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Flunarizine (CID 941361) - Compound BioActivity Data
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BioActivity Outcomes:
Active(98)
 
 
Inactive(192)
 
 
Inconclusive(96)
 
 
Unspecified(126)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
 
 
7TM GPCR Srsx(19)
 
 
 
 
Na trans asso..(10)
 
 
p450(10)
 
 
 
 
NR LBD ER(9)
 
 
 
 
BioAssay Types:
Confirmatory(195)
 
 
 
 
Literature(118)
 
 
 
 
 
Screening(34)
 
 
 
Summary(24)
 
 
 
BioActivity Types:
Potency(206)
 
 
 
 
IC50(160)
 
 
 
 
 
Kd(3)
 
 
Ki(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 414    Data Row: 512   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103199419]
Kd 0.00501Calcium channel-blocking activity by determined by ability to antagonize calcium-induced contractions of isolated rabbit aortic strips [AID167568, Type: Literature]
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2
[SID103199419]
IC50 0.025DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) [AID625223, Type: other]Sigma non-opioid intracellular receptor 1 [gi:74752153]
View
3
[SID103199419]
Ki 0.053Inhibition of [3H]- batrachotoxin binding to sodium channel in rat neocortical membrane [AID205281, Type: Literature]Sodium channel protein type 1 subunit alpha [gi:116447]
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4
[SID103199419]
Ki 0.053Inhibition of [3H]- batrachotoxin binding to sodium channel in rat neocortical membrane [AID205281, Type: Literature]Sodium channel protein type 3 subunit alpha [gi:116449]
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5
[SID103199419]
Ki 0.053Inhibition of [3H]- batrachotoxin binding to sodium channel in rat neocortical membrane [AID205281, Type: Literature]Sodium channel protein type 2 subunit alpha [gi:116448]
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6
[SID103199419]
IC50 0.062DRUGMATRIX: Sigma2 radioligand binding (ligand: [3H] Ifenprodil) [AID625224, Type: other]
View
7
[SID103199419]
IC50 0.08Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole cell patch clamp assay [AID471769, Type: Literature]
View
8
[SID103199419]
IC50 0.097DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: other]D(3) dopamine receptor [gi:1169206]
View
9
[SID103199419]
IC50 0.12Inhibition of veratridine-induced guanidine flux in cardiac voltage-gated sodium channel (veratridine block vs. Na release) [AID217929, Type: Literature]
View
10
[SID103199419]
IC50 0.158DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) [AID625269, Type: other]Histamine H1 receptor [gi:547645]
View
11
[SID103199419]
IC50 0.177DRUGMATRIX: Calcium Channel Type L, Phenylalkylamine radioligand binding (ligand: [3H] (-)-Desmethoxyverapamil (D-888)) [AID625234, Type: other]
View
12
[SID103199419]
ID50 0.18Inhibition of [Ca2+] uptake in rat aorta, K+. [AID182966, Type: Literature]
View
13
[SID103199419]
ID50 0.22Inhibition of contraction in rat aorta, K+. [AID182976, Type: Literature]
View
14
[SID103199419]
IC50 0.222DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) [AID625203, Type: other]Alpha-2C adrenergic receptor [gi:20141211]
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15
[SID103199419]
IC50 0.228Inhibition of [3H]raclopride binding to Dopamine receptor D2 of rat striatum membranes [AID61405, Type: Literature]D(2) dopamine receptor [gi:47117674]
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16
[SID103199419]
IC50 0.228Concentration required for 50% inhibitory effect on Dopamine receptor D2 determined in competition experiments with [3H]raclopride [AID64281, Type: Literature]
View
17
[SID103199419]
IC50 0.263DRUGMATRIX: Sodium Channel, Site 2 radioligand binding (ligand: [3H] Batrachotoxin) [AID625225, Type: other]
View
18
[SID103199419]
IC50 0.27Inhibitory concentration against KCl induced rat thoracic aorta contraction [AID225480, Type: Literature]
View
19
[SID103199419]
IC50 0.29Inhibition of veratridine-induced depolarization in rat cerebrocortical synaptosomes using the voltage sensitive fluorescent dye Rhodamine 6G [AID180152, Type: Literature]Sodium channel protein type 2 subunit alpha [gi:116448]
View
20
[SID103199419]
IC50 0.29Inhibition of veratridine-induced depolarization of rat cerebrocortical synaptosomes using a membrane potential sensitive fluorescent dye, rhodamine 6G [AID227650, Type: Literature]Sodium channel protein type 2 subunit alpha [gi:116448]
View
21
[SID103199419]
IC50 0.29Inhibition of veratridine-induced depolarization of rat cerebrocortical synaptosomes using a membrane potential sensitive fluorescent dye, rhodamine 6G [AID227650, Type: Literature]Sodium channel protein type 3 subunit alpha [gi:116449]
View
22
[SID103199419]
