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imidazole (CID 795) - Compound BioActivity Data
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BioActivity Outcomes:
Active(1)
 
 
Inactive(322)
 
 
Inconclusive(15)
 
 
Unspecified(24)
 
 
Top Targets:
NR LBD PPAR(21)
 
 
 
NR LBD ER(16)
 
 
NR LBD AR(16)
 
 
 
NR LBD TR(10)
 
 
NR LBD Fxr(10)
 
 
BioAssay Types:
Confirmatory(274)
 
 
 
Summary(48)
 
 
 
Literature(26)
 
 
 
 
BioActivity Types:
Potency(273)
 
 
 
IC50(7)
 
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 264    Data Row: 362   Total Pages: 8   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103176105]
IC50 40Inhibition of purified mouse inducible nitric oxide synthase catalyzed [14C]L-citrulline production at a compound concentration of 1 mM in presence of 50 uM L-arginine [AID147271, Type: Literature]
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2
[SID103176105]
Ki 175Inhibition of nNOS assessed as conversion of L-[3H]arginine to L-[3H]citrulline [AID404423, Type: Literature]
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3
[SID103176105]
IC50 368Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 by LDH assay [AID497160, Type: Literature]
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4
[SID103176105]
IC50 670Inhibitory activity against thromboxane A2 synthetase [AID212779, Type: Literature]
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5
[SID103176105]
IC50 3675Cytotoxicity against CHO cells after 48 hrs by MTT assay [AID497161, Type: Literature]
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6
[SID103176105]
IC50 4000Inhibition of porcine aorta prostacyclin PGI-2 synthase [AID155525, Type: Literature]
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7
[SID103176105]
IC50 10000Inhibition of ram seminal vesicle Cyclooxygenase [AID161184, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
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8
[SID103176105]
IC50 10000Inhibition of ram seminal vesicle Cyclooxygenase [AID161184, Type: Literature]Prostaglandin G/H synthase 2 [gi:3914304]
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9
[SID103176105]
Antifungal activity against yeast AD1-8u expressing Candida albicans CaMdr1p by agar disk diffusion assay [AID537734, Type: Literature]
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10
[SID103176105]
Selectivity ratio of IC50 for Plasmodium falciparum to IC50 for CHO cells [AID497162, Type: Literature]
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11
[SID103176105]
Enhanced styrene oxide hydrolase activity pH 8.7 [AID208343, Type: Literature]Epoxide hydrolase 1 [gi:123928]
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12
[SID103176105]
Enhancement of epoxide hydrolase activity [AID70214, Type: Literature]Epoxide hydrolase 1 [gi:123928]
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13
[SID103176105]
Inhibition of Thromboxane synthetase at 100 uM [AID213129, Type: Literature]Thromboxane-A synthase [gi:254763392]
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14
[SID103176105]
Maximum enhancement of styrene oxide hydrolase activity was reported at compound concentration of 1e-1M [AID208350, Type: Literature]
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15
[SID103176105]
The pKa value was measured at N15 chemical shift changes due to protonation [AID233501, Type: Literature]
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16
[SID103176105]
Ionization constant (pKa) [AID25092, Type: Literature]
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17
[SID103176105]
Dissociation constant was evaluated [AID25595, Type: Literature]
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18
[SID103176105]
pKa value by 1H NMR spectroscopy [AID26364, Type: other]
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19
[SID103176105]
Dissociation constant (pKa, calculated using GNN method) [AID26397, Type: Literature]
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20
[SID103176105]
Partition coefficient (logP) [AID26810, Type: Literature]
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21
[SID103176105]
Antifungal activity against yeast AD1-8u expressing Candida albicans CaCdr1p by agar disk diffusion assay [AID537736, Type: Literature]
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22
[SID17388974]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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23
[SID103176105]
Dissociation constant, pKa of the compound at pH 2 to 3 by spectrophotometric analysis [AID687184, Type: Literature]
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24
[SID103176105]
Dissociation constant, pKa of the compound at pH 11 to 12 by spectrophotometric analysis [AID687185, Type: Literature]
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25
[SID103176105]
Dissociation constant, pKa of the compound [AID701844, Type: Literature]
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26
[SID17388974]
Potency 0.3981qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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27
[SID17388974]
Potency 33.4915qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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28
[SID17388974]
Potency qHTS assay for environmental chemicals that activate the Aryl hydrocarbon Receptor (AhR) signaling pathway [AID651777, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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29
[SID144208702]
AhR Potency (uM) qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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30
[SID144208702]
Potency-Replicate_1 qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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31
[SID144213662]
Potency-Replicate_1 qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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32
[SID17388974]
Potency qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay [AID995, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
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33
[SID17388974]
qHTS Assay for Inhibitors of YjeE [AID605, Type: confirmatory]tRNA threonylcarbamoyladenosine biosynthesis protein TsaE [gi:84028058]
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34
[SID17388974]
Potency qHTS Assay for Modulators of Hemoglobin Beta Chain Splicing [AID925, Type: confirmatory]hemoglobin subunit beta [Homo sapiens] [gi:4504349]
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35
[SID144208702]
Ratio Potency (uM) qHTS assay for small molecule activators of the heat shock response signaling pathway: Summary [AID743228, Type: summary]heat shock protein beta-1 [Homo sapiens] [gi:4504517]
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36
[SID144208702]
Potency-Replicate_1 qHTS assay for small molecule activators of the heat shock response signaling pathway [AID743210, Type: confirmatory]heat shock protein beta-1 [Homo sapiens] [gi:4504517]
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37
[SID144213662]
Ratio Potency (uM) qHTS assay for small molecule activators of the heat shock response signaling pathway: Summary [AID743228, Type: summary]heat shock protein beta-1 [Homo sapiens] [gi:4504517]
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38
[SID144213662]
Potency-Replicate_1 qHTS assay for small molecule activators of the heat shock response signaling pathway [AID743210, Type: confirmatory]heat shock protein beta-1 [Homo sapiens] [gi:4504517]
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39
[SID17388974]
Potency qHTS assay for small molecule activators of the rat pregnane X receptor (rPXR) signaling pathway [AID651751, Type: confirmatory]pregnane X receptor [Rattus norvegicus] [gi:5702233]
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40
[SID17388974]
Potency qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 [Homo sapiens] [gi:31542939]
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41
[SID17388974]
Potency qHTS Assay for Identification of Small Molecule Inducers of Hypoxia Response [AID2120, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapiens] [gi:32879895]
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42
[SID17388974]
qHTS Assay for Inhibitors of RGS12 GoLoco Motif Activity (Red Fluorophore) [AID880, Type: confirmatory]guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1 [Homo sapiens] [gi:33946324]
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43
[SID17388974]
Potency qHTS assay for small molecule activators of the nuclear factor-kappa B (NF-kB) signaling pathway [AID651749, Type: confirmatory]nuclear factor NF-kappa-B p105 subunit isoform 1 [Homo sapiens] [gi:34577122]
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44
[SID17388974]
Potency qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor [AID926, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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45
[SID17388974]
Potency qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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46
[SID17388974]
Potency qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium [AID1457, Type: confirmatory]Inositol monophosphatase 1 [gi:44888968]
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47
[SID17388974]
IkB Signaling [AID445, Type: confirmatory]NF-kappa-B inhibitor alpha [Homo sapiens] [gi:10092619]
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48
[SID17388974]
Potency qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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49
[SID17388974]
Potency qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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50
[SID17388974]
Potency qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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