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anthra(1,9-cd)pyrazol-6(2H)-one (CID 8515) - Compound BioActivity Data
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BioActivity Outcomes:
Active(261)
 
 
Inactive(905)
 
 
Inconclusive(137)
 
 
Unspecified(580)
 
 
Top Targets:
7tm 4(36)
 
 
STKc JNK(27)
 
 
 
 
CYCLIN(26)
 
 
 
PTKc EphR A(15)
 
 
 
 
PLDc mTdp1 2(14)
 
 
 
 
BioAssay Types:
Literature(964)
 
 
 
 
 
Confirmatory(556)
 
 
 
 
 
Screening(296)
 
 
 
 
Summary(16)
 
 
 
 
BioActivity Types:
Potency(450)
 
 
 
 
 
Kd(120)
 
 
 
IC50(35)
 
 
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1416    Data Row: 1883   Total Pages: 95   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID174515438]
Kd 0.022Average Binding Constant for JNK3; NA=Not Active at 10 uM [AID256636, Type: Literature]Mitogen-activated protein kinase 10 [gi:2507196]
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2
[SID174515438]
Kd 0.025Average Binding Constant for BIKE; NA=Not Active at 10 uM [AID256571, Type: Literature]BMP-2-inducible protein kinase [gi:34222653]
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3
[SID174515438]
Kd 0.035Average Binding Constant for AAK1; NA=Not Active at 10 uM [AID256609, Type: Literature]AP2-associated protein kinase 1 [gi:300669613]
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4
[SID174515438]
Kd 0.038Average Binding Constant for GAK; NA=Not Active at 10 uM [AID256612, Type: Literature]Cyclin-G-associated kinase [gi:17375734]
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5
[SID174515438]
IC50 0.04Inhibition of human JNK1 [AID325696, Type: Literature]Mitogen-activated protein kinase 8 [gi:2507195]
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6
[SID174515438]
IC50 0.04Inhibition of JNK1 [AID473195, Type: Literature]
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7
[SID174515438]
IC50 0.04Inhibition of JNK2 [AID473196, Type: Literature]
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8
[SID174515438]
IC50 0.04Inhibition of human JNK2 [AID325697, Type: Literature]Mitogen-activated protein kinase 9 [gi:85700366]
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9
[SID174515438]
Kd 0.084Average Binding Constant for JNK2; NA=Not Active at 10 uM [AID256637, Type: Literature]Mitogen-activated protein kinase 9 [gi:85700366]
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10
[SID174515438]
IC50 0.09Inhibition of JNK3 [AID473197, Type: Literature]
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11
[SID174515438]
IC50 0.09Inhibition of human JNK3 [AID325698, Type: Literature]Mitogen-activated protein kinase 10 [gi:2507196]
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12
[SID208012163]
Kd 0.098Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]
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13
[SID208012163]
Kd 0.098Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]
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14
[SID174515438]
Kd 0.098Average Binding Constant for TTK; NA=Not Active at 10 uM [AID256599, Type: Literature]Dual specificity protein kinase TTK [gi:160112977]
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15
[SID174515438]
IC50 0.098Inhibition of MPS1 (unknown origin) [AID747744, Type: Literature]Dual specificity protein kinase TTK [gi:160112977]
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16
[SID174515438]
Kd 0.1Average Binding Constant for JNK1; NA=Not Active at 10 uM [AID256622, Type: Literature]Mitogen-activated protein kinase 8 [gi:2507195]
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17
[SID174515438]
IC50 0.11Inhibition of human JNK1 by radiometric assay [AID319311, Type: Literature]Mitogen-activated protein kinase 8 [gi:2507195]
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18
[SID46392887]
IC50 0.15Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB [AID977608, Type: Literature]Chain A, The Structure Of Jnk3 In Complex With A Dihydroanthrapyrazole Inhibitor [gi:34809766]
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19
[SID46392887]
IC50 0.15Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB [AID977608, Type: Literature]Chain A, The Structure Of Jnk3 In Complex With A Dihydroanthrapyrazole Inhibitor [gi:34809766]
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20
[SID174515438]
Kd 0.18Average Binding Constant for PCTK1; NA=Not Active at 10 uM [AID256588, Type: Literature]Cyclin-dependent kinase 16 [gi:266425]
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