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ACRIDINE (CID 9215) - Compound BioActivity Data
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BioActivity Outcomes:
Active(18)
 
 
Inactive(58)
 
 
Inconclusive(8)
 
 
Unspecified(26)
 
 
Top Targets:
PLDc mTdp1 2(3)
 
 
 
RIP(2)
 
 
NR LBD TR(2)
 
 
ANK(2)
 
 
Tubulin-bindi..(2)
 
 
 
BioAssay Types:
Confirmatory(58)
 
 
 
 
 
Literature(37)
 
 
 
Screening(8)
 
 
 
BioActivity Types:
Potency(55)
 
 
 
 
 
IC50(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 103    Data Row: 110   Total Pages: 6   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID124892352]
Potency 10qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID124892352]
Potency 12.5893qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID103218718]
IC50 45Concentration required to inhibit the cell growth by 50 % after 48 hr in L1210 leukemic cells. [AID98558, Type: Literature]
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4
[SID103218718]
IC50 45Cytotoxic potency required to inhibit L1210 cell growth by 50% after cell drug contact for 48 hrs [AID98563, Type: Literature]
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5
[SID103218718]
Binding affinity to calf thymus DNA up to 5 mM [AID733186, Type: Literature]
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6
[SID26755289]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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7
[SID26755289]
A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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8
[SID26755289]
A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
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9
[SID26755289]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
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10
[SID103218718]
Inhibitory concentration against ethidium:Calf thymus DNA(0.1:1) binding at pH 5 [AID46169, Type: Literature]
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11
[SID103218718]
Inhibitory concentration against ethidium in DNA-binding assay [AID54658, Type: Literature]
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12
[SID103218718]
Concentration required to give 50% fluorescence quenching of bound ethidium for [ethidium]: [(poly dG-dC)]2 DNA in ratio of 0.1:1 at pH 5 [AID55499, Type: Literature]
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13
[SID103218718]
Concentration required to give 50% fluorescence quenching of bound ethidium for [ethidium]: [poly(dA-dT)]2 DNA in ratio of 0.1:1 at pH 5 [AID55500, Type: Literature]
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14
[SID103218718]
Inhibitory concentration against ethidium in DNA-binding assay with [poly(dA-dT)]2 (synthetic oligonucleotide) [AID225777, Type: Literature]
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15
[SID103218718]
Inhibitory concentration against ethidium in DNA-binding assay with [poly(dG-dC)]2 (synthetic oligonucleotide) [AID225778, Type: Literature]
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16
[SID103218718]
Displacement of gentamycin from RNA bulge site of Escherichia coli 16S ribosomal 27-nucleotide A-site RNA by water Logsy NMR spectroscopy based noncompetitive binding assay [AID375067, Type: Literature]
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17
[SID103218718]
Displacement of gentamycin from RNA bulge site of Escherichia coli 16S ribosomal 27-nucleotide A-site RNA by T2 filter NMR spectroscopy based competitive binding assay [AID375070, Type: Literature]
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18
[SID103218718]
Binding affinity to Escherichia coli 16S ribosomal 27-nucleotide A-site RNA by ID imino spectrum based NMR spectroscopy [AID375072, Type: Literature]
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19
[SID103218718]
IC50 100Concentration required to inhibit the cell growth by 50 % after 96 hr A2780 leukemic cells. [AID10004, Type: Literature]
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20
[SID103218718]
IC50 100Cytotoxic potency required to inhibit A2780 cell growth by 50% after cell drug contact for 96 hrs [AID10007, Type: Literature]
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