Paraoxon (CID 9395) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(9)
 
 
Inactive(32)
 
 
Inconclusive(11)
 
 
Unspecified(22)
 
 
Top Targets:
alpha CA I II..(9)
 
 
 
Esterase lipa..(9)
 
 
 
NR LBD PPAR(5)
 
 
 
NR LBD TR(4)
 
 
Hydrolase 4(2)
 
 
BioAssay Types:
Literature(33)
 
 
 
 
 
Confirmatory(26)
 
 
 
BioActivity Types:
Potency(26)
 
 
 
IC50(9)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 66    Data Row: 74   Total Pages: 2   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103191824]
IC50 0.013Displacement of acetylcholine from AChE in Swiss Webster mouse brain after 5 mins [AID503579, Type: Literature]Acetylcholinesterase [gi:113038]
View
2
[SID103191824]
IC50 0.013Displacement of acetylcholine from AChE in Swiss Webster mouse brain after 5 mins [AID503579, Type: Literature]Acetylcholinesterase [gi:113038]
View
3
[SID103191824]
IC50 0.059Inhibition of esterase activity of human carbonic anhydrase 2 by CO2 hydration method [AID525933, Type: Literature]Carbonic anhydrase 2 [gi:115456]
View
4
[SID103191824]
IC50 0.338Inhibition of esterase activity of human carbonic anhydrase 1 by CO2 hydration method [AID525930, Type: Literature]Carbonic anhydrase 1 [gi:115449]
View
5
[SID103191824]
IC50 0.54Inhibition of FAAH-mediated [3H]anadamide hydrolysis in mouse brain [AID409759, Type: Literature]Fatty-acid amide hydrolase 1 [gi:6225311]
View
6
[SID103191824]
IC50 1.021Inhibition of esterase activity of mouse carbonic anhydrase 13 by CO2 hydration method [AID525936, Type: Literature]Carbonic anhydrase 13 [gi:30580372]
View
7
[SID103191824]
IC50 1.2Displacement of 2-arachidonylglycerol from MAGL in Swiss Webster mouse brain after 5 mins [AID503381, Type: Literature]Monoglyceride lipase [gi:47117040]
View
8
[SID103191824]
IC50 1.2Displacement of 2-arachidonylglycerol from MAGL in Swiss Webster mouse brain after 5 mins [AID503381, Type: Literature]Monoglyceride lipase [gi:47117040]
View
9
[SID103191824]
IC50 1.2Displacement of [3H]CP-55940 from CB1 receptor in mouse brain [AID409760, Type: Literature]Cannabinoid receptor 1 [gi:1345697]
View
10
[SID103191824]
IC50 2.3Inhibition of MAGL-mediated 2-arachidonoylglycerol hydrolysis in mouse brain [AID409757, Type: Literature]Monoglyceride lipase [gi:47117040]
View
11
[SID103191824]
IC50 2.3Inhibition of MAGL-mediated 2-arachidonoylglycerol hydrolysis in mouse brain [AID409757, Type: Literature]Monoglyceride lipase [gi:47117040]
View
12
[SID103191824]
IC50 5.9Displacement of [3H]anandamide from FAAH in Swiss Webster mouse brain after 5 mins [AID503576, Type: Literature]Fatty-acid amide hydrolase 1 [gi:6225311]
View
13
[SID103191824]
Km 1645Activity at human carbonic anhydrase 2 by UV-vis spectroscopy [AID525932, Type: Literature]Carbonic anhydrase 2 [gi:115456]
View
14
[SID103191824]
Km 1683Activity at human carbonic anhydrase 1 by UV-vis spectroscopy [AID525929, Type: Literature]Carbonic anhydrase 1 [gi:115449]
View
15
[SID103191824]
Km 2202Activity at mouse carbonic anhydrase 13 by UV-vis spectroscopy [AID525935, Type: Literature]Carbonic anhydrase 13 [gi:30580372]
View
16
[SID103191824]
Km 7600Kinetic constant Km from initial velocity assay against Organophosphorus acid anhydrolase from Alteromonas sp. JD6.5 [AID150557, Type: Literature]
View
17
[SID103191824]
 LD50 expresses the acute toxicity measured after 24 hr in rats [AID184635, Type: Literature]
View
18
[SID103191824]
 Ratio of kinetic constant Kcat to Km by linear fit to data against OPAA from Alteromonas sp. JD6.5 [AID227955, Type: Literature]
View
19
[SID103191824]
 Partition coefficient (logP) [AID23272, Type: Literature]
View
20
[SID103191824]
 pKa rate constant at 25 degree Centigrade [AID26095, Type: Literature]
View
21
[SID103191824]
 Kinetic constant Kcat from initial velocity assay (at 7.6 mM substrate) against Organophosphorus acid anhydrolase from Alteromonas sp. JD6.5 [AID150555, Type: Literature]
View
22
[SID26757694]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
View
23
[SID103191824]
 Ratio of Kcat to Km for human carbonic anhydrase 2 [AID525931, Type: Literature]Carbonic anhydrase 2 [gi:115456]
