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MLS000684008 (CID 906542) - Compound BioActivity Data
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BioActivity Outcomes:
Active(230)
 
 
Inactive(516)
 
 
Inconclusive(42)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(44)
 
 
 
Esterase lipa..(12)
 
 
 
CASc(10)
 
 
 
G-alpha(8)
 
 
 
Tryp SPc(8)
 
 
 
BioAssay Types:
Screening(495)
 
 
 
 
Confirmatory(258)
 
 
 
 
 
Literature(22)
 
 
 
BioActivity Types:
Potency(144)
 
 
 
 
 
IC50(58)
 
 
 
 
AC50(36)
 
 
 
EC50(10)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 716    Data Row: 789   Total Pages: 40   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24788424]
EC50_uM 0.0191Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity [AID435010, Type: confirmatory]recombinase A [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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2
[SID24788424]
Potency 0.0316Inhibitors of USP1/UAF1: Primary Screen [AID743255, Type: confirmatory]USP1 protein, partial [Homo sapiens] [gi:118600387]
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3
[SID99351059]
AC50_uM 0.047RecA Intein Measured in Biochemical System Using Plate Reader - 2047-02_Inhibitor_Dose_DryPowder_Activity [AID493229, Type: confirmatory]recombinase A [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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4
[SID24788424]
IC50_Mean 0.079Dose response confirmation of uHTS hits for Apaf-1 in a Fluorescent assay [AID588524, Type: confirmatory]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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5
[SID99351059]
AC50_uM 0.143GFP-RecA MOA-DTT Measured in Biochemical System Using Plate Reader - 2047-05_Inhibitor_Dose_DryPowder_Activity [AID493233, Type: confirmatory]recombinase A [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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6
[SID24788424]
IC50_Mean 0.145Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]caspase-3 preproprotein [Homo sapiens] [gi:14790119]
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7
[SID24788424]
IC50_Mean 0.145Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]caspase-9 isoform alpha precursor [Homo sapiens] [gi:14790124]
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8
[SID24788424]
AC50_uM 0.1764Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Non-Covalent Inhibitors of RecA-Intein Splicing Activity [AID449750, Type: confirmatory]replicative DNA helicase [Mycobacterium tuberculosis H37Rv] [gi:15607200]
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9
[SID24788424]
IC50 0.21004Epi Absorbance-based biochemical high throughput dose response assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2) [AID743297, Type: confirmatory]tyrosyl-DNA phosphodiesterase 2 [Homo sapiens] [gi:23510348]
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10
[SID24788424]
AC50_uM 0.219VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_Dose_CherryPick_Activity [AID720632, Type: confirmatory]Caspase 6, apoptosis-related cysteine peptidase [Homo sapiens] [gi:13325293]
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11
[SID24788424]
AC50_uM 0.284MLPCN Dyrk1A Kinase Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_Dose_CherryPick_Activity [AID588345, Type: confirmatory]dual specificity tyrosine-phosphorylation-regulated kinase 1A [Rattus norvegicus] [gi:6978787]
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12
[SID24788424]
AC50_uM 0.317Caspase 9 Counterscreen for Selectivity Fluorescent Measured in Biochemical System Using Plate Reader - 7052-06_Inhibitor_Dose_CherryPick_Activity [AID743293, Type: confirmatory]Caspase-9 [gi:28558771]
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13
[SID24788424]
IC50 0.36621Fluorescence-based biochemical high throughput screening dose response assay to identify inhibitors of Crimean-Congo Hemorrhagic Fever (CCHF) viral ovarian tumor domain protease (vOTU): Pep-AMC substrate [AID720578, Type: confirmatory]putative polyprotein [Crimean-Congo hemorrhagic fever virus] [gi:76364066]
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14
[SID24788424]
AC50_uM 0.371Caspase 7 Counterscreen for Selectivity Fluorescent Measured in Cell-Based System Using Plate Reader - 7052-04_Inhibitor_Dose_CherryPick_Activity [AID743295, Type: confirmatory]Caspase-7 [gi:1730092]
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15
[SID24788424]
EC50_uM 0.4098Fluorescence Cell-Free Homogeneous Counter Screen to Identify Inhibitors of GFP Chromophore Formation [AID434968, Type: confirmatory]recombinase A [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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16
[SID24788424]
AC50_uM 0.436Caspase 8 Counterscreen for Selectivity Fluorescent Measured in Biochemical System Using Plate Reader - 7052-05_Inhibitor_Dose_CherryPick_Activity [AID743294, Type: confirmatory]Caspase-8 [gi:2493531]
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17
[SID24788424]
Potency 0.4467qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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18
[SID24788424]
AC50_uM 0.493Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_Dose_CherryPick_Activity [AID624132, Type: confirmatory]
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19
[SID24788424]
AC50_uM 0.5ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_Dose_CherryPick_Activity [AID651703, Type: confirmatory]transforming acidic coiled-coil-containing protein 3 [Homo sapiens] [gi:5454102]
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20
[SID24788424]
AC50_uM 0.5ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_Dose_CherryPick_Activity [AID651703, Type: confirmatory]aryl hydrocarbon receptor nuclear translocator [Homo sapiens] [gi:2702319]
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