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5-(2,4-dimethoxyphenyl)-3-phenyl-1,2,4-oxadiazole (CID 893238) - Compound BioActivity Data
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BioActivity Outcomes:
Active(68)
 
 
Inactive(768)
 
 
Inconclusive(33)
 
 
Unspecified(10)
 
 
Top Targets:
7tm 4(48)
 
 
alkPPc(16)
 
 
Bcl-2 like(12)
 
 
Death TRAILR..(12)
 
 
 
 
Tryp SPc(11)
 
 
 
BioAssay Types:
Screening(580)
 
 
 
 
 
Confirmatory(261)
 
 
 
 
 
Literature(16)
 
 
 
 
BioActivity Types:
Potency(168)
 
 
 
 
 
IC50(54)
 
 
 
 
EC50(12)
 
 
 
AC50(5)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 796    Data Row: 879   Total Pages: 44   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103591772]
IC50 0.054Inhibition of luciferin binding site of Photuris pennsylvanica luciferase by noncompetitive inhibition assay [AID366888, Type: Literature]Luciferin 4-monooxygenase [gi:41688574]
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2
[SID4254716]
Potency 0.058qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504466, Type: confirmatory]ATAD5 protein, partial [Homo sapiens] [gi:116283940]
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3
[SID4254716]
Potency 0.0757qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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4
[SID103591772]
IC50 0.2Inhibition of luciferin binding site of Photinus pyralis luciferase by noncompetitive inhibition assay [AID366887, Type: Literature]Luciferin 4-monooxygenase [gi:126501]
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5
[SID4254716]
Potency 0.4467qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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6
[SID4254716]
Potency 0.5012qHTS Assay for Inhibitors of Firefly Luciferase [AID411, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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7
[SID4254716]
AC50_uM 0.621Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition Measured in Cell-Based System Using Plate Reader - 7011-01_Antagonist_Dose_CherryPick_Activity_Set2 [AID743343, Type: confirmatory]
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8
[SID4254716]
AC50_uM 1.05LGR2:Counterscreen with MC4R Measured in Cell-Based System Using Plate Reader - 7011-02_Antagonist_Dose_CherryPick_Activity [AID743444, Type: confirmatory]MSH [Drosophila melanogaster] [gi:1098680]
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9
[SID4254716]
Potency 1.6353qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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10
[SID4254716]
Potency 3.5481qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]Niemann-Pick C1 protein precursor [Homo sapiens] [gi:255652944]
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11
[SID4254716]
Potency 3.9811qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]ras-related protein Rab-9A [Homo sapiens] [gi:4759012]
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12
[SID4254716]
Potency 4.4668VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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13
[SID4254716]
Potency 5.0119qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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14
[SID4254716]
Potency 6.3096qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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15
[SID4254716]
Potency 11.2202Counterscreen for Luciferase (Kinase-Glo TM) Inhibition [AID1379, Type: confirmatory]luciferase [Photuris pennsylvanica] [gi:1669525]
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16
[SID103591772]
IC50 13.9Inhibition of luciferin binding site of Photuris pennsylvanica luciferase by noncompetitive KinaseGlo luminescent assay [AID366886, Type: Literature]Luciferin 4-monooxygenase [gi:41688574]
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17
[SID4254716]
Potency 14.1254qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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18
[SID4254716]
Potency 14.1254qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK) [AID1721, Type: confirmatory]pyruvate kinase [Leishmania mexicana mexicana] [gi:290753097]
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19
[SID4254716]
AC50_uM 28.41A549 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-06_Antagonist_Dose_CherryPick_Activity [AID743412, Type: confirmatory]
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20
[SID4254716]
AC50_uM 31.92HEK293 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-01_Antagonist_Dose_CherryPick_Activity [AID743446, Type: confirmatory]
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