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7-Benzyl-8-isopropylsulfanyl-3-methyl-3,7-dihydro-purine-2,6-dione (CID 814607) - Compound BioActivity Data
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BioActivity Outcomes:
Active(5)
 
 
Inactive(536)
 
 
Inconclusive(7)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
7TM GPCR Srsx(15)
 
 
NACHT(10)
 
 
 
TRP 2(5)
 
 
CAP ED(5)
 
 
BioAssay Types:
Screening(366)
 
 
Confirmatory(173)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(125)
 
 
 
 
IC50(42)
 
 
 
EC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 507    Data Row: 549   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID87544799]
IC50_Mean 1.22SAR analysis of compounds that inhibit NOD1 - Set 2 [AID2466, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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2
[SID89650209]
IC50_Mean 1.99SAR analysis of compounds that inhibit NOD1 - Set 3 [AID2798, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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3
[SID87544799]
IC50 3.31SAR analysis of GM-Tri-DAP induced IL-8 secretion in MCF-7/NOD1 cells - Set 2 [AID2505, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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4
[SID87544799]
IC50_Mean 18.1SAR analysis of compounds that inhibit NOD2 - Set 2 [AID2475, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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5
[SID87544799]
IC50 18.49SAR analysis of NF-kappaB dependent luciferase using DAP as an inducer - Set 2 [AID2793, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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6
[SID49643095]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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7
[SID49643095]
Potency 1.7783qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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8
[SID87544799]
IC50_Mean 20SAR analysis of compounds that are cytotoxic to HEK293 - Set 2 [AID2469, Type: confirmatory]
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9
[SID89650209]
IC50_Mean 20SAR analysis of compounds that are cytotoxic to HEK293 - Set 3 [AID2800, Type: confirmatory]
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10
[SID89650209]
IC50_Mean 20SAR analysis of compounds that inhibit NOD2 - Set 3 [AID2799, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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11
[SID87544799]
IC50_Mean 20SAR analysis of inhibitors of TNFa specific NF-kB induction - Set 2 [AID2483, Type: confirmatory]tumor necrosis factor [Homo sapiens] [gi:25952111]
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12
[SID89650209]
IC50_Mean 20SAR analysis of inhibitors of TNFa specific NF-kB induction - Set 3 [AID2801, Type: confirmatory]tumor necrosis factor [Homo sapiens] [gi:25952111]
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13
[SID87544799]
IC50 25SAR analysis of NF-kappaB dependent luciferase using Doxorucibin as an inducer - Set 2 [AID2789, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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14
[SID87544799]
IC50 25SAR analysis of NF-kappaB dependent luciferase using PMA/Ionomycin as an inducer - 2 [AID2792, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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15
[SID87544799]
IC50 25SAR analysis of Muramyl dipeptide (MDP) induced IL-8 secretion in MCF-7/NOD2 cells - Set 2 [AID2503, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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16
[SID87544799]
IC50 25SAR analysis of Tumor necrosis factor alpha (TNF-alpha) induced IL-8 secretion in MCF-7/NOD1 cells - Set 2 [AID2504, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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17
[SID49643095]
Potency 70.7946qHTS assay for re-activators of p53 using a Luc reporter [AID504706, Type: confirmatory]P53 [Homo sapiens] [gi:23491729]
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18
[SID49643095]
Potency 89.1251qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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19
[SID49643095]
Fluorescence polarization-based cell-based primary high throughput screening assay to identify inhibitors of insulin-degrading enzyme (IDE) [AID434962, Type: screening]insulin-degrading enzyme isoform 1 [Homo sapiens] [gi:155969707]
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20
[SID49643095]
Fluorescence polarization-based cell-based primary high throughput screening assay to identify activators of insulin-degrading enzyme (IDE) [AID493087, Type: screening]insulin-degrading enzyme isoform 1 [Homo sapiens] [gi:155969707]
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21
[SID99495693]
Inhibition of the MLL-AF4-AF9 Interaction in Pediatric Leukemia Measured in Biochemical System Using Plate Reader - 2160-01_Inhibitor_SinglePoint_HTS_Activity [AID651704, Type: screening]protein AF-9 isoform a [Homo sapiens] [gi:156104889]
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22
[SID49643095]
uHTS Fluorescent assay for identification of inhibitors of hexokinase domain containing I (HKDC1) [AID493160, Type: screening]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
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23
[SID49643095]
uHTS Fluorescent assay for identification of activators of hexokinase domain containing I (HKDC1) [AID493187, Type: screening]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
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24
