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Phenformin (CID 8249) - Compound BioActivity Data
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BioActivity Outcomes:
Active(3)
 
 
Inactive(194)
 
 
Inconclusive(13)
 
 
Unspecified(75)
 
 
Top Targets:
p450(14)
 
 
 
 
HSD10-like SD..(4)
 
 
MFS(3)
 
 
KAZAL SLC21(3)
 
 
Firefly Luc l..(3)
 
 
BioAssay Types:
Literature(134)
 
 
 
 
 
Confirmatory(115)
 
 
 
Screening(19)
 
 
BioActivity Types:
Potency(89)
 
 
 
IC50(9)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 213    Data Row: 285   Total Pages: 6   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103426218]
IC50 27Inhibition of MAMC O-dealkylation mediated by human Cytochrome P450 2D6 expressed in human lymphoblastoid cell line [AID54570, Type: Literature]Cytochrome P450 2D6 [gi:84028191]
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2
[SID103426218]
IC50 45.4Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D2 expressed in Saccharomyces cerivisiae [AID54564, Type: Literature]Cytochrome P450 2D26 [gi:117242]
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3
[SID48416408]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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4
[SID103426218]
IC50 10TP_TRANSPORTER: inhibition of Cimetidine uptake (Cimetidine: 1 uM) in Xenopus laevis oocytes [AID680364, Type: other]Solute carrier family 22 member 1 [gi:313104181]
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5
[SID103426218]
Km 15.6TP_TRANSPORTER: uptake in OCT1-expressing CHO cells [AID679316, Type: other]Solute carrier family 22 member 1 [gi:81872095]
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6
[SID103426218]
IC50 65TP_TRANSPORTER: inhibition of Cimetidine uptake (Cimetidine: 1 uM) in Xenopus laevis oocytes [AID680369, Type: other]Solute carrier family 22 member 2 [gi:313104182]
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7
[SID103426218]
IC50 180In vitro inhibition of glucose oxidation by the compound in isolated rat fat cells [AID179736, Type: Literature]
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8
[SID103426218]
IC50 833Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D4 expressed in Saccharomyces cerivisiae [AID54566, Type: Literature]Cytochrome P450 2D4 [gi:117244]
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9
[SID103426218]
IC50 1927Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D3 expressed in Saccharomyces cerivisiae [AID54565, Type: Literature]Cytochrome P450 2D3 [gi:3915646]
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10
[SID11112448]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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11
[SID103426218]
IC50 Antimicrobial activity against Plasmodium falciparum [AID496819, Type: Literature]
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12
[SID103426218]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans [AID588211, Type: Literature]
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13
[SID103426218]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents [AID588212, Type: Literature]
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14
[SID103426218]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents [AID588213, Type: Literature]
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15
[SID103426218]
Hypoglycemic activity was given as differences between the mean changes in blood glucose concentration in control group and the treated group after a dose of 25 mg/kg, ip [AID75532, Type: Literature]
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16
[SID103426218]
Evaluated in normal, fasted guinea pig for the percentage reduction in blood glucose level after 5 hr as compared to pretreatment blood glucose values at a dose of 25 mg of free base / kg body weight administered orally [AID77195, Type: Literature]
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17
[SID103426218]
Percent reduction in blood glucose after perorally administration of compound at 25 mg/kg in in normal fasted guinea pig [AID77203, Type: Literature]
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18
[SID103426218]
Evaluated in normal, fasted monkey for the percentage reduction in blood glucose level after 5 hr as compared to pretreatment blood glucose values at a dose of 10 mg of free base / kg body weight administered orally [AID126663, Type: Literature]
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19
[SID103426218]
Lethal dose after intraperitoneal administration in mouse [AID134583, Type: Literature]
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20
[SID103426218]
Lethal dose after peroral administration in mouse [AID134584, Type: Literature]
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21
[SID103426218]
Percent change in blood glucose in normal rats at a hypoglycemic dose of 2.0 mmol/kg. against control [AID172905, Type: Literature]
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22
[SID103426218]
Compound evaluated for hypoglycemic activity by lowering blood glucose in normal rats by 20% after oral administration; highest dose tested;inactive(less than 10% blood sugar decrease) [AID173794, Type: Literature]
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23
[SID103426218]
Compound evaluated for hypoglycemic activity by lowering blood glucose in streptozotocin-diabetic rats by 20% after oral administration [AID173795, Type: Literature]
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24
[SID103426218]
