indole (CID 798) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(12)
 
 
Inactive(103)
 
 
Unspecified(31)
 
 
Top Targets:
DUF3652(2)
 
 
Geminin(2)
 
 
alpha CA I II..(2)
 
 
Menin(2)
 
 
NR LBD ROR li..(2)
 
 
BioAssay Types:
Literature(104)
 
 
 
 
Confirmatory(29)
 
 
Screening(2)
 
 
BioActivity Types:
Potency(28)
 
 
IC50(5)
 
 
 
Kd(5)
 
 
Ki(5)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 85    Data Row: 146   Total Pages: 3   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103179045]
IC50 1.78Cytotoxicity against human SK-N-SH cells after 48 hrs by MTT assay [AID652686, Type: Literature]
View
2
[SID103179045]
Ki 2.33Inhibition of human carbonic anhydrase 4 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis [AID644086, Type: Literature]Carbonic anhydrase 4 [gi:115465]
View
3
[SID103179045]
Ki 3.63Inhibition of human carbonic anhydrase 6 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis [AID644087, Type: Literature]Carbonic anhydrase 6 [gi:116241278]
View
4
[SID103179045]
IC50 15.58Cytotoxicity against human MRC5 cells after 48 hrs by MTT assay [AID652688, Type: Literature]
View
5
[SID103179045]
Ki 17.6Inhibition of bovine carbonic anhydrase 3 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis [AID644088, Type: Literature]Carbonic anhydrase 3 [gi:118572923]
View
6
[SID103179045]
Ki 27.4Inhibition of human carbonic anhydrase 1 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis [AID644084, Type: Literature]Carbonic anhydrase 1 [gi:115449]
View
7
[SID103179045]
Ki 32.5Inhibition of human carbonic anhydrase 2 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis [AID644085, Type: Literature]Carbonic anhydrase 2 [gi:115456]
View
8
[SID103179045]
 Binding affinity to amyloid beta (1 to 42) oligomers by fluorescence quenching after 30 mins [AID475507, Type: Literature]
View
9
[SID103179045]
 Binding affinity to amyloid beta (1 to 42) fibrils by change in fluorescence at 100 uM after 10 mins [AID475504, Type: Literature]
View
10
[SID103179045]
 Binding affinity to amyloid beta (1 to 42) oligomers by change in fluorescence at 100 uM after 10 mins [AID475505, Type: Literature]
View
11
[SID144206089]
 qHTS of D3 Dopamine Receptor Agonist: qHTS [AID652048, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
View
12
[SID144206089]
 qHTS of D3 Dopamine Receptor Agonist: qHTS [AID652048, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
View
13
[SID144206089]
 qHTS of D3 Dopamine Receptor Agonist: qHTS [AID652048, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
View
14
[SID144206089]
 qHTS of D3 Dopamine Receptor Agonist: qHTS [AID652048, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
View
15
[SID144206089]
 qHTS of D3 Dopamine Receptor Potentiators: qHTS [AID652051, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
View
16
[SID144206089]
 qHTS of D3 Dopamine Receptor Potentiators: qHTS [AID652051, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
View
17
[SID144206089]
 qHTS of D3 Dopamine Receptor Potentiators: qHTS [AID652051, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
View
18
[SID144206089]
 qHTS of D3 Dopamine Receptor Potentiators: qHTS [AID652051, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
View
19
[SID103179045]
IC50 100Cytotoxicity against human A549 cells after 48 hrs by MTT assay [AID652687, Type: Literature]
View
20
[SID103179045]
IC50 100Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay [AID652685, Type: Literature]
View
21
[SID103179045]
Kd 290Dissociation constant against T4 lysozyme mutant L99A [AID238119, Type: Literature]Lysozyme [gi:126605]
View
22
[SID103179045]
Kd 300Dissociation constant for Leukocyte function associated antigen 1 (LFA-1) [AID99595, Type: Literature]
View
23
[SID103179045]
