3-tert-butyl-4-hydroxyanisole (CID 8456) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(5)
 
 
Inactive(675)
 
 
Inconclusive(10)
 
 
Unspecified(25)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
NR LBD PPAR(11)
 
 
 
alkPPc(10)
 
 
Bcl-2 like(10)
 
 
NR LBD TR(8)
 
 
 
BioAssay Types:
Screening(414)
 
 
 
Confirmatory(233)
 
 
 
 
Literature(39)
 
 
 
 
BioActivity Types:
Potency(183)
 
 
 
 
IC50(39)
 
 
 
 
EC50(8)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 670    Data Row: 715   Total Pages: 15   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103465969]
IC50 43Antioxidant activity assessed as DPPH free radical scavenging activity [AID375499, Type: Literature]
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2
[SID48413346]
 DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results [AID1189, Type: other]
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3
[SID48413346]
 DSSTox (CPDBAS) Carcinogenic Potency Database Summary Mouse Bioassay Results [AID1199, Type: other]
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4
[SID48413346]
 DSSTox (CPDBAS) Carcinogenic Potency Database Summary MultiCellCall Results [AID1205, Type: other]
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5
[SID48413346]
 DSSTox (CPDBAS) Carcinogenic Potency Database Summary Rat Bioassay Results [AID1208, Type: other]
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6
[SID103465969]
IC50 79.16Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins [AID436183, Type: Literature]
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7
[SID103465969]
 Antioxidant activity assessed as DPPH radical scavenging activity [AID358554, Type: Literature]
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8
[SID103465969]
 Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins [AID378648, Type: Literature]
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9
[SID103465969]
 Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins [AID351016, Type: Literature]
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10
[SID26754492]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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11
[SID103465969]
 Antioxidant activity assessed as DPPH radical scavenging activity [AID450085, Type: Literature]
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12
[SID103465969]
 Antioxidant activity assessed as ABTS radical scavenging activity [AID450086, Type: Literature]
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13
[SID103465969]
 Antioxidant activity assessed as DMPD radical scavenging activity [AID450087, Type: Literature]
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14
[SID103465969]
 Antioxidant activity assessed as superoxide anion scavenging activity by NBT reduction assay [AID450088, Type: Literature]
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15
[SID103465969]
 Antioxidant activity assessed as hydrogen peroxide radical scavenging activity [AID450089, Type: Literature]
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16
[SID103465969]
 Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by spectrometric assay method [AID463979, Type: Literature]
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17
[SID103465969]
 Antioxidant activity assessed as DPPH free radical scavenging activity at 1 mM/ml after 30 mins [AID481841, Type: Literature]
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18
[SID103465969]
 Antioxidant activity against lipid peroxidation at 90 uM after 10 hrs by ferric thiocyanate method relative to control [AID489697, Type: Literature]
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19
[SID103465969]
 Antioxidant activity assessed as DPPH free radical scavenging activity at 25 uM after 20 mins relative to control [AID489698, Type: Literature]
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20
[SID103465969]
 Antioxidant activity assessed as potassium ferric cyanide ion reducing power at 100 uM after 20 mins [AID492090, Type: Literature]
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21
[SID103465969]
 Antioxidant activity assessed as total reducing activity after 30 mins by spectrophotometric analysis [AID538395, Type: Literature]
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22
[SID103465969]
 Antioxidant activity assessed as ferric ion reducing ability by spectrophotometric analysis [AID538396, Type: Literature]
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23
[SID103465969]
 Antioxidant activity assessed as EDTA chelating effect after 10 mins by spectrophotometric analysis [AID538397, Type: Literature]
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24
[SID103465969]
 Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins by spectrophotometric analysis [AID538398, Type: Literature]
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25
[SID103465969]
 Antioxidant activity assessed as nitric oxide scavenging activity after 150 mins by spectrophotometric analysis [AID538399, Type: Literature]
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26
[SID103465969]
 Antioxidant activity assessed as super oxide scavenging activity after 150 mins by spectrophotometric analysis [AID538400, Type: Literature]
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27
[SID11532886]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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28
[SID11532886]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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29
[SID103465969]
 Specific activity of expressed human recombinant UGT1A6 [AID624609, Type: Literature]UDP-glucuronosyltransferase 1-6 [gi:29840832]
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30
[SID103465969]
 Specific activity of expressed human recombinant UGT1A9 [AID624612, Type: Literature] [gi:29839451]
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31
[SID103465969]
 Specific activity of expressed human recombinant UGT1A1 [AID624606, Type: Literature]UDP-glucuronosyltransferase 1-1 [gi:136729]
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32
[SID11532886]
Potency 16.5113Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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33
[SID11532886]
Potency 18.526Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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34
[SID48413346]
 DSSTox (CPDBAS) Carcinogenic Potency Database Summary Hamster Bioassay Results [AID1191, Type: other]
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35
[SID48413346]
 DSSTox (CPDBAS) Carcinogenic Potency Database Salmonella Mutagenicity [AID1194, Type: other]
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36
[SID103465969]
IC50 Antioxidant activity assessed as superoxide free radical scavenging activity after 30 mins by xanthine oxidase method [AID436181, Type: Literature]
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37
[SID103465969]
IC50 Antioxidant activity assessed as superoxide free radical scavenging activity after 60 mins by xanthine oxidase method [AID436182, Type: Literature]
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38
[SID11532886]
 HTS to identify inhibitors of TNF-alpha Induced Cell Death in Jurkat FADD-/- Cells. [AID463075, Type: screening]
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39
[SID11532886]
 Fluorescence-based counterscreen for orexin 1 receptor (OX1R) antagonists: cell-based assay to identify antagonists of the parental CHO cell line [AID463079, Type: screening]
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40
[SID11532886]
 uHTS identification of small molecule activators of the adaptive arm of the Unfolded Protein response via a luminescent-based reporter assay [AID463104, Type: screening]
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41
[SID11532886]
 384-well Z-Lyte format Hck-Nef inhibitor HTS run at the PMLSC [AID463187, Type: screening]
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42
[SID11532886]
 Phenotypic HTS multiplex for antifungal efflux pump inhibitors [AID485275, Type: screening]
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43
[SID11532886]
Potency qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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44
[SID11532886]
 Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_SinglePoint_HTS_Activity [AID488862, Type: screening]
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45
[SID11532886]
IC50 Elucidation of physiology of non-replicating, drug-tolerant Mycobacterium tuberculosis [AID488890, Type: confirmatory]
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46
[SID11532886]
IC50 Primary and Confirmatory Screening for Inhibitors of Bacterial Capsule Biogenesis [AID488966, Type: confirmatory]
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47
[SID11532886]
Potency qHTS Assay to Find Inhibitors of Chronic Active B-Cell Receptor Signaling [AID493014, Type: confirmatory]
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48
[SID11532886]
 Heat Shock Factor-1 (HSF-1) Measured in Cell-Based System Using Plate Reader - 2038-01_Activator_SinglePoint_HTS_Activity [AID504408, Type: screening]
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49
[SID11532886]
Potency Nrf2 qHTS screen for inhibitors: counterscreen for cytotoxicity [AID504648, Type: confirmatory]
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50
[SID103465969]
 Antibacterial activity against Escherichia coli at 1 mg/ml by agar well diffusion method [AID351017, Type: Literature]
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