IC50 0.29Inhibition of veratridine-induced depolarization in rat cerebrocortical synaptosomes using the voltage sensitive fluorescent dye Rhodamine 6G [AID180152, Type: Literature]Sodium channel protein type 3 subunit alpha [gi:116449]
View
23
[SID103199419]
IC50 0.29Inhibition of veratridine-induced depolarization in rat cerebrocortical synaptosomes using the voltage sensitive fluorescent dye Rhodamine 6G [AID180152, Type: Literature]Sodium channel protein type 1 subunit alpha [gi:116447]
View
24
[SID103199419]
IC50 0.29Inhibition of veratridine-induced depolarization of rat cerebrocortical synaptosomes using a membrane potential sensitive fluorescent dye, rhodamine 6G [AID227650, Type: Literature]Sodium channel protein type 1 subunit alpha [gi:116447]
View
25
[SID103199419]
IC50 0.31Blocking of rat Voltage-dependent L-type calcium channel alpha1c/alpha2delta-1/beta1b activity expressed in HEK293 cells assessed as whole cell current by whole cell patch clamp assay [AID472026, Type: Literature]
View
26
[SID103199419]
IC50 0.35Inhibition of [3H]BTX binding to cardiac voltage-gated sodium channel [AID217926, Type: Literature]
View
27
[SID103199419]
IC50 0.352DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) [AID625253, Type: other]D(2) dopamine receptor [gi:118206]
View
28
[SID103199419]
IC50 0.407DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: other]5-hydroxytryptamine receptor 2A [gi:543727]
View
29
[SID103199419]
IC50 0.42Inhibition of veratridine-induced Na+ influx in chinese hamster ovary cells expressing alpha subunit of rat brain type voltage-gated sodium channel type 2 [AID146837, Type: Literature]Sodium channel protein type 2 subunit alpha [gi:116448]
View
30
[SID103199419]
IC50 0.49Inhibitory activity against type IIA sodium channel in CNaIIA-1 cell line expressed in CHO cells [AID215805, Type: Literature]
View
31
[SID103199419]
IC50 0.499DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: other]Sodium-dependent serotonin transporter [gi:400630]
View
32
[SID103199419]
Kd 0.53Binding affinity to T-type alpha1G calcium channel [AID549670, Type: Literature]
View
33
[SID103199419]
IC50 0.581DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) [AID625201, Type: other]Alpha-2A adrenergic receptor [gi:1351829]
View
34
[SID103199419]
IC50 0.584DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625256, Type: other]Sodium-dependent dopamine transporter [gi:266667]
View
35
[SID103199419]
IC50 0.6Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex [AID205267, Type: Literature]
View
36
[SID103199419]
IC50 0.6058DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) [AID625171, Type: other]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
37
[SID103199419]
IC50 0.669DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: other]5-hydroxytryptamine receptor 2C [gi:112816]
View
38
[SID103199419]
IC50 0.78Inhibition of calcium channel L type in IMR32 cells [AID293102, Type: Literature]
View
39
[SID103199419]
Kd 0.84Binding affinity to T-type alpha1I calcium channel [AID549671, Type: Literature]
View
40
[SID103199419]
IC50 1.012DRUGMATRIX: Calcium Channel Type L, Dihydropyridine radioligand binding (ligand: [3H] Nitrendipine) [AID625216, Type: other]
View
41
[SID103199419]
IC50 1.085DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625200, Type: other]Alpha-1D adrenergic receptor [gi:1168243]
View
42
[SID103199419]
IC50 1.088DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625198, Type: other]Alpha-1D adrenergic receptor [gi:1168244]
View
43
[SID103199419]
IC50 1.088DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625217, Type: other]5-hydroxytryptamine receptor 2B [gi:1168220]
View
44
[SID103199419]
IC50 1.096DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) [AID625199, Type: other]Alpha-1B adrenergic receptor [gi:543734]
View
45
[SID103199419]
IC50 1.107DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625155, Type: other]Muscarinic acetylcholine receptor M5 [gi:543761]
View
46
[SID103199419]
IC50 1.12DRUGMATRIX: Calcium Channel Type L, Benzothiazepine radioligand binding (ligand: [3H] Diltiazem) [AID625215, Type: other]
View
47
[SID103199419]
IC50 1.339DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625207, Type: other]Sodium-dependent noradrenaline transporter [gi:128616]
View
48
[SID103199419]
IC50 1.479DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625153, Type: other]Muscarinic acetylcholine receptor M3 [gi:113125]
View
49
[SID103199419]
IC50 1.67Inhibition of calcium channel Cav2.2 in IMR32 cells [AID293101, Type: Literature]Voltage-dependent N-type calcium channel subunit alpha-1B [gi:1705854]
View
50
[SID103199419]
IC50 1.893DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) [AID625202, Type: other]Alpha-2B adrenergic receptor [gi:27151763]
View