Ro 90-7501 (CID 824226) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(72)
 
 
Inactive(150)
 
 
Inconclusive(43)
 
 
Unspecified(4)
 
 
Top Targets:
HELICc(10)
 
 
PLN02808(8)
 
 
 
Pyr redox dim(7)
 
 
Menin(6)
 
 
 
NR LBD TR(6)
 
 
 
 
BioAssay Types:
Confirmatory(234)
 
 
 
 
 
Screening(17)
 
 
Literature(12)
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(233)
 
 
 
 
 
IC50(8)
 
 
 
EC50(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 198    Data Row: 269   Total Pages: 6   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103712730]
IC50 0.00022Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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2
[SID103712730]
IC50 0.00028Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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3
[SID103712730]
IC50 0.00052Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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4
[SID103712730]
IC50 0.00074Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay [AID524792, Type: Literature]
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5
[SID103712730]
IC50 0.00074Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
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6
[SID103712730]
IC50 0.00083Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
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7
[SID103712730]
IC50 0.001Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay [AID524793, Type: Literature]
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8
[SID103712730]
EC50 0.0556NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay [AID449704, Type: other]
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9
[SID26753597]
Potency 0.0631qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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10
[SID26753597]
Potency 0.0631qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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11
[SID26753597]
Potency 0.0631qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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12
[SID103712730]
EC50 0.1196NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay [AID449703, Type: other]
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13
[SID26753597]
Potency 0.2512qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2 [AID1883, Type: confirmatory]
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14
[SID26753597]
Potency 0.2617Quantitative high throughput screen for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID488745, Type: confirmatory]
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15
[SID26753597]
Potency 0.3548qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 3D7 [AID1876, Type: confirmatory]
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16
[SID26753597]
Potency 0.4147Quantitative high throughput screen for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID488752, Type: confirmatory]
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17
[SID26753597]
Potency 0.7079qHTS for differential inhibitors of proliferation of Plasmodium falciparum line D10 [AID1877, Type: confirmatory]
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18
[SID26753597]
Potency 0.7943qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 7G8 [AID1815, Type: confirmatory]
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19
[SID26753597]
Potency 0.7943qHTS for differential inhibitors of proliferation of Plasmodium falciparum line HB3 [AID1886, Type: confirmatory]
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20
[SID26753597]
Potency 0.8913qHTS for differential inhibitors of proliferation of Plasmodium falciparum line GB4 [AID1816, Type: confirmatory]
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21
[SID26753597]
Potency 1qHTS for differential inhibitors of proliferation of Plasmodium falciparum line Dd2 [AID1882, Type: confirmatory]
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22
[SID26753597]
Potency 1.122qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway [AID895, Type: confirmatory]NFKB1 protein [Homo sapiens] [gi:21620132]
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23
[SID26753597]
Potency 1.122qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway [AID895, Type: confirmatory]NFKB1 protein [Homo sapiens] [gi:21620132]
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24
[SID26753597]
Potency 1.122qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway [AID895, Type: confirmatory]NFKB1 protein [Homo sapiens] [gi:21620132]
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25
[SID26753597]
Potency 1.122qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway [AID895, Type: confirmatory]NFKB1 protein [Homo sapiens] [gi:21620132]
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26
[SID26753597]
Potency 1.4125qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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27
[SID26753597]
Potency 1.4125qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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28
[SID29215159]
Potency 2.6679qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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29
[SID29215159]
Potency 2.6679qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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30
[SID90340820]
Potency 2.6679qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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31
[SID90340820]
Potency 2.6679qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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32
[SID29215158]
Potency 2.8184qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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33
[SID29215158]
Potency 2.8184qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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34
[SID26753597]
Potency 3.9811qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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35
[SID26753597]
Potency 3.9811qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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36
[SID124891661]
Potency 3.9811qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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37
[SID124891661]
Potency 3.9811qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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38
[SID26753597]
Potency 4.4668qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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39
[SID26753597]
Potency 4.4668qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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40
[SID90340820]
Potency 5.0119qHTS for Inhibitors of Glutaminase (GLS): LOPAC Validation [AID624146, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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41
[SID124891661]
Potency 5.0119qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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42
[SID124891661]
Potency 5.0119qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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43
[SID26753597]
Potency 6.3096qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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44
[SID26753597]
Potency 6.3096qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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45
[SID124891661]
Potency 8.9125qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]
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46
[SID26753597]
Potency 8.9125qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2353, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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47
[SID26753597]
Potency 10qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent) [AID1478, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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48
[SID124891661]
Potency 10qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]
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49
[SID26753597]
Potency 10qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium [AID1457, Type: confirmatory]Inositol monophosphatase [gi:44888968]
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50
[SID26753597]
Potency 10qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium [AID1457, Type: confirmatory]Inositol monophosphatase [gi:44888968]
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