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3-Hydroxyanthranilic Acid (CID 86) - Compound BioActivity Data
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BioActivity Outcomes:
Active(41)
 
 
Inactive(464)
 
 
Inconclusive(5)
 
 
Unspecified(40)
 
 
Top Targets:
7TM GPCR Srx(14)
 
 
 
7TM GPCR Srsx(11)
 
 
 
CASc(8)
 
 
 
TRP 2(5)
 
 
CAP ED(5)
 
 
BioAssay Types:
Screening(368)
 
 
 
Confirmatory(103)
 
 
 
 
 
Literature(69)
 
 
 
 
BioActivity Types:
Potency(70)
 
 
 
 
 
IC50(19)
 
 
 
 
AC50(8)
 
 
 
EC50(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 514    Data Row: 550   Total Pages: 11   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID47193877]
IC50_Mean 1.44Dose Response confirmation of uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay [AID504765, Type: confirmatory]glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium berghei] [gi:12381848]
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2
[SID47193877]
AC50_uM 1.59VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_Dose_CherryPick_Activity [AID720632, Type: confirmatory]Caspase 6, apoptosis-related cysteine peptidase [Homo sapiens] [gi:13325293]
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3
[SID47193877]
EC50_uM 5.43Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity [AID435010, Type: confirmatory]RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)] [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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4
[SID47193877]
EC50_uM 6.102Fluorescence Cell-Free Homogeneous Counter Screen to Identify Inhibitors of GFP Chromophore Formation [AID434968, Type: confirmatory]RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)] [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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5
[SID47193877]
AC50_uM 6.14Caspase 7 Counterscreen for Selectivity Fluorescent Measured in Cell-Based System Using Plate Reader - 7052-04_Inhibitor_Dose_CherryPick_Activity [AID743295, Type: confirmatory]Caspase-7 [gi:1730092]
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6
[SID47193877]
IC50 7.18A biochemical assay using the ADP-Hunter methodology, purified TAg, and ATP to identify compounds that inhibit the ATPase activity of Tag - Counter Screen [AID2501, Type: confirmatory]
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7
[SID47193877]
IC50 20.09Identification of SV40 T antigen inhibitors: A route to novel anti-viral reagents [AID1903, Type: confirmatory]large T antigen [Simian virus 40] [gi:297591903]
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8
[SID47193877]
AC50_uM 27.17Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Non-Covalent Inhibitors of RecA-Intein Splicing Activity [AID449750, Type: confirmatory]Probable replicative DNA helicase DnaB [Mycobacterium tuberculosis H37Rv] [gi:15607200]
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9
[SID47193877]
Potency 39.8107qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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10
[SID47193877]
IC50_Mean 40.9Dose Response orthogonal kinetic assay utilizing the direct detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase [AID540269, Type: confirmatory]glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium berghei] [gi:12381848]
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11
[SID47193877]
Potency 56.2341qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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12
[SID47193877]
Single concentration confirmation of uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay [AID504753, Type: screening]glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium berghei] [gi:12381848]
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13
[SID47193877]
FRET-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID485270, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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14
[SID47193877]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of human platelet-activating factor acetylhydrolase 1B, catalytic subunit 3 (PAFAH1B3) [AID492972, Type: screening]platelet-activating factor acetylhydrolase IB subunit gamma [Homo sapiens] [gi:225543099]
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15
[SID47193877]
Fluorescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of RecA Intein Splicing Activity [AID2221, Type: screening]RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)] [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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16
[SID47193877]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID588726, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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17
[SID47193877]
Fluorescence-based biochemical high throughput confirmation assay for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID651616, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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18
[SID46393285]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Structure And Function Of Phenazine-biosynthesis Protein Phzf From Pseudomonas Fluorescens 2-79 [gi:56554120]
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19
[SID47193877]
Fluorescence-based biochemical high throughput screening primary assay to identify inhibitors of Crimean-Congo Hemorrhagic Fever (CCHF) viral ovarian tumor domain protease (vOTU): Pep-AMC substrate [AID651958, Type: screening]putative polyprotein [Crimean-Congo hemorrhagic fever virus] [gi:76364066]
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20
[SID47193877]
uHTS Fluorescent assay for identification of inhibitors of Apaf-1 [AID489030, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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21
[SID47193877]
uHTS identification of small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay [AID504690, Type: screening]glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium berghei] [gi:12381848]
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22
[SID47193877]
VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID686996, Type: screening]Caspase 6, apoptosis-related cysteine peptidase [Homo sapiens] [gi:13325293]
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23
[SID103583212]
Antiasthmatic effect in ovalbumin-challenged BALB/c mouse assessed as decrease in peribronchial eosinophil infiltration in bronchoalveolar lavage fluid [AID386217, Type: Literature]
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24
[SID103583212]
Antiasthmatic effect in ovalbumin-challenged BALB/c mouse assessed as decrease in perivascular eosinophil infiltration in bronchoalveolar lavage fluid [AID386218, Type: Literature]
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25
[SID47193877]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]integrase [Human immunodeficiency virus 1] [gi:2853980]
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26
[SID47193877]
Fluorescence polarization-based counterscreen for RBBP9 inhibitors: primary biochemical high throughput screening assay to identify inhibitors of the oxidoreductase glutathione S-transferase omega 1(GSTO1). [AID1974, Type: screening]glutathione S-transferase omega-1 isoform 1 [Homo sapiens] [gi:4758484]
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27
[SID47193877]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]lens epithelium-derived growth factor p75 [Homo sapiens] [gi:6708281]
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28
[SID47193877]
Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis: Fluroescence-based biochemical high throughput Glycerophosphate Dehydrogenase-Triosephosphate Isomerase (GDH-TPI) assay to identify assay artifacts [AID652141, Type: screening]
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29
[SID103583212]
Inhibition of TCR-mediated NF-kappaB activation in transgenic BALB/c mouse TH2 cells at 100 uM by EMSA [AID385961, Type: Literature]
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30
[SID103583212]
Inhibition of TCR-mediated NF-kappaB activation in human Jurkat cells at 100 uM by EMSA [AID385965, Type: Literature]
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31
[SID103583212]
Inhibition of CD28-induced NF-kappaB activation in human Jurkat cells by EMSA [AID385980, Type: Literature]
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32
[SID103583212]
Inhibition of CD3/CD28-induced NF-kappaB activation in human Jurkat cells by EMSA [AID385981, Type: Literature]
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33
[SID103583212]
Inhibition of PDK1 phosphorylation in human Jurkat cells by western blotting [AID385982, Type: Literature]
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34
[SID103583212]
Inhibition of PDK1 phosphorylation in transgenic BALB/c mouse TH2 cells by western blotting [AID385983, Type: Literature]
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35
[SID103583212]
Induction of apoptosis in ovalbumin-challenged transgenic BALB/c mouse TH2 cells transfected in SCID mouse assessed as decrease in viable cell in lungs [AID386231, Type: Literature]
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36
[SID103583212]
Induction of apoptosis in transgenic TH1 cells after 48 hrs by FACS [AID385989, Type: Literature]
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37
[SID103583212]
Antiproliferative activity in transgenic BALB/c mouse TH2 cells assessed as [3H]thymidine incorporation after 30 mins [AID386006, Type: Literature]
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38
[SID103583212]
Induction of apoptosis in transgenic BALB/c mouse TH2 cells after 48 hrs by FACS [AID386007, Type: Literature]
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39
[SID103583212]
Induction of apoptosis in human human Jurkat cells after 48 hrs by FACS [AID386008, Type: Literature]
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40
[SID103583212]
Antiasthmatic activity in ovalbumin-challenged BALB/c mouse assessed as reduction in airway hyperresponsiveness at 100 ug, intratracheally administered 4 hrs after challenge [AID386010, Type: Literature]
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41
[SID103583212]
Antiasthmatic activity in ovalbumin-challenged BALB/c mouse assessed as reduction in airway resistance at 100 ug, intratracheally administered 4 hrs after challenge [AID386213, Type: Literature]
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42
[SID103583212]
Antiasthmatic effect in ovalbumin-challenged BALB/c mouse assessed as decrease in eosinophil infiltration in bronchoalveolar lavage fluid [AID386214, Type: Literature]
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43
[SID103583212]
Antiasthmatic effect in ovalbumin-challenged BALB/c mouse assessed as decrease in IL5 level in bronchoalveolar lavage fluid by ELISA [AID386215, Type: Literature]
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44
[SID103583212]
Antiasthmatic effect in ovalbumin-challenged BALB/c mouse assessed as decrease in IL13 level in bronchoalveolar lavage fluid by ELISA [AID386216, Type: Literature]
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45
[SID103583212]
Inhibition of IL4 production in transgenic BALB/c mouse TH2 cells at 100 uM after 48 hrs [AID385991, Type: Literature]
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46
[SID103583212]
Inhibition of IL4 production in transgenic BALB/c mouse TH2 cells at 50 uM after 48 hrs [AID385992, Type: Literature]
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47
[SID103583212]
Inhibition of IL4 production in transgenic BALB/c mouse TH2 cells at 10 uM after 48 hrs [AID385993, Type: Literature]
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48
[SID103583212]
Inhibition of IL5 production in transgenic BALB/c mouse TH2 cells at 100 uM after 48 hrs [AID385995, Type: Literature]
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49
[SID103583212]
Inhibition of IL5 production in transgenic BALB/c mouse TH2 cells at 50 uM after 48 hrs [AID385996, Type: Literature]
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50
[SID103583212]
Inhibition of IL5 production in transgenic BALB/c mouse TH2 cells at 10 uM after 48 hrs [AID385997, Type: Literature]
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