Compound evaluated for hypoglycemic activity by lowering blood glucose in normal rats by 50% after oral administration; inactive(less than 10% blood sugar decrease) [AID176493, Type: Literature]
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25
[SID103426218]
Rise in the blood glucose level after 0 min following 10 mg/kg oral dose in fasted nondiabetic rats [AID179727, Type: Literature]
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26
[SID103426218]
Rise in the blood glucose level after 0 min following 100 mg/kg oral dose in fasted nondiabetic rats [AID179728, Type: Literature]
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27
[SID103426218]
Rise in the blood glucose level after 0 min following 150 mg/kg oral dose in fasted nondiabetic rats [AID179729, Type: Literature]
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28
[SID103426218]
Rise in the blood glucose level after 0 min following 300 mg/kg oral dose in fasted nondiabetic rats [AID179876, Type: Literature]
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29
[SID103426218]
Rise in the blood glucose level after 0 min following 50 mg/kg oral dose in fasted nondiabetic rats [AID179877, Type: Literature]
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30
[SID103426218]
Rise in the blood glucose level after 30 min following 10 mg/kg oral dose in fasted nondiabetic rats [AID179878, Type: Literature]
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31
[SID103426218]
Rise in the blood glucose level after 30 min following 100 mg/kg oral dose in fasted nondiabetic rats [AID179879, Type: Literature]
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32
[SID103426218]
Rise in the blood glucose level after 30 min following 150 mg/kg oral dose in fasted nondiabetic rats [AID179880, Type: Literature]
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33
[SID103426218]
Rise in the blood glucose level after 30 min following 300 mg/kg oral dose in fasted nondiabetic rats [AID179882, Type: Literature]
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34
[SID103426218]
Rise in the blood glucose level after 30 min following 50 mg/kg oral dose in fasted nondiabetic rats [AID179883, Type: Literature]
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35
[SID103426218]
Rise in the blood glucose level at 10 mg/kg oral dose in fasted nondiabetic rats [AID179884, Type: Literature]
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36
[SID103426218]
Rise in the blood glucose level at 100 mg/kg oral dose in fasted nondiabetic rats [AID179885, Type: Literature]
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37
[SID103426218]
Rise in the blood glucose level at 150 mg/kg oral dose in fasted nondiabetic rats [AID179886, Type: Literature]
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38
[SID103426218]
Rise in the blood glucose level at 300 mg/kg oral dose in fasted nondiabetic rats [AID179888, Type: Literature]
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39
[SID103426218]
Rise in the blood glucose level at 50 mg/kg oral dose in fasted nondiabetic rats [AID179889, Type: Literature]
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40
[SID103426218]
Percent inhibition of glucose rise, following 10 mg/kg oral dose in fasted nondiabetic rats [AID182468, Type: Literature]
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41
[SID103426218]
Percent inhibition of glucose rise, following 100 mg/kg oral dose in fasted nondiabetic rats [AID182469, Type: Literature]
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42
[SID103426218]
Percent inhibition of glucose rise, following 150 mg/kg oral dose in fasted nondiabetic rats [AID182470, Type: Literature]
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43
[SID103426218]
Percent inhibition of glucose rise, following 300 mg/kg oral dose in fasted nondiabetic rats [AID182472, Type: Literature]
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44
[SID103426218]
Percent inhibition of glucose rise, following 50 mg/kg oral dose in fasted nondiabetic rats [AID182473, Type: Literature]
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45
[SID103426218]
Lethal dose required to produce 50% lethality in male and female carworth farms CF-1 strain mice weighing 16-25 g administered intraperitoneally [AID184645, Type: Literature]
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46
[SID103426218]
Lethal dose required to produce 50% lethality in male and female carworth farms CF-1 strain mice weighing 16-25 g administered orally [AID184646, Type: Literature]
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47
[SID103426218]
Evaluated in alloxanized, diabetic rat for the percentage reduction in blood glucose level after 5 hr as compared to pretreatment blood glucose values at a dose of 100 mg of free base / kg body weight administered orally [AID188229, Type: Literature]
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48
[SID103426218]
Evaluated in glucose-primed, fasted rat for the percentage reduction in blood glucose level after 2 hr as compared to control groups at a dose of 100 mg of free base / kg body weight administered orally [AID188241, Type: Literature]
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49
[SID103426218]
Percent reduction in blood glucose after perorally administration of compound at 100 mg/kg in glucose-primed rat [AID188896, Type: Literature]
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50
[SID103426218]
Percent reduction in blood glucose after perorally administration of compound at 100 mg/kg in in alloxanized rat [AID188897, Type: Literature]
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