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Phenformin (CID 8249) - Compound BioActivity Data
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BioActivity Outcomes:
Active(3)
 
 
Inactive(194)
 
 
Inconclusive(13)
 
 
Unspecified(98)
 
 
Top Targets:
p450(14)
 
 
 
 
MFS(7)
 
 
HSD10-like SD..(4)
 
 
P53(3)
 
 
Firefly Luc l..(3)
 
 
BioAssay Types:
Literature(160)
 
 
 
 
 
Confirmatory(115)
 
 
 
Screening(19)
 
 
BioActivity Types:
Potency(89)
 
 
 
IC50(9)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 236    Data Row: 308   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103426218]
IC50 27Inhibition of MAMC O-dealkylation mediated by human Cytochrome P450 2D6 expressed in human lymphoblastoid cell line [AID54570, Type: Literature]Cytochrome P450 2D6 [gi:84028191]
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2
[SID103426218]
IC50 45.4Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D2 expressed in Saccharomyces cerevisiae [AID54564, Type: Literature]Cytochrome P450 2D26 [gi:117242]
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3
[SID48416408]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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4
[SID103426218]
IC50 10TP_TRANSPORTER: inhibition of Cimetidine uptake (Cimetidine: 1 uM) in Xenopus laevis oocytes [AID680364, Type: Literature]Solute carrier family 22 member 1 [gi:313104181]
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5
[SID103426218]
Km 15.6TP_TRANSPORTER: uptake in OCT1-expressing CHO cells [AID679316, Type: Literature]Solute carrier family 22 member 1 [gi:81872095]
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6
[SID103426218]
IC50 65TP_TRANSPORTER: inhibition of Cimetidine uptake (Cimetidine: 1 uM) in Xenopus laevis oocytes [AID680369, Type: Literature]Solute carrier family 22 member 2 [gi:313104182]
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7
[SID103426218]
IC50 180In vitro inhibition of glucose oxidation by the compound in isolated rat fat cells [AID179736, Type: Literature]
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8
[SID103426218]
IC50 833Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D4 expressed in Saccharomyces cerevisiae [AID54566, Type: Literature]Cytochrome P450 2D4 [gi:117244]
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9
[SID103426218]
IC50 1927Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D3 expressed in Saccharomyces cerevisiae [AID54565, Type: Literature]Cytochrome P450 2D3 [gi:3915646]
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10
[SID103426218]
IC50 Antimicrobial activity against Plasmodium falciparum [AID496819, Type: Literature]
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11
[SID11112448]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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12
[SID103426218]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans [AID588211, Type: Literature]
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13
[SID103426218]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents [AID588212, Type: Literature]
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14
[SID103426218]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents [AID588213, Type: Literature]
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15
[SID103426218]
Inhibition of human liver OATP1B1 expressed in HEK293 Flp-In cells assessed as reduction in E17-betaG uptake at 20 uM by scintillation counting [AID699539, Type: Literature]Solute carrier organic anion transporter family member 1B1 [gi:12643959]
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16
[SID103426218]
Inhibition of human liver OATP1B3 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E17-betaG uptake at 20 uM incubated for 5 mins by scintillation counting [AID699540, Type: Literature]Solute carrier organic anion transporter family member 1B3 [gi:27734563]
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17
[SID103426218]
Cellular uptake in human HEK293 cells assessed as human OCT2-mediated drug transport at 2.5 uM after 4 mins by LC-MS/MS analysis relative to passive uptake [AID771314, Type: Literature]Solute carrier family 22 member 2 [gi:313104182]
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18
[SID103426218]
Cellular uptake in human HEK293 cells assessed as human OCT2-mediated drug transport at 2.5 uM after 4 mins by LC-MS/MS analysis [AID771316, Type: Literature]Solute carrier family 22 member 2 [gi:313104182]
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19
[SID103426218]
Effect on human MRP2-mediated estradiol-17-beta-glucuronide transport in Sf9 cells inverted membrane vesicles relative to control [AID404304, Type: Literature]Canalicular multispecific organic anion transporter 1 [gi:308153583]
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20
[SID103426218]
Inhibition of human liver OATP2B1 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E3S uptake at 20 uM incubated for 5 mins by scintillation counting [AID699541, Type: Literature]Solute carrier organic anion transporter family member 2B1 [gi:313104012]
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