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2-fluoroadenosine (CID 8975) - Compound BioActivity Data
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BioActivity Outcomes:
Active(135)
 
 
Inactive(484)
 
 
Inconclusive(14)
 
 
Unspecified(5)
 
 
Top Targets:
7TM GPCR Srx(16)
 
 
 
7TM GPCR Srsx(11)
 
 
Bcl-2 like(11)
 
 
 
RGS RGS4(6)
 
 
 
Alpha TIF(6)
 
 
BioAssay Types:
Screening(385)
 
 
 
 
Confirmatory(178)
 
 
 
 
 
Literature(70)
 
 
 
 
 
BioActivity Types:
Potency(104)
 
 
 
 
 
AC50(25)
 
 
 
 
EC50(23)
 
 
 
IC50(22)
 
 
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 521    Data Row: 638   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID47193876]
Potency 0.058qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID47193876]
EC50 0.07Luminescence Cell-Based HTS Dose Confimation to Identify Inhibitors of of 5'UTR Stem-Loop Driven Alpha-Synuclein mRNA Translation in H4 Neuroglioblastoma Cells [AID2454, Type: confirmatory]
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3
[SID47193876]
EC50 0.084Luminescence Cell-Based Dose Response to Identify Inhibitors of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4-C Neuroglioblastoma Cells [AID2452, Type: confirmatory]
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4
[SID47193876]
EC50 0.088Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Platelet Dense Granule Release [AID1889, Type: confirmatory]
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5
[SID103211611]
Ki 0.099Affinity for human Adenosine A3 receptor expressed in CHO cell [AID34574, Type: Literature]
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6
[SID47193876]
EC50 0.1Luminescence Cell-Based Dose Response HTS to Identify Inhibitors of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells [AID1994, Type: confirmatory]
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7
[SID47193876]
EC50 0.1Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of of 5'UTR Stem-Loop Driven Alpha-Synuclein mRNA Translation in H4 Neuroglioblastoma Cells [AID1988, Type: confirmatory]
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8
[SID47193876]
EC50 0.124Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT RAS-Independent Fibroblast [AID1933, Type: confirmatory]
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9
[SID47193876]
Potency 0.1636qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID47193876]
EC50 0.199Luminescence Cell-Based Dose Response to Identify Inhibitors of Luciferase Translation or Activity in H4-C Neuroglioblastoma Cells [AID2458, Type: confirmatory]
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11
[SID47193876]
Potency 0.2311qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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12
[SID47193876]
EC50 0.242Luminescence Cell-Based Dose Response HTS to Identify Inhibitors of Luciferase Translation or Activity in H4 Neuroglioblastoma Cells [AID1990, Type: confirmatory]
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13
[SID47193876]
AC50_uM 0.26Cell fusion assay for clade C HIV-1ZM109 Env Measured in Cell-Based System Using Plate Reader - 7013-05_Inhibitor_Dose_CherryPick_Activity [AID652058, Type: confirmatory]
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14
[SID47193876]
AC50_uM 0.271CEM21 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7013-03_Inhibitor_Dose_CherryPick_Activity [AID652042, Type: confirmatory]
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15
[SID47193876]
EC50 0.3A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhimurium identified in the primary screen [AID2253, Type: confirmatory]
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16
[SID47193876]
AC50_uM 0.341HIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_Dose_CherryPick_Activity [AID652057, Type: confirmatory]
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17
[SID47193876]
EC50_uM 0.348Fluorescence Cell-Based Dose Response to Characterize Compounds Cytotoxic to RAS-Dependent BJ-TERT-LT-ST Fibroblast [AID2631, Type: confirmatory]
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18
[SID47193876]
EC50 0.35A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhi identified in the primary screen [AID2252, Type: confirmatory]
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19
[SID47193876]
EC50 0.46Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT-LT-ST RAS-Independent Fibroblast [AID1935, Type: confirmatory]
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20
[SID47193876]
Potency 0.4611qHTS for Inhibitors of TGF-b: Cytotox Counterscreen for Cherry Picks [AID720535, Type: confirmatory]
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21
[SID47193876]
Potency 0.5805qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks [AID720534, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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22
[SID47193876]
Potency 0.6513qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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23
[SID47193876]
EC50 0.674Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to DRD Non-Viral Oncogenic Fibroblast [AID1934, Type: confirmatory]
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24
[SID47193876]
AC50_uM 0.6991ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
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25
[SID47193876]
Potency 0.7943qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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26
