pentane (CID 8003) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Inactive(231)
 
 
Inconclusive(9)
 
 
Unspecified(16)
 
 
Top Targets:
NR LBD PPAR(5)
 
 
NR LBD TR(4)
 
 
 
P53(3)
 
 
NR LBD VDR(3)
 
 
NR LBD ROR li..(3)
 
 
BioAssay Types:
Confirmatory(168)
 
 
 
Literature(77)
 
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(132)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 187    Data Row: 256   Total Pages: 6   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17388845]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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2
[SID103179369]
 Solubility in water was determined; values expressed as -log [AID13316, Type: Literature]
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3
[SID103179369]
 Aqueous solubility [AID19262, Type: Literature]
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4
[SID103179369]
 Partition coefficient in water-hexadecane (P16) was determined [AID23718, Type: Literature]
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5
[SID103179369]
 Partition coefficient in alkanes was determined [AID23726, Type: Literature]
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6
[SID103179369]
 Partition coefficient in water-cyclohexane was determined [AID23729, Type: Literature]
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7
[SID103179369]
 Partition coefficient (logP) [AID23737, Type: Literature]
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8
[SID103179369]
 logBB, log(C brain / C blood) [AID26047, Type: Literature]
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9
[SID103179369]
 Toxicity determined using Tadpole Narcosis Test [AID212400, Type: Literature]
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10
[SID103179369]
 Lipophilicity determined as logarithm of the partition coefficient in the alkane/water system [AID237685, Type: Literature]
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11
[SID103179369]
 Convulsant activity in Sprague-Dawley rat assessed as partial pressure in atmosphere at which convulsion takes place [AID416913, Type: Literature]
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12
[SID17388845]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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13
[SID103179369]
 In-vitro air to lung partition coefficients of the compound, logK(lung) (human/rat) [AID603950, Type: Literature]
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14
[SID103179369]
 In-vitro air to blood partition coefficients of the compound, logK(blood) (human/rat) [AID603951, Type: Literature]
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15
[SID103179369]
 In-vitro blood to lung partition coefficients of the compound, logP(lung) (human/rat) [AID603952, Type: Literature]
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16
[SID103179369]
 Octanol-water partition coefficient, log P of the compound [AID603957, Type: Literature]
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17
[SID17388845]
Potency 0.1qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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18
[SID17388845]
Potency 0.1qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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19
[SID17388845]
Potency 0.1qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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20
[SID17388845]
Potency Inhibitors of USP1/UAF1: Pilot qHTS [AID504865, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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21
[SID17388845]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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22
[SID17388845]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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23
[SID17388845]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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24
[SID17388845]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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25
[SID17388845]
Potency qHTS assay for small molecule antagonists of vitamin D receptor signaling [AID588541, Type: confirmatory]vitamin D (1,25- dihydroxyvitamin D3) receptor [Homo sapiens] [gi:216409708]
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26
[SID17388845]
Potency qHTS assay for small molecule antagonists of vitamin D receptor signaling [AID588541, Type: confirmatory]vitamin D (1,25- dihydroxyvitamin D3) receptor [Homo sapiens] [gi:216409708]
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27
[SID17388845]
Potency qHTS assay for small molecule antagonists of vitamin D receptor signaling [AID588541, Type: confirmatory]vitamin D (1,25- dihydroxyvitamin D3) receptor [Homo sapiens] [gi:216409708]
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28
[SID17388845]
Potency qHTS assay for small molecule antagonists of vitamin D receptor signaling [AID588541, Type: confirmatory]vitamin D (1,25- dihydroxyvitamin D3) receptor [Homo sapiens] [gi:216409708]
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29
[SID17388845]
Potency qHTS assay for small molecule agonists of vitamin D receptor signaling [AID588543, Type: confirmatory]vitamin D (1,25- dihydroxyvitamin D3) receptor [Homo sapiens] [gi:216409708]
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30
[SID17388845]
Potency qHTS assay for small molecule agonists of vitamin D receptor signaling [AID588543, Type: confirmatory]vitamin D (1,25- dihydroxyvitamin D3) receptor [Homo sapiens] [gi:216409708]
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31
[SID17388845]
Potency qHTS assay for small molecule agonists of vitamin D receptor signaling [AID588543, Type: confirmatory]vitamin D (1,25- dihydroxyvitamin D3) receptor [Homo sapiens] [gi:216409708]
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32
[SID17388845]
Potency qHTS assay for small molecule agonists of vitamin D receptor signaling [AID588543, Type: confirmatory]vitamin D (1,25- dihydroxyvitamin D3) receptor [Homo sapiens] [gi:216409708]
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33
[SID17388845]
Potency qHTS assay for small molecule antagonists of farnesoid X receptor signaling [AID588526, Type: confirmatory]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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34
[SID17388845]
Potency qHTS assay for small molecule antagonists of farnesoid X receptor signaling [AID588526, Type: confirmatory]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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35
[SID17388845]
Potency qHTS assay for small molecule antagonists of farnesoid X receptor signaling [AID588526, Type: confirmatory]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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36
[SID17388845]
Potency qHTS assay for small molecule antagonists of farnesoid X receptor signaling [AID588526, Type: confirmatory]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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37
[SID17388845]
Potency qHTS assay for small molecule agonists of farnesoid X receptor signaling [AID588527, Type: confirmatory]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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38
[SID17388845]
Potency qHTS assay for small molecule agonists of farnesoid X receptor signaling [AID588527, Type: confirmatory]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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39
[SID17388845]
Potency qHTS assay for small molecule agonists of farnesoid X receptor signaling [AID588527, Type: confirmatory]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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40
[SID17388845]
Potency qHTS assay for small molecule agonists of farnesoid X receptor signaling [AID588527, Type: confirmatory]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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41
[SID17388845]
Potency qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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42
[SID17388845]
Potency VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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43
[SID17388845]
Potency qHTS assay to identify small molecules that stimulate Tumor Necrosis Factor-alpha (TNF-alpha) secretion [AID651757, Type: confirmatory]TNF gene product [Homo sapiens] [gi:25952111]
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44
[SID17388845]
Potency qHTS assay to identify small molecules that stimulate Tumor Necrosis Factor-alpha (TNF-alpha) secretion [AID651757, Type: confirmatory]TNF gene product [Homo sapiens] [gi:25952111]
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45
[SID17388845]
Potency qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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46
[SID17388845]
Potency qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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47
[SID17388845]
Potency qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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48
[SID17388845]
Potency qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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49
[SID17388845]
Potency qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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50
[SID17388845]
Potency qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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