Kd 300Inhibition of JY-8 cell adhesion via leukocyte function associated antigen 1 (LFA-1) to ICAM-1 [AID99593, Type: other]Intercellular adhesion molecule 1 [gi:68067956]
View
24
[SID103179045]
Kd 3000Dissociation constant against adenosine kinase [AID34005, Type: Literature]
View
25
[SID103179045]
Kd 3000Inhibition of human adenosine kinase [AID220591, Type: Literature]
View
26
[SID103179045]
IC50 10000Inhibition of [alpha-32P]ATP binding to DnaA protein purified from Escherichia coli [AID56359, Type: other]
View
27
[SID103179045]
 Residual porcine GSK-3-alpha/beta kinase activity with L240C/N297Q mutant cytochrome P450 2A6 extract [AID73213, Type: Literature]
View
28
[SID103179045]
 Residual porcine GSK-3-alpha/beta kinase activity with wild-type cytochrome P450 2A6 extract [AID73214, Type: Literature]
View
29
[SID103179045]
 Residual Cyclin-dependent kinase 5-p35nck5a activity with L240C/N297Q mutant cytochrome P450 2A6 extract [AID54188, Type: Literature]
View
30
[SID103179045]
 Residual Cyclin-dependent kinase 5-p35nck5a activity with wild-type cytochrome P450 2A6 extract [AID54189, Type: Literature]
View
31
[SID103179045]
 Aqueous solubility [AID19262, Type: Literature]
View
32
[SID103179045]
 Partition coefficient (logP) [AID23454, Type: Literature]
View
33
[SID103179045]
 Partition coefficient (logP) [AID23714, Type: Literature]
View
34
[SID103179045]
 Capacity ratio (log k'w) [AID23978, Type: Literature]
View
35
[SID103179045]
 Partition coefficient (logP) [AID236904, Type: Literature]
View
36
[SID103179045]
 Lipophilicity determined as logarithm of the partition coefficient in the alkane/water system [AID237685, Type: Literature]
View
37
[SID103179045]
 Permeability coefficient through artificial membrane in presence of unstirred water layer by PAMPA [AID288184, Type: Literature]
View
38
[SID103179045]
 Partition coefficient, log P of the compound [AID288192, Type: Literature]
View
39
[SID103179045]
 Antimicrobial activity Propionibacterium acnes ATCC 11827 after 2 days by broth dilution method [AID332912, Type: other]
View
40
[SID103179045]
 Octanol-water distribution coefficient, log D at pH 7.4 by shake-flask technique [AID343398, Type: Literature]
View
41
[SID103179045]
 Hexadecane-water distribution coefficient, log D at pH 7.4 by shake-flask technique [AID343680, Type: Literature]
View
42
[SID103179045]
 Binding constant against bovine serum albumin [AID203473, Type: Literature]
View
43
[SID103179045]
 Ratio of EC50 for Hepatitis C virus 796 infected in HuH7 cells to EC50 for Hepatitis C virus 796 harboring NNI P495L mutant site in NS5B infected in HuH7 cells [AID571750, Type: Literature]
View
44
[SID103179045]
 Ratio of EC50 for Hepatitis C virus 796 infected in HuH7 cells to EC50 for Hepatitis C virus 796 harboring NNI M423T mutant site in NS5B infected in HuH7 cells [AID571751, Type: Literature]
View
45
[SID103179045]
 Ratio of EC50 for Hepatitis C virus 796 infected in HuH7 cells to EC50 for Hepatitis C virus 796 harboring NNI M414Q mutant site in NS5B infected in HuH7 cells [AID571752, Type: Literature]
View
46
[SID103179045]
 Ratio of EC50 for Hepatitis C virus 796 infected in HuH7 cells to EC50 for Hepatitis C virus 796 harboring NNI Y448A mutant site in NS5B infected in HuH7 cells [AID571753, Type: Literature]
View
47
[SID103179045]
 Ratio of EC50 for Hepatitis C virus 796 infected in HuH7 cells to EC50 for Hepatitis C virus 796 harboring NNI H95R mutant site in NS5B infected in HuH7 cells [AID571754, Type: Literature]
View
48
[SID103179045]
 Ratio of EC50 for Hepatitis C virus 796 infected in HuH7 cells to EC50 for Hepatitis C virus 796 harboring NNI C316Y mutant site in NS5B infected in HuH7 cells [AID571755, Type: Literature]
View
49
[SID50112792]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
View
50
[SID50112792]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_1, Type: Literature]
View