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anthra(1,9-cd)pyrazol-6(2H)-one (CID 8515) - Compound BioActivity Data
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BioActivity Outcomes:
Active(246)
 
 
Inactive(894)
 
 
Inconclusive(138)
 
 
Unspecified(580)
 
 
Top Targets:
PKc like(75)
 
 
 
 
PKc(69)
 
 
 
 
STKc AGC(42)
 
 
 
 
CYCLIN(26)
 
 
 
STKc JNK(25)
 
 
 
 
BioAssay Types:
Confirmatory(554)
 
 
 
 
 
Literature(423)
 
 
 
 
 
Screening(293)
 
 
 
 
Summary(16)
 
 
 
 
BioActivity Types:
Potency(447)
 
 
 
 
 
Kd(118)
 
 
 
IC50(31)
 
 
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1401    Data Row: 1858   Total Pages: 38   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103472531]
Kd 0.022Average Binding Constant for JNK3 ; NA=Not Active at 10 uM [AID256636, Type: Literature]Mitogen-activated protein kinase 10 [gi:2507196]
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2
[SID103472531]
Kd 0.025Average Binding Constant for BIKE ; NA=Not Active at 10 uM [AID256571, Type: Literature]BMP-2-inducible protein kinase [gi:34222653]
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3
[SID103472531]
Kd 0.035Average Binding Constant for AAK1 ; NA=Not Active at 10 uM [AID256609, Type: Literature]AP2-associated protein kinase 1 [gi:300669613]
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4
[SID103472531]
Kd 0.038Average Binding Constant for GAK ; NA=Not Active at 10 uM [AID256612, Type: Literature]Cyclin-G-associated kinase [gi:17375734]
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5
[SID103472531]
IC50 0.04Inhibition of human JNK1 [AID325696, Type: Literature]Mitogen-activated protein kinase 8 [gi:2507195]
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6
[SID103472531]
IC50 0.04Inhibition of JNK1 [AID473195, Type: Literature]
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7
[SID103472531]
IC50 0.04Inhibition of JNK2 [AID473196, Type: Literature]
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8
[SID103472531]
IC50 0.04Inhibition of human JNK2 [AID325697, Type: Literature]Mitogen-activated protein kinase 9 [gi:85700366]
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9
[SID103472531]
Kd 0.084Average Binding Constant for JNK2 ; NA=Not Active at 10 uM [AID256637, Type: Literature]Mitogen-activated protein kinase 9 [gi:85700366]
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10
[SID103472531]
IC50 0.09Inhibition of JNK3 [AID473197, Type: Literature]
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11
[SID103472531]
IC50 0.09Inhibition of human JNK3 [AID325698, Type: Literature]Mitogen-activated protein kinase 10 [gi:2507196]
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12
[SID103472531]
Kd 0.098Average Binding Constant for TTK ; NA=Not Active at 10 uM [AID256599, Type: Literature]Dual specificity protein kinase TTK [gi:160112977]
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13
[SID103472531]
Kd 0.1Average Binding Constant for JNK1 ; NA=Not Active at 10 uM [AID256622, Type: Literature]Mitogen-activated protein kinase 8 [gi:2507195]
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14
[SID103472531]
IC50 0.11Inhibition of human JNK1 by radiometric assay [AID319311, Type: Literature]Mitogen-activated protein kinase 8 [gi:2507195]
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15
[SID103472531]
Kd 0.18Average Binding Constant for PCTK1 ; NA=Not Active at 10 uM [AID256588, Type: Literature]Cyclin-dependent kinase 16 [gi:266425]
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16
[SID103472531]
Kd 0.22Average Binding Constant for STK3_m ; NA=Not Active at 10 uM [AID256574, Type: Literature]Serine/threonine-protein kinase 3 [gi:46577548]
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17
[SID103472531]
Kd 0.26Average Binding Constant for CLK4 ; NA=Not Active at 10 uM [AID256577, Type: Literature]Dual specificity protein kinase CLK4 [gi:34922132]
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18
[SID103472531]
Kd 0.3Average Binding Constant for CLK2 ; NA=Not Active at 10 uM [AID256596, Type: Literature]Dual specificity protein kinase CLK2 [gi:1705919]
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19
[SID11114107]
Potency 0.3981qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
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20
[SID103472531]
Kd 0.41Average Binding Constant for DAPK3 ; NA=Not Active at 10 uM [AID256659, Type: Literature]Death-associated protein kinase 3 [gi:38604691]
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21
[SID103472531]
Kd 0.46Average Binding Constant for PIM2 ; NA=Not Active at 10 uM [AID256570, Type: Literature]Serine/threonine-protein kinase pim-2 [gi:20139243]
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22
[SID103472531]
Kd 0.48Average Binding Constant for TNIK ; NA=Not Active at 10 uM [AID256566, Type: Literature]TRAF2 and NCK-interacting protein kinase [gi:29840818]
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23
[SID103472531]
Kd 0.48Average Binding Constant for PHkg2 ; NA=Not Active at 10 uM [AID256618, Type: Literature]Phosphorylase b kinase gamma catalytic chain, liver/testis isoform [gi:125536]
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24
[SID103472531]
Kd 0.51Average Binding Constant for STK16 ; NA=Not Active at 10 uM [AID256606, Type: Literature]Serine/threonine-protein kinase 16 [gi:46577677]
