CHEMBL1958138
(CID
809076
) -
BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(
2
)
Top Targets:
Lipoxygenase(
2
)
BioAssay Types:
Literature(
2
)
BioActivity Types:
IC50(
2
)
SAR
Target summary
Data download
Chemical Probe
Active
Inactive
Inconclusive
Unspecified
Total Bioassays: 2 Data Row: 2 Total Pages: 1
Sort:
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#
Substance
Activity
BioAssay
Target
Links
Outcome
Type
Value [μM]
1
[SID
136937514
]
Active
IC50
0.43
Inhibition of 5-lipoxygenase in S100 cell free fraction of human polymorphonuclear leukocytes assessed as reduction in 5-LO product formation preincubated for 15 mins measured after 10 mins by HPLC analysis [AID
650763
, Type: Literature]
Arachidonate 5-lipoxygenase [gi:
126407
]
View
X
Row No.
1
Structure
Substance
SID
136937514
CID
809076
Outcome
Active
IC50
0.43 [uM]
BioAssay
Inhibition of 5-lipoxygenase in S100 cell free fraction of human polymorphonuclear leukocytes assessed as reduction in 5-LO product formation preincubated for 15 mins measured after 10 mins by HPLC analysis
AID
650763
BioAssay type
Literature
Target
Arachidonate 5-lipoxygenase [gi:
126407
]
PubMed
22326163
Data Table
2
[SID
136937514
]
Active
IC50
1.22
Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as reduction in A23187 and AA-stimulated 5-LO product formation preincubated for 15 mins prior stimulation measured after 10 mins by HPLC analysis [AID
650762
, Type: Literature]
Arachidonate 5-lipoxygenase [gi:
126407
]
View
X
Row No.
2
Structure
Substance
SID
136937514
CID
809076
Outcome
Active
IC50
1.22 [uM]
BioAssay
Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as reduction in A23187 and AA-stimulated 5-LO product formation preincubated for 15 mins prior stimulation measured after 10 mins by HPLC analysis
AID
650762
BioAssay type
Literature
Target
Arachidonate 5-lipoxygenase [gi:
126407
]
PubMed
22326163
Data Table
Chemical Probe 
Active 
Inactive 
Inconclusive 
Unspecified 
