Bookmark and Share
STK105963 (CID 893238) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(68)
 
 
Inactive(761)
 
 
Inconclusive(33)
 
 
Unspecified(10)
 
 
Top Targets:
7TM GPCR Srx(26)
 
 
7TM GPCR Srsx(21)
 
 
alkPPc(16)
 
 
Bcl-2 like(12)
 
 
Death TRAILR..(12)
 
 
 
 
BioAssay Types:
Screening(579)
 
 
 
 
 
Confirmatory(261)
 
 
 
 
 
Literature(10)
 
 
 
 
BioActivity Types:
Potency(168)
 
 
 
 
 
IC50(54)
 
 
 
 
EC50(12)
 
 
 
AC50(5)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 795    Data Row: 872   Total Pages: 18   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103591772]
IC50 0.054Inhibition of luciferin binding site of Photuris pennsylvanica luciferase by noncompetitive inhibition assay [AID366888, Type: Literature]Luciferin 4-monooxygenase [gi:41688574]
View
2
[SID4254716]
Potency 0.058qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504466, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
View
3
[SID4254716]
Potency 0.0757qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
View
4
[SID103591772]
IC50 0.2Inhibition of luciferin binding site of Photinus pyralis luciferase by noncompetitive inhibition assay [AID366887, Type: Literature]Luciferin 4-monooxygenase [gi:126501]
View
5
[SID4254716]
Potency 0.4467qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
View
6
[SID4254716]
Potency 0.5012qHTS Assay for Inhibitors of Firefly Luciferase [AID411, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
View
7
[SID4254716]
AC50_uM 0.621Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition Measured in Cell-Based System Using Plate Reader - 7011-01_Antagonist_Dose_CherryPick_Activity_Set2 [AID743343, Type: confirmatory]
View
8
[SID4254716]
AC50_uM 1.05LGR2:Counterscreen with MC4R Measured in Cell-Based System Using Plate Reader - 7011-02_Antagonist_Dose_CherryPick_Activity [AID743444, Type: confirmatory]MSH [Drosophila melanogaster] [gi:1098680]
View
9
[SID4254716]
Potency 1.6353qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
View
10
[SID4254716]
Potency 3.5481qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]Niemann-Pick C1 protein precursor [Homo sapiens] [gi:255652944]
View
11
[SID4254716]
Potency 3.9811qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]ras-related protein Rab-9A [Homo sapiens] [gi:4759012]
View
12
[SID4254716]
Potency 4.4668VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
View
13
[SID4254716]
Potency 5.0119qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
View
14
[SID4254716]
Potency 6.3096qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
View
15
[SID4254716]
Potency 11.2202Counterscreen for Luciferase (Kinase-Glo TM) Inhibition [AID1379, Type: confirmatory]luciferase [Photuris pennsylvanica] [gi:1669525]
View
16
[SID103591772]
IC50 13.9Inhibition of luciferin binding site of Photuris pennsylvanica luciferase by noncompetitive KinaseGlo luminescent assay [AID366886, Type: Literature]Luciferin 4-monooxygenase [gi:41688574]
View
17
[SID4254716]
Potency 14.1254qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK) [AID1721, Type: confirmatory]pyruvate kinase [Leishmania mexicana mexicana] [gi:290753097]
View
18
[SID4254716]
Potency 14.1254qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
View
19
[SID4254716]
AC50_uM 28.41A549 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-06_Antagonist_Dose_CherryPick_Activity [AID743412, Type: confirmatory]
View
20
[SID4254716]
AC50_uM 31.92HEK293 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-01_Antagonist_Dose_CherryPick_Activity [AID743446, Type: confirmatory]
View
21
[SID4254716]
AC50_uM 47.56HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Antagonist_Dose_CherryPick_Activity [AID743416, Type: confirmatory]
View
22
[SID4254716]
MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - inhibitors [AID1813, Type: screening]
View
23
[SID4254716]
Luminescence-based counterscreen assay for HSP90 inhibitors: biochemical high throughput screening assay to identify inhibitors of native luciferase. [AID1847, Type: screening]
View
24
[SID4254716]
Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_SinglePoint_HTS_Activity [AID488862, Type: screening]
View
25
[SID4254716]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Full-Length Luciferase Counterscreen assay [AID504607, Type: screening]
View
26
[SID4254716]
7011-01_Antagonist_SinglePoint_HTS_Activity [AID720647, Type: screening]
