BAS 03192405 (CID 838877) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(104)
 
 
Inactive(638)
 
 
Inconclusive(31)
 
 
Unspecified(12)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
alkPPc(14)
 
 
Death TRAILR..(12)
 
 
 
 
Tryp SPc(11)
 
 
 
Bcl-2 like(11)
 
 
BioAssay Types:
Screening(519)
 
 
 
 
 
Confirmatory(238)
 
 
 
 
 
Literature(17)
 
 
 
 
BioActivity Types:
Potency(145)
 
 
 
 
 
IC50(62)
 
 
 
 
 
EC50(18)
 
 
 
 
AC50(6)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 775    Data Row: 785   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103566186]
IC50 0.038Inhibition of luciferin binding site of Photuris pennsylvanica luciferase by noncompetitive inhibition assay [AID366888, Type: Literature]Luciferin 4-monooxygenase [gi:41688574]
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2
[SID7975271]
Potency 0.0757qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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3
[SID103566186]
IC50 0.08Inhibition of luciferin binding site of Photinus pyralis luciferase by noncompetitive inhibition assay [AID366887, Type: Literature]Luciferin 4-monooxygenase [gi:126501]
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4
[SID103566186]
IC50 0.1Inhibition of Photinus pyralis luciferase [AID328182, Type: Literature]
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5
[SID7975271]
EC50 0.122Luminescence Biochemical Dose Response HTS to Identify Inhibitors of Luciferase [AID1891, Type: confirmatory]
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6
[SID103566186]
IC50 0.14Inhibition of Photinus pyralis luciferase by Steady-Glo reporter gene assay [AID328185, Type: Literature]
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7
[SID7975271]
EC50 0.16Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) [AID2382, Type: confirmatory]Hsf1 protein [Mus musculus] [gi:62740231]
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8
[SID7975271]
EC50 0.16Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) [AID2382, Type: confirmatory]Hsf1 protein [Mus musculus] [gi:62740231]
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9
[SID7975271]
EC50 0.189Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Platelet Dense Granule Release [AID1889, Type: confirmatory]
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10
[SID7975271]
Potency 0.2512qHTS Assay for Inhibitors of Firefly Luciferase [AID411, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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11
[SID88443004]
IC50 0.28494Late stage results from the probe development effort to identify inhibitors of kruppel-like factor 5 (KLF5): luminescence-based cell-based dose response assay for inhibitors of KLF5 [AID2750, Type: confirmatory]Kruppel-like factor 5 [Homo sapiens] [gi:124263658]
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12
[SID103566186]
IC50 0.3Inhibition of Photinus pyralis luciferase by BrightGlo reporter gene assay [AID328186, Type: Literature]
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13
[SID7975271]
IC50 0.3596Luminescence-based dose response cell-based high throughput screening assay for inhibitors of kruppel-like factor 5 (KLF5). [AID1973, Type: confirmatory]Kruppel-like factor 5 [Homo sapiens] [gi:124263658]
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14
[SID103566186]
IC50 0.5Inhibition of Photinus pyralis luciferase by Easy lite assay [AID328183, Type: Literature]
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15
[SID7975271]
IC50 0.967Dose response confirmation of uHTS chemical inhibitors of both B-cell and T-cell specific antigen receptor-induced NF-kB activation in a 697B cell line using a luminescence assay [AID489034, Type: confirmatory]
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16
[SID7975271]
Potency 1qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]RAB9A gene product [Homo sapiens] [gi:4759012]
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17
[SID7975271]
IC50 1.17Dose response confirmation of uHTS of chemical inhibitors of both B-cell and T-cell specific antigen receptor-induced NF-kB activation in a Jurkat cell line using a luminescence assay [AID489004, Type: confirmatory]
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18
[SID7975271]
Potency 1.4125VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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19
[SID7975271]
Potency 1.5849qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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20
[SID7975271]
Potency 1.5849qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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21
[SID7975271]
Potency 1.5849qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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22
[SID7975271]
Potency 1.5849qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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23
[SID7975271]
IC50 1.69Dose response counterscreen of uHTS chemical inhibitors of both B-cell and T-cell specific antigen receptor-induced NF-kB activation in a HEK-293T cell line using a luminescence assay [AID489020, Type: confirmatory]
