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malonic acid (CID 867) - Compound BioActivity Data
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BioActivity Outcomes:
Active(12)
 
 
Inactive(89)
 
 
Inconclusive(4)
 
 
Unspecified(8)
 
 
Top Targets:
NR LBD PPAR(8)
 
 
NR LBD AR(7)
 
 
NR LBD ER(7)
 
 
NR LBD Fxr(4)
 
 
NR LBD GR(4)
 
 
 
BioAssay Types:
Confirmatory(62)
 
 
 
Summary(24)
 
 
 
Literature(20)
 
 
 
 
BioActivity Types:
Potency(80)
 
 
 
 
IC50(6)
 
 
 
Ki(3)
 
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 110    Data Row: 113   Total Pages: 6   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144207732]
Ratio Potency (uM) 19.3705qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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2
[SID103166340]
IC50 24.9Inhibition of human recombinant N-terminal His-tagged serine racemase expressed in Escherichia coli BL21(DE3) using L-serine as substrate after 10 mins by fluorescence assay [AID726220, Type: Literature]Serine racemase [gi:20139924]
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3
[SID46392736]
IC50 40000Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB [AID977608, Type: Literature]Chain A, Crystal Structure Of Sh2 In Complex With Malonicacid. [gi:46015002]
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4
[SID46392736]
IC50 40000Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB [AID977608, Type: Literature]Chain A, Crystal Structure Of Sh2 In Complex With Malonicacid. [gi:46015002]
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5
[SID46394104]
Ki 50000Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, The Structure Of Mitochondrial Pepck, Complex With Mn And Gdp [gi:110591371]
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6
[SID46394104]
Ki 50000Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, The Structure Of Mitochondrial Pepck, Complex With Mn And Gdp [gi:110591371]
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7
[SID46392736]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystal Structure Of Sh2 In Complex With Malonicacid. [gi:46015002]
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8
[SID46394104]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, The Structure Of Mitochondrial Pepck, Complex With Mn And Gdp [gi:110591371]
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9
[SID103166340]
Inhibition of human mitochondrial NADP-ME E59L mutant expressed in Escherichia coli XL-1 assessed as residual enzyme activity by spectrophotometry in presence of fumarate [AID429164, Type: Literature]
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10
[SID103166340]
Inhibition of human mitochondrial NADP-ME E59L mutant expressed in Escherichia coli XL-1 assessed as residual enzyme activity by spectrophotometry in absence of fumarate [AID429165, Type: Literature]
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11
[SID103166340]
Inhibition of wild type human recombinant mitochondrial NADP-ME expressed in Escherichia coli BL21 assessed as residual enzyme activity by spectrophotometry in absence of fumarate [AID429166, Type: Literature]NADP-dependent malic enzyme, mitochondrial [gi:215274021]
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12
[SID103166340]
Inhibition of wild type human recombinant mitochondrial NADP-ME expressed in Escherichia coli BL21 assessed as residual enzyme activity by spectrophotometry in presence of fumarate [AID429167, Type: Literature]NADP-dependent malic enzyme, mitochondrial [gi:215274021]
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13
[SID103166340]
Ki 71Inhibition of mouse recombinant serine racemase transfected in bacterial expression system [AID443635, Type: Literature]Serine racemase [gi:20139954]
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14
[SID103166340]
IC50 1355Inhibition of human recombinant N-terminal His-tagged DDO expressed in Escherichia coli BL21(DE3) using D-aspartate as substrate by colorimetric assay [AID726223, Type: Literature]D-aspartate oxidase [gi:2494037]
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15
[SID103166340]
Kd 5000Binding affinity to 6-His-tagged human LDHA (2 to 322 amino acid residue) expressed in Escherichia coli BL21 (DE3) cells by NMR analysis in presence of NADH [AID671895, Type: Literature]L-lactate dehydrogenase A chain [gi:126047]
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16
[SID103166340]
IC50 10000Inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-serine as substrate by colorimetric assay [AID726222, Type: Literature]D-amino-acid oxidase [gi:25453448]
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17
[SID103166340]
IC50 40000Inhibitory activity against SH2 domain of human p60 c-Src tyrosine kinase using surface plasmon resonance (SPR) assay. [AID224309, Type: Literature]
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18
[SID103166340]
Ionization constant (pKa2) by treating potentiometric titration data according to the method Noyes [AID233504, Type: Literature]
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19
[SID103166340]
Antileukemic activity of compound against the P-388 lymphocytic leukemic BDF1 male mice at 0.6(mg/kg)/day, administered intraperitoneally; 11.0/9.66 (Treated/control) [AID110256, Type: Literature]
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20
[SID103166340]
In vivo antileukemic activity against P-388 lymphocytic leukemia in BDF1 male mice at 0.6(mg/kg)/day intraperitoneal dose expressed as T/C [AID121636, Type: Literature]
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