Bookmark and Share
2-[(2-phenylethyl)thio]nicotinic acid (CID 888706) - Compound BioActivity Data
.
BioActivity Outcomes:
Probe(1)
 
 
Active(46)
 
 
Inactive(802)
 
 
Inconclusive(22)
 
 
Unspecified(7)
 
 
Top Targets:
7TM GPCR Srx(26)
 
 
7TM GPCR Srsx(20)
 
 
alkPPc(16)
 
 
Bcl-2 like(12)
 
 
Tryp SPc(9)
 
 
BioAssay Types:
Screening(576)
 
 
 
 
 
Confirmatory(266)
 
 
 
 
 
Literature(5)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(165)
 
 
 
 
 
IC50(48)
 
 
EC50(30)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 807    Data Row: 878   Total Pages: 18   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID57578335]
Project utilizing multiplex HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases [AID1772, Type: summary]ras protein, partial [Homo sapiens] [gi:190938]
View
2
[SID4257303]
EC50_MICROM 0.02017Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype [AID1340, Type: confirmatory]Rac1 protein [Homo sapiens] [gi:8574038]
View
3
[SID4257303]
EC50_MICROM 0.02542Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac activated mutant [AID1339, Type: confirmatory]Rac1 protein [Homo sapiens] [gi:8574038]
View
4
[SID4257303]
EC50_MICROM 0.09481Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant [AID1341, Type: confirmatory]ras protein, partial [Homo sapiens] [gi:190938]
View
5
[SID4257303]
EC50_MICROM 0.09996Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype [AID1334, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
View
6
[SID4257303]
EC50_MICROM 0.1422Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID1335, Type: confirmatory]ras protein, partial [Homo sapiens] [gi:190938]
View
7
[SID4257303]
EC50_MICROM 0.183Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype [AID1336, Type: confirmatory]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
View
8
[SID4257303]
EC50_MICROM 0.358Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype [AID1337, Type: confirmatory]Ras-related protein Rab-2A [gi:46577642]
View
9
[SID4257303]
Potency 6.012qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
View
10
[SID4257303]
Potency 11.2202VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
View
11
[SID4257303]
Potency 15.8489qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
View
12
[SID4257303]
EC50 20.1Luminescent HTS for small molecule inhibitors of MT1-MMP transcription [AID618, Type: confirmatory]matrix metalloproteinase 1 [Homo sapiens] [gi:6690534]
View
13
[SID4257303]
HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype [AID757, Type: screening]Rac1 protein [Homo sapiens] [gi:8574038]
View
14
[SID4257303]
HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac activated mutant [AID764, Type: screening]Rac1 protein [Homo sapiens] [gi:8574038]
View
15
[SID4257303]
Single concentration confirmation of uHTS for inhibitors of Sentrin-specific protease 6 (SENP6) using a Luminescent assay [AID488915, Type: screening]SUMO-1-specific protease [Homo sapiens] [gi:6166485]
View
16
[SID4257303]
uHTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 6 (SENP6) [AID2599, Type: screening]SUMO-1-specific protease [Homo sapiens] [gi:6166485]
View
17
[SID4257303]
Single concentration confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay [AID488918, Type: screening]caspase-3 preproprotein [Homo sapiens] [gi:14790119]
View
18
[SID4257303]
HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype [AID760, Type: screening]Ras-related protein Rab-2A [gi:46577642]
View
19
[SID57578335]
Activator binding kinetics on Ras and Ras-related GTPases, specifically Rab2_wt [AID1763, Type: screening]Ras-related protein Rab-2A [gi:46577642]
View
20
[SID4257303]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
View
21
[SID4257303]
A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
View
22
[SID4257303]
A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
View
23
[SID4257303]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
View
24
[SID4257303]
Primary Cell Based High Throughput Screening Assay for Enhancers of Beta-Glucosidase Activity [AID784, Type: screening]Glucosylceramidase [gi:55584151]
View
25
[SID57578335]
