo sapiens] [gi:119579178]
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12
[SID7971145]
 Primary cell-based high throughput assay for inhibitors of the Janus kinase 2 mutant JAK2V617F [AID1446, Type: screening]Janus kinase 2 (a protein tyrosine kinase) [Homo sapiens] [gi:119579178]
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13
[SID7971145]
 Luminescence-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): agonists of MC4R [AID540308, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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14
[SID7971145]
 Luminescence-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): agonists of MC4R [AID540308, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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15
[SID7971145]
 Dose-response cell-based assay for activators of the Retinoic Acid Receptor-related orphan receptor A (RORA) [AID681, Type: confirmatory]Nuclear receptor ROR-alpha [gi:548814]
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16
[SID7971145]
 Dose-response cell-based assay for activators of the Retinoic Acid Receptor-related orphan receptor A (RORA) [AID681, Type: confirmatory]Nuclear receptor ROR-alpha [gi:548814]
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17
[SID7971145]
 Dose-response cell-based assay for activators of the Retinoic Acid Receptor-related orphan receptor A (RORA) [AID681, Type: confirmatory]Nuclear receptor ROR-alpha [gi:548814]
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18
[SID7971145]
 Dose-response cell-based assay for activators of the Retinoic Acid Receptor-related orphan receptor A (RORA) [AID681, Type: confirmatory]Nuclear receptor ROR-alpha [gi:548814]
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19
[SID7971145]
 Primary Cell-based High Throughput Screening assay for activators of the Retinoic Acid Receptor-related orphan receptor A (RORA) [AID560, Type: screening]Nuclear receptor ROR-alpha [gi:548814]
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20
[SID7971145]
 Primary Cell-based High Throughput Screening assay for activators of the Retinoic Acid Receptor-related orphan receptor A (RORA) [AID560, Type: screening]Nuclear receptor ROR-alpha [gi:548814]
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21
[SID7971145]
 Primary Cell-based High Throughput Screening assay for activators of the Retinoic Acid Receptor-related orphan receptor A (RORA) [AID560, Type: screening]Nuclear receptor ROR-alpha [gi:548814]
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22
[SID7971145]
 Primary Cell-based High Throughput Screening assay for activators of the Retinoic Acid Receptor-related orphan receptor A (RORA) [AID560, Type: screening]Nuclear receptor ROR-alpha [gi:548814]
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23
[SID7971145]
 Cell Proliferation & Viability (Cytotoxicity) Primary Assay 60K MLSMR [AID463, Type: screening]
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24
[SID7971145]
 Cell Proliferation & Viability (Cytotoxicity) Dose Response Assay 60K MLSMR [AID464, Type: confirmatory]
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25
[SID7971145]
EC50 Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7 cells) [AID430, Type: confirmatory]
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26
[SID7971145]
 Human H69AR Lung Tumor Cell Growth Inhibition Assay - 86K Screen [AID598, Type: screening]
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27
[SID7971145]
 Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [AID626, Type: screening]
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28
[SID7971145]
 Allosteric Modulators of D1 Receptors: Primary Screen [AID641, Type: screening]
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29
[SID7971145]
 Allosteric Modulators of D1 Receptors: Confirmation Screen [AID642, Type: other]
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30
[SID7971145]
 Allosteric Modulators of D1 Receptors: Secondary Assay 2 [AID647, Type: other]
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31
[SID7971145]
 Human Endothelial Cell Proliferation Assay in 384-well format [AID648, Type: screening]
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32
[SID7971145]
 High Throughput Screen to Identify Compounds that Suppress the Growth of Human Colon Tumor Cells Lacking Oncogenic Beta Catenin Expression - Pilot Screen [AID823, Type: screening]
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33
[SID7971145]
 High Throughput Screen to Identify Compounds that Suppress the Growth of Cells with a Deletion of the PTEN Tumor Suppressor - Pilot Screen [AID824, Type: screening]
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34
[SID7971145]
 Human Lung Fibroblast Proliferation Assay [AID719, Type: screening]
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35
[SID7971145]
 Counterscreen for inhibitors of Janus kinase 2 mutant JAK2V617F: Cell-based high throughput assay to identify inhibitors of parental Ba/F3 cell viability. [AID1486, Type: screening]
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36
[SID7971145]
 Luminescence-based confirmation cell-based assay for cytotoxic compounds using the IEC-6 intestinal epithelial cell line. [AID1907, Type: screening]
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37
[SID7971145]
 Profiling the NIH Molecular Libraries Small Molecule Repository: Autofluorescence at 339/460 nm [AID709, Type: screening]
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38
[SID7971145]
 MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators [AID1814, Type: screening]
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39
[SID7971145]
 Luminescence-based counterscreen assay for KLF5 inhibitors: cell-based high throughput screening assay to identify cytotoxic compounds using the IEC-6 intestinal epithelial cell line. [AID1825, Type: screening]
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40
[SID7971145]
 Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Full-Length Luciferase Counterscreen assay [AID504607, Type: screening]
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41
[SID7971145]
 HIV-1 RT-RNase H MLSCN HTS MH077605 [AID565, Type: screening]Chain A, Hiv-1 Reverse Transcriptase Mol_id: 1; Molecule: Hiv-1 Reverse Transcriptase; Chain: A, B; [gi:1431733]
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42
[SID7971145]
IC50 High Throughput Imaging Assay for Beta-Catenin [AID1665, Type: confirmatory]catenin beta-1 [Homo sapiens] [gi:4503131]
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43
[SID7971145]
IC50 High Throughput Imaging Assay for Beta-Catenin [AID1665, Type: confirmatory]catenin beta-1 [Homo sapiens] [gi:4503131]
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44
[SID7971145]
 qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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45
[SID7971145]
 qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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46
[SID7971145]
 qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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47
[SID7971145]
 qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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48
[SID7971145]
 Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]Breast cancer type 1 susceptibility protein [gi:728984]
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49
[SID7971145]
 Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]Breast cancer type 1 susceptibility protein [gi:728984]
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50
[SID7971145]
 HTS for Estrogen Receptor-beta Coactivator Binding inhibitors [AID633, Type: screening]estrogen receptor beta isoform 1 [Homo sapiens] [gi:10835013]
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