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indole (CID 798) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(16)
 
 
Inactive(336)
 
 
Inconclusive(25)
 
 
Unspecified(33)
 
 
Top Targets:
NR LBD PPAR(24)
 
 
 
NR LBD ER(21)
 
 
NR LBD AR(21)
 
 
 
NR LBD VDR(13)
 
 
 
NR LBD GR(12)
 
 
 
BioAssay Types:
Confirmatory(219)
 
 
 
 
Literature(108)
 
 
 
 
Summary(72)
 
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(272)
 
 
 
 
Kd(7)
 
 
Ki(5)
 
 
IC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 173    Data Row: 410   Total Pages: 9   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103179045]
IC50 1.78Cytotoxicity against human SK-N-SH cells after 48 hrs by MTT assay [AID652686, Type: Literature]
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2
[SID103179045]
Ki 2.33Inhibition of human carbonic anhydrase 4 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis [AID644086, Type: Literature]Carbonic anhydrase 4 [gi:115465]
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3
[SID103179045]
Ki 3.63Inhibition of human carbonic anhydrase 6 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis [AID644087, Type: Literature]Carbonic anhydrase 6 [gi:116241278]
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4
[SID103179045]
IC50 15.58Cytotoxicity against human MRC5 cells after 48 hrs by MTT assay [AID652688, Type: Literature]
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5
[SID103179045]
Ki 17.6Inhibition of bovine carbonic anhydrase 3 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis [AID644088, Type: Literature]Carbonic anhydrase 3 [gi:118572923]
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6
[SID144213254]
AhR Potency (uM) 22.5385qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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7
[SID144213254]
Potency-Replicate_1 27.306qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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8
[SID103179045]
Ki 27.4Inhibition of human carbonic anhydrase 1 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis [AID644084, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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9
[SID144208875]
AhR Potency (uM) 27.9132qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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10
[SID144208875]
Potency-Replicate_1 30.14qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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11
[SID103179045]
Ki 32.5Inhibition of human carbonic anhydrase 2 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis [AID644085, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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12
[SID144206089]
qHTS of D3 Dopamine Receptor Agonist: qHTS [AID652048, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
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13
[SID144206089]
qHTS of D3 Dopamine Receptor Potentiators: qHTS [AID652051, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
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14
[SID103179045]
Binding affinity to amyloid beta (1 to 42) oligomers by fluorescence quenching after 30 mins [AID475507, Type: Literature]
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15
[SID103179045]
Binding affinity to amyloid beta (1 to 42) fibrils by change in fluorescence at 100 uM after 10 mins [AID475504, Type: Literature]
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16
[SID103179045]
Binding affinity to amyloid beta (1 to 42) oligomers by change in fluorescence at 100 uM after 10 mins [AID475505, Type: Literature]
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17
[SID103179045]
IC50 100Cytotoxicity against human A549 cells after 48 hrs by MTT assay [AID652687, Type: Literature]
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18
[SID103179045]
IC50 100Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay [AID652685, Type: Literature]
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19
[SID103179045]
Kd 290Dissociation constant against T4 lysozyme mutant L99A [AID238119, Type: Literature]Lysozyme [gi:126605]
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20
[SID103179045]
Kd 300Dissociation constant for Leukocyte function associated antigen 1 (LFA-1) [AID99595, Type: Literature]
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21
[SID103179045]
Kd 300Inhibition of JY-8 cell adhesion via leukocyte function associated antigen 1 (LFA-1) to ICAM-1 [AID99593, Type: Literature]Integrin alpha-L [gi:88911345]
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22
[SID103179045]
Kd 300Inhibition of JY-8 cell adhesion via leukocyte function associated antigen 1 (LFA-1) to ICAM-1 [AID99593, Type: Literature]Intercellular adhesion molecule 1 [gi:68067956]
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23
[SID103179045]
Kd 300Inhibition of JY-8 cell adhesion via leukocyte function associated antigen 1 (LFA-1) to ICAM-1 [AID99593, Type: Literature]Integrin beta-2 [gi:124056465]