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24
[SID7975271]
EC50 1.691Luminescence Cell-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to BJeLR RAS-Dependent Fibroblast [AID1936, Type: confirmatory]
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25
[SID7975271]
Potency 2.2387Counterscreen for Luciferase (Kinase-Glo TM) Inhibition [AID1379, Type: confirmatory]luciferase [Photuris pennsylvanica] [gi:1669525]
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26
[SID7975271]
Potency 2.5119qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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27
[SID103566186]
IC50 2.6Inhibition of Photinus pyralis luciferase by PK-Light assay [AID328181, Type: Literature]
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28
[SID7975271]
Potency 3.1623qHTS Assay for Anthrax Lethal Toxin Internalization [AID912, Type: confirmatory]lethal factor [Bacillus anthracis str. A2012] [gi:21392848]
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29
[SID7975271]
Potency 3.1623qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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30
[SID7975271]
Potency 3.1623qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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31
[SID7975271]
Potency 3.1623qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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32
[SID7975271]
Potency 3.1623qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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33
[SID7975271]
EC50 3.272Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to DRD Non-Viral Oncogenic Fibroblast [AID1934, Type: confirmatory]
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34
[SID7975271]
EC50 3.638Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT RAS-Independent Fibroblast [AID1933, Type: confirmatory]
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35
[SID7975271]
AC50 3.75Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_Dose_CherryPick_Activity [AID624132, Type: confirmatory]
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36
[SID7975271]
AC50 5.26Shn3: Cytotox assay Measured in Cell-Based System Using Plate Reader - 2134-03_Inhibitor_Dose_CherryPick_Activity [AID624134, Type: confirmatory]
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37
[SID7975271]
Potency 7.0795qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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38
[SID7975271]
IC50 9.085Luminescence-based counterscreen assay for KLF5 inhibitors: dose response cell-based high throughput screening assay to identify cytotoxic compounds using the IEC-6 intestinal epithelial cell line. [AID1975, Type: confirmatory]
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39
[SID7975271]
Potency 10qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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40
[SID7975271]
Potency 10.3225qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]
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41
[SID103566186]
IC50 11.3Inhibition of luciferin binding site of Photuris pennsylvanica luciferase by noncompetitive KinaseGlo luminescent assay [AID366886, Type: Literature]Luciferin 4-monooxygenase [gi:41688574]
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42
[SID7975271]
Potency 11.5821qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]
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43
[SID7975271]
Potency 12.5893qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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44
[SID7975271]
Potency 14.1254qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK) [AID1721, Type: confirmatory]pyruvate kinase [Leishmania mexicana mexicana] [gi:290753097]
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45
[SID7975271]
Potency 25.1189qHTS Assay for Activators of ClpP [AID651965, Type: confirmatory]ClpP [Bacillus subtilis] [gi:2668494]
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46
[SID7975271]
AC50 32.66Shn3: Dual-Go Shn3RL cells Measured in Cell-Based System Using Plate Reader - 2134-02_Inhibitor_Dose_CherryPick_Activity [AID624133, Type: confirmatory]
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47
[SID7975271]
Potency 39.8107qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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48
[SID7975271]
Potency 39.8107qHTS Assay for Inhibitors of the HIV-1 protein Vpr [AID651644, Type: confirmatory]Vpr [Human immunodeficiency virus 1] [gi:28872817]
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49
[SID7975271]
Potency 52.6732Confirmation qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID2701, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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50
[SID7975271]
 Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of COUP-TFII (NR2F2) [AID686940, Type: screening]
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