ethyl acetate (CID 8857) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(2)
 
 
Inactive(229)
 
 
Inconclusive(11)
 
 
Unspecified(21)
 
 
Top Targets:
NR LBD PPAR(5)
 
 
NR LBD TR(4)
 
 
P53(3)
 
 
NR LBD VDR(3)
 
 
NR LBD ROR li..(3)
 
 
BioAssay Types:
Confirmatory(168)
 
 
 
Literature(82)
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(132)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 194    Data Row: 263   Total Pages: 6   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID48415193]
 DSSTox (EPAFHM) EPA Fathead Minnow Acute Toxicity [AID1188, Type: other]
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2
[SID48415982]
 DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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3
[SID103176101]
Km 230000Compound was tested for hydrolysis by acetylcholinesterase and the kinetic constant, (Km) an apparent dissociation constant, and related to the enzyme's affinity for the substrate was reported. [AID18079, Type: Literature]
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4
[SID103176101]
 Aqueous solubility [AID19262, Type: Literature]
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5
[SID103176101]
 Partition coefficient (logP) [AID23251, Type: Literature]
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6
[SID103176101]
 Partition coefficient (logP) (benzene) [AID23252, Type: Literature]
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7
[SID103176101]
 Partition coefficient (logP) (carbon tetrachloride) [AID23253, Type: Literature]
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8
[SID103176101]
 Partition coefficient (logP) (chloroform) [AID23254, Type: Literature]
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9
[SID103176101]
 Partition coefficient (logP) (ether) [AID23255, Type: Literature]
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10
[SID103176101]
 Partition coefficient (logP) (hexane) [AID23256, Type: Literature]
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11
[SID103176101]
 Partition coefficient (logP) [AID23443, Type: Literature]
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12
[SID103176101]
 Second-order rate constant (M-1 s-1) for the alkaline hydrolysis in water at 30 degrees C [AID28486, Type: Literature]
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13
[SID103176101]
 Toxicity determined using Microtox Test [AID159270, Type: Literature]
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14
[SID103176101]
 Eye irritation potential accessed using Draize in vivo rabbit eye irritation test [AID167125, Type: Literature]
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15
[SID103176101]
 Toxicity determined using Tadpole Narcosis Test [AID212400, Type: Literature]
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16
[SID103176101]
 Ratio of Kcat to Km was reported. [AID229782, Type: Literature]
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17
[SID103176101]
 Lipophilicity determined as logarithm of the partition coefficient in the alkane/water system [AID237685, Type: Literature]
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18
[SID103176101]
 Octanol-water partition coefficient, log P of the compound [AID343683, Type: Literature]
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19
[SID103176101]
 Alkane-water partition coefficient, log P of the compound [AID343684, Type: Literature]
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20
[SID17389574]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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21
[SID103176101]
 Compound was tested for hydrolysis by acetylcholinesterase and the kinetic constant KOH- was reported. [AID15289, Type: Literature]
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22
[SID103176101]
 Compound was tested for hydrolysis by acetylcholinesterase and the kinetic constant (kcat) which is a first-order rate constant was determined [AID17473, Type: Literature]
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23
[SID17389574]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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24
[SID17389574]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_1, Type: other]
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25
[SID17389574]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_2, Type: other]
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26
[SID17389574]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_3, Type: other]
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27
[SID17389574]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_4, Type: other]
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28
[SID17389574]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_5, Type: other]
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29
[SID17389574]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_6, Type: other]
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30
[SID17389574]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_7, Type: other]
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31
[SID17389574]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_8, Type: other]
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32
[SID17389574]
Potency qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 1 hr assay [AID651754, Type: confirmatory]
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33
[SID17389574]
Potency qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 5 hr assay [AID651755, Type: confirmatory]
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34
[SID17389574]
Potency Biochemical firefly luciferase enzyme assay for NPC [AID624030, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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35
[SID17389574]
Potency qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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36
[SID17389574]
Potency qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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37
[SID17389574]
Potency qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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38
[SID17389574]
Potency qHTS of Trypanosoma Brucei Inhibitors [AID624173, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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39
[SID17389574]
 qHTS Assay for Inhibitors of YjeE [AID605, Type: confirmatory]UPF0079 ATP-binding protein yjeE [gi:84028058]
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40
[SID17389574]
 Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) [AID584, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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41
[SID17389574]
 Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID585, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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42
[SID17389574]
Potency qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore) [AID892, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
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43
[SID17389574]
Potency qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Green Fluorophore) [AID875, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
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44
[SID17389574]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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45
[SID17389574]
Potency qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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46
[SID17389574]
Potency qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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47
[SID17389574]
Potency qHTS assay for small molecule agonists of glucocorticoid receptor signaling [AID588532, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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48
[SID17389574]
Potency qHTS assay for small molecule agonists of glucocorticoid receptor signaling [AID588532, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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49
[SID17389574]
Potency qHTS assay for small molecule agonists of glucocorticoid receptor signaling [AID588532, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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50
[SID17389574]
Potency qHTS assay for small molecule agonists of glucocorticoid receptor signaling [AID588532, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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