View
27
[SID4254716]
Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_SinglePoint_HTS_Activity [AID651661, Type: screening]
View
28
[SID4254716]
Allosteric Modulators of D1 Receptors: Primary Screen [AID641, Type: screening]
View
29
[SID4254716]
Counter Screen for Luciferase-based Primary Inhibition Assays [AID1006, Type: screening]
View
30
[SID4254716]
Identification of compounds which are cytotoxic to PPC-1 cells. [AID1447, Type: screening]
View
31
[SID4254716]
Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) [AID2796, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
View
32
[SID4254716]
Primary screen for compounds that activate Alzheimer's amyloid precursor [AID1276, Type: screening]amyloid precursor protein [Homo sapiens] [gi:257380]
View
33
[SID4254716]
Pyruvate Kinase [AID361, Type: confirmatory]pyruvate kinase [Geobacillus stearothermophilus] [gi:285623]
View
34
[SID4254716]
Primary Cell-based High Throughput Screening assay for inhibitors of the Retinoic Acid Receptor-related orphan receptor A (RORA) [AID561, Type: screening]Nuclear receptor ROR-alpha [gi:548814]
View
35
[SID4254716]
Counterscreen for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1): A cell-based dose-response assay for inhibition of the RAR-related orphan receptor A (RORA) [AID599, Type: confirmatory]Nuclear receptor ROR-alpha [gi:548814]
View
36
[SID4254716]
Dose-response cell-based assay for inhibitors of the Retinoic Acid Receptor-related orphan receptor A (RORA) [AID610, Type: confirmatory]Nuclear receptor ROR-alpha [gi:548814]
View
37
[SID4254716]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]Breast cancer type 1 susceptibility protein [gi:728984]
View
38
[SID4254716]
uHTS for the identification of compounds that potentiate TRAIL-induced apoptosis of cancer cells [AID1443, Type: screening]tumor necrosis factor ligand superfamily member 10 isoform 1 [Homo sapiens] [gi:4507593]
View
39
[SID4254716]
High Content Assay for Compounds that inhibit the Assembly of the Perinucleolar Compartment [AID2417, Type: screening]polypyrimidine tract-binding protein 1 isoform a [Homo sapiens] [gi:4506243]
View
40
[SID4254716]
Luminescence-based cell-based high throughput confirmation assay to identify inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2) [AID652008, Type: screening]nuclear receptor coactivator 2 [Homo sapiens] [gi:5729858]
View
41
[SID4254716]
Single concentration confirmation of uHTS for inhibitors of Sentrin-specific protease 6 (SENP6) using a Luminescent assay [AID488915, Type: screening]SUMO-1-specific protease [Homo sapiens] [gi:6166485]
View
42
[SID4254716]
uHTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 6 (SENP6) [AID2599, Type: screening]SUMO-1-specific protease [Homo sapiens] [gi:6166485]
View
43
[SID4254716]
Primary cell-based high throughput screening assay to measure STAT1 inhibition [AID920, Type: screening]signal transducer and activator of transcription 1-alpha/beta isoform alpha [Homo sapiens] [gi:6274552]
View
44
[SID4254716]
EC50 Luminescent HTS for small molecule inhibitors of MT1-MMP transcription [AID618, Type: confirmatory]matrix metalloproteinase 1 [Homo sapiens] [gi:6690534]
View
45
[SID4254716]
Single concentration confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay [AID488918, Type: screening]caspase-3 preproprotein [Homo sapiens] [gi:14790119]
View
46
[SID4254716]
Primary cell-based high throughput screening assay to measure STAT3 inhibition [AID862, Type: screening]STAT3 [Homo sapiens] [gi:13272532]
View
47
[SID4254716]
uHTS identification of HIF-2a Inhibitors in a luminesence assay [AID624352, Type: screening]endothelial PAS domain-containing protein 1 [Homo sapiens] [gi:40254439]
View
48
[SID4254716]
Inhibitors of Epstein-Barr LMP1 inducible NF-kappaB luciferase reporter Measured in Cell-Based System Using Plate Reader - 2122-01_Inhibitor_SinglePoint_HTS_Activity [AID504558, Type: screening]LMP1 [Human herpesvirus 4] [gi:23893668]
View
49
[SID4254716]
Primary Cell-based High Throughput Screening assay for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID525, Type: screening]steroidogenic factor 1 [Homo sapiens] [gi:20070193]
View
50
[SID4254716]
Dose-response cell-based assay for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID600, Type: confirmatory]steroidogenic factor 1 [Homo sapiens] [gi:20070193]
View