Bookmark and Share
Paraoxon (CID 9395) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(24)
 
 
Inactive(141)
 
 
Inconclusive(65)
 
 
Unspecified(25)
 
 
Top Targets:
NR LBD PPAR(21)
 
 
 
 
NR LBD AR(16)
 
 
 
 
NR LBD ER(16)
 
 
 
 
Esterase lipa..(13)
 
 
 
 
NR LBD Fxr(10)
 
 
 
 
BioAssay Types:
Confirmatory(155)
 
 
 
 
Summary(48)
 
 
 
 
Literature(37)
 
 
 
 
 
BioActivity Types:
Potency(191)
 
 
 
 
IC50(9)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 161    Data Row: 255   Total Pages: 6   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103191824]
IC50 0.013Displacement of acetylcholine from AChE in Swiss Webster mouse brain after 5 mins [AID503579, Type: Literature]Acetylcholinesterase [gi:113038]
View
2
[SID103191824]
IC50 0.059Inhibition of esterase activity of human carbonic anhydrase 2 by CO2 hydration method [AID525933, Type: Literature]Carbonic anhydrase 2 [gi:115456]
View
3
[SID103191824]
IC50 0.338Inhibition of esterase activity of human carbonic anhydrase 1 by CO2 hydration method [AID525930, Type: Literature]Carbonic anhydrase 1 [gi:115449]
View
4
[SID103191824]
IC50 0.54Inhibition of FAAH-mediated [3H]anadamide hydrolysis in mouse brain [AID409759, Type: Literature]Fatty-acid amide hydrolase 1 [gi:6225311]
View
5
[SID103191824]
IC50 1.021Inhibition of esterase activity of mouse carbonic anhydrase 13 by CO2 hydration method [AID525936, Type: Literature]Carbonic anhydrase 13 [gi:30580372]
View
6
[SID103191824]
IC50 1.2Displacement of 2-arachidonylglycerol from MAGL in Swiss Webster mouse brain after 5 mins [AID503381, Type: Literature]Monoglyceride lipase [gi:47117040]
View
7
[SID103191824]
IC50 1.2Displacement of [3H]CP-55940 from CB1 receptor in mouse brain [AID409760, Type: Literature]Cannabinoid receptor 1 [gi:1345697]
View
8
[SID103191824]
IC50 2.3Inhibition of MAGL-mediated 2-arachidonoylglycerol hydrolysis in mouse brain [AID409757, Type: Literature]Monoglyceride lipase [gi:47117040]
View
9
[SID103191824]
IC50 5.9Displacement of [3H]anandamide from FAAH in Swiss Webster mouse brain after 5 mins [AID503576, Type: Literature]Fatty-acid amide hydrolase 1 [gi:6225311]
View
10
[SID144213364]
Ratio Potency (uM) 14.6183qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
View
11
[SID144213364]
Potency-Replicate_1 15.4845qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
View
12
[SID144209622]
Ratio Potency (uM) 17.5909qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
View
13
[SID144209622]
Potency-Replicate_1 19.7373qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
View
14
[SID144209622]
Potency-Replicate_1 22.1456qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway [AID743191, Type: confirmatory]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
View
15
[SID144209622]
Potency-Replicate_1 22.1456qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
16
[SID144209622]
Ratio Potency (uM) 22.1456qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743078, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
17
[SID144213364]
Potency-Replicate_1 38.8952qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
18
[SID144213364]
Ratio Potency (uM) 43.6412qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743078, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
19
[SID144213364]
Potency-Replicate_1 54.4827qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
View
20
[SID144209622]
AR Potency (uM) 55.1482qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line: Summary [AID743054, Type: summary]AR protein [Homo sapiens] [gi:124375976]
View
21
[SID144209622]
Potency-Replicate_1 61.8773qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
View
22
[SID144209622]
qHTS assay to identify aromatase inhibitors: Summary [AID743139, Type: summary]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
View
23
[SID144213364]
qHTS assay to identify aromatase inhibitors: Summary [AID743139, Type: summary]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
