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Inositol (CID 892) - Compound BioActivity Data
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BioActivity Outcomes:
Active(11)
 
 
Inactive(1743)
 
 
Inconclusive(23)
 
 
Unspecified(29)
 
 
Top Targets:
7TM GPCR Srx(57)
 
 
 
7TM GPCR Srsx(47)
 
 
NR LBD PPAR(16)
 
 
 
B zip1(16)
 
 
 
CAP ED(15)
 
 
BioAssay Types:
Screening(1025)
 
 
 
 
Confirmatory(569)
 
 
 
 
 
Literature(112)
 
 
 
 
 
Summary(48)
 
 
 
BioActivity Types:
Potency(510)
 
 
 
 
 
IC50(39)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 665    Data Row: 1806   Total Pages: 37   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID136925215]
IC50 2Inhibition of Phosphoinositide specific phospholipase C (PI-PLC) from Bacillus cereus on the internal face of the cell membrane. [AID158606, Type: Literature]
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2
[SID104243012]
IC50 10Inhibition of Phosphoinositide specific phospholipase C (PI-PLC) from Bacillus cereus on the internal face of the cell membrane. [AID158606, Type: Literature]
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3
[SID144205195]
Potency 14.9631qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID56320900]
HTS for Identification of VLA-4 Allosteric Modulators from MLPCN library [AID2557, Type: screening]integrin alpha-4 precursor [Homo sapiens] [gi:67191027]
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5
[SID53812881]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystal Structure Of The Trimeric Neck And Carbohydrate Recognition Domain Of Human Surfactant Protein D In Complex With Myoinositol [gi:149242688]
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6
[SID56324719]
Inhibitors of Epstein-Barr LMP1 inducible NF-kappaB luciferase reporter Measured in Cell-Based System Using Plate Reader - 2122-01_Inhibitor_SinglePoint_HTS_Activity [AID504558, Type: screening]LMP1 [Human herpesvirus 4] [gi:23893668]
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7
[SID56320893]
HTS for Identification of VLA-4 Allosteric Modulators from MLPCN library [AID2557, Type: screening]integrin alpha-4 precursor [Homo sapiens] [gi:67191027]
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8
[SID103622347]
Effect on amyloid beta 42 aggregation assessed as inhibition of fiber formation at 3 mM [AID361504, Type: Literature]
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9
[SID56320900]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]muscarinic acetylcholine receptor M1 [Homo sapiens] [gi:37622910]
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10
[SID73813]
NCI human tumor cell line growth inhibition assay. Data for the SNB-75 Central Nervous System cell line [AID55, Type: confirmatory]
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11
[SID48416105]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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12
[SID103622347]
IC50 410Inhibition of Phosphoinositide specific phospholipase C (PI-PLC) from Bacillus cereus on the internal face of the cell membrane. [AID158606, Type: Literature]
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13
[SID136925215]
IC50 475.7Inhibition of Baker's yeast Alpha-glucosidase-1 using p-nitrophenyl-alpha-D-glucopyranoside as substrate preincubated for 10 mins prior substrate addition measured after 20 mins by spectrophotometry [AID647234, Type: Literature]
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14
[SID104243012]
Km 580Oxidation catalyzed by inositol dehydrogenase at pH 9.13. [AID27334, Type: Literature]
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15
[SID123092460]
IC50 1256.1Inhibition of Baker's yeast Alpha-glucosidase-1 using p-nitrophenyl-alpha-D-glucopyranoside as substrate preincubated for 10 mins prior substrate addition measured after 20 mins by spectrophotometry [AID647234, Type: Literature]
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16
[SID104243012]
Ratio of Kcat to Km for Neisseria meningitidis lgtC [AID500279, Type: Literature]
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17
[SID104243012]
Literature-mined public compounds from Greene et al multi-species hepatotoxicity modelling dataset [AID588209, Type: Literature]
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18
[SID104243012]
Human drug-induced liver injury (DILI) modelling dataset from Ekins et al [AID588210, Type: Literature]
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19
[SID104243012]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans [AID588211, Type: Literature]
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20
[SID104243012]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents [AID588212, Type: Literature]
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21
[SID104243012]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents [AID588213, Type: Literature]
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22
[SID104243012]
Literature-mined public compounds from Kruhlak et al phospholipidosis modelling dataset [AID588220, Type: Literature]
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23
[SID104243012]
Drug Induced Liver Injury Prediction System (DILIps) validation dataset; compound DILI positive/negative as observed in O'Brien data [AID625294, Type: Literature]
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24
