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2-fluoroadenosine (CID 8975) - Compound BioActivity Data
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BioActivity Outcomes:
Active(135)
 
 
Inactive(491)
 
 
Inconclusive(14)
 
 
Unspecified(5)
 
 
Top Targets:
7TM GPCR Srx(16)
 
 
 
Bcl-2 like(11)
 
 
 
7TM GPCR Srsx(11)
 
 
Alpha TIF(6)
 
 
RGS RGS4(6)
 
 
 
BioAssay Types:
Screening(386)
 
 
 
 
Confirmatory(178)
 
 
 
 
 
Literature(76)
 
 
 
 
 
BioActivity Types:
Potency(104)
 
 
 
 
 
AC50(25)
 
 
 
 
EC50(23)
 
 
 
IC50(22)
 
 
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 522    Data Row: 645   Total Pages: 33   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID47193876]
Potency 0.058qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID47193876]
EC50 0.07Luminescence Cell-Based HTS Dose Confimation to Identify Inhibitors of of 5'UTR Stem-Loop Driven Alpha-Synuclein mRNA Translation in H4 Neuroglioblastoma Cells [AID2454, Type: confirmatory]
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3
[SID47193876]
EC50 0.084Luminescence Cell-Based Dose Response to Identify Inhibitors of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4-C Neuroglioblastoma Cells [AID2452, Type: confirmatory]
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4
[SID47193876]
EC50 0.088Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Platelet Dense Granule Release [AID1889, Type: confirmatory]
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5
[SID103211611]
Ki 0.099Affinity for human Adenosine A3 receptor expressed in CHO cell [AID34574, Type: Literature]
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6
[SID47193876]
EC50 0.1Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of of 5'UTR Stem-Loop Driven Alpha-Synuclein mRNA Translation in H4 Neuroglioblastoma Cells [AID1988, Type: confirmatory]
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7
[SID47193876]
EC50 0.1Luminescence Cell-Based Dose Response HTS to Identify Inhibitors of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells [AID1994, Type: confirmatory]
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8
[SID47193876]
EC50 0.124Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT RAS-Independent Fibroblast [AID1933, Type: confirmatory]
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9
[SID47193876]
Potency 0.1636qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID47193876]
EC50 0.199Luminescence Cell-Based Dose Response to Identify Inhibitors of Luciferase Translation or Activity in H4-C Neuroglioblastoma Cells [AID2458, Type: confirmatory]
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11
[SID47193876]
Potency 0.2311qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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12
[SID47193876]
EC50 0.242Luminescence Cell-Based Dose Response HTS to Identify Inhibitors of Luciferase Translation or Activity in H4 Neuroglioblastoma Cells [AID1990, Type: confirmatory]
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13
[SID47193876]
AC50_uM 0.26Cell fusion assay for clade C HIV-1ZM109 Env Measured in Cell-Based System Using Plate Reader - 7013-05_Inhibitor_Dose_CherryPick_Activity [AID652058, Type: confirmatory]
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14
[SID47193876]
AC50_uM 0.271CEM21 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7013-03_Inhibitor_Dose_CherryPick_Activity [AID652042, Type: confirmatory]
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15
[SID47193876]
EC50 0.3A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhimurium identified in the primary screen [AID2253, Type: confirmatory]
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16
[SID47193876]
AC50_uM 0.341HIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_Dose_CherryPick_Activity [AID652057, Type: confirmatory]
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17
[SID47193876]
EC50_uM 0.348Fluorescence Cell-Based Dose Response to Characterize Compounds Cytotoxic to RAS-Dependent BJ-TERT-LT-ST Fibroblast [AID2631, Type: confirmatory]
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18
[SID47193876]
EC50 0.35A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhi identified in the primary screen [AID2252, Type: confirmatory]
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19
[SID47193876]
EC50 0.46Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT-LT-ST RAS-Independent Fibroblast [AID1935, Type: confirmatory]
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20
[SID47193876]
Potency 0.4611qHTS for Inhibitors of TGF-b: Cytotox Counterscreen for Cherry Picks [AID720535, Type: confirmatory]
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