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CHEMBL405317 (CID 838877) - Compound BioActivity Data
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BioActivity Outcomes:
Active(114)
 
 
Inactive(738)
 
 
Inconclusive(36)
 
 
Unspecified(12)
 
 
Top Targets:
7tm 4(44)
 
 
alkPPc(14)
 
 
Tryp SPc(13)
 
 
 
Bcl-2 like(12)
 
 
Death TRAILR..(12)
 
 
 
 
BioAssay Types:
Screening(594)
 
 
 
 
 
Confirmatory(271)
 
 
 
 
 
Literature(23)
 
 
 
 
BioActivity Types:
Potency(167)
 
 
 
 
 
IC50(66)
 
 
 
 
 
EC50(18)
 
 
 
 
AC50(11)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 818    Data Row: 900   Total Pages: 45   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103566186]
IC50 0.038Inhibition of luciferin binding site of Photuris pennsylvanica luciferase by noncompetitive inhibition assay [AID366888, Type: Literature]Luciferin 4-monooxygenase [gi:41688574]
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2
[SID7975271]
Potency 0.0757qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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3
[SID103566186]
IC50 0.08Inhibition of luciferin binding site of Photinus pyralis luciferase by noncompetitive inhibition assay [AID366887, Type: Literature]Luciferin 4-monooxygenase [gi:126501]
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4
[SID103566186]
IC50 0.1Inhibition of Photinus pyralis luciferase [AID328182, Type: Literature]
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5
[SID7975271]
EC50 0.122Luminescence Biochemical Dose Response HTS to Identify Inhibitors of Luciferase [AID1891, Type: confirmatory]
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6
[SID103566186]
IC50 0.14Inhibition of Photinus pyralis luciferase by Steady-Glo reporter gene assay [AID328185, Type: Literature]
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7
[SID7975271]
EC50 0.16Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) [AID2382, Type: confirmatory]Hsf1 protein [Mus musculus] [gi:62740231]
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8
[SID7975271]
EC50 0.189Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Platelet Dense Granule Release [AID1889, Type: confirmatory]
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9
[SID7975271]
AC50_uM 0.236Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition Measured in Cell-Based System Using Plate Reader - 7011-01_Antagonist_Dose_CherryPick_Activity_Set2 [AID743343, Type: confirmatory]
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10
[SID7975271]
Potency 0.2512qHTS Assay for Inhibitors of Firefly Luciferase [AID411, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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11
[SID7975271]
AC50_uM 0.261LGR2:Counterscreen with MC4R Measured in Cell-Based System Using Plate Reader - 7011-02_Antagonist_Dose_CherryPick_Activity [AID743444, Type: confirmatory]MSH [Drosophila melanogaster] [gi:1098680]
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12
[SID88443004]
IC50 0.28494Late stage results from the probe development effort to identify inhibitors of kruppel-like factor 5 (KLF5): luminescence-based cell-based dose response assay for inhibitors of KLF5 [AID2750, Type: confirmatory]Kruppel-like factor 5 [Homo sapiens] [gi:124263658]
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13
[SID103566186]
IC50 0.3Inhibition of Photinus pyralis luciferase by BrightGlo reporter gene assay [AID328186, Type: Literature]
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14
[SID7975271]
IC50 0.3596Luminescence-based dose response cell-based high throughput screening assay for inhibitors of kruppel-like factor 5 (KLF5). [AID1973, Type: confirmatory]Kruppel-like factor 5 [Homo sapiens] [gi:124263658]
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15
[SID103566186]
IC50 0.5Inhibition of Photinus pyralis luciferase by Easy lite assay [AID328183, Type: Literature]
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16
[SID7975271]
IC50_Mean 0.967Dose response confirmation of uHTS chemical inhibitors of both B-cell and T-cell specific antigen receptor-induced NF-kB activation in a 697B cell line using a luminescence assay [AID489034, Type: confirmatory]
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17
[SID7975271]
Potency 1qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]ras-related protein Rab-9A [Homo sapiens] [gi:4759012]
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18
[SID7975271]
IC50_Mean 1.17Dose response confirmation of uHTS of chemical inhibitors of both B-cell and T-cell specific antigen receptor-induced NF-kB activation in a Jurkat cell line using a luminescence assay [AID489004, Type: confirmatory]
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19
[SID7975271]
Potency 1.4125VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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20
[SID7975271]
Potency 1.5849qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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