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(4-amino-3-phenyl-2-sulfanylidene-1,3-thiazol-5-yl)-(4-methylpiperazin-1-yl)methanone (CID 889170) - Compound BioActivity Data
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BioActivity Outcomes:
Active(44)
 
 
Inactive(812)
 
 
Inconclusive(33)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(48)
 
 
PTPc(15)
 
 
 
alkPPc(14)
 
 
Bcl-2 like(12)
 
 
DSPc(12)
 
 
 
BioAssay Types:
Screening(567)
 
 
 
 
Confirmatory(287)
 
 
 
 
 
Literature(11)
 
 
 
BioActivity Types:
Potency(177)
 
 
 
 
 
IC50(71)
 
 
 
EC50(12)
 
 
AC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 815    Data Row: 890   Total Pages: 45   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85176601]
IC50_Mean 0.0586MOA HePTP Fluorescent secondary assay for identification of redox-state modulating compounds [AID2068, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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2
[SID4260621]
Potency 0.1995qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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3
[SID4260621]
Potency 0.1995qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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4
[SID85176601]
IC50_Mean 0.26SAR VHR1 Fluorescent Assay for In Vitro dose response studies Set 2 [AID2684, Type: confirmatory]dual specificity protein phosphatase 3 [Homo sapiens] [gi:4758208]
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5
[SID85176601]
IC50_Mean 0.53SAR VHR1 absorbance Assay for In Vitro dose response studies. [AID1958, Type: confirmatory]dual specificity protein phosphatase 3 [Homo sapiens] [gi:4758208]
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6
[SID4260621]
Potency 0.631qHTS of Trypanosoma Brucei Inhibitors: Confirmatory Assay for Cherry-picked Compounds [AID720569, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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7
[SID4260621]
Potency 0.8913qHTS of Trypanosoma Brucei Inhibitors: Orthogonal Assay for Cherry-picked Compounds [AID720584, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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8
[SID85176601]
IC50_Mean 0.921SAR analysis of compounds that inhibit VHR1, Fluorescent Assay - Set 2 [AID449733, Type: confirmatory]dual specificity protein phosphatase 3 [Homo sapiens] [gi:4758208]
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9
[SID85176601]
IC50_Mean 1.05SAR analysis of chemical inhibitors of HePTP using a Fluorescent assay - Set 2 [AID2678, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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10
[SID85176601]
IC50_Mean 1.14SAR analysis of compounds that inhibit HePTP - Set 2 [AID449736, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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11
[SID4260621]
IC50 1.27uHTS absorbance assay for the identification of compounds that inhibit VHR1. [AID1654, Type: confirmatory]dual specificity protein phosphatase 3 [Homo sapiens] [gi:4758208]
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12
[SID4260621]
Potency 1.5003qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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13
[SID85176601]
IC50_Mean 2.225Fluorescent secondary assay for dose-response confirmation of chemical inhibitors of HePTP [AID1077, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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14
[SID4260621]
Potency 3.1623qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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15
[SID4260621]
IC50 3.53Fluorescent assay for identification of compounds that inhibit VHR1 [AID1878, Type: confirmatory]dual specificity protein phosphatase 3 [Homo sapiens] [gi:4758208]
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16
[SID4260621]
Potency 3.7933Tb PFK orthogonal confirmatory assay using ATP depletion (Kinase-Glo Plus) as an alternative measure of Tb PFK activity: Hit Validation [AID504636, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:72386991]
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17
[SID87544819]
IC50_Mean 4.82SAR analysis of compounds that inhibit VHR1, Fluorescent Assay - Set 2 [AID449733, Type: confirmatory]dual specificity protein phosphatase 3 [Homo sapiens] [gi:4758208]
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18
[SID4260621]
Potency 5.3582Inhibitors of T. brucei phosphofructokinase: Hit Validation [AID504637, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:72386991]
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19
[SID4260621]
IC50_Mean 5.51Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay [AID504719, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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20
[SID4260621]
Potency 5.6101qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-biphosphate Aldolase In Complex With Phosphoglycolohydroxamate [gi:122920737]
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