imidacloprid (CID 86418) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(17)
 
 
Inactive(502)
 
 
Inconclusive(12)
 
 
Unspecified(26)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
7TM GPCR Srsx(6)
 
 
NR LBD TR(6)
 
 
 
TRP 2(5)
 
 
NR LBD PPAR(5)
 
 
BioAssay Types:
Screening(320)
 
 
 
 
Confirmatory(183)
 
 
 
 
 
Literature(38)
 
 
 
 
BioActivity Types:
Potency(152)
 
 
 
 
 
IC50(28)
 
 
 
Ki(8)
 
 
EC50(4)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 520    Data Row: 557   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103565844]
Ki 0.0019Binding affinity for nAChR with [3H]imidacloprid in Myzus persicae [AID147718, Type: Literature]
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2
[SID103565844]
Ki 0.0021Binding affinity for nAChR with [3H]imidacloprid in Drosophila [AID147717, Type: Literature]
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3
[SID103565844]
Ki 0.0022Potency to displace [3H]IMI binding to Nicotinic acetylcholine receptor from Drosophila head membranes [AID145345, Type: Literature]
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4
[SID103565844]
IC50 0.0036Displacement of [3H]IMI from peach-potato aphid alpha2/rat beta2 nAChR hybrid recombinant receptor [AID344086, Type: Literature]
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5
[SID103565844]
IC50 0.0043Displacement of [3H]IMI from nAChR in Drosophila brain [AID344082, Type: Literature]
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6
[SID103565844]
Ki 0.05Binding affinity for nAChR with [3H]-nicotine in rat alpha4 beta2 membranes [AID145520, Type: other]
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7
[SID103565844]
Ki 0.18Displacement of [3H]EPI from Aplysia AChBP expressed in HEK293S cells by scintillation proximity assay [AID318726, Type: Literature]
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8
[SID103565844]
Ki 0.267Displacement of [3H]ACE from Aplysia AChBP expressed in HEK293S cells by scintillation proximity assay [AID318725, Type: Literature]
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9
[SID103565844]
Ki 0.29Binding affinity for nAChR with [3H]nicotine in rat brain [AID145517, Type: other]
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10
[SID103565844]
Ki 0.72Potency to displace [3H]nicotine binding to Nicotinic acetylcholine receptor alpha4-beta2 immuno-isolated from M10 cells [AID146171, Type: Literature]
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11
[SID50086524]
Potency 1.122qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase-type plasminogen activator [Mus musculus] [gi:6679377]
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12
[SID50086524]
Potency 1.122qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase-type plasminogen activator [Mus musculus] [gi:6679377]
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13
[SID50086524]
Potency 2.5929qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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14
[SID50086524]
Potency 2.5929qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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15
[SID50086524]
Potency 2.5929qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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16
[SID103565844]
IC50 2.6Displacement of [3H]nicotine from chick alpha4beta2 nAChR [AID344087, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:113062]
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17
[SID144206909]
Potency 6.6838qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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18
[SID144206909]
Potency 6.6838qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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19
[SID144206909]
Potency 6.6838qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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20
[SID144206909]
Potency 8.4144qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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21
[SID144206909]
Potency 8.4144qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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22
[SID144206909]
Potency 8.4144qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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23
[SID50086524]
 Luminescence-based counterscreen assay for KLF5 inhibitors: cell-based high throughput screening assay to identify cytotoxic compounds using the IEC-6 intestinal epithelial cell line. [AID1825, Type: screening]
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24
[SID50086524]
 Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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25
[SID103565844]
 Selectivity ratio of Ki of Nicotinic acetylcholine receptor of Drosophila to Nicotinic acetylcholine receptor alpha4-beta2 [AID145850, Type: Literature]
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26
[SID103565844]
 Inhibition of [3H]1-((5-azido-6-chloropyridin-3-yl)methyl)-3-methyl-2-nitroguanidine incorporation into AchBP assessed as protection of photoaffinity labeling at 500 pmol [AID318727, Type: Literature]
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27
[SID103565844]
 Insecticidal activity against Aphis gossypii glover in cotton/melon plant [AID323211, Type: Literature]
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28
[SID103565844]
 Insecticidal activity against Myzus persicae Sulzer in raddish plant [AID323212, Type: Literature]
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29
[SID103565844]
 Insecticidal activity against Aphis gossypii glover in cotton/melon plant by contact plant assay [AID323214, Type: Literature]
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30
[SID103565844]
 Insecticidal activity against Aphis gossypii glover in cotton/melon plant by systemic plant assay [AID323215, Type: Literature]
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31
[SID103565844]
 Insecticidal activity against Myzus persicae Sulzer in raddish plant by contact plant assay [AID323216, Type: Literature]
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32
[SID103565844]
 Insecticidal activity against Myzus persicae Sulzer in raddish plant by systemic plant assay [AID323217, Type: Literature]
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33
[SID103565844]
 Toxicity in ip dosed Swiss Webster mouse [AID344080, Type: Literature]
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34
[SID103565844]
 Ratio of IC50 for Drosophila nAChR to chick alpha4beta2 nAChR [AID344089, Type: Literature]
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35
[SID103565844]
 Lipophilicity, log P of the compound [AID344090, Type: Literature]
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36
[SID103565844]
 Insecticidal activity against intrathoracically dosed houseflies at >10 um/g [AID344091, Type: Literature]
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37
[SID103565844]
 Insecticidal activity against Musca domestica Takatsuki assessed as mortality injected into thorax measured after 24 hrs [AID352725, Type: Literature]
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38
[SID103565844]
 Octanol-water partition coefficient, log P of the compound [AID352729, Type: Literature]
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39
[SID103565844]
 Insecticidal activity against Aphis craccivora assessed as mortality at 500 mg/L [AID371212, Type: Literature]
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40
[SID103565844]
 Insecticidal activity against Aphis craccivora [AID371213, Type: Literature]
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41
[SID103565844]
 Insecticidal activity against imidacloprid-sensitive Nilaparvata lugens [AID371214, Type: Literature]
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42
[SID103565844]
 Insecticidal activity against imidacloprid-resistant Nilaparvata lugens [AID371215, Type: Literature]
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43
[SID103565844]
 Insecticidal activity against houseflies [AID344083, Type: Literature]
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44
[SID103565844]
 Anticonvulsant activity [AID227700, Type: Literature]
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45
[SID103565844]
 Permeability coefficient through artificial membrane in presence of unstirred water layer by PAMPA [AID288184, Type: Literature]
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46
[SID103565844]
 Permeability coefficient through artificial membrane in presence of stirred water layer [AID288185, Type: Literature]
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47
[SID103565844]
 Membrane retention in permeability experiment with artificial membrane [AID288191, Type: Literature]
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48
[SID103565844]
 Partition coefficient, log P of the compound [AID288192, Type: Literature]
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49
[SID26757127]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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50
[SID50086524]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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