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Niacin (CID 938) - Compound BioActivity Data
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BioActivity Outcomes:
Active(90)
 
 
Inactive(1285)
 
 
Inconclusive(60)
 
 
Unspecified(1497)
 
 
Top Targets:
7tm 4(77)
 
 
 
p450(31)
 
 
 
 
NR LBD PPAR(30)
 
 
 
NR LBD ER(26)
 
 
 
NR LBD AR(22)
 
 
 
 
BioAssay Types:
Confirmatory(689)
 
 
 
 
Screening(528)
 
 
 
 
Literature(353)
 
 
 
 
 
Summary(72)
 
 
 
BioActivity Types:
Potency(541)
 
 
 
 
IC50(188)
 
 
 
 
EC50(47)
 
 
 
 
Ki(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2486    Data Row: 2932   Total Pages: 147   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103179145]
EC50 0.026Agonist activity at cynomolgus monkey GPR109a [AID570175, Type: Literature]
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2
[SID103179145]
EC50 0.02692Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay [AID428323, Type: Literature]
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3
[SID103179145]
EC50 0.027Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay [AID482808, Type: Literature]
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4
[SID103179145]
EC50 0.029Agonist activity at mouse GPR109a [AID570177, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:81917230]
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5
[SID103179145]
EC50 0.029Agonist activity at mouse GPR109a [AID663587, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:81917230]
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6
[SID103179145]
EC50 0.03Agonist activity at dog GPR109a [AID570178, Type: Literature]
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7
[SID103179145]
EC50 0.031Agonist activity at dog GPR109a [AID663588, Type: Literature]
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8
[SID103179145]
Ki 0.033Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane. [AID147092, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:81912960]
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9
[SID103179145]
EC50 0.039Agonist activity at rat GPR109a [AID570176, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:81912960]
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10
[SID103179145]
EC50 0.039Agonist activity at rat GPR109a [AID663586, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:81912960]
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11
[SID103179145]
Ki 0.05Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cells [AID361878, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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12
[SID103179145]
EC50 0.051Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay [AID672092, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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13
[SID103179145]
IC50 0.06Antidyslipidemic activity in human adipocytes assessed as inhibition of isoproteranol-induced production of free fatty acids [AID482676, Type: Literature]
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14
[SID103179145]
IC50 0.07Inhibition of lipolysis in IBMX-stimulated human adipocytes assessed as glycerol release after 5 hrs [AID353305, Type: Literature]
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15
[SID103179145]
IC50 0.08Inhibition of lipolysis in human adipocytes assessed as free glycerol level [AID483096, Type: Literature]
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16
[SID103179145]
Ki 0.082Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry [AID464646, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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17
[SID103179145]
EC50 0.099Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation [AID663584, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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18
[SID103179145]
EC50 0.1Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation [AID570185, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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19
[SID103179145]
EC50 0.1Agonist activity at human HM74A [AID640870, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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20
[SID103179145]
Ki 0.104Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin [AID464647, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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