Bookmark and Share
alpha-Tocopherol (CID 86472) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(5)
 
 
Inactive(764)
 
 
Inconclusive(22)
 
 
Unspecified(28)
 
 
Top Targets:
NR LBD AR(28)
 
 
 
 
NR LBD ER(28)
 
 
7TM GPCR Srsx(21)
 
 
NR LBD PPAR(20)
 
 
 
7TM GPCR Srx(19)
 
 
BioAssay Types:
Confirmatory(367)
 
 
 
 
 
Screening(326)
 
 
 
Summary(78)
 
 
 
Literature(44)
 
 
 
 
BioActivity Types:
Potency(417)
 
 
 
 
 
IC50(14)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 540    Data Row: 819   Total Pages: 41   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144213754]
Potency-Replicate_1 48.9722qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743224, Type: confirmatory]
View
2
[SID144213754]
Potency-Replicate_1 48.9722qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
View
3
[SID57264399]
HTS to identify compounds that promote myeloid differentiation with MLPCN compound set [AID624256, Type: screening] [geneid:3205]
View
4
[SID103282296]
IC50 Inhibition of bovine mitochondrial electron transport protein complex 3 dUQH2:cytochrome c oxidoreductase activity by spectrophotometry [AID1064574, Type: Literature]
View
5
[SID103282296]
Prodrug conversion in 3D restructured human skin model assessed as conversion of compound to dl-alpha-tocopherol at 2% after 4 hrs by HPLC analysis [AID631221, Type: Literature]
View
6
[SID103282296]
IC50 500Compound was tested for antiproliferative activity against human breast cancer cell line MCF-7 in MTT assay [AID103204, Type: Literature]
View
7
[SID103282296]
IC50 1000Inhibition of bovine mitochondrial electron transport protein complex 2 succinate:DCPIP oxidoreductase activity by spectrophotometry [AID1064575, Type: Literature]
View
8
[SID103282296]
Drug degradation in mouse N18TG2 cells assessed as alpha-TOH formation at 10 nmol after 24 hrs by HPLC analysis [AID1064556, Type: Literature]
View
9
[SID103282296]
Protection against H2O2-induced cell damage in NHEK assessed as inhibition of PGE2 production at 2 uM pretreated for 24 hrs before H2O2 challenge measured after 24 hrs by enzymatic immunoassay [AID631235, Type: Literature]
View
10
[SID103282296]
Protection against t-BHP-induced cell damage in NHEK assessed as inhibition of PGE2 production at 2 uM pretreated for 24 hrs before t-BHP challenge measured after 24 hrs by enzymatic immunoassay [AID631240, Type: Literature]
View
11
[SID103282296]
Protection against IL1-beta-induced cell damage in NHEK assessed as inhibition of PGE2 production at 2 uM pretreated for 24 hrs before IL1-beta challenge measured after 24 hrs by enzymatic immunoassay [AID631276, Type: Literature]
View
12
[SID103282296]
Protection against IL1-beta-induced cell damage in NHEK assessed as inhibition of PGE2 production at 0.5 uM pretreated for 24 hrs before IL1-beta challenge measured after 24 hrs by enzymatic immunoassay [AID631277, Type: Literature]
View
13
[SID103282296]
Protection against IL1-beta-induced cell damage in NHEK assessed as inhibition of PGE2 production at 0.1 uM pretreated for 24 hrs before IL1-beta challenge measured after 24 hrs by enzymatic immunoassay [AID631278, Type: Literature]
View
14
[SID103282296]
In vivo activity against hypocholesterol (CHOL) by Alloxan-induced hyperlipoperoxidemia method in BALB/c mice after peroral administration at 50 mg/Kg dose [AID111626, Type: Literature]
View
15
[SID103282296]
In vivo activity against hypocholesterol (CHOL) by using Alloxan-induced hyperlipoperoxidemia method in BALB/c mice after peroral administration at 10 mg/Kg dose [AID111627, Type: Literature]
View
16
[SID103282296]
In vivo activity against hypocholesterol (CHOL) by using Alloxan-induced hyperlipoperoxidemia method in BALB/c mice after peroral administration at 100 mg/Kg dose [AID111628, Type: Literature]
View
17
[SID103282296]
In vivo activity against hypocholesterol (CHOL) by using Alloxan-induced hyperlipoperoxidemia method in BALB/c mice after peroral administration at 300 mg/Kg dose [AID111631, Type: Literature]
View
18
[SID103282296]
In vivo activity against serum lipid peroxidation level (s-LPO) by using Alloxan-induced hyperlipoperoxidemia method in BALB/c mice after peroral administration at 10 mg/Kg dose [AID111632, Type: Literature]
View
19
[SID103282296]
In vivo activity against serum lipid peroxidation level (s-LPO) by using Alloxan-induced hyperlipoperoxidemia method in BALB/c mice after peroral administration at 100 mg/Kg dose [AID111633, Type: Literature]
View
20
[SID103282296]
In vivo activity against serum lipid peroxidation level (s-LPO) by using Alloxan-induced hyperlipoperoxidemia method in BALB/c mice after peroral administration at 300 mg/Kg dose [AID111636, Type: Literature]
View