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Paraoxon (CID 9395) - Compound BioActivity Data
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BioActivity Outcomes:
Active(22)
 
 
Inactive(152)
 
 
Inconclusive(56)
 
 
Unspecified(25)
 
 
Top Targets:
NR LBD PPAR(21)
 
 
 
 
NR LBD AR(16)
 
 
 
 
NR LBD ER(16)
 
 
 
 
Esterase lipa..(13)
 
 
 
 
NR LBD Fxr(10)
 
 
 
 
BioAssay Types:
Confirmatory(155)
 
 
 
 
Summary(48)
 
 
 
 
Literature(37)
 
 
 
 
 
BioActivity Types:
Potency(191)
 
 
 
 
IC50(9)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 161    Data Row: 255   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103191824]
IC50 0.013Displacement of acetylcholine from AChE in Swiss Webster mouse brain after 5 mins [AID503579, Type: Literature]Acetylcholinesterase [gi:113038]
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2
[SID103191824]
IC50 0.059Inhibition of esterase activity of human carbonic anhydrase 2 by CO2 hydration method [AID525933, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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3
[SID103191824]
IC50 0.338Inhibition of esterase activity of human carbonic anhydrase 1 by CO2 hydration method [AID525930, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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4
[SID103191824]
IC50 0.54Inhibition of FAAH-mediated [3H]anandamide hydrolysis in mouse brain [AID409759, Type: Literature]Fatty-acid amide hydrolase 1 [gi:6225311]
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5
[SID103191824]
IC50 1.021Inhibition of esterase activity of mouse carbonic anhydrase 13 by CO2 hydration method [AID525936, Type: Literature]Carbonic anhydrase 13 [gi:30580372]
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6
[SID103191824]
IC50 1.2Displacement of 2-arachidonylglycerol from MAGL in Swiss Webster mouse brain after 5 mins [AID503381, Type: Literature]Monoglyceride lipase [gi:47117040]
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7
[SID103191824]
IC50 1.2Displacement of [3H]CP-55940 from CB1 receptor in mouse brain [AID409760, Type: Literature]Cannabinoid receptor 1 [gi:1345697]
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8
[SID103191824]
IC50 2.3Inhibition of MAGL-mediated 2-arachidonoylglycerol hydrolysis in mouse brain [AID409757, Type: Literature]Monoglyceride lipase [gi:47117040]
View
9
[SID103191824]
IC50 5.9Displacement of [3H]anandamide from FAAH in Swiss Webster mouse brain after 5 mins [AID503576, Type: Literature]Fatty-acid amide hydrolase 1 [gi:6225311]
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10
[SID144213364]
Ratio Potency (uM) 14.6183qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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11
[SID144213364]
Potency-Replicate_1 15.4845qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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12
[SID144209622]
Ratio Potency (uM) 17.5909qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
View
13
[SID144209622]
Potency-Replicate_1 19.7373qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
View
14
[SID144209622]
Potency-Replicate_1 22.1456qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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15
[SID144209622]
Potency-Replicate_1 22.1456qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway [AID743191, Type: confirmatory]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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16
[SID144209622]
Ratio Potency (uM) 22.1456qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743078, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
17
[SID144213364]
Potency-Replicate_1 38.8952qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
18
[SID144213364]
Ratio Potency (uM) 43.6412qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743078, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
19
[SID144209622]
AR Potency (uM) 55.1482qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line: Summary [AID743054, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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20
[SID144213364]
qHTS assay to identify aromatase inhibitors: Summary [AID743139, Type: summary]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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