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BioActivity Data for Compound Deanol (CID 7902)

BioActivity Outcomes:
Active(3)
 
 
Inactive(299)
 
 
Inconclusive(23)
 
 
Unspecified(5)
 
 
Top Targets:
NR LBD ER(21)
 
 
NR LBD AR(21)
 
 
 
 
NR LBD PPAR(18)
 
 
 
NR LBD GR(12)
 
 
 
NR LBD TR(11)
 
 
BioAssay Types:
Confirmatory(239)
 
 
 
 
Summary(73)
 
 
 
Screening(7)
 
 
Literature(6)
 
 
 
BioAssay Categories:
In vivo(1)
 
 
Biochemical(4)
 
 
 
 
Toxicity(18)
 
 
BioActivity Types:
Potency(295)
 
 
 
 
IC50(2)
 
 
Ki(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 165    Data Row: 330   Total Pages: 17   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103322998]
Ki 21Inhibition of [3H]choline brain uptake through choline transporter was determined in situ brain perfusion studies in Male Fischer-344 rats [AID52132, Type: Literature]
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2
[SID144206714]
Potency-Replicate_1 21.1317qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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3
[SID48415844]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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4
[SID103322998]
Ki 55.7186Inhibition of [3H]choline uptake at choline transporter 1 in mouse brain synaptosome [AID494749, Type: Literature]High affinity choline transporter 1 [gi:56404887]
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5
[SID103322998]
IC50 200Inhibition of Holtzman rat brain choline acetyltransferase using [1-14C-acetyl]-CoA as substrate at 1 mM incubated 20 mins prior to substrate addition measured after 30 mins by liquid scintillation counting analysis [AID1144084, Type: Literature]Choline O-acetyltransferase [gi:416805]
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6
[SID103322998]
IC50 1300Inhibitory activity against Plasmodium falciparum [AID158688, Type: Literature]
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7
[SID103322998]
pKa (acid-base dissociation constant) as determined by Morgenthaler ref: ChemMedChem 2007 [AID781327, Type: Literature]
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8
[SID103322998]
Lipid solubility measured as chloroform-water partition coefficient [AID21086, Type: Literature]
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9
[SID144206714]
Potency-Replicate_1 4.7716qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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10
[SID144213161]
Potency-Replicate_1 61.1306qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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11
[SID144209019]
Potency-Replicate_1 qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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12
[SID144206714]
Potency-Replicate_1 qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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13
[SID144213161]
Potency-Replicate_1 qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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14
[SID144209019]
Potency-Replicate_1 qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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15
[SID144206714]
Potency-Replicate_1 qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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16
[SID144213161]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cells [AID720680, Type: confirmatory]
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17
[SID144213161]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HepG2 cell free culture [AID720684, Type: confirmatory]
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18
[SID144206714]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HepG2 cell free culture [AID720685, Type: confirmatory]
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19
[SID144213161]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HepG2 cell free culture [AID720685, Type: confirmatory]
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20
[SID144213161]
Potency-Replicate_1 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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