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BioActivity Data for Compound piperidine (CID 8082)

BioActivity Outcomes:
Active(1)
 
 
Inactive(95)
 
 
Inconclusive(3)
 
 
Unspecified(12)
 
 
Top Targets:
NR LBD PPAR(8)
 
 
NR LBD AR(7)
 
 
NR LBD ER(7)
 
 
 
NR LBD Fxr(4)
 
 
NR LBD GR(4)
 
 
BioAssay Types:
Confirmatory(68)
 
 
 
Summary(26)
 
 
 
Literature(14)
 
 
 
 
BioAssay Categories:
Biochemical(8)
 
 
 
Toxicity(7)
 
 
ADME(1)
 
 
Cell-based(1)
 
 
BioActivity Types:
Potency(88)
 
 
 
Kd(2)
 
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 111    Data Row: 111   Total Pages: 6   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103178965]
Kd 0.12Ability to enhance the binding of (+/-)-[3H]nicotine to the rat brain P2 fraction at binding site 2 [AID30389, Type: Literature]
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2
[SID103178965]
Kd 69Ability to enhance the binding of (+/-)-[3H]nicotine to the rat brain P2 fraction at binding site 3. [AID30391, Type: Literature]
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3
[SID103178965]
Compounds was evaluated for their ability to enhance (+/-)-[3H]nicotine binding at a dose range 10 E -9 - 10 E -6 M was reported [AID30528, Type: Literature]
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4
[SID103178965]
Dissociation constant, pKa of the compound [AID701844, Type: Literature]
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5
[SID103178965]
pKa (acid-base dissociation constant) as determined by Liao ref: J Chem Info Model 2009 [AID781325, Type: Literature]
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6
[SID103178965]
pKa (acid-base dissociation constant) as determined by Morgenthaler ref: ChemMedChem 2007 [AID781327, Type: Literature]
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7
[SID103178965]
Compound was evaluated for ability to enhance the binding of (+/-)-[3H]nicotine to the rat brain P2 fraction at binding site 1; 10e-9-10e-6 [AID30386, Type: Literature]
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8
[SID103178965]
Maximum percent of inhibition of binding was determined [AID30378, Type: Literature]
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9
[SID103178965]
Maximum percent of enhancement of binding. [AID30377, Type: Literature]
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10
[SID103178965]
Association constant was determined [AID25336, Type: Literature]
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11
[SID103178965]
Dissociation constant, pKa of the compound [AID342464, Type: Literature]
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12
[SID103178965]
Ki Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation counting [AID630741, Type: Literature]Proton-coupled amino acid transporter 1 [gi:51316800]
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13
[SID103178965]
Inhibition of Thromboxane synthetase at 100 uM [AID213129, Type: Literature]Thromboxane-A synthase [gi:254763392]
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14
[SID144208373]
Potency-Replicate_1 qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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15
[SID144208373]
Ratio Potency (uM) qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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16
[SID144208373]
Potency-Replicate_1 qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 [AID651632, Type: confirmatory]ATPase family AAA domain-containing protein 5 [gi:296439460]
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17
[SID144208373]
ATAD5 Potency (uM) qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5: Summary [AID720516, Type: summary]ATPase family AAA domain-containing protein 5 [gi:296439460]
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18
[SID144208373]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway [AID720691, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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19
[SID144208373]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway [AID720692, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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20
[SID144208373]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway: Summary [AID720719, Type: summary]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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