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alpha-Tocopherol (CID 86472) - Compound BioActivity Data
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BioActivity Outcomes:
Active(4)
 
 
Inactive(747)
 
 
Inconclusive(26)
 
 
Unspecified(26)
 
 
Top Targets:
NR LBD AR(28)
 
 
 
 
NR LBD ER(28)
 
 
7TM GPCR Srsx(21)
 
 
NR LBD PPAR(20)
 
 
 
7TM GPCR Srx(19)
 
 
BioAssay Types:
Confirmatory(364)
 
 
 
 
 
Screening(325)
 
 
 
Summary(78)
 
 
 
Literature(32)
 
 
 
 
BioActivity Types:
Potency(414)
 
 
 
 
 
IC50(12)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 532    Data Row: 803   Total Pages: 17   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144213754]
Potency-Replicate_1 48.9722qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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2
[SID144213754]
Potency-Replicate_1 48.9722qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743224, Type: confirmatory]
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3
[SID57264399]
HTS to identify compounds that promote myeloid differentiation with MLPCN compound set [AID624256, Type: screening] [geneid:3205]
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4
[SID103282296]
Prodrug conversion in 3D restructured human skin model assessed as conversion of compound to dl-alpha-tocopherol at 2% after 4 hrs by HPLC analysis [AID631221, Type: Literature]
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5
[SID103282296]
IC50 500Compound was tested for antiproliferative activity against human breast cancer cell line MCF-7 in MTT assay [AID103204, Type: Literature]
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6
[SID103282296]
In vivo activity against hypocholesterol (CHOL) by Alloxan-induced hyperlipoperoxidemia method in BALB/c mice after peroral administration at 50 mg/Kg dose [AID111626, Type: Literature]
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7
[SID103282296]
In vivo activity against serum lipid peroxidation level (s-LPO) by using Alloxan-induced hyperlipoperoxidemia method in BALB/c mice after peroral administration at 50 mg/Kg dose [AID111638, Type: Literature]
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8
[SID103282296]
In vivo activity against triglycerides (TG) by Alloxan-induced hyperlipoperoxidemia method in BALB/c mice after peroral administration at 50 mg/Kg dose [AID111639, Type: Literature]
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9
[SID103282296]
In vivo activity against triglycerides (TG) by using Alloxan-induced hyperlipoperoxidemia method in BALB/c mice after peroral administration at 10 mg/Kg dose [AID111640, Type: Literature]
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10
[SID103282296]
In vivo activity against triglycerides (TG) by using Alloxan-induced hyperlipoperoxidemia method in BALB/c mice after peroral administration at 100 mg/Kg dose [AID111641, Type: Literature]
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11
[SID103282296]
In vivo activity against triglycerides (TG) by using Alloxan-induced hyperlipoperoxidemia method in BALB/c mice after peroral administration at 300 mg/Kg dose [AID111644, Type: Literature]
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12
[SID103282296]
In vitro inhibitory activity against rat microsomal lipid peroxidation (m-LPO) [AID179764, Type: Literature]
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13
[SID103282296]
In vivo activity against hypocholesterol (CHOL) by using Alloxan-induced hyperlipoperoxidemia method in BALB/c mice after peroral administration at 10 mg/Kg dose [AID111627, Type: Literature]
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14
[SID103282296]
In vivo activity against hypocholesterol (CHOL) by using Alloxan-induced hyperlipoperoxidemia method in BALB/c mice after peroral administration at 100 mg/Kg dose [AID111628, Type: Literature]
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15
[SID103282296]
In vivo activity against hypocholesterol (CHOL) by using Alloxan-induced hyperlipoperoxidemia method in BALB/c mice after peroral administration at 300 mg/Kg dose [AID111631, Type: Literature]
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16
[SID103282296]
In vivo activity against serum lipid peroxidation level (s-LPO) by using Alloxan-induced hyperlipoperoxidemia method in BALB/c mice after peroral administration at 10 mg/Kg dose [AID111632, Type: Literature]
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17
[SID103282296]
In vivo activity against serum lipid peroxidation level (s-LPO) by using Alloxan-induced hyperlipoperoxidemia method in BALB/c mice after peroral administration at 100 mg/Kg dose [AID111633, Type: Literature]
View
18
[SID103282296]
In vivo activity against serum lipid peroxidation level (s-LPO) by using Alloxan-induced hyperlipoperoxidemia method in BALB/c mice after peroral administration at 300 mg/Kg dose [AID111636, Type: Literature]
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19
[SID103282296]
Antioxidant activity in rat liver microsomes assessed as inhibition of lipid peroxide formation after 30 mins [AID336950, Type: Literature]
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20
[SID103282296]
Inhibition of soybean arachidonate 15-lipoxygenase by oxygen electrode method [AID336951, Type: Literature]
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21
[SID103282296]
Antioxidant activity assessed as inhibition of Fe2+-induced lipid peroxidation after 15 to 60 mins by TBARS assay relative to control [AID416726, Type: Literature]
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22
[SID103282296]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans [AID588211, Type: Literature]
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23
