Niacin (CID 938) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(82)
 
 
Inactive(904)
 
 
Inconclusive(45)
 
 
Unspecified(1637)
 
 
Top Targets:
7TM GPCR Srx(31)
 
 
 
p450(20)
 
 
 
7TM GPCR Srsx(18)
 
 
 
Bcl-2 like(10)
 
 
alkPPc(10)
 
 
BioAssay Types:
Screening(460)
 
 
 
 
Confirmatory(338)
 
 
 
 
Literature(255)
 
 
 
 
 
BioActivity Types:
Potency(262)
 
 
 
 
IC50(175)
 
 
 
 
EC50(45)
 
 
 
 
Ki(4)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2484    Data Row: 2668   Total Pages: 54   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103179145]
EC50 0.026Agonist activity at cynomolgus monkey GPR109a [AID570175, Type: other]
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2
[SID103179145]
EC50 0.027Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay [AID482808, Type: Literature]
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3
[SID103179145]
EC50 0.029Agonist activity at mouse GPR109a [AID663587, Type: other]
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4
[SID103179145]
EC50 0.029Agonist activity at mouse GPR109a [AID570177, Type: other]Hydroxycarboxylic acid receptor 2 [gi:81917230]
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5
[SID103179145]
EC50 0.03Agonist activity at dog GPR109a [AID570178, Type: other]
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6
[SID103179145]
EC50 0.031Agonist activity at dog GPR109a [AID663588, Type: other]
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7
[SID103179145]
Ki 0.033Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane. [AID147092, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:81912960]
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8
[SID103179145]
EC50 0.039Agonist activity at rat GPR109a [AID570176, Type: other]Hydroxycarboxylic acid receptor 2 [gi:81912960]
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9
[SID103179145]
EC50 0.039Agonist activity at rat GPR109a [AID663586, Type: other]
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10
[SID103179145]
Ki 0.05Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cells [AID361878, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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11
[SID103179145]
EC50 0.051Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay [AID672092, Type: Literature]
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12
[SID103179145]
IC50 0.06Antidyslipidemic activity in human adipocytes assessed as inhibition of isoproteranol-induced production of free fatty acids [AID482676, Type: Literature]
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13
[SID103179145]
IC50 0.07Inhibition of lipolysis in IBMX-stimulated human adipocytes assessed as glycerol release after 5 hrs [AID353305, Type: Literature]
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14
[SID103179145]
IC50 0.08Inhibition of lipolysis in human adipocytes assessed as free glycerol level [AID483096, Type: Literature]
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15
[SID103179145]
Ki 0.082Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry [AID464646, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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16
[SID103179145]
EC50 0.099Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation [AID663584, Type: other]
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17
[SID103179145]
EC50 0.1Agonist activity at human HM74A [AID640870, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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18
[SID103179145]
EC50 0.1Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation [AID570185, Type: other]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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19
[SID103179145]
Ki 0.104Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin [AID464647, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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20
[SID103179145]
EC50 0.12Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test [AID308653, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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21
[SID103179145]
EC50 0.12Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation [AID281255, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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22
[SID103179145]
IC50 0.13Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cells [AID387341, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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23
[SID103179145]
IC50 0.14Displacement of [3H]niacin from human GPR109A [AID304077, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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24
[SID103179145]
IC50 0.14Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cells [AID484757, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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25
[SID103179145]
IC50 0.14Displacement of [3H]niacin from human GPR109A expressed in CHO cells [AID353308, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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26
[SID103179145]
IC50 0.14Displacement of [3H]niacin from human GPR109A [AID311975, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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27
[SID103179145]
IC50 0.14Displacement of [3H]nicotinic acid from human GPR10a receptor [AID493975, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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28
[SID103179145]
IC50 0.14Displacement of [3H]nicotinic acid from human GPR109a receptor [AID353291, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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29
[SID103179145]
IC50 0.14Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serum [AID433725, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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30
[SID103179145]
IC50 0.14Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serum [AID433727, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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31
[SID103179145]
IC50 0.14Displacement of [3H]nicotinic acid from mouse GPR109a receptor [AID353290, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:81917230]
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32
[SID103179145]
IC50 0.14Displacement of [3H]niacin from mouse GPR109A [AID304083, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:81917230]
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33
[SID103179145]
IC50 0.14Displacement of [3H]nicotinic acid from mouse GPR10a receptor [AID493974, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:81917230]
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34
[SID103179145]
IC50 0.14Displacement of [3H]niacin from GRP109A receptor [AID482998, Type: Literature]
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35
[SID103179145]
IC50 0.14Displacement of [3H]Niacin from human niacin receptor expressed in CHO cells [AID404383, Type: Literature]
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36
[SID103179145]
IC50 0.15Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cells [AID387213, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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37
[SID103179145]
EC50 0.27Agonist activity at mouse GPR109A by [35S]GTP-gamma-S binding assay [AID304084, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:81917230]
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38
[SID103179145]
EC50 0.27Activity at human PUMA-G receptor by [35S]GTP-gamma-S binding assay [AID311985, Type: Literature]
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39
[SID103179145]
EC50 0.527Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay [AID464650, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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40
[SID103179145]
EC50 0.58Activation of GPR109A receptor in CHOK1 cells assessed as ERK1/2 MAP kinase activation by ELISA [AID331033, Type: Literature]
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41
[SID103179145]
EC50 0.67Agonist activity at rat GPR109A expressed by [35S]GTPgammaS binding assay [AID353326, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:81912960]
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42
[SID103179145]
EC50 0.9Inhibition of isoproterenol-induced lipolysis in human subcutaneous adipocytes after 5 hrs [AID331027, Type: Literature]
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43
[SID103179145]
EC50 0.96Potency required for stimulation of [35S]GTP gamma-S binding to rat spleen was determined [AID175888, Type: Literature]
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44
[SID103179145]
IC50 1Agonist activity at human niacin receptor expressed in CHO cells by GTPgammaS binding assay [AID404384, Type: Literature]
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45
[SID103179145]
EC50 1Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serum [AID483095, Type: Literature]
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46
[SID103179145]
EC50 1Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assay [AID433730, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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47
[SID103179145]
EC50 1Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assay [AID387214, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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48
[SID103179145]
EC50 1Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assay [AID484758, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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49
[SID103179145]
EC50 1Agonist activity at human GPR106A by [35S]GTPgammaS binding assay [AID311976, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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50
[SID103179145]
EC50 1Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay [AID353307, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
View