Activator binding kinetics on Ras and Ras-related GTPases, specifically Ras_act (activated mutant) [AID1761, Type: screening]ras protein, partial [Homo sapiens] [gi:190938]
View
26
[SID57578335]
Activator binding kinetics on Ras and Ras-related GTPases, specifically Ras_wt [AID1759, Type: screening]ras protein, partial [Homo sapiens] [gi:190938]
View
27
[SID4257303]
High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Primary Screen [AID1239, Type: screening]nuclear factor NF-kappa-B p105 subunit isoform 1 [Homo sapiens] [gi:34577122]
View
28
[SID4257303]
HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype [AID758, Type: screening]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
View
29
[SID4257303]
Allosteric Modulators of D1 Receptors: Primary Screen [AID641, Type: screening]
View
30
[SID57578335]
Activator binding kinetics on Ras and Ras-related GTPases, specifically Rab7_wt [AID1760, Type: screening]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
View
31
[SID4257303]
HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID759, Type: screening]ras protein, partial [Homo sapiens] [gi:190938]
View
32
[SID4257303]
Parallel artificial membrane permeability assay at pH 7.4 [AID624339, Type: other]
View
33
[SID4257303]
Early assessment of compound solubility in 1x PBS - Set 2 [AID624321, Type: other]
View
34
[SID4257303]
Early assessment of compound solubility in aqueous buffer - Set 2 [AID624323, Type: other]
View
35
[SID4257303]
Wnt/Beta-catenin HTS Measured in Cell-Based System Using Plate Reader - 2161-01_Activator_SinglePoint_HTS_Activity [AID743398, Type: screening]
View
36
[SID4257303]
Luminescence-based counterscreen assay for HSP90 inhibitors: biochemical high throughput screening assay to identify inhibitors of native luciferase. [AID1847, Type: screening]
View
37
[SID4257303]
High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Primary Screen [AID1239, Type: screening]transcription factor p65 isoform 1 [Homo sapiens] [gi:223468676]
View
38
[SID4257303]
Single concentration confirmation of uHTS for inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay [AID488912, Type: screening]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
View
39
[SID4257303]
Single concentration confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Luminescent Interference Counterscreen assay [AID488919, Type: screening]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
View
40
[SID4257303]
HTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 8 (SENP8) [AID2540, Type: screening]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
View
41
[SID57578335]
Activator binding kinetics on Ras and Ras-related GTPases, specifically Cdc42_wt [AID1758, Type: screening]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
View
42
[SID57578335]
Activator binding kinetics on Ras and Ras-related GTPases, specifically Cdc42_act (activated mutant) [AID1762, Type: screening]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
View
43
[SID4257303]
HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype [AID761, Type: screening]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
View
44
[SID4257303]
Luminescence-based primary biochemical high throughput screening assay to identify inhibitors of the Heat Shock Protein 90 (HSP90) [AID1789, Type: screening]HSP90AA1 protein [Homo sapiens] [gi:83318444]
View
45
[SID4257303]
Luminescence-based confirmation biochemical high throughput screening assay for inhibitors of the Heat Shock Protein 90 (HSP90) [AID1846, Type: screening]HSP90AA1 protein [Homo sapiens] [gi:83318444]
View
46
[SID4257303]
uHTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 7 (SENP7) [AID434973, Type: screening]SUMO1/sentrin specific peptidase 7 [Homo sapiens] [gi:120538355]
View
47
[SID4257303]
Single concentration confirmation of uHTS for inhibitors of Sentrin-specific protease 7 (SENP7) using a Luminescent assay [AID488917, Type: screening]SUMO1/sentrin specific peptidase 7 [Homo sapiens] [gi:120538355]
View
48
[SID4257303]
Plasma Stability Mouse - Set 2 [AID624419, Type: other]
View
49
[SID4257303]
Plasma Stability Human - 2 [AID624420, Type: other]
View
50
[SID4257303]
Mouse hepatic microsome stability - Set 2 [AID624451, Type: screening]
View