[SID103282296]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents [AID588212, Type: Literature]
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24
[SID103282296]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents [AID588213, Type: Literature]
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25
[SID103282296]
Protection against H2O2-induced cell damage in NHEK assessed as inhibition of PGE2 production at 2 uM pretreated for 24 hrs before H2O2 challenge measured after 24 hrs by enzymatic immunoassay [AID631235, Type: Literature]
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26
[SID103282296]
Protection against t-BHP-induced cell damage in NHEK assessed as inhibition of PGE2 production at 2 uM pretreated for 24 hrs before t-BHP challenge measured after 24 hrs by enzymatic immunoassay [AID631240, Type: Literature]
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27
[SID103282296]
Protection against IL1-beta-induced cell damage in NHEK assessed as inhibition of PGE2 production at 2 uM pretreated for 24 hrs before IL1-beta challenge measured after 24 hrs by enzymatic immunoassay [AID631276, Type: Literature]
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28
[SID103282296]
Protection against IL1-beta-induced cell damage in NHEK assessed as inhibition of PGE2 production at 0.5 uM pretreated for 24 hrs before IL1-beta challenge measured after 24 hrs by enzymatic immunoassay [AID631277, Type: Literature]
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29
[SID103282296]
Protection against IL1-beta-induced cell damage in NHEK assessed as inhibition of PGE2 production at 0.1 uM pretreated for 24 hrs before IL1-beta challenge measured after 24 hrs by enzymatic immunoassay [AID631278, Type: Literature]
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30
[SID57264399]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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31
[SID57264399]
Potency 0.8913A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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32
[SID144205044]
Potency-Replicate_1 3.378qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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33
[SID57264399]
Potency 7.3078qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation [AID540253, Type: confirmatory]importin subunit beta-1 isoform 1 [Homo sapiens] [gi:19923142]
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34
[SID57264399]
Potency 7.3078qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation [AID540253, Type: confirmatory]snurportin-1 [Homo sapiens] [gi:5031833]
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35
[SID57264399]
Potency 7.3078qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation [AID540253, Type: confirmatory]GTP-binding nuclear protein Ran [Homo sapiens] [gi:5453555]
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36
[SID144207016]
Potency-Replicate_1 9.5205qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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37
[SID29218011]
Potency 28.1838qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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38
[SID144205044]
Potency-Replicate_1 33.4915qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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39
[SID144205044]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the thyroid receptor (TR) signaling pathway [AID743066, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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40
[SID144205044]
TR Potency (uM) qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway: Summary [AID743067, Type: summary]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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41
[SID144205117]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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42
[SID144205117]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the thyroid receptor (TR) signaling pathway [AID743066, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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43
[SID144205117]
TR Potency (uM) qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway: Summary [AID743067, Type: summary]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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44
[SID144207016]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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45
[SID144207016]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the thyroid receptor (TR) signaling pathway [AID743066, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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46
[SID144207016]
TR Potency (uM) qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway: Summary [AID743067, Type: summary]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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47
[SID144213754]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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48
[SID144213754]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the thyroid receptor (TR) signaling pathway [AID743066, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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49
[SID144213754]
TR Potency (uM) qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway: Summary [AID743067, Type: summary]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
View
50
[SID57264399]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of A1 Apoptosis. [AID2462, Type: screening]Chain A, Human Bcl2-A1 In Complex With Bim-Bh3 Peptide [gi:167013344]
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