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4,6-Dimethyl-2-(5-phenyl-[1,3,4]oxadiazol-2-ylmethylsulfanyl)-nicotinonitrile (CID 848023) - Compound BioActivity Data
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BioActivity Outcomes:
Active(72)
 
 
Inactive(680)
 
 
Inconclusive(21)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(24)
 
 
 
7TM GPCR Srsx(20)
 
 
alkPPc(12)
 
 
Bcl-2 like(11)
 
 
G-alpha(8)
 
 
 
BioAssay Types:
Screening(524)
 
 
 
 
 
Confirmatory(225)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(148)
 
 
 
 
 
IC50(45)
 
 
 
 
AC50(15)
 
 
 
EC50(9)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 705    Data Row: 775   Total Pages: 39   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17508366]
AC50_uM 0.024MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set3 [AID493073, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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2
[SID17508366]
AC50_uM 0.024MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set4 [AID493102, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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3
[SID17508366]
AC50_uM 0.024MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set2 [AID493177, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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4
[SID17508366]
IC50 0.05462Counterscreen for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3):Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) [AID624395, Type: confirmatory]transactivating tegument protein VP16 [Human herpesvirus 1] [gi:9629429]
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5
[SID17508366]
EC50 0.16Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) [AID2382, Type: confirmatory]Hsf1 protein [Mus musculus] [gi:62740231]
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6
[SID17508366]
AC50_uM 0.281Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition Measured in Cell-Based System Using Plate Reader - 7011-01_Antagonist_Dose_CherryPick_Activity_Set2 [AID743343, Type: confirmatory]
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7
[SID17508366]
AC50_uM 0.321LGR2:Counterscreen with MC4R Measured in Cell-Based System Using Plate Reader - 7011-02_Antagonist_Dose_CherryPick_Activity [AID743444, Type: confirmatory]MSH [Drosophila melanogaster] [gi:1098680]
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8
[SID17508366]
Potency 1.1582qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [Marburg marburgvirus] [gi:420597]
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9
[SID17508366]
Potency 1.1582qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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10
[SID17508366]
Potency 2.5929A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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11
[SID17508366]
Potency 3.0131qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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12
[SID17508366]
Potency 3.9811qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 [Homo sapiens] [gi:31542939]
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13
[SID17508366]
IC50 6.41325HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction [AID2485, Type: confirmatory]tumor necrosis factor [Homo sapiens] [gi:25952111]
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14
[SID17508366]
Potency 8.1995A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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15
[SID17508366]
EC50 10.546uHTS luminescence assay for the identification of compounds that inhibit NOD1 [AID1578, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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16
[SID17508366]
Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3): Luminescence-based cell-based high throughput assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) [AID588794, Type: screening]transactivating tegument protein VP16 [Human herpesvirus 1] [gi:9629429]
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17
[SID17508366]
Counterscreen for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1): Luminescence-based cell-based high throughput assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16). [AID588824, Type: screening]transactivating tegument protein VP16 [Human herpesvirus 1] [gi:9629429]
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18
[SID17508366]
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2) [AID651957, Type: screening]nuclear receptor coactivator 2 [Homo sapiens] [gi:5729858]
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19
[SID17508366]
Luminescence-based cell-based high throughput confirmation assay to identify inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2) [AID652008, Type: screening]nuclear receptor coactivator 2 [Homo sapiens] [gi:5729858]
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20
[SID17508366]
Counterscreen for inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2): Luminescence-based cell-based high throughput assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) [AID652007, Type: screening]transactivating tegument protein VP16 [Human herpesvirus 1] [gi:9629429]
View