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benzil (CID 8651) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(34)
 
 
Inactive(84)
 
 
Inconclusive(13)
 
 
Unspecified(18)
 
 
Top Targets:
Esterase lipa..(35)
 
 
 
NR LBD PPAR(8)
 
 
 
NR LBD AR(7)
 
 
NR LBD ER(7)
 
 
NR LBD Fxr(4)
 
 
BioAssay Types:
Confirmatory(62)
 
 
 
Literature(52)
 
 
 
Summary(24)
 
 
 
BioActivity Types:
Potency(80)
 
 
 
Ki(34)
 
 
 
IC50(12)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 147    Data Row: 149   Total Pages: 3   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103460170]
Ki 0.0069Inhibition constant against human liver carboxylesterase 1 using 4-MUA (4-methylumbelliferone acetate) [AID239005, Type: Literature]Liver carboxylesterase 1 [gi:119576]
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2
[SID103460170]
Ki 0.0136Inhibition constant against rabbit liver carboxylesterase using 4-MUA (4-methylumbelliferone acetate) [AID238980, Type: Literature]
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3
[SID103460170]
Ki 0.0147Inhibition constant against human intestinal carboxylesterase 2 (hiCE) using nitrophenyl acetate (o-NPA) as substrate [AID239272, Type: Literature]Cocaine esterase [gi:46576349]
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4
[SID103460170]
Ki 0.0147Inhibition constant against human intestinal carboxylesterase 2 (hiCE) using o-NPA (nitrophenyl acetate) as substrate [AID239273, Type: Literature]Cocaine esterase [gi:46576349]
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5
[SID103460170]
Ki 0.0147Inhibition constant against human intestinal carboxylesterase (hiCE) expressed in Sf21 cells using 3 mM o-NPA [AID239717, Type: Literature]Cocaine esterase [gi:46576349]
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6
[SID103460170]
Ki 0.01479Inhibition of human intestinal carboxylesterase [AID412227, Type: Literature]
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7
[SID103460170]
Ki 0.015Inhibition of human liver carboxylesterase1 using o-nitrophenyl acetate as substrate after 5 mins by spectrophotometry [AID612130, Type: Literature]Liver carboxylesterase 1 [gi:119576]
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8
[SID103460170]
Ki 0.015Inhibition of human iCE using o-NPA as substrate by spectrophotometric assay [AID731514, Type: Literature]Cocaine esterase [gi:46576349]
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9
[SID103460170]
Ki 0.0151Inhibition of human intestinal carboxylesterase [AID295501, Type: Literature]Cocaine esterase [gi:46576349]
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10
[SID103460170]
IC50 0.019Inhibition of rabbit liver carboxylesterase after 5 mins [AID316371, Type: Literature]
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11
[SID103460170]
Ki 0.024Inhibition constant against human intestinal carboxylesterase 2 using 4-MUA (4-methylumbelliferone acetate) as substrate [AID239314, Type: Literature]Cocaine esterase [gi:46576349]
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12
[SID103460170]
IC50 0.027Inhibition of human recombinant carboxylesterase 1 after 5 mins [AID316365, Type: Literature]Liver carboxylesterase 1 [gi:119576]
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13
[SID103460170]
IC50 0.029Inhibition of rabbit liver carboxylesterase after 15 mins [AID316372, Type: Literature]
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14
[SID103460170]
IC50 0.038Inhibition of human recombinant carboxylesterase 2 after 5 mins [AID316367, Type: Literature]Cocaine esterase [gi:46576349]
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15
[SID103460170]
IC50 0.043Inhibition of human recombinant carboxylesterase 1 after 15 mins [AID316366, Type: Literature]Liver carboxylesterase 1 [gi:119576]
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16
[SID103460170]
IC50 0.044Inhibition of human recombinant carboxylesterase 2 after 15 mins [AID316368, Type: Literature]Cocaine esterase [gi:46576349]
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17
[SID103460170]
Ki 0.04467Inhibition of human carboxylesterase 1 [AID412228, Type: Literature]Liver carboxylesterase 1 [gi:119576]
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18
[SID103460170]
Ki 0.045Inhibition of human CE1 using o-NPA as substrate by spectrophotometric assay [AID731515, Type: Literature]Liver carboxylesterase 1 [gi:119576]
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19
[SID103460170]
Ki 0.045Inhibition of human intestinal carboxylesterase using o-nitrophenyl acetate as substrate after 5 mins by spectrophotometry [AID612131, Type: Literature]Cocaine esterase [gi:46576349]
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20
[SID103460170]
Ki 0.0451Inhibition of human carboxylesterase 1 [AID295502, Type: Literature]Liver carboxylesterase 1 [gi:119576]
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21
[SID103460170]
Ki 0.0451Inhibition constant against human liver carboxylesterase 1 (hCE1) using nitrophenyl acetate (o-NPA) as substrate [AID239197, Type: Literature]Liver carboxylesterase 1 [gi:119576]
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22
[SID103460170]
Ki 0.0451Inhibition constant against human liver carboxylesterase 1 using o-NPA (nitrophenyl acetate) [AID239063, Type: Literature]Liver carboxylesterase 1 [gi:119576]
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23
[SID103460170]
Ki 0.0451Inhibition constant against human liver carboxylesterase (hCE1) expressed in Sf21 cells using 3 mM o-NPA [AID239708, Type: Literature]
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24
[SID103460170]
Ki 0.10233Inhibition of rabbit carboxylesterase [AID412229, Type: Literature]