[SID49643095]
High throughput screening of activators of transient receptor potential cation channel C6 (TRPC6) [AID2550, Type: screening]short transient receptor potential channel 6 isoform 1 [Mus musculus] [gi:160333370]
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25
[SID49643095]
High throughput screening of inhibitors of transient receptor potential cation channel C6 (TRPC6) [AID2553, Type: screening]short transient receptor potential channel 6 isoform 1 [Mus musculus] [gi:160333370]
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26
[SID49643095]
uHTS identification of modulators of interaction between CendR and NRP-1 using Fluorescence Polarization assay [AID602438, Type: screening]Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin-1 [gi:160877737]
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27
[SID49643095]
Potency qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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28
[SID49643095]
Plate Read Microorganism-Based Primary HTS to Identify Modulators of the AI-2 Quorum Sensing System [AID2094, Type: screening]LuxS [Vibrio harveyi] [gi:166202459]
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29
[SID49643095]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of A1 Apoptosis. [AID2462, Type: screening]Chain A, Human Bcl2-A1 In Complex With Bim-Bh3 Peptide [gi:167013344]
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30
[SID49643095]
High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set [AID588497, Type: Literature]botulinum neurotoxin type F, BoNT/F [Clostridium botulinum Bf] [gi:168184763]
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31
[SID49643095]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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32
[SID49643095]
Potency qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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33
[SID49643095]
Potency qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
View
34
[SID49643095]
uHTS Fluorescent assay for identification of inhibitors of Apaf-1 [AID489030, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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35
[SID49643095]
uHTS Fluorescent assay for identification of activators of Apaf-1 [AID489031, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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36
[SID49643095]
Potency HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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37
[SID49643095]
Potency qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter [AID463254, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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38
[SID49643095]
Potency VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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39
[SID49643095]
Potency qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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40
[SID49643095]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen [AID2100, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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41
[SID49643095]
TRFRET-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): antagonists of MC4R [AID540295, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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42
[SID49643095]
Luminescence-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): agonists of MC4R [AID540308, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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43
[SID99495693]
Luminescence-based cell-based primary high throughput screening assay to identify activators of the function of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, BRM) [AID652017, Type: screening]SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, isoform CRA_a [Homo sapiens] [gi:119579215]
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44
[SID99495693]
QFRET-based biochemical high throughput primary assay to identify inhibitors of human group III secreted phospholipase A2 enzyme (HGIII-sPLA2) [AID743126, Type: screening]phospholipase A2, group III [Homo sapiens] [gi:119580345]
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45
[SID49643095]
Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and the receptor-interacting serine-threonine kinase 2 (RIPK2) [AID624267, Type: screening]caspase recruitment domain family, member 15 [Homo sapiens] [gi:119603173]
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46
[SID49643095]
Fluorescence-based primary cell-based high throughput screening assay to identify antagonists of the G-protein coupled receptor 7 (GPR7). [AID1861, Type: screening]neuropeptides B/W receptor 1 [Homo sapiens] [gi:119607128]
View
47
[SID49643095]
uHTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 7 (SENP7) [AID434973, Type: screening]SUMO1/sentrin specific peptidase 7 [Homo sapiens] [gi:120538355]
View
48
[SID49643095]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the HTRA serine peptidase 1 (HTRA1) [AID504803, Type: screening]HTRA1 protein [gi:121945198]
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49
[SID49643095]
Potency qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-biphosphate Aldolase In Complex With Phosphoglycolohydroxamate [gi:122920737]
View
50
[SID49643095]
Primary cell-based high throughput screening assay to identify inhibitors of kruppel-like factor 5 (KLF5) [AID1700, Type: screening]Kruppel-like factor 5 [Homo sapiens] [gi:124263658]
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