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Flunarizine (CID 941361) - Compound BioActivity Data
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BioActivity Outcomes:
Active(92)
 
 
Inactive(200)
 
 
Inconclusive(97)
 
 
Unspecified(314)
 
 
Top Targets:
7tm 4(39)
 
 
 
 
Na trans asso..(10)
 
 
p450(10)
 
 
 
 
NR LBD ER(9)
 
 
 
 
NR LBD AR(8)
 
 
 
 
BioAssay Types:
Confirmatory(313)
 
 
 
 
 
Literature(141)
 
 
 
 
 
Screening(35)
 
 
 
Summary(24)
 
 
 
BioActivity Types:
Potency(208)
 
 
 
 
IC50(161)
 
 
 
 
 
Kd(3)
 
 
Ki(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 604    Data Row: 703   Total Pages: 36   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103199419]
Kd 0.00501Calcium channel-blocking activity by determined by ability to antagonize calcium-induced contractions of isolated rabbit aortic strips [AID167568, Type: Literature]
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2
[SID103199419]
IC50 0.025DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) [AID625223, Type: confirmatory]Sigma non-opioid intracellular receptor 1 [gi:74752153]
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3
[SID103199419]
Ki 0.053Inhibition of [3H]- batrachotoxin binding to sodium channel in rat neocortical membrane [AID205281, Type: Literature]Sodium channel protein type 3 subunit alpha [gi:116449]
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4
[SID103199419]
Ki 0.053Inhibition of [3H]- batrachotoxin binding to sodium channel in rat neocortical membrane [AID205281, Type: Literature]Sodium channel protein type 1 subunit alpha [gi:116447]
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5
[SID103199419]
Ki 0.053Inhibition of [3H]- batrachotoxin binding to sodium channel in rat neocortical membrane [AID205281, Type: Literature]Sodium channel protein type 2 subunit alpha [gi:116448]
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6
[SID103199419]
IC50 0.062DRUGMATRIX: Sigma2 radioligand binding (ligand: [3H] Ifenprodil) [AID625224, Type: confirmatory]
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7
[SID103199419]
IC50 0.08Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole cell patch clamp assay [AID471769, Type: Literature]
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8
[SID103199419]
IC50 0.097DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: confirmatory]D(3) dopamine receptor [gi:1169206]
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9
[SID103199419]
IC50 0.12Inhibition of veratridine-induced guanidine flux in cardiac voltage-gated sodium channel (veratridine block vs. Na release) [AID217929, Type: Literature]
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10
[SID103199419]
IC50 0.158DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) [AID625269, Type: confirmatory]Histamine H1 receptor [gi:547645]
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11
[SID103199419]
IC50 0.177DRUGMATRIX: Calcium Channel Type L, Phenylalkylamine radioligand binding (ligand: [3H] (-)-Desmethoxyverapamil (D-888)) [AID625234, Type: confirmatory]
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12
[SID103199419]
ID50 0.18Inhibition of [Ca2+] uptake in rat aorta, K+. [AID182966, Type: Literature]
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13
[SID103199419]
ID50 0.22Inhibition of contraction in rat aorta, K+. [AID182976, Type: Literature]
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14
[SID103199419]
IC50 0.222DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) [AID625203, Type: confirmatory]Alpha-2C adrenergic receptor [gi:20141211]
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15
[SID103199419]
IC50 0.228Inhibition of [3H]raclopride binding to Dopamine receptor D2 of rat striatum membranes [AID61405, Type: Literature]D(2) dopamine receptor [gi:47117674]
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16
[SID103199419]
IC50 0.228Concentration required for 50% inhibitory effect on Dopamine receptor D2 determined in competition experiments with [3H]raclopride [AID64281, Type: Literature]
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17
[SID103199419]
IC50 0.263DRUGMATRIX: Sodium Channel, Site 2 radioligand binding (ligand: [3H] Batrachotoxin) [AID625225, Type: confirmatory]
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18
[SID103199419]
IC50 0.27Inhibitory concentration against KCl induced rat thoracic aorta contraction [AID225480, Type: Literature]
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19
[SID103199419]
IC50 0.29Inhibition of veratridine-induced depolarization of rat cerebrocortical synaptosomes using a membrane potential sensitive fluorescent dye, rhodamine 6G [AID227650, Type: Literature]Sodium channel protein type 2 subunit alpha [gi:116448]
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20
[SID103199419]
IC50 0.29Inhibition of veratridine-induced depolarization in rat cerebrocortical synaptosomes using the voltage sensitive fluorescent dye Rhodamine 6G [AID180152, Type: Literature]Sodium channel protein type 2 subunit alpha [gi:116448]
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