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BioActivity Data for Compound Thyroxine (CID 853)

BioActivity Outcomes:
Active(6)
 
 
Inactive(58)
 
 
Inconclusive(11)
 
 
Unspecified(8)
 
 
Top Targets:
PLDc mTdp1 2(3)
 
 
P53(2)
 
 
NR LBD TR(2)
 
 
NR LBD ROR li..(2)
 
 
Menin(2)
 
 
 
BioAssay Types:
Confirmatory(68)
 
 
 
 
Literature(7)
 
 
 
Screening(1)
 
 
BioAssay Categories:
In vivo(7)
 
 
 
Biochemical(6)
 
 
 
Toxicity(4)
 
 
 
BioActivity Types:
Potency(65)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 79    Data Row: 83   Total Pages: 5   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26748394]
Potency 10qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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2
[SID26748394]
Potency 10qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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3
[SID26748394]
Potency 12.5893qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase, partial [Homo sapiens] [gi:1832253]
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4
[SID26748394]
Potency 15.8489qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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5
[SID48416621]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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6
[SID103224528]
Concentration at which 50% total binding against prealbumin protein occurs [AID161428, Type: Literature]
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7
[SID103224528]
Relative binding affinity to prealbumin was determined from the competition binding assays and is expressed relative to L-T4 [AID161427, Type: Literature]
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8
[SID569463]
NCI In Vivo Anticancer Drug Screen. Data for tumor model Nontumored Animals (Toxicity Test) in CD2F1 (CDF1) mice [AID188, Type: other]
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9
[SID569463]
NCI In Vivo Anticancer Drug Screen. Data for tumor model Nontumored Animals (Toxicity Test) in B6D2F1 (BDF1) mice [AID186, Type: other]
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10
[SID103224528]
Binding affinity to rat thyroid hormone receptor [AID1145381, Type: Literature]
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11
[SID103224528]
In vivo antigoiter activity in rat [AID1146020, Type: Literature]
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12
[SID103224528]
Displacement of radiolabelled L-T3 from thyroid hormone receptor in intact rat hepatic nuclei relative to T3 [AID1146021, Type: Literature]
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13
[SID103224528]
Binding affinity to rat hepatic solubilized nuclear thyroid hormone receptor relative to L-T3 [AID1146022, Type: Literature]
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14
[SID103224528]
Binding affinity to thyroxine binding globulin (unknown origin) relative to T4 [AID1146023, Type: Literature]Thyroxine-binding globulin [gi:1351236]
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15
[SID26748394]
Potency 31.6228qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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16
[SID26748394]
Potency qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1 [AID900, Type: confirmatory]caspase-1 isoform alpha precursor [Homo sapiens] [gi:15431328]
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17
[SID26748394]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide [AID1766, Type: confirmatory]menin isoform 1 [Homo sapiens] [gi:18860839]
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18
[SID26748394]
Potency Counterscreen for Luciferase (Kinase-Glo TM) Inhibition [AID1379, Type: confirmatory]luciferase [Photuris pennsylvanica] [gi:1669525]
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19
[SID26748394]
Potency qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-7 [AID889, Type: confirmatory]Caspase-7 [gi:1730092]
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20
[SID26748394]
Potency qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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