Bookmark and Share

BioActivity Data for Compound Phenformin (CID 8249)

BioActivity Outcomes:
Active(3)
 
 
Inactive(194)
 
 
Inconclusive(13)
 
 
Unspecified(100)
 
 
Top Targets:
p450(14)
 
 
 
 
MFS(7)
 
 
HSD10-like SD..(4)
 
 
ePHD KMT2A(3)
 
 
KAZAL SLC21(3)
 
 
BioAssay Types:
Literature(162)
 
 
 
 
 
Confirmatory(115)
 
 
 
Screening(19)
 
 
BioAssay Categories:
In vitro(6)
 
 
In vivo(1)
 
 
Biochemical(10)
 
 
 
Toxicity(22)
 
 
 
ADME(21)
 
 
 
Cell-based(20)
 
 
 
BioActivity Types:
Potency(89)
 
 
 
IC50(9)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 238    Data Row: 310   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103426218]
IC50 27Inhibition of MAMC O-dealkylation mediated by human Cytochrome P450 2D6 expressed in human lymphoblastoid cell line [AID54570, Type: Literature]Cytochrome P450 2D6 [gi:84028191]
View
2
[SID103426218]
IC50 45.4Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D2 expressed in Saccharomyces cerevisiae [AID54564, Type: Literature]Cytochrome P450 2D26 [gi:117242]
View
3
[SID48416408]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
View
4
[SID103426218]
IC50 10TP_TRANSPORTER: inhibition of Cimetidine uptake (Cimetidine: 1 uM) in Xenopus laevis oocytes [AID680364, Type: Literature]Solute carrier family 22 member 1 [gi:313104181]
View
5
[SID103426218]
Km 15.6TP_TRANSPORTER: uptake in OCT1-expressing CHO cells [AID679316, Type: Literature]Solute carrier family 22 member 1 [gi:81872095]
View
6
[SID103426218]
IC50 65TP_TRANSPORTER: inhibition of Cimetidine uptake (Cimetidine: 1 uM) in Xenopus laevis oocytes [AID680369, Type: Literature]Solute carrier family 22 member 2 [gi:313104182]
View
7
[SID103426218]
IC50 180In vitro inhibition of glucose oxidation by the compound in isolated rat fat cells [AID179736, Type: Literature]
View
8
[SID103426218]
IC50 833Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D4 expressed in Saccharomyces cerevisiae [AID54566, Type: Literature]Cytochrome P450 2D4 [gi:117244]
View
9
[SID103426218]
IC50 1927Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D3 expressed in Saccharomyces cerevisiae [AID54565, Type: Literature]Cytochrome P450 2D3 [gi:3915646]
View
10
[SID103426218]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans [AID588211, Type: Literature]
View
11
[SID103426218]
Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D1 expressed in Saccharomyces cerevisiae; ND=no data [AID54563, Type: Literature]Cytochrome P450 2D1 [gi:117241]
View
12
[SID103426218]
Inhibition of human liver OATP1B1 expressed in HEK293 Flp-In cells assessed as reduction in E17-betaG uptake at 20 uM by scintillation counting [AID699539, Type: Literature]Solute carrier organic anion transporter family member 1B1 [gi:12643959]
View
13
[SID103426218]
Highest frequency of moderate liver toxicity observed during clinical trials, expressed as a percentage. [column '% BIOL' in source] [AID1079932, Type: Literature]
View
14
[SID103426218]
Highest frequency of acute liver toxicity observed during clinical trials, expressed as a percentage. [column '% AIGUE' in source] [AID1079934, Type: Literature]
View
15
[SID103426218]
Granulomatous liver disease, proven histopathologically. Value is number of references indexed. [column 'GRAN' in source] [AID1079940, Type: Literature]
View
16
[SID103426218]
Proposed mechanism(s) of liver damage. [column 'MEC' in source] [AID1079949, Type: Literature]
View
17
[SID103426218]
Hypoglycemic activity in alloxan-induced diabetic albino mouse assessed as decrease in blood glucose level at 1 mmol/kg, po administered 6 days after alloxan injection measured after 2 to 4 hrs by automated glucose oxidase method relative to control [AID1124003, Type: Literature]
View
18
[SID103426218]
Hypoglycemic activity in alloxan-induced diabetic albino mouse assessed as decrease in blood glucose level at 1 mmol/kg, po administered 6 days after alloxan injection measured after 1 to 3 hrs by automated glucose oxidase method relative to control [AID1124005, Type: Literature]
View
19
[SID103426218]
Times to onset, minimal and maximal, observed in the indexed observations. [column 'DELAI' in source] [AID1079948, Type: Literature]
View
20
[SID103426218]
Comments (NB not yet translated). [column 'COMMENTAIRES' in source] [AID1079947, Type: Literature]
View