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BioActivity Data for Compound indole (CID 798)

BioActivity Outcomes:
Active(26)
 
 
Inactive(400)
 
 
Inconclusive(15)
 
 
Unspecified(43)
 
 
Top Targets:
NR LBD PPAR(24)
 
 
 
NR LBD ER(21)
 
 
NR LBD AR(21)
 
 
 
NR LBD VDR(13)
 
 
NR LBD GR(12)
 
 
 
BioAssay Types:
Confirmatory(257)
 
 
 
 
 
Literature(122)
 
 
 
 
Summary(87)
 
 
 
 
Screening(10)
 
 
 
BioAssay Categories:
In vitro(3)
 
 
Biochemical(29)
 
 
 
 
Toxicity(22)
 
 
 
 
ADME(6)
 
 
 
Cell-based(16)
 
 
 
 
BioActivity Types:
Potency(318)
 
 
 
 
Kd(9)
 
 
 
IC50(8)
 
 
 
AC50(6)
 
 
 
Ki(5)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 216    Data Row: 484   Total Pages: 25   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144208875]
Potency-Replicate_1 1.3463qHTS assay to identify small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID1159521, Type: confirmatory]RAR-related orphan receptor gamma [Mus musculus] [gi:15928672]
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2
[SID103179045]
IC50 1.78Cytotoxicity against human SK-N-SH cells after 48 hrs by MTT assay [AID652686, Type: Literature]
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3
[SID103179045]
Ki 2.33Inhibition of human carbonic anhydrase 4 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis [AID644086, Type: Literature]Carbonic anhydrase 4 [gi:115465]
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4
[SID144208875]
Potency-Replicate_1 2.6862qHTS assay to identify small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway - cell viability counter screen [AID1159520, Type: confirmatory]
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5
[SID103179045]
Ki 3.63Inhibition of human carbonic anhydrase 6 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis [AID644087, Type: Literature]Carbonic anhydrase 6 [gi:116241278]
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6
[SID144208875]
Antagonist Potency (uM) 6.37006qHTS assay to identify small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway: Summary [AID1159523, Type: summary]RAR-related orphan receptor gamma [Mus musculus] [gi:15928672]
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7
[SID103179045]
IC50 15.58Cytotoxicity against human MRC5 cells after 48 hrs by MTT assay [AID652688, Type: Literature]
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8
[SID103179045]
Ki 17.6Inhibition of bovine carbonic anhydrase 3 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis [AID644088, Type: Literature]Carbonic anhydrase 3 [gi:118572923]
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9
[SID144213254]
AhR Potency (uM) 22.5385qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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10
[SID144213254]
Potency-Replicate_1 27.306qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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11
[SID103179045]
Ki 27.4Inhibition of human carbonic anhydrase 1 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis [AID644084, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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12
[SID144208875]
AhR Potency (uM) 27.9132qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
View
13
[SID144208875]
Potency-Replicate_1 30.14qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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14
[SID103179045]
Ki 32.5Inhibition of human carbonic anhydrase 2 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis [AID644085, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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15
[SID144208875]
Potency-Replicate_1 42.9427qHTS assay to identify small molecule agonists of the AP-1 signaling pathway - cell viability counter screen [AID1159525, Type: confirmatory]
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16
[SID144208875]
Potency-Replicate_1 48.1825qHTS assay to identify small molecule agonists of the RXR signaling pathway - cell viability counter screen [AID1159529, Type: confirmatory]
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17
[SID208011784]
Kd 290Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]
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18
[SID208011784]
Kd 290Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]
View
19
[SID103179045]
Potentiation of 1000 ppm Bacillus thuringiensis-induced pathogenicity against Plutella xylostella (diamondback moth) fourth-instar larvae at 10000 ppm measured 48 hr post compound treatment [AID1092122, Type: Literature]
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20
[SID103179045]
Antiulcer activity in po dosed albino rat pyloric ligation model assessed as inhibition of gastric secretion administered as single dose 1 to 24 hrs prior to ligation [AID1133966, Type: Literature]
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