syringaldehyde (CID 8655) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(4)
 
 
Inactive(4)
 
 
Unspecified(23)
 
 
BioAssay Types:
Literature(31)
 
 
 
 
BioActivity Types:
IC50(4)
 
 
SAR
Target summary
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 31    Data Row: 31   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103513903]
 Induction of supercoiled pSP64 plasmid DNA cleavage assessed as increase in nicked form 2 at 2.5 uM by agarose gel electrophoresis in presence of Cu2+ [AID377525, Type: Literature]
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2
[SID103513903]
 Antidiabetic activity in STZ-induced diabetic Wistar rats assessed as increase in response to exogenous insulin at 7.2 mg/kg, iv tid for 3 days [AID685327, Type: Literature]
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3
[SID103513903]
 Antihyperglycemic activity in Wistar rats assessed as reduction in plasma glucose levels at 7.2 mg/kg, iv administered 30 mins prior to glucose challenge measured after 5 mins [AID685328, Type: Literature]
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4
[SID103513903]
 Antihyperglycemic activity in Wistar rats assessed as reduction in plasma glucose levels at 7.2 mg/kg, iv administered 30 mins prior to glucose challenge measured after 30 mins [AID685329, Type: Literature]
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5
[SID103513903]
IC50 100Antiinflammatory activity in human neutrophils assessed as fMLP-induced superoxide release after 5 mins by spectrometry [AID311335, Type: Literature]
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6
[SID103513903]
IC50 100Antioxidant activity assessed as DPPH free radical scavenging activity within 10 mins [AID445109, Type: Literature]
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7
[SID103513903]
MIC 137.26Antitubercular activity against Mycobacterium tuberculosis 90-221387 [AID403754, Type: Literature]
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8
[SID103513903]
IC50 300Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs [AID436320, Type: Literature]
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9
[SID103513903]
MIC 400Antitubercular activity against Mycobacterium tuberculosis H37Rv after 2 weeks by agar dilution method [AID405575, Type: Literature]
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10
[SID103513903]
 Induction of pSP64 plasmid DNA relaxation by agarose gel electrophoresis in presence of Cu2+ [AID377522, Type: Literature]
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11
[SID103513903]
 Induction of supercoiled pSP64 plasmid DNA cleavage assessed as increase in nicked form 2 at 10 uM by agarose gel electrophoresis [AID377523, Type: Literature]
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12
[SID103513903]
 Inhibition of 12-O-tetradecanoylphorbol-13-acetate induced EBV-early antigen activation in human Raji cells assessed as EA activation at 32 nmol relative to TPA [AID377570, Type: Literature]
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13
[SID103513903]
 Inhibition of 12-O-tetradecanoylphorbol-13-acetate induced EBV-early antigen activation in human Raji cells assessed as EA activation at 16 nmol relative to TPA [AID377571, Type: Literature]
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14
[SID103513903]
 Inhibition of 12-O-tetradecanoylphorbol-13-acetate induced EBV-early antigen activation in human Raji cells assessed as EA activation at 3.2 nmol relative to TPA [AID377572, Type: Literature]
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15
[SID103513903]
 Inhibition of 12-O-tetradecanoylphorbol-13-acetate induced EBV-early antigen activation in human Raji cells assessed as EA activation at 0.32 mol relative to TPA [AID377573, Type: Literature]
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16
[SID103513903]
 Cytotoxicity against human Raji cells assessed as cell viability at 32 nmol by trypan blue assay [AID377574, Type: Literature]
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17
[SID103513903]
 Cytotoxicity against human Raji cells assessed as cell viability at 16 nmol by trypan blue assay [AID377575, Type: Literature]
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18
[SID103513903]
 Cytotoxicity against human Raji cells assessed as cell viability at 3.2 nmol by trypan blue assay [AID377576, Type: Literature]
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19
[SID103513903]
 Cytotoxicity against human Raji cells assessed as cell viability at 0.32 nmol by trypan blue assay [AID377577, Type: Literature]
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20
[SID103513903]
 Antioxidant activity against linoleic acid assessed as inhibition of beta-carotene bleaching at 12 uM after 180 mins [AID445112, Type: Literature]
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21
[SID103513903]
IC50 Cytotoxicity against mouse L1210 cells [AID282835, Type: Literature]
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22
[SID103513903]
 Activity against caspase-mediated apoptosis in mouse L1210 cells [AID282834, Type: Literature]
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23
[SID103513903]
 Antihyperglycemic activity in STZ-induced diabetic Wistar rats assessed as reduction in plasma glucose levels at 1.8 mg/kg, iv administered as bolus dose measured after 60 mins [AID685323, Type: Literature]
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24
[SID103513903]
 Antihyperglycemic activity in Wistar rats assessed as reduction in plasma glucose levels at 7.2 mg/kg, iv administered as bolus dose measured after 60 mins [AID685325, Type: Literature]
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25
[SID103513903]
 Induction of glucose uptake in rat L6 cells after 60 mins by 2-NBDG fluorescence assay [AID685326, Type: Literature]
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26
[SID103513903]
 Antihyperglycemic activity in STZ-induced diabetic Wistar rats assessed as reduction in plasma glucose levels at 7.2 mg/kg, iv administered as bolus dose measured after 60 mins [AID685322, Type: Literature]
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27
[SID103513903]
 Antihyperglycemic activity in iv dosed STZ-induced diabetic Wistar rats assessed as reduction in plasma glucose levels administered as bolus dose measured after 60 mins [AID685321, Type: Literature]
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28
[SID103513903]
 Antihyperglycemic activity in Wistar rats assessed as reduction in plasma glucose levels at 7.2 mg/kg, iv administered 30 mins prior to glucose challenge measured after 120 mins [AID685320, Type: Literature]
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29
[SID103513903]
 Prooxidant effect on Cu2+-induced pBR322 DNA damage at 0.35 to 45 uM after 1 hr [AID445117, Type: Literature]
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30
[SID103513903]
 Induction of supercoiled pSP64 plasmid DNA cleavage assessed as increase in linear duplex form 3 by agarose gel electrophoresis [AID377529, Type: Literature]
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31
[SID103513903]
 Antioxidant activity assessed as inhibition of AAPH-induced lipid peroxidation in human plasma LDL after 18 hrs by gel electrophoresis [AID445110, Type: Literature]
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