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SMR000072313 (CID 889170) - Compound BioActivity Data
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BioActivity Outcomes:
Active(44)
 
 
Inactive(805)
 
 
Inconclusive(31)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(26)
 
 
7TM GPCR Srsx(21)
 
 
PTPc(15)
 
 
 
alkPPc(14)
 
 
Bcl-2 like(12)
 
 
BioAssay Types:
Screening(564)
 
 
 
 
Confirmatory(287)
 
 
 
 
 
Literature(5)
 
 
 
BioActivity Types:
Potency(177)
 
 
 
 
 
IC50(71)
 
 
 
EC50(12)
 
 
AC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 812    Data Row: 881   Total Pages: 18   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85176601]
IC50_Mean 0.0586MOA HePTP Fluorescent secondary assay for identification of redox-state modulating compounds [AID2068, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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2
[SID4260621]
Potency 0.1995qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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3
[SID4260621]
Potency 0.1995qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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4
[SID85176601]
IC50_Mean 0.26SAR VHR1 Fluorescent Assay for In Vitro dose response studies Set 2 [AID2684, Type: confirmatory]dual specificity protein phosphatase 3 [Homo sapiens] [gi:4758208]
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5
[SID85176601]
IC50_Mean 0.53SAR VHR1 absorbance Assay for In Vitro dose response studies. [AID1958, Type: confirmatory]dual specificity protein phosphatase 3 [Homo sapiens] [gi:4758208]
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6
[SID4260621]
Potency 0.631qHTS of Trypanosoma Brucei Inhibitors: Confirmatory Assay for Cherry-picked Compounds [AID720569, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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7
[SID4260621]
Potency 0.8913qHTS of Trypanosoma Brucei Inhibitors: Orthogonal Assay for Cherry-picked Compounds [AID720584, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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8
[SID85176601]
IC50_Mean 0.921SAR analysis of compounds that inhibit VHR1, Fluorescent Assay - Set 2 [AID449733, Type: confirmatory]dual specificity protein phosphatase 3 [Homo sapiens] [gi:4758208]
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9
[SID85176601]
IC50_Mean 1.05SAR analysis of chemical inhibitors of HePTP using a Fluorescent assay - Set 2 [AID2678, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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10
[SID85176601]
IC50_Mean 1.14SAR analysis of compounds that inhibit HePTP - Set 2 [AID449736, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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11
[SID4260621]
IC50 1.27uHTS absorbance assay for the identification of compounds that inhibit VHR1. [AID1654, Type: confirmatory]dual specificity protein phosphatase 3 [Homo sapiens] [gi:4758208]
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12
[SID4260621]
Potency 1.5003qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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13
[SID85176601]
IC50_Mean 2.225Fluorescent secondary assay for dose-response confirmation of chemical inhibitors of HePTP [AID1077, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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14
[SID4260621]
Potency 3.1623qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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15
[SID4260621]
IC50 3.53Fluorescent assay for identification of compounds that inhibit VHR1 [AID1878, Type: confirmatory]dual specificity protein phosphatase 3 [Homo sapiens] [gi:4758208]
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16
[SID4260621]
Potency 3.7933Tb PFK orthogonal confirmatory assay using ATP depletion (Kinase-Glo Plus) as an alternative measure of Tb PFK activity: Hit Validation [AID504636, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei] [gi:72386991]
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17
[SID87544819]
IC50_Mean 4.82SAR analysis of compounds that inhibit VHR1, Fluorescent Assay - Set 2 [AID449733, Type: confirmatory]dual specificity protein phosphatase 3 [Homo sapiens] [gi:4758208]
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18
[SID4260621]
Potency 5.3582Inhibitors of T. brucei phosphofructokinase: Hit Validation [AID504637, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei] [gi:72386991]
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19
[SID4260621]
IC50_Mean 5.51Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay [AID504719, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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20
[SID4260621]
Potency 5.6101qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-biphosphate Aldolase In Complex With Phosphoglycolohydroxamate [gi:122920737]
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21
[SID87544819]
IC50_Mean 7.06SAR analysis of compounds that inhibit HePTP - Set 2 [AID449736, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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22
[SID4260621]
IC50_Mean 7.25Dose Response confirmation of uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay [AID504765, Type: confirmatory]glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium berghei] [gi:12381848]
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23
[SID4260621]
Potency 7.9433qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 [Homo sapiens] [gi:31542939]
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24
[SID4260621]
Potency 10.6213qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation in Primary Screen [AID602199, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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25
[SID4260621]
Potency 10.691qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase [AID485367, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei] [gi:72386991]
