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malonic acid (CID 867) - Compound BioActivity Data
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BioActivity Outcomes:
Active(8)
 
 
Inactive(85)
 
 
Inconclusive(8)
 
 
Unspecified(8)
 
 
Top Targets:
NR LBD PPAR(8)
 
 
NR LBD AR(7)
 
 
NR LBD ER(7)
 
 
NR LBD Fxr(4)
 
 
NR LBD GR(4)
 
 
 
BioAssay Types:
Confirmatory(62)
 
 
 
Summary(24)
 
 
 
Literature(16)
 
 
 
 
BioActivity Types:
Potency(80)
 
 
 
 
IC50(4)
 
 
 
Kd(1)
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 108    Data Row: 109   Total Pages: 3   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144207732]
Ratio Potency (uM) 19.3705qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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2
[SID103166340]
IC50 24.9Inhibition of human recombinant N-terminal His-tagged serine racemase expressed in Escherichia coli BL21(DE3) using L-serine as substrate after 10 mins by fluorescence assay [AID726220, Type: Literature]Serine racemase [gi:20139924]
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3
[SID46392736]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystal Structure Of Sh2 In Complex With Malonicacid. [gi:46015002]
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4
[SID103166340]
Inhibition of human mitochondrial NADP-ME E59L mutant expressed in Escherichia coli XL-1 assessed as residual enzyme activity by spectrophotometry in presence of fumarate [AID429164, Type: Literature]
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5
[SID103166340]
Inhibition of human mitochondrial NADP-ME E59L mutant expressed in Escherichia coli XL-1 assessed as residual enzyme activity by spectrophotometry in absence of fumarate [AID429165, Type: Literature]
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6
[SID46394104]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, The Structure Of Mitochondrial Pepck, Complex With Mn And Gdp [gi:110591371]
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7
[SID103166340]
Inhibition of wild type human recombinant mitochondrial NADP-ME expressed in Escherichia coli BL21 assessed as residual enzyme activity by spectrophotometry in absence of fumarate [AID429166, Type: Literature]NADP-dependent malic enzyme, mitochondrial [gi:215274021]
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8
[SID103166340]
Inhibition of wild type human recombinant mitochondrial NADP-ME expressed in Escherichia coli BL21 assessed as residual enzyme activity by spectrophotometry in presence of fumarate [AID429167, Type: Literature]NADP-dependent malic enzyme, mitochondrial [gi:215274021]
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9
[SID103166340]
Ki 71Inhibition of mouse recombinant serine racemase transfected in bacterial expression system [AID443635, Type: Literature]Serine racemase [gi:20139954]
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10
[SID103166340]
IC50 1355Inhibition of human recombinant N-terminal His-tagged DDO expressed in Escherichia coli BL21(DE3) using D-aspartate as substrate by colorimetric assay [AID726223, Type: Literature]D-aspartate oxidase [gi:2494037]
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11
[SID103166340]
Kd 5000Binding affinity to 6-His-tagged human LDHA (2 to 322 amino acid residue) expressed in Escherichia coli BL21 (DE3) cells by NMR analysis in presence of NADH [AID671895, Type: Literature]L-lactate dehydrogenase A chain [gi:126047]
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12
[SID103166340]
IC50 10000Inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-serine as substrate by colorimetric assay [AID726222, Type: Literature]D-amino-acid oxidase [gi:25453448]
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13
[SID103166340]
IC50 40000Inhibitory activity against SH2 domain of human p60 c-Src tyrosine kinase using surface plasmon resonance (SPR) assay. [AID224309, Type: Literature]
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14
[SID103166340]
Ionization constant (pKa2) by treating potentiometric titration data according to the method Noyes [AID233504, Type: Literature]
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15
[SID103166340]
Antileukemic activity of compound against the P-388 lymphocytic leukemic BDF1 male mice at 0.6(mg/kg)/day, administered intraperitoneally; 11.0/9.66 (Treated/control) [AID110256, Type: Literature]
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16
[SID103166340]
In vivo antileukemic activity against P-388 lymphocytic leukemia in BDF1 male mice at 0.6(mg/kg)/day intraperitoneal dose expressed as T/C [AID121636, Type: Literature]
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17
[SID144207732]
Potency-Replicate_1 0.3865qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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18
[SID144207732]
Potency-Replicate_1 qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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19
[SID144207732]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway - cell viability counter screen [AID720693, Type: confirmatory]
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20
[SID144207732]
Potency-Replicate_1 qHTS assay for small molecule disruptors of the mitochondrial membrane potential - cell viability [AID720634, Type: confirmatory]