[SID104243012]
Drug Induced Liver Injury Prediction System (DILIps) validation dataset; compound DILI positive/negative as observed in Pfizer data [AID625295, Type: Literature]
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25
[SID73813]
NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line [AID125, Type: confirmatory]
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26
[SID29215342]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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27
[SID136925215]
Inhibition of rat intestinal alpha-glucosidase sucrase using sucrose as substrate at 10 mg/mL preincubated for 10 mins prior substrate addition measured after 40 mins by spectrophotometry [AID647239, Type: Literature]Sucrase-isomaltase, intestinal [gi:1351132]
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28
[SID123092460]
Inhibition of rat intestinal alpha-glucosidase sucrase using sucrose as substrate at 10 mg/mL preincubated for 10 mins prior substrate addition measured after 40 mins by spectrophotometry [AID647239, Type: Literature]Sucrase-isomaltase, intestinal [gi:1351132]
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29
[SID104243012]
Compound was tested for inhibition of Human acrosin by polyols [AID30433, Type: Literature]
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30
[SID104243012]
Oxidation catalyzed by inositol dehydrogenase at pH 9.13. [AID27144, Type: Literature]
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31
[SID104243012]
Oxidation catalyzed by inositol dehydrogenase at pH 9.13. [AID27145, Type: Literature]
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32
[SID56320894]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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33
[SID56324719]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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34
[SID136925215]
Inhibition of rat intestinal alpha-glucosidase maltase using maltose as substrate at 10 mg/mL preincubated for 10 mins prior substrate addition measured after 40 mins by spectrophotometry [AID647237, Type: Literature]Lysosomal alpha-glucosidase [gi:81885339]
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35
[SID123092460]
Inhibition of rat intestinal alpha-glucosidase maltase using maltose as substrate at 10 mg/mL preincubated for 10 mins prior substrate addition measured after 40 mins by spectrophotometry [AID647237, Type: Literature]Lysosomal alpha-glucosidase [gi:81885339]
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36
[SID104243012]
Michaelis Menten constant was determined [AID228549, Type: Literature]
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37
[SID104243012]
Tested as substrate of phosphatidylinositol synthase in mouse brain by measuring percent CMP formation compared with myo-inositol tested at 5 mM [AID155658, Type: Literature]
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38
[SID104243012]
Compound was tested for the inhibition of Phosphatidylinositol-Specific Phospholipase C (PI-PLC) in the presence of PEG-600 at concentration of 40.0 mM [AID158604, Type: Literature]
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39
[SID104243012]
Compound was tested for the inhibition of Phosphoinositide specific phospholipase C (PI-PLC) in the presence of buffer at concentration of 40.0 mM [AID158605, Type: Literature]
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40
[SID56320900]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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41
[SID56320894]
Potency 0.2311A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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42
[SID56320894]
Potency 0.631qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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43
[SID56320893]
Potency 7.3753Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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44
[SID56320900]
Potency 50.1187qHTS of PTHR Inhibitors: Primary Screen [AID743266, Type: confirmatory]parathyroid hormone/parathyroid hormone-related peptide receptor precursor [Homo sapiens] [gi:296080761]
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45
[SID56320900]
IC50 (with Meropenem) 100Screen and Counter Screen to Identify Novel Compounds that Selectively Sensitize Mycobacterium Tuberculosis to Beta-lactam Antibiotics [AID434987, Type: confirmatory]
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46
[SID56320900]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis. [AID435005, Type: screening]
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47
[SID56320900]
Counterscreen for inhibitors of AddAB: absorbance-based bacterial cell-based high throughput screening assay to identify inhibitors of bacterial viability [AID449728, Type: screening]
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48
[SID56320900]
IC50 High Throughput Screening Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in 7H9 Media [AID449762, Type: confirmatory]
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49
[SID56324719]
MLPCN Ras selective lethality-BJeLR viability [AID1554, Type: screening]
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50
[SID56324719]
MLPCN Platelet Activation -Dense Granule Release [AID1663, Type: screening]
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