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24
[SID103179045]
Kd 3000Dissociation constant against adenosine kinase [AID34005, Type: Literature]
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25
[SID103179045]
Kd 3000Inhibition of human adenosine kinase [AID220591, Type: Literature]
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26
[SID103179045]
IC50 10000Inhibition of [alpha-32P]ATP binding to DnaA protein purified from Escherichia coli [AID56359, Type: other]
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27
[SID103179045]
Residual porcine GSK-3-alpha/beta kinase activity with L240C/N297Q mutant cytochrome P450 2A6 extract [AID73213, Type: Literature]
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28
[SID103179045]
Residual porcine GSK-3-alpha/beta kinase activity with wild-type cytochrome P450 2A6 extract [AID73214, Type: Literature]
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29
[SID103179045]
Residual Cyclin-dependent kinase 5-p35nck5a activity with L240C/N297Q mutant cytochrome P450 2A6 extract [AID54188, Type: Literature]
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30
[SID103179045]
Residual Cyclin-dependent kinase 5-p35nck5a activity with wild-type cytochrome P450 2A6 extract [AID54189, Type: Literature]
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31
[SID103179045]
Aqueous solubility [AID19262, Type: Literature]
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32
[SID103179045]
Partition coefficient (logP) [AID23454, Type: Literature]
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33
[SID103179045]
Partition coefficient (logP) [AID23714, Type: Literature]
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34
[SID103179045]
Capacity ratio (log k'w) [AID23978, Type: Literature]
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35
[SID103179045]
Partition coefficient (logP) [AID236904, Type: Literature]
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36
[SID103179045]
Lipophilicity determined as logarithm of the partition coefficient in the alkane/water system [AID237685, Type: Literature]
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37
[SID103179045]
Permeability coefficient through artificial membrane in presence of unstirred water layer by PAMPA [AID288184, Type: Literature]
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38
[SID103179045]
Partition coefficient, log P of the compound [AID288192, Type: Literature]
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39
[SID103179045]
Antimicrobial activity Propionibacterium acnes ATCC 11827 after 2 days by broth dilution method [AID332912, Type: Literature]
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40
[SID103179045]
Octanol-water distribution coefficient, log D at pH 7.4 by shake-flask technique [AID343398, Type: Literature]
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41
[SID103179045]
Hexadecane-water distribution coefficient, log D at pH 7.4 by shake-flask technique [AID343680, Type: Literature]
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42
[SID50112792]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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43
[SID103179045]
Binding constant against bovine serum albumin [AID203473, Type: Literature]
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44
[SID103179045]
Ratio of EC50 for Hepatitis C virus 796 infected in HuH7 cells to EC50 for Hepatitis C virus 796 harboring NNI P495L mutant site in NS5B infected in HuH7 cells [AID571750, Type: Literature]
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45
[SID103179045]
Ratio of EC50 for Hepatitis C virus 796 infected in HuH7 cells to EC50 for Hepatitis C virus 796 harboring NNI M423T mutant site in NS5B infected in HuH7 cells [AID571751, Type: Literature]
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46
[SID103179045]
Ratio of EC50 for Hepatitis C virus 796 infected in HuH7 cells to EC50 for Hepatitis C virus 796 harboring NNI M414Q mutant site in NS5B infected in HuH7 cells [AID571752, Type: Literature]
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47
[SID103179045]
Ratio of EC50 for Hepatitis C virus 796 infected in HuH7 cells to EC50 for Hepatitis C virus 796 harboring NNI Y448A mutant site in NS5B infected in HuH7 cells [AID571753, Type: Literature]
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48
[SID103179045]
Ratio of EC50 for Hepatitis C virus 796 infected in HuH7 cells to EC50 for Hepatitis C virus 796 harboring NNI H95R mutant site in NS5B infected in HuH7 cells [AID571754, Type: Literature]
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49
[SID103179045]
Ratio of EC50 for Hepatitis C virus 796 infected in HuH7 cells to EC50 for Hepatitis C virus 796 harboring NNI C316Y mutant site in NS5B infected in HuH7 cells [AID571755, Type: Literature]
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50
[SID144208875]
Potency-Replicate_1 21.3375qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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