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BioActivity Data for Compound 2,4-dihydroxybenzophenone (CID 8572)

BioActivity Outcomes:
Active(65)
 
 
Inactive(772)
 
 
Inconclusive(66)
 
 
Unspecified(4)
 
 
Top Targets:
7tm 4(41)
 
 
 
NR LBD PPAR(22)
 
 
 
NR LBD ER(14)
 
 
 
 
NR LBD AR(14)
 
 
 
Bcl-2 like(13)
 
 
 
BioAssay Types:
Screening(480)
 
 
 
 
Confirmatory(333)
 
 
 
 
 
Summary(52)
 
 
 
 
Literature(15)
 
 
 
BioAssay Categories:
In vivo(1)
 
 
Biochemical(136)
 
 
 
 
 
Toxicity(18)
 
 
 
 
ADME(1)
 
 
Cell-based(140)
 
 
 
Organism-base..(11)
 
 
BioActivity Types:
Potency(314)
 
 
 
 
 
IC50(40)
 
 
 
 
 
EC50(8)
 
 
 
AC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 744    Data Row: 907   Total Pages: 46   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24832765]
Absolute IC50 0.42Dose Response Confirmation for Small Molecule Inhibitors of Epstein-Barr Virus [AID1419, Type: confirmatory]BZLF2 [Human herpesvirus 4 type 2] [gi:139424501]
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2
[SID24832765]
EC50_uM 5.033Fluorescence Polarization Cell-Free Homogeneous Dose Retest to Confirm Inhibitors of the LANA Histone H2A/H2B Interaction [AID435023, Type: confirmatory]LANA [Human herpesvirus 8] [gi:139472804]
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3
[SID24832765]
AC50_uM 5.378C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_Dose_CherryPick_Activity [AID504725, Type: confirmatory]LANA [Human herpesvirus 8] [gi:312275222]
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4
[SID24832765]
Potency 5.7988qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101: Hit Validation [AID651600, Type: confirmatory]tumor susceptibility gene 101 protein [Homo sapiens] [gi:5454140]
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5
[SID24832765]
AC50_uM 7.299C-LANA Counter Screen: DNA intercalators Measured in Biochemical System Using Plate Reader - 2117-02_Inhibitor_Dose_CherryPick_Activity_Set2 [AID504727, Type: confirmatory]LANA [Human herpesvirus 8] [gi:312275222]
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6
[SID144213182]
Potency-Replicate_1 9.6885qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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7
[SID144208483]
Potency-Replicate_1 9.876qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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8
[SID24832765]
AC50_uM 11.13Fluorescence polarization to screen for inhibitors that disrupt the protein-protein interaction between Keap1 and Nrf2 Measured in Biochemical System Using Plate Reader - 2119-01_Inhibitor_Dose_CherryPick_Activity [AID588683, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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9
[SID24832765]
AC50_uM 11.13Fluorescence polarization to screen for inhibitors that disrupt the protein-protein interaction between Keap1 and Nrf2 Measured in Biochemical System Using Plate Reader - 2119-01_Inhibitor_Dose_CherryPick_Activity [AID588683, Type: confirmatory]kelch-like ECH-associated protein 1 [Homo sapiens] [gi:45269145]
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10
[SID24832765]
Potency 11.9173qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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11
[SID144208483]
Potency-Replicate_1 19.8712qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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12
[SID144208483]
Ratio Potency (uM) 21.4634qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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13
[SID144208483]
Ratio Potency (uM) 23.8735qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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14
[SID144208483]
Potency-Replicate_1 27.8345qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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15
[SID24832765]
Potency 28.1838Inhibitors of USP1/UAF1: Primary Screen [AID743255, Type: confirmatory]USP1 protein, partial [Homo sapiens] [gi:118600387]
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16
[SID144213182]
Potency-Replicate_1 30.6379qHTS assay to identify small molecule agonists of the thyroid receptor (TR) signaling pathway [AID743066, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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17
[SID144213182]
Potency-Replicate_1 30.6379qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID743202, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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18
[SID144213182]
Potency-Replicate_1 38.8952qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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19
[SID144213182]
Ratio Potency (uM) 47.1342qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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20
[SID144208483]
Potency-Replicate_1 55.5371qHTS assay to identify small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID1159521, Type: confirmatory]RAR-related orphan receptor gamma [Mus musculus] [gi:15928672]
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