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25
[SID103472531]
Kd 0.61Average Binding Constant for DAPK2 ; NA=Not Active at 10 uM [AID256651, Type: Literature]Death-associated protein kinase 2 [gi:38605084]
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26
[SID103472531]
Kd 0.68Average Binding Constant for ULK3 m ; NA=Not Active at 10 uM [AID256563, Type: Literature]Serine/threonine-protein kinase ULK3 [gi:115311890]
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27
[SID103472531]
Kd 0.77Average Binding Constant for STK18 ; NA=Not Active at 10 uM [AID256607, Type: Literature]Serine/threonine-protein kinase PLK4 [gi:160113150]
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28
[SID144203818]
Potency-Replicate_1 0.784qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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29
[SID144203818]
Ratio Potency (uM) 0.921978qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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30
[SID103472531]
IC50 0.957Inhibition of JAK3 [AID389516, Type: Literature]
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31
[SID103472531]
Kd 0.98Average Binding Constant for Aurora2 ; NA=Not Active at 10 uM [AID256613, Type: Literature]Aurora kinase A [gi:27923855]
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32
[SID103472531]
Kd 1Average Binding Constant for MKNK2 ; NA=Not Active at 10 uM [AID256576, Type: Literature]MAP kinase-interacting serine/threonine-protein kinase 2 [gi:90102033]
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33
[SID103472531]
Kd 1.4Average Binding Constant for CAMK1D ; NA=Not Active at 10 uM [AID256584, Type: Literature]Calcium/calmodulin-dependent protein kinase type 1D [gi:56404610]
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34
[SID103472531]
Kd 1.7Average Binding Constant for RPS6KA5 (Kin.Dom 1) ; NA=Not Active at 10 uM [AID256648, Type: Literature]Ribosomal protein S6 kinase alpha-5 [gi:37999482]
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35
[SID103472531]
Kd 1.8Average Binding Constant for MARK2 ; NA=Not Active at 10 uM [AID256608, Type: Literature]Serine/threonine-protein kinase MARK2 [gi:62510922]
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36
[SID103472531]
Kd 2.1Average Binding Constant for STK17A ; NA=Not Active at 10 uM [AID256568, Type: Literature]Serine/threonine-protein kinase 17A [gi:317373279]
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37
[SID103472531]
Kd 2.2Average Binding Constant for RPS6KA2 (Kin.Dom. 1) ; NA=Not Active at 10 uM [AID256627, Type: Literature]Ribosomal protein S6 kinase alpha-2 [gi:90110031]
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38
[SID103472531]
Kd 2.2Average Binding Constant for STK4 ; NA=Not Active at 10 uM [AID256586, Type: Literature]Serine/threonine-protein kinase 4 [gi:13124559]
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39
[SID103472531]
Kd 2.3Average Binding Constant for SLK ; NA=Not Active at 10 uM [AID256578, Type: Literature]STE20-like serine/threonine-protein kinase [gi:74762732]
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40
[SID103472531]
Kd 2.3Average Binding Constant for STK38L ; NA=Not Active at 10 uM [AID256677, Type: Literature]Serine/threonine-protein kinase 38-like [gi:56749668]
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41
[SID103472531]
Kd 2.4Average Binding Constant for p38-gamma ; NA=Not Active at 10 uM [AID256615, Type: Literature]Mitogen-activated protein kinase 12 [gi:2851522]
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42
[SID103472531]
Kd 3.1Average Binding Constant for CSNK1E ; NA=Not Active at 10 uM [AID256644, Type: Literature]Casein kinase I isoform epsilon [gi:1346369]
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43
[SID11114107]
Potency 3.1623qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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44
[SID103472531]
Kd 3.2Average Binding Constant for CDK2 ; NA=Not Active at 10 uM [AID256632, Type: Literature]Cyclin-dependent kinase 2 [gi:116051]
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45
[SID103472531]
Kd 3.7Average Binding Constant for CSNK1G1 ; NA=Not Active at 10 uM [AID256655, Type: Literature]Casein kinase I isoform gamma-1 [gi:18202957]
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46
[SID11114107]
Potency 3.9811qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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47
[SID11114107]
Potency 3.9811qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1: Spectroscopic Profiling in AFC Spectral Region [AID923, Type: confirmatory]
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48
[SID103472531]
Kd 4Average Binding Constant for EPHA3 ; NA=Not Active at 10 uM [AID256601, Type: Literature]Ephrin type-A receptor 3 [gi:116241351]
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49
[SID103472531]
Kd 4.1Average Binding Constant for CAMK1 ; NA=Not Active at 10 uM [AID256643, Type: Literature]Calcium/calmodulin-dependent protein kinase type 1 [gi:3122301]
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50
[SID103472531]
Kd 4.2Average Binding Constant for CAMK1G ; NA=Not Active at 10 uM [AID256581, Type: Literature]Calcium/calmodulin-dependent protein kinase type 1G [gi:73620970]
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