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BioActivity Data for Compound maltol (CID 8369)

BioActivity Outcomes:
Active(6)
 
 
Inactive(1200)
 
 
Inconclusive(25)
 
 
Unspecified(22)
 
 
Top Targets:
7tm 4(45)
 
 
 
NR LBD PPAR(27)
 
 
 
NR LBD ER(16)
 
 
 
NR LBD AR(16)
 
 
 
NR LBD TR(14)
 
 
 
BioAssay Types:
Confirmatory(601)
 
 
 
 
 
Screening(515)
 
 
 
 
Summary(54)
 
 
 
Literature(43)
 
 
 
BioAssay Categories:
In vitro(2)
 
 
In vivo(3)
 
 
Biochemical(141)
 
 
 
Toxicity(47)
 
 
 
 
 
ADME(6)
 
 
Cell-based(139)
 
 
 
Organism-base..(13)
 
 
BioActivity Types:
Potency(499)
 
 
 
 
 
IC50(39)
 
 
EC50(7)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 998    Data Row: 1253   Total Pages: 63   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26747324]
Potency 15.8489qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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2
[SID11532903]
Potency 25.1189qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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3
[SID11532903]
Potency 35.4813qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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4
[SID144210438]
Potency-Replicate_1 50.8878qHTS assay to identify small molecule agonists of the thyroid receptor (TR) signaling pathway [AID743066, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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5
[SID11532903]
qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
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6
[SID11532903]
uHTS determination of small molecule cytotoxicity in a fluorescence assay to identify cystic fibrosis induced NFkb Inhibitors [AID602141, Type: screening]
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7
[SID103202970]
Inhibition of human recombinant MMP1 at 1 mM after 30 mins [AID566702, Type: Literature]Interstitial collagenase [gi:116852]
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8
[SID103202970]
Inhibition of human recombinant MMP2 at 1 mM after 30 mins [AID566703, Type: Literature]72 kDa type IV collagenase [gi:116856]
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9
[SID103202970]
Inhibition of human recombinant MMP3 at 1 mM after 30 mins [AID566704, Type: Literature]Stromelysin-1 [gi:116857]
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10
[SID103202970]
Inhibition of human recombinant MMP8 at 1 mM after 30 mins [AID566705, Type: Literature]Neutrophil collagenase [gi:116862]
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11
[SID103202970]
Inhibition of human recombinant 5-lipoxygenase at 1 mM after 10 mins by fluorescence assay [AID566700, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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12
[SID103202970]
Anti-inflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced superoxide anion generation [AID616299, Type: Literature]
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13
[SID103202970]
Anti-inflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced elastase release [AID616383, Type: Literature]
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14
[SID103202970]
Inhibition of mushroom tyrosinase at 1 mM after 10 mins [AID566699, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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15
[SID103202970]
Inhibition of mouse recombinant iNOS at 1 mM after 40 mins by colorimetric assay [AID566707, Type: Literature]Nitric oxide synthase, inducible [gi:266649]
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16
[SID17388942]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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17
[SID103202970]
Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM [AID977599, Type: Literature]
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18
[SID103202970]
Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM [AID977602, Type: Literature]
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19
[SID103202970]
Inhibition constant of compound against binding of Yeast Glyoxalase I [AID74123, Type: Literature]
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20
[SID103202970]
Compound was tested for their chelating potential with Indium-III complex determined by distribution coefficient method. [AID24628, Type: Literature]
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