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25
[SID103460170]
Ki 0.103Inhibition of rabbit carboxylesterase [AID295503, Type: Literature]
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26
[SID103460170]
Ki 0.103Inhibition constant against rabbit liver carboxylesterase using o-NPA (nitrophenyl acetate) [AID239046, Type: Literature]
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27
[SID103460170]
Ki 0.103Inhibition constant against rabbit liver carboxylesterase (rCE) using nitrophenyl acetate (o-NPA) as substrate [AID239167, Type: Literature]
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28
[SID103460170]
Ki 0.103Inhibition of rabbit liver carboxylesterase using o-nitrophenyl acetate as substrate after for 5 mins by spectrophotometry [AID612132, Type: Literature]Liver carboxylesterase 1 [gi:51338757]
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29
[SID103460170]
Ki 0.175Inhibition of human intestinal carboxylesterase assessed as hydrolysis of CPT-11 after 5 mins by HPLC [AID612137, Type: Literature]Cocaine esterase [gi:46576349]
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30
[SID103460170]
Ki 0.175Inhibition constant against human intestinal carboxylesterase 2 using CPT-11 [AID238766, Type: Literature]Cocaine esterase [gi:46576349]
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31
[SID103460170]
Ki 0.185Inhibition constant against rabbit liver carboxylesterase using CPT-11 [AID238666, Type: Literature]
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32
[SID103460170]
IC50 0.37Inhibition of pig liver carboxylesterase after 5 mins [AID316369, Type: Literature]Liver carboxylesterase [gi:2494384]
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33
[SID103460170]
IC50 0.83Inhibition of pig liver carboxylesterase after 15 mins [AID316370, Type: Literature]Liver carboxylesterase [gi:2494384]
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34
[SID103460170]
IC50 22.9Cytotoxicity against human U373MG cells expressing human intestinal carboxylesterase after 4 days in drug free medium by coulter counter in presence of CPT-11 [AID612133, Type: Literature]
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35
[SID103460170]
IC50 40Inhibition of human recombinant FAAH after 5 mins [AID316373, Type: Literature]Fatty-acid amide hydrolase 1 [gi:60416391]
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36
[SID103460170]
IC50 40Inhibition of human recombinant FAAH after 15 mins [AID316374, Type: Literature]Fatty-acid amide hydrolase 1 [gi:60416391]
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37
[SID103460170]
Ki 100Inhibition of human acetylcholinesterase using acetylthiocholine as substrate by spectrophotometry [AID612134, Type: Literature]Acetylcholinesterase [gi:113037]
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38
[SID103460170]
Ki 100Inhibition of human acetylcholinesterase 1 [AID302992, Type: Literature]Acetylcholinesterase [gi:113037]
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39
[SID103460170]
Ki 100Inhibition of human AChE [AID295504, Type: Literature]Acetylcholinesterase [gi:113037]
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40
[SID103460170]
Ki 100Inhibition of 1 mM acetylthiocholine (AcTCh) binding to human Acetylcholinesterase [AID239391, Type: Literature]Acetylcholinesterase [gi:113037]
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41
[SID103460170]
Ki 100Inhibition constant against human Acetylcholinesterase (hAcChE) using acetylthiocholine (AcTCh) as substrate [AID239122, Type: Literature]Acetylcholinesterase [gi:113037]
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42
[SID103460170]
Ki 100Inhibition constant against human Butyrylcholinesterase (hBuChE) using butyrylthiocholine (BuTCh) as substrate [AID239166, Type: Literature]Cholinesterase [gi:116353]
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43
[SID103460170]
Ki 100Inhibition of human BChE [AID295505, Type: Literature]Cholinesterase [gi:116353]
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44
[SID103460170]
Ki 100Inhibition of human butyrylcholinesterase [AID302993, Type: Literature]Cholinesterase [gi:116353]
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45
[SID103460170]
Ki 100Inhibition of human butyrylcholinesterase using butyrylthiocholine as substrate by spectrophotometry [AID612135, Type: Literature]Cholinesterase [gi:116353]
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46
[SID103460170]
IC50 100Cytotoxicity against human U373MG cells expressing human intestinal carboxylesterase after 4 days in drug free medium by coulter counter [AID612142, Type: Literature]
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47
[SID103460170]
Reduction of CPT-11 sensitization to human U373MG cells expressing human iCE treated 1 hr before CPT-11 challenge measured after 72 hrs relative to DMSO control [AID731516, Type: Literature]
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48
[SID103460170]
Lipophilicity, log P of the compound [AID412236, Type: Literature]
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49
[SID103460170]
Reduction of CPT-11 induced cytotoxicity against human U373MG cells at 10 uM pre-incubated for 1 hr measured after 4 days in drug free medium by coulter counter [AID612139, Type: Literature]
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50
[SID103460170]
Inhibition of intestinal carboxylesterase in human U373MG cells using 4-methylumbelliferone acetate as substrate at 10 uM after 1 hrs pre-incubation by fluorimetry [AID612138, Type: Literature]Cocaine esterase [gi:46576349]
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