View
24
[SID144213364]
qHTS assay to identify small molecule antagonists of the farnesoid-X-receptor (FXR) signaling pathway: Summary [AID743240, Type: summary]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
View
25
[SID103191824]
Km 1645Activity at human carbonic anhydrase 2 by UV-vis spectroscopy [AID525932, Type: Literature]Carbonic anhydrase 2 [gi:115456]
View
26
[SID103191824]
Km 1683Activity at human carbonic anhydrase 1 by UV-vis spectroscopy [AID525929, Type: Literature]Carbonic anhydrase 1 [gi:115449]
View
27
[SID103191824]
Km 2202Activity at mouse carbonic anhydrase 13 by UV-vis spectroscopy [AID525935, Type: Literature]Carbonic anhydrase 13 [gi:30580372]
View
28
[SID103191824]
Km 7600Kinetic constant Km from initial velocity assay against Organophosphorus acid anhydrolase from Alteromonas sp. JD6.5 [AID150557, Type: Literature]
View
29
[SID103191824]
LD50 expresses the acute toxicity measured after 24 hr in rats [AID184635, Type: Literature]
View
30
[SID103191824]
Ratio of kinetic constant Kcat to Km by linear fit to data against OPAA from Alteromonas sp. JD6.5 [AID227955, Type: Literature]
View
31
[SID103191824]
Time taken for 50% to be consumed by serum PON1 was determined [AID8206, Type: Literature]
View
32
[SID103191824]
Partition coefficient (logP) [AID23272, Type: Literature]
View
33
[SID103191824]
pKa rate constant at 25 degree Centigrade [AID26095, Type: Literature]
View
34
[SID103191824]
Kinetic constant Kcat from initial velocity assay (at 7.6 mM substrate) against Organophosphorus acid anhydrolase from Alteromonas sp. JD6.5 [AID150555, Type: Literature]
View
35
[SID26757694]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
View
36
[SID103191824]
Ratio of Kcat to Km for mouse carbonic anhydrase 13 [AID525934, Type: Literature]Carbonic anhydrase 13 [gi:30580372]
View
37
[SID103191824]
Inhibition of rat brain AChE by time-dependent inhibition assay [AID741583, Type: Literature]Acetylcholinesterase [gi:584716]
View
38
[SID103191824]
Inhibition of rat brain AChE by concentration-dependent inhibition assay [AID741584, Type: Literature]Acetylcholinesterase [gi:584716]
View
39
[SID103191824]
Ratio of Kcat to Km for human carbonic anhydrase 2 [AID525931, Type: Literature]Carbonic anhydrase 2 [gi:115456]
View
40
[SID103191824]
Ratio of Kcat to Km for human carbonic anhydrase 1 [AID525928, Type: Literature]Carbonic anhydrase 1 [gi:115449]
View
41
[SID103191824]
Inhibition of electric eel recombinant AChE [AID459096, Type: Literature]Acetylcholinesterase [gi:14916521]
View
42
[SID103191824]
Inhibition of electric eel AChE at 1 mM by Ellman's assay [AID460740, Type: Literature]Acetylcholinesterase [gi:14916521]
View
43
[SID103191824]
Inhibition of electric eel AChE at 100 uM by Ellman's assay [AID460995, Type: Literature]Acetylcholinesterase [gi:14916521]
View
44
[SID103191824]
Inhibition of electric eel AChE at 10 uM by Ellman's assay [AID460996, Type: Literature]Acetylcholinesterase [gi:14916521]
View
45
[SID103191824]
Inhibition of electric eel AChE by concentration-dependent inhibition assay [AID741587, Type: Literature]Acetylcholinesterase [gi:14916521]
View
46
[SID103191824]
Inhibition of human recombinant AChE at 1 mM by Ellman's assay [AID460997, Type: Literature]Acetylcholinesterase [gi:113037]
View
47
[SID103191824]
Inhibition of human recombinant AChE at 100 uM by Ellman's assay [AID460998, Type: Literature]Acetylcholinesterase [gi:113037]
View
48
[SID103191824]
Inhibition of human recombinant AChE at 10 uM by Ellman's assay [AID460999, Type: Literature]Acetylcholinesterase [gi:113037]
View
49
[SID103191824]
Inhibition of mouse recombinant AChE [AID459095, Type: Literature]Acetylcholinesterase [gi:113038]
View
50
[SID144213364]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the farnesoid-X-receptor (FXR) signaling pathway - cell viability counter screen [AID743221, Type: confirmatory]
View