ACRIDINE (CID 9215) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(15)
 
 
Inactive(52)
 
 
Inconclusive(7)
 
 
Unspecified(26)
 
 
Top Targets:
Tubulin-bindi..(2)
 
 
 
NR LBD TR(2)
 
 
NR LBD ROR li..(2)
 
 
RIP(2)
 
 
Pyr redox dim(2)
 
 
BioAssay Types:
Confirmatory(51)
 
 
 
 
 
Literature(36)
 
 
 
Screening(6)
 
 
 
BioActivity Types:
Potency(49)
 
 
 
 
 
IC50(4)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 98    Data Row: 100   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID124892352]
Potency 10qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID124892352]
Potency 10qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID124892352]
Potency 10qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID124892352]
Potency 12.5893qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID124892352]
Potency 12.5893qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID124892352]
Potency 12.5893qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID103218718]
IC50 45Cytotoxic potency required to inhibit L1210 cell growth by 50% after cell drug contact for 48 hrs [AID98563, Type: Literature]
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8
[SID103218718]
IC50 45Concentration required to inhibit the cell growth by 50 % after 48 hr in L1210 leukemic cells. [AID98558, Type: Literature]
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9
[SID103218718]
 Displacement of gentamycin from RNA bulge site of Escherichia coli 16S ribosomal 27-nucleotide A-site RNA by water Logsy NMR spectroscopy based noncompetitive binding assay [AID375067, Type: Literature]
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10
[SID103218718]
 Displacement of gentamycin from RNA bulge site of Escherichia coli 16S ribosomal 27-nucleotide A-site RNA by T2 filter NMR spectroscopy based competitive binding assay [AID375070, Type: Literature]
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11
[SID103218718]
 Binding affinity to Escherichia coli 16S ribosomal 27-nucleotide A-site RNA by ID imino spectrum based NMR spectroscopy [AID375072, Type: Literature]
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12
[SID26755289]
 Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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13
[SID26755289]
 A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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14
[SID103218718]
 Concentration required to give 50% fluorescence quenching of bound ethidium for [ethidium] : [poly(dA-dT)]2 DNA in ratio of 0.1:1 at pH 5 [AID55500, Type: Literature]
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15
[SID103218718]
 Inhibitory concentration against ethidium in DNA-binding assay with [poly(dA-dT)]2 (synthetic oligonucleotide) [AID225777, Type: Literature]
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16
[SID103218718]
 Inhibitory concentration against ethidium in DNA-binding assay with [poly(dG-dC)]2 (synthetic oligonucleotide) [AID225778, Type: Literature]
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17
[SID103218718]
 Inhibitory concentration against ethidium:Calf thymus DNA(0.1:1) binding at pH 5 [AID46169, Type: Literature]
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18
[SID103218718]
 Inhibitory concentration against ethidium in DNA-binding assay [AID54658, Type: Literature]
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19
[SID103218718]
 Concentration required to give 50% fluorescence quenching of bound ethidium for [ethidium] : [(poly dG-dC)]2 DNA in ratio of 0.1:1 at pH 5 [AID55499, Type: Literature]
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20
[SID103218718]
IC50 100Concentration required to inhibit the cell growth by 50 % after 96 hr A2780 leukemic cells. [AID10004, Type: Literature]
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21
[SID103218718]
IC50 100Cytotoxic potency required to inhibit A2780 cell growth by 50% after cell drug contact for 96 hrs [AID10007, Type: Literature]
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22
[SID103218718]
CC50 142Inhibitory concentration against DNA-bound ethidium for cytotoxicity [AID55304, Type: Literature]
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23
[SID103218718]
CC50 142Drug concentration required to produce 50% inhibition of fluorescence bound ethidium to CT-DNA (1.26:1) (+/-SEM 5%) [AID220346, Type: Literature]
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24
[SID103218718]
 Partition coefficient, log P of the compound [AID310931, Type: Literature]
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25
[SID103218718]
 Permeability across PAMPA membrane after 7 hrs [AID310933, Type: Literature]
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26
[SID103218718]
 Binding affinity to beta cyclodextrin [AID346025, Type: Literature]
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27
[SID103218718]
 logD (measured by HPLC) (as log k') [AID23961, Type: Literature]
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28
[SID103218718]
 Change in DNA-melting (deltaTm) with calf thymus DNA at pH 65.0 [AID54988, Type: Literature]
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29
[SID103218718]
 Change in DNA-melting (deltaTm) with calf thymus DNA at pH 7.0 [AID54990, Type: Literature]
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30
[SID103218718]
 logD (measured by HPLC) (as log k') [AID23959, Type: Literature]
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31
[SID103218718]
 logD (measured by HPLC) (as log k') [AID23963, Type: Literature]
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32
[SID103218718]
 logD (measured by HPLC) (as log k') [AID23965, Type: Literature]
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33
[SID103218718]
 logD (measured by HPLC) (as log k') [AID23968, Type: Literature]
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34
[SID103218718]
 logD (measured by HPLC) (as log k') [AID23970, Type: Literature]
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35
[SID103218718]
 logD (measured by HPLC) (as log k') [AID23971, Type: Literature]
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36
[SID103218718]
 Partition coefficient (logD, measured by HPLC, log k') [AID23973, Type: Literature]
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37
[SID103218718]
 Partition coefficient (logD7.4) [AID26296, Type: Literature]
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38
[SID103218718]
 Partition coefficient (logP) (dodecane) [AID28956, Type: Literature]
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39
[SID103218718]
 Partition coefficient (logP) [AID28957, Type: Literature]
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40
[SID103218718]
 Inhibitory concentration against ethidium:calf thymus DNA (1.26:1) binding at pH 5 [AID46133, Type: Literature]
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41
[SID103218718]
 Inhibitory concentration against ethidium:Calf thymus DNA (1.26:1) binding at pH 7 [AID46135, Type: Literature]
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42
[SID103218718]
 Induced change in DNA-melting (deltaTm) with [poly(dA-dT)]2 at pH 65.0 [AID55630, Type: Literature]
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43
[SID103218718]
 Induced change in DNA-melting (deltaTm) with [poly(dG-dC)]2 at pH 65.0 [AID55632, Type: Literature]
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44
[SID103218718]
 Antagonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced inward Na+ current at >= 10 uM [AID420787, Type: Literature]5-hydroxytryptamine receptor 3A [gi:1168222]
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45
[SID103218718]
 Antagonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced inward Na+ current at >= 10 uM [AID420787, Type: Literature]5-hydroxytryptamine receptor 3A [gi:1168222]
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46
[SID103218718]
 Antagonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced inward Na+ current at >= 10 uM [AID420787, Type: Literature]5-hydroxytryptamine receptor 3A [gi:1168222]
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47
[SID124892352]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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48
[SID124892352]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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49
[SID26755289]
Potency 50.1187qHTS Assay for Identification of Novel General Anesthetics [AID485281, Type: confirmatory]Chain A, Horse Spleen Apoferritin [gi:254220970]
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50
[SID124892352]
Potency 79.4328qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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