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26
[SID4260621]
Potency 44.6684Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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27
[SID4260621]
IC50_Mean 50.3Dose Response orthogonal kinetic assay utilizing the direct detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase [AID540269, Type: confirmatory]glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium berghei] [gi:12381848]
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28
[SID4260621]
IC50_Mean 54.6Dose Response orthogonal assay utilizing the direct end-point detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase [AID540252, Type: confirmatory]glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium berghei] [gi:12381848]
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29
[SID4260621]
Potency 100qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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30
[SID4260621]
IC50 190.59Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens [AID624330, Type: confirmatory]rac GTPase-activating protein 1 [Homo sapiens] [gi:21361397]
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31
[SID4260621]
uHTS identification of small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay [AID504690, Type: screening]glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium berghei] [gi:12381848]
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32
[SID4260621]
Single concentration confirmation of uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay [AID504753, Type: screening]glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium berghei] [gi:12381848]
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33
[SID4260621]
Single concentration confirmation of uHTS for APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay [AID493152, Type: screening]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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34
[SID4260621]
uHTS identification of APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay [AID493012, Type: screening]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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35
[SID4260621]
HIV-1 RT-RNase H MLSCN HTS MH077605 Confirmation Assay [AID651, Type: screening]Chain A, High Resolution Structures Of Hiv-1 Rt From Four Rt- Inhibitor Complexes [gi:1431733]
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36
[SID4260621]
HIV-1 RT-RNase H MLSCN MH077605 Probe Assessment: Dose response Assay [AID652, Type: confirmatory]Chain A, High Resolution Structures Of Hiv-1 Rt From Four Rt- Inhibitor Complexes [gi:1431733]
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37
[SID4260621]
HIV-1 RT-RNase H MLSCN HTS MH077605 [AID565, Type: screening]Chain A, High Resolution Structures Of Hiv-1 Rt From Four Rt- Inhibitor Complexes [gi:1431733]
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38
[SID4260621]
High Content Assay for Compounds that inhibit the Assembly of the Perinucleolar Compartment [AID2417, Type: screening]polypyrimidine tract-binding protein 1 isoform a [Homo sapiens] [gi:4506243]
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39
[SID4260621]
qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen [AID2472, Type: screening]glyceraldehyde-3-phosphate dehydrogenase isoform 1 [Homo sapiens] [gi:7669492]
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40
[SID4260621]
QFRET-based primary biochemical high throughput screening assay to identify inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). [AID1822, Type: screening]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23505220]
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41
[SID4260621]
Fluorescence polarization-based biochemical high throughput confirmation assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) [AID687036, Type: screening]PRMT1 protein [Homo sapiens] [gi:32425330]
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42
[SID4260621]
Primary biochemical fluorescence polarization-based high throughput screening assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) [AID652257, Type: screening]PRMT1 protein [Homo sapiens] [gi:32425330]
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43
[SID4260621]
Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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44
[SID4260621]
uHTS identification of small molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assay [AID588621, Type: screening]tyrosine-protein phosphatase non-receptor type 5 isoform a [Homo sapiens] [gi:90652859]
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45
[SID4260621]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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46
[SID4260621]
IC50_Mean 80Human Glucose-6-Phosphate Dehydrogenase Dose Response Selectivity Assay for Inhibitors of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase [AID504792, Type: confirmatory]glucose-6-phosphate 1-dehydrogenase isoform b [Homo sapiens] [gi:108773793]
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47
[SID85176601]
IC50_Mean 99SAR VHR1 Fluorescent Assay for In Vitro dose response studies [AID1957, Type: confirmatory]dual specificity protein phosphatase 3 [Homo sapiens] [gi:4758208]
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48
[SID85176601]
IC50_Mean 99In Vitro MKP-3 Dose Response Assay for SAR Study [AID1055, Type: confirmatory]dual specificity protein phosphatase 6 [Rattus norvegicus] [gi:16758752]
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49
[SID85176601]
IC50_Mean 100SAR analysis of inhibitors of MKP-3 - Set 2 [AID2679, Type: confirmatory]dual specificity protein phosphatase 6 [Rattus norvegicus] [gi:16758752]
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50
[SID89650242]
IC50_Mean 100SAR analysis of compounds that inhibit HePTP - Set 2 [AID449736, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
View