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21
[SID144207732]
Potency-Replicate_1 qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway - cell viability counter screen [AID743203, Type: confirmatory]
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22
[SID144207732]
Potency-Replicate_1 qHTS assay for small molecule activators of the heat shock response signaling pathway - cell viability counter screen [AID743209, Type: confirmatory]
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23
[SID144207732]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743211, Type: confirmatory]
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24
[SID144207732]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743213, Type: confirmatory]
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25
[SID144207732]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the farnesoid-X-receptor (FXR) signaling pathway - cell viability counter screen [AID743218, Type: confirmatory]
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26
[SID144207732]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the farnesoid-X-receptor (FXR) signaling pathway - cell viability counter screen [AID743221, Type: confirmatory]
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27
[SID144207732]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743224, Type: confirmatory]
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28
[SID144207732]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743225, Type: confirmatory]
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29
[SID73835]
NCI Yeast Anticancer Drug Screen. Data for the rad50 strain [AID155, Type: other]
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30
[SID73835]
NCI Yeast Anticancer Drug Screen. Data for the mec2-1 strain [AID157, Type: other]
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31
[SID73835]
NCI Yeast Anticancer Drug Screen. Data for the sgs1 mgt1 strain [AID161, Type: other]
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32
[SID73835]
NCI Yeast Anticancer Drug Screen. Data for the cln2 rad14 strain [AID165, Type: other]
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33
[SID73835]
NCI Yeast Anticancer Drug Screen. Data for the bub3 strain [AID167, Type: other]
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34
[SID73835]
NCI Yeast Anticancer Drug Screen. Data for the mlh1 rad18 strain [AID175, Type: other]
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35
[SID48414851]
DSSTox (DBPCAN) EPA Water Disinfection By-Products with Carcinogenicity Estimates [AID1201, Type: other]
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36
[SID144207732]
Ratio Potency (uM) qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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37
[SID144207732]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HepG2 cells [AID720674, Type: confirmatory]
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38
[SID144207732]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HepG2 cells [AID720675, Type: confirmatory]
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39
[SID144207732]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cells [AID720678, Type: confirmatory]
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40
[SID144207732]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HEK293 cells [AID720679, Type: confirmatory]
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41
[SID144207732]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cells [AID720680, Type: confirmatory]
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42
[SID144207732]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cell free culture [AID720681, Type: confirmatory]
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43
[SID144207732]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cell free culture [AID720682, Type: confirmatory]
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44
[SID144207732]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HEK293 cell free culture [AID720683, Type: confirmatory]
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45
[SID144207732]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HepG2 cell free culture [AID720684, Type: confirmatory]
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46
[SID144207732]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HepG2 cell free culture [AID720685, Type: confirmatory]
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47
[SID144207732]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HepG2 cell free culture [AID720686, Type: confirmatory]
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48
[SID144207732]
Ratio Potency (uM) qHTS assay for small molecule activators of the heat shock response signaling pathway: Summary [AID743228, Type: summary]heat shock protein beta-1 [Homo sapiens] [gi:4504517]
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49
[SID144207732]
Potency-Replicate_1 qHTS assay for small molecule activators of the heat shock response signaling pathway [AID743210, Type: confirmatory]heat shock protein beta-1 [Homo sapiens] [gi:4504517]
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50
[SID144207732]
Potency-Replicate_1 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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