View
24
[SID103191824]
 Time taken for 50% to be consumed by serum PON1 was determined [AID8206, Type: Literature]
View
25
[SID103191824]
 Ratio of Kcat to Km for human carbonic anhydrase 1 [AID525928, Type: Literature]Carbonic anhydrase 1 [gi:115449]
View
26
[SID103191824]
 Inhibition of electric eel recombinant AChE [AID459096, Type: Literature]Acetylcholinesterase [gi:14916521]
View
27
[SID103191824]
 Inhibition of electric eel AChE at 1 mM by Ellman's assay [AID460740, Type: Literature]Acetylcholinesterase [gi:14916521]
View
28
[SID103191824]
 Inhibition of electric eel AChE at 100 uM by Ellman's assay [AID460995, Type: Literature]Acetylcholinesterase [gi:14916521]
View
29
[SID103191824]
 Inhibition of electric eel AChE at 10 uM by Ellman's assay [AID460996, Type: Literature]Acetylcholinesterase [gi:14916521]
View
30
[SID103191824]
 Inhibition of human recombinant AChE at 1 mM by Ellman's assay [AID460997, Type: Literature]Acetylcholinesterase [gi:113037]
View
31
[SID103191824]
 Inhibition of human recombinant AChE at 100 uM by Ellman's assay [AID460998, Type: Literature]Acetylcholinesterase [gi:113037]
View
32
[SID103191824]
 Inhibition of human recombinant AChE at 10 uM by Ellman's assay [AID460999, Type: Literature]Acetylcholinesterase [gi:113037]
View
33
[SID103191824]
 Ratio of Kcat to Km for mouse carbonic anhydrase 13 [AID525934, Type: Literature]Carbonic anhydrase 13 [gi:30580372]
View
34
[SID103191824]
 Inhibition of mouse recombinant AChE [AID459095, Type: Literature]Acetylcholinesterase [gi:113038]
View
35
[SID103191824]
 Inhibition of mouse recombinant AChE [AID459095, Type: Literature]Acetylcholinesterase [gi:113038]
View
36
[SID26757694]
Potency qHTS assay for small molecule activators of the rat pregnane X receptor (rPXR) signaling pathway [AID651751, Type: confirmatory]pregnane X receptor [Rattus norvegicus] [gi:5702233]
View
37
[SID26757694]
Potency qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1469, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
View
38
[SID26757694]
Potency qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1469, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
View
39
[SID26757694]
Potency qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1469, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
View
40
[SID26757694]
Potency Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
View
41
[SID26757694]
Potency Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
View
42
[SID26757694]
Potency Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
View
43
[SID26757694]
Potency qHTS assay for small molecule antagonists of thyroid hormone receptor beta signaling [AID588547, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
View
44
[SID26757694]
Potency qHTS assay for small molecule antagonists of thyroid hormone receptor beta signaling [AID588547, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
View
45
[SID26757694]
Potency qHTS assay for small molecule antagonists of thyroid hormone receptor beta signaling [AID588547, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
View
46
[SID26757694]
Potency qHTS assay for small molecule agonists of thyroid hormone receptor beta signaling [AID588545, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
View
47
[SID26757694]
Potency qHTS assay for small molecule agonists of thyroid hormone receptor beta signaling [AID588545, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
View
48
[SID26757694]
Potency qHTS assay for small molecule agonists of thyroid hormone receptor beta signaling [AID588545, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
View
49
[SID26757694]
Potency qHTS assay for small molecule agonists of vitamin D receptor signaling [AID588543, Type: confirmatory]vitamin D (1,25- dihydroxyvitamin D3) receptor [Homo sapiens] [gi:216409708]
View
50
[SID26757694]
Potency qHTS assay for small molecule agonists of vitamin D receptor signaling [AID588543, Type: confirmatory]vitamin D (1,25- dihydroxyvitamin D3) receptor [Homo sapiens] [gi:216409708]
View