[SID47193876]
Potency 0.7943qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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27
[SID47193876]
Potency 0.92Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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28
[SID47193876]
AC50_uM 0.981HSF-1 induced GFP reporter and Doxycycline induced RFP reporter Measured in Cell-Based System Using Plate Reader - 2038-03_Inhibitor_DoseNoFile_CherryPick_Internal-Standard_Set3 [AID493085, Type: confirmatory]Hsf1 protein [Mus musculus] [gi:62740231]
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29
[SID47193876]
Potency 1qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS [AID720579, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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30
[SID47193876]
Potency 1.122qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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31
[SID47193876]
Potency 1.1582qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks [AID720536, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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32
[SID47193876]
AC50_uM 1.348Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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33
[SID47193876]
EC50 1.354Luminescence Cell-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to BJeLR RAS-Dependent Fibroblast [AID1936, Type: confirmatory]
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34
[SID47193876]
IC50_Mean 1.37Dose response confirmation of uHTS chemical inhibitors of both B-cell and T-cell specific antigen receptor-induced NF-kB activation in a 697B cell line using a luminescence assay [AID489034, Type: confirmatory]
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35
[SID47193876]
AC50_uM 1.4Control Cell Fusion Counterscreen Assay Measured in Cell-Based System Using Plate Reader - 7013-02_Inhibitor_Dose_CherryPick_Activity [AID652040, Type: confirmatory]
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36
[SID99222861]
AC50_uM 1.5Secondary assay of A1 inhibitors in Mouse Embryonic Fibroblasts with alternate A1 construct Measured in Cell-Based System Using Plate Reader - 2045-05_Inhibitor_Dose_DryPowder_Activity [AID488891, Type: confirmatory]
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37
[SID47193876]
AC50_uM 1.607HSF-1 induced GFP reporter and Doxycycline induced RFP reporter Measured in Cell-Based System Using Plate Reader - 2038-03_Inhibitor_DoseNoFile_CherryPick_Activity_Set3 [AID493083, Type: confirmatory]Hsf1 protein [Mus musculus] [gi:62740231]
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38
[SID47193876]
AC50_uM 1.92HIV-1 Cell Fusion assay for clade B Env AD8 Measured in Cell-Based System Using Plate Reader - 7013-04_Inhibitor_Dose_CherryPick_Activity [AID652062, Type: confirmatory]
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39
[SID47193876]
Potency 1.9857qHTS Assay for Inhibitors of Hepatitis C Virus (HCV): Confirmation Assay for Cherry-picked Compounds [AID720575, Type: confirmatory]hepatitis C virus polyprotein [Hepatitis C virus] [gi:295901482]
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40
[SID47193876]
Potency 1.9953qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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41
[SID99222861]
AC50_uM 2.35Secondary assay of A1 inhibitors in Mouse Embryonic Fibroblasts with alternate pro-apoptotic inducer Measured in Cell-Based System Using Plate Reader - 2045-08_Inhibitor_Dose_DryPowder_Activity [AID488897, Type: confirmatory]
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42
[SID47193876]
IC50_Mean 2.35Dose response confirmation of uHTS of chemical inhibitors of both B-cell and T-cell specific antigen receptor-induced NF-kB activation in a Jurkat cell line using a luminescence assay [AID489004, Type: confirmatory]
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43
[SID47193876]
IC50 2.649High Throughput Screen to Identify Inhibitors of Mycobacterium tuberculosis H37Rv [AID1626, Type: confirmatory]
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44
[SID103211611]
EC50 2.66Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor [AID34265, Type: Literature]
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45
[SID99222861]
AC50_uM 2.87Inhibitors of A1-dependent Mouse Embryonic Fibroblasts Measured in Cell-Based System Using Plate Reader - 2045-01_Inhibitor_Dose_DryPowder_Activity_Set3 [AID488858, Type: confirmatory]
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46
[SID47193876]
Potency 3.1623qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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47
[SID47193876]
IC50 3.757A screen for inhibitors of the PhoP regulon in Salmonella Typhi using a modified counterscreen [AID1985, Type: confirmatory]
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48
[SID47193876]
Potency 4.1095A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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49
[SID47193876]
EC50 5.464Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) [AID2382, Type: confirmatory]Hsf1 protein [Mus musculus] [gi:62740231]
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50
[SID47193876]
Potency 6.2794qHTS Assay for Inhibitors of Hepatitis C Virus (HCV): Cytotoxicity Counterscreen for Cherry-picked Compounds [AID720576, Type: confirmatory]
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