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ACRIDINE (CID 9215) - Compound BioActivity Data
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BioActivity Outcomes:
Active(18)
 
 
Inactive(58)
 
 
Inconclusive(8)
 
 
Unspecified(26)
 
 
Top Targets:
PLDc mTdp1 2(3)
 
 
 
RIP(2)
 
 
NR LBD TR(2)
 
 
ANK(2)
 
 
Tubulin-bindi..(2)
 
 
 
BioAssay Types:
Confirmatory(58)
 
 
 
 
 
Literature(37)
 
 
 
Screening(8)
 
 
 
BioActivity Types:
Potency(55)
 
 
 
 
 
IC50(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 103    Data Row: 110   Total Pages: 3   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID124892352]
Potency 10qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID124892352]
Potency 12.5893qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID103218718]
IC50 45Concentration required to inhibit the cell growth by 50 % after 48 hr in L1210 leukemic cells. [AID98558, Type: Literature]
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4
[SID103218718]
IC50 45Cytotoxic potency required to inhibit L1210 cell growth by 50% after cell drug contact for 48 hrs [AID98563, Type: Literature]
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5
[SID103218718]
Binding affinity to calf thymus DNA up to 5 mM [AID733186, Type: Literature]
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6
[SID26755289]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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7
[SID26755289]
A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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8
[SID26755289]
A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
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9
[SID26755289]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
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10
[SID103218718]
Inhibitory concentration against ethidium:Calf thymus DNA(0.1:1) binding at pH 5 [AID46169, Type: Literature]
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11
[SID103218718]
Inhibitory concentration against ethidium in DNA-binding assay [AID54658, Type: Literature]
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12
[SID103218718]
Concentration required to give 50% fluorescence quenching of bound ethidium for [ethidium] : [(poly dG-dC)]2 DNA in ratio of 0.1:1 at pH 5 [AID55499, Type: Literature]
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13
[SID103218718]
Concentration required to give 50% fluorescence quenching of bound ethidium for [ethidium] : [poly(dA-dT)]2 DNA in ratio of 0.1:1 at pH 5 [AID55500, Type: Literature]
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14
[SID103218718]
Inhibitory concentration against ethidium in DNA-binding assay with [poly(dA-dT)]2 (synthetic oligonucleotide) [AID225777, Type: Literature]
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15
[SID103218718]
Inhibitory concentration against ethidium in DNA-binding assay with [poly(dG-dC)]2 (synthetic oligonucleotide) [AID225778, Type: Literature]
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16
[SID103218718]
Displacement of gentamycin from RNA bulge site of Escherichia coli 16S ribosomal 27-nucleotide A-site RNA by water Logsy NMR spectroscopy based noncompetitive binding assay [AID375067, Type: Literature]
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17
[SID103218718]
Displacement of gentamycin from RNA bulge site of Escherichia coli 16S ribosomal 27-nucleotide A-site RNA by T2 filter NMR spectroscopy based competitive binding assay [AID375070, Type: Literature]
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18
[SID103218718]
Binding affinity to Escherichia coli 16S ribosomal 27-nucleotide A-site RNA by ID imino spectrum based NMR spectroscopy [AID375072, Type: Literature]
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19
[SID103218718]
IC50 100Concentration required to inhibit the cell growth by 50 % after 96 hr A2780 leukemic cells. [AID10004, Type: Literature]
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20
[SID103218718]
IC50 100Cytotoxic potency required to inhibit A2780 cell growth by 50% after cell drug contact for 96 hrs [AID10007, Type: Literature]
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21
[SID103218718]
CC50 142Drug concentration required to produce 50% inhibition of fluorescence bound ethidium to CT-DNA (1.26:1) (+/-SEM 5%) [AID220346, Type: Literature]
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22
[SID103218718]
CC50 142Inhibitory concentration against DNA-bound ethidium for cytotoxicity [AID55304, Type: Literature]
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23
[SID124892352]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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24
[SID103218718]
Antagonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced inward Na+ current at >= 10 uM [AID420787, Type: Literature]5-hydroxytryptamine receptor 3A [gi:1168222]
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25
[SID103218718]
logD (measured by HPLC) (as log k') [AID23959, Type: Literature]
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26
[SID103218718]
logD (measured by HPLC) (as log k') [AID23961, Type: Literature]
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27
[SID103218718]
logD (measured by HPLC) (as log k') [AID23963, Type: Literature]
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28
[SID103218718]
logD (measured by HPLC) (as log k') [AID23965, Type: Literature]
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29
[SID103218718]
logD (measured by HPLC) (as log k') [AID23968, Type: Literature]
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30
[SID103218718]
logD (measured by HPLC) (as log k') [AID23970, Type: Literature]
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31
[SID103218718]
logD (measured by HPLC) (as log k') [AID23971, Type: Literature]
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32
[SID103218718]
Partition coefficient (logD, measured by HPLC, log k') [AID23973, Type: Literature]
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33
[SID103218718]
Partition coefficient (logD7.4) [AID26296, Type: Literature]
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34
[SID103218718]
Partition coefficient (logP) (dodecane) [AID28956, Type: Literature]
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35
[SID103218718]
Partition coefficient (logP) [AID28957, Type: Literature]
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36
[SID103218718]
Inhibitory concentration against ethidium:calf thymus DNA (1.26:1) binding at pH 5 [AID46133, Type: Literature]
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37
[SID103218718]
Inhibitory concentration against ethidium:Calf thymus DNA (1.26:1) binding at pH 7 [AID46135, Type: Literature]
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38
[SID103218718]
Partition coefficient, log P of the compound [AID310931, Type: Literature]
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39
[SID103218718]
Permeability across PAMPA membrane after 7 hrs [AID310933, Type: Literature]
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40
[SID103218718]
Binding affinity to beta cyclodextrin [AID346025, Type: Literature]
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41
[SID103218718]
Induced change in DNA-melting (deltaTm) with [poly(dA-dT)]2 at pH 65.0 [AID55630, Type: Literature]
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42
[SID103218718]
Induced change in DNA-melting (deltaTm) with [poly(dG-dC)]2 at pH 65.0 [AID55632, Type: Literature]
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43
[SID103218718]
Change in DNA-melting (deltaTm) with calf thymus DNA at pH 65.0 [AID54988, Type: Literature]
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44
[SID103218718]
Change in DNA-melting (deltaTm) with calf thymus DNA at pH 7.0 [AID54990, Type: Literature]
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45
[SID26755289]
Potency 50.1187qHTS Assay for Identification of Novel General Anesthetics [AID485281, Type: confirmatory]Chain A, Horse Spleen Apoferritin [gi:254220970]
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46
[SID124892352]
Potency 79.4328qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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47
[SID124892352]
qHTS for Agonists of the Human Mucolipin Transient Receptor Potential 1 (TRPML1) [AID624414, Type: screening]mucolipin-1 [Homo sapiens] [gi:10092597]
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48
[SID26755289]
Potency qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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49
[SID124892352]
Potency qHTS for Inhibitors of Vif-A3G Interactions: qHTS [AID602310, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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50
[SID26755289]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]menin isoform 1 [Homo sapiens] [gi:18860839]
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