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3-tert-butyl-4-hydroxyanisole (CID 8456) - Compound BioActivity Data
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BioActivity Outcomes:
Active(9)
 
 
Inactive(915)
 
 
Inconclusive(46)
 
 
Unspecified(25)
 
 
Top Targets:
NR LBD PPAR(27)
 
 
 
7TM GPCR Srx(23)
 
 
7TM GPCR Srsx(17)
 
 
NR LBD AR(16)
 
 
 
NR LBD ER(16)
 
 
BioAssay Types:
Screening(482)
 
 
 
Confirmatory(392)
 
 
 
 
 
Summary(48)
 
 
 
 
Literature(39)
 
 
 
 
BioActivity Types:
Potency(372)
 
 
 
 
 
IC50(43)
 
 
 
 
EC50(8)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 799    Data Row: 995   Total Pages: 20   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144210402]
Potency-Replicate_1 24.3365qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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2
[SID144210402]
Ratio Potency (uM) 25.2886qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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3
[SID144209020]
Potency-Replicate_1 30.7002qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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4
[SID103465969]
IC50 43Antioxidant activity assessed as DPPH free radical scavenging activity [AID375499, Type: Literature]
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5
[SID26754492]
Potency-Replicate_1 50.1187qHTS assay for small molecule activators of the human pregnane X receptor (PXR) signaling pathway [AID720659, Type: confirmatory]pregnane X nuclear receptor [Homo sapiens] [gi:325495557]
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6
[SID48413346]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results [AID1189, Type: other]
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7
[SID48413346]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary Mouse Bioassay Results [AID1199, Type: other]
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8
[SID48413346]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary MultiCellCall Results [AID1205, Type: other]
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9
[SID48413346]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary Rat Bioassay Results [AID1208, Type: other]
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10
[SID103465969]
IC50 79.16Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins [AID436183, Type: Literature]
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11
[SID103465969]
Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins [AID378648, Type: Literature]
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12
[SID103465969]
Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins [AID351016, Type: Literature]
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13
[SID11532886]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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14
[SID103465969]
Specific activity of expressed human recombinant UGT1A1 [AID624606, Type: Literature]UDP-glucuronosyltransferase 1-1 [gi:136729]
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15
[SID103465969]
Antioxidant activity assessed as DPPH radical scavenging activity [AID358554, Type: Literature]
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16
[SID103465969]
Antioxidant activity assessed as DPPH radical scavenging activity [AID450085, Type: Literature]
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17
[SID103465969]
Antioxidant activity assessed as ABTS radical scavenging activity [AID450086, Type: Literature]
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18
[SID103465969]
Antioxidant activity assessed as DMPD radical scavenging activity [AID450087, Type: Literature]
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19
[SID103465969]
Antioxidant activity assessed as superoxide anion scavenging activity by NBT reduction assay [AID450088, Type: Literature]
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20
[SID103465969]
Antioxidant activity assessed as hydrogen peroxide radical scavenging activity [AID450089, Type: Literature]
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21
[SID103465969]
Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by spectrometric assay method [AID463979, Type: Literature]
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22
[SID103465969]
Antioxidant activity assessed as DPPH free radical scavenging activity at 1 mM/ml after 30 mins [AID481841, Type: Literature]
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23
[SID103465969]
Antioxidant activity against lipid peroxidation at 90 uM after 10 hrs by ferric thiocyanate method relative to control [AID489697, Type: Literature]
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24
[SID103465969]
Antioxidant activity assessed as DPPH free radical scavenging activity at 25 uM after 20 mins relative to control [AID489698, Type: Literature]
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25
[SID103465969]
Antioxidant activity assessed as potassium ferric cyanide ion reducing power at 100 uM after 20 mins [AID492090, Type: Literature]
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26
[SID103465969]
Antioxidant activity assessed as total reducing activity after 30 mins by spectrophotometric analysis [AID538395, Type: Literature]
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27
[SID103465969]
Antioxidant activity assessed as ferric ion reducing ability by spectrophotometric analysis [AID538396, Type: Literature]
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28
[SID103465969]
Antioxidant activity assessed as EDTA chelating effect after 10 mins by spectrophotometric analysis [AID538397, Type: Literature]
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29
[SID103465969]
Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins by spectrophotometric analysis [AID538398, Type: Literature]
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30
[SID103465969]
Antioxidant activity assessed as nitric oxide scavenging activity after 150 mins by spectrophotometric analysis [AID538399, Type: Literature]
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31
[SID103465969]
Antioxidant activity assessed as super oxide scavenging activity after 150 mins by spectrophotometric analysis [AID538400, Type: Literature]
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32
[SID26754492]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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33
[SID103465969]
Specific activity of expressed human recombinant UGT1A9 [AID624612, Type: Literature]UDP-glucuronosyltransferase 1-9 [gi:29839451]
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34
[SID103465969]
Specific activity of expressed human recombinant UGT1A6 [AID624609, Type: Literature]UDP-glucuronosyltransferase 1-6 [gi:29840832]
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35
[SID144209020]
Potency-Replicate_1 1.3713qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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36
[SID11532886]
Potency 16.5113Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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37
[SID11532886]
Potency 18.526Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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38
[SID144210402]
Potency-Replicate_1 43.2771qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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39
[SID144210402]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway - cell viability counter screen [AID720693, Type: confirmatory]
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40
[SID144210402]
Potency-Replicate_1 qHTS assay for small molecule disruptors of the mitochondrial membrane potential - cell viability [AID720634, Type: confirmatory]
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41
[SID144210402]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway - cell viability counter screen [AID743074, Type: confirmatory]
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42
[SID144210402]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line - cell viability counter screen [AID743081, Type: confirmatory]
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43
[SID144210402]
Potency-Replicate_1 qHTS assay to identify aromatase inhibitors - cell viability counter screen [AID743084, Type: confirmatory]
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44
[SID144210402]
Potency-Replicate_1 qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway - cell viability counter screen [AID743086, Type: confirmatory]
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45
[SID144210402]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway - cell viability counter screen [AID743194, Type: confirmatory]
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46
[SID144210402]
Potency-Replicate_1 qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway - cell viability counter screen [AID743203, Type: confirmatory]
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47
[SID144210402]
Potency-Replicate_1 qHTS assay for small molecule activators of the heat shock response signaling pathway - cell viability counter screen [AID743209, Type: confirmatory]
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48
[SID144210402]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743211, Type: confirmatory]
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49
[SID144210402]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743213, Type: confirmatory]
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50
[SID144210402]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the farnesoid-X-receptor (FXR) signaling pathway - cell viability counter screen [AID743218, Type: confirmatory]
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