T6188955 (CID 9099810) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(2)
 
 
Inactive(1)
 
 
Unspecified(3)
 
 
Top Targets:
Rac1 like(3)
 
 
 
Cdc42(1)
 
 
RhoA like(1)
 
 
BioAssay Types:
Literature(6)
 
 
 
 
BioActivity Types:
IC50(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 6    Data Row: 6   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103692691]
 Inhibition of Cdc42 [AID421038, Type: Literature]
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2
[SID103692691]
 Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of ratio of Rac1GTP/Rac1 levels at 25 uM after 4 hrs by pull-down assay [AID421037, Type: Literature]Ras-related C3 botulinum toxin substrate 1 [gi:51702787]
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3
[SID103692691]
 Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of ratio of Rac1GTP/Rac1 levels at 25 uM after 4 hrs by pull-down assay [AID421037, Type: Literature]Ras-related C3 botulinum toxin substrate 1 [gi:51702787]
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4
[SID103692691]
IC50 57.2Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of Rac1GTP level after 4 hrs by G-LISA [AID421036, Type: Literature]Ras-related C3 botulinum toxin substrate 1 [gi:51702787]
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5
[SID103692691]
IC50 57.2Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of Rac1GTP level after 4 hrs by G-LISA [AID421036, Type: Literature]Ras-related C3 botulinum toxin substrate 1 [gi:51702787]
View
6
[SID103692691]
 Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of Rac1GTP level at 50 uM after 4 hrs by G-LISA relative to control [AID421035, Type: Literature]Ras-related C3 botulinum toxin substrate 1 [gi:51702787]
View
7
[SID103692691]
 Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of Rac1GTP level at 50 uM after 4 hrs by G-LISA relative to control [AID421035, Type: Literature]Ras-related C3 botulinum toxin substrate 1 [gi:51702787]
View
8
[SID103692691]
 Inhibition of PDGF-BB-stimulated Cdc42 activity in human aortic smooth muscle cells assessed as reduction in ratio of Cdc42GTP/Cdc42 levels at 25 uM after 4 hrs by pull-down assay [AID421039, Type: Literature]Cell division control protein 42 homolog [gi:322510015]
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9
[SID103692691]
 Inhibition of PDGF-BB-stimulated Cdc42 activity in human aortic smooth muscle cells assessed as reduction in ratio of Cdc42GTP/Cdc42 levels at 25 uM after 4 hrs by pull-down assay [AID421039, Type: Literature]Cell division control protein 42 homolog [gi:322510015]
View
10
[SID103692691]
 Inhibition of PDGF-BB-stimulated RhoA activity in human aortic smooth muscle cells assessed as reduction in ratio of RhoAGTP/RhoA levels at 25 uM after 4 hrs by pull-down assay [AID421040, Type: Literature]Transforming protein RhoA [gi:47606458]
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