Hypoxanthine (CID 790) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(8)
 
 
Inactive(161)
 
 
Inconclusive(2)
 
 
Unspecified(13)
 
 
Top Targets:
globin(3)
 
 
PLN02808(2)
 
 
PMP22 Claudin(2)
 
 
PNPH(2)
 
 
 
PRTases typeI(2)
 
 
BioAssay Types:
Literature(80)
 
 
 
 
Confirmatory(77)
 
 
 
 
Screening(7)
 
 
BioActivity Types:
Potency(74)
 
 
 
 
IC50(2)
 
 
 
Ki(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 117    Data Row: 184   Total Pages: 4   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103503976]
IC50 4.2Inhibition of [3H]hypoxanthine uptake in Plasmodium falciparum 3D7 [AID274547, Type: Literature]
View
2
[SID103503976]
Ki 17Tested for its ability to inhibit calf spleen purine nucleoside phosphorylase (PNP) [AID164770, Type: Literature]
View
3
[SID26749634]
Potency 79.4328qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
View
4
[SID103503976]
Ki Inhibition of Plasmodium falciparum HGXPRT at pH 7.4 [AID274550, Type: Literature]
View
5
[SID103503976]
 Inhibition of Plasmodium falciparum HGXPRT at pH 8.5 [AID274563, Type: Literature]
View
6
[SID103503976]
 Inhibition of human HGPRT at pH 8.5 [AID274562, Type: Literature]Hypoxanthine-guanine phosphoribosyltransferase [gi:123497]
View
7
[SID103503976]
 Inhibition of human HGPRT at pH 7.4 [AID274549, Type: Literature]Hypoxanthine-guanine phosphoribosyltransferase [gi:123497]
View
8
[SID46393408]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Purine Nucleoside Phosphorylase [gi:157834116]
View
9
[SID103503976]
IC50 700Displacement of [3H]diazepam from benzodiazepine receptor in rat cerebral cortex membrane [AID401477, Type: other]
View
10
[SID103503976]
 Insulin release in rat pancreatic beta-cells after 15 minutes of administration at 1 mM was measured [AID252792, Type: Literature]
View
11
[SID103503976]
 Protection against 40 nM methotrexate-induced growth inhibition of human CCRF-CEM cells at 10 uM relative to control [AID282398, Type: Literature]
View
12
[SID103503976]
 Protection against 5000 nM N-[4-[(2-amino-6-methyl-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)thio]-2fluorobenzoyl]-L-glutamic acid-induced growth inhibition of human CCRF-CEM cells at 10 uM relative to control [AID282400, Type: Literature]
View
13
[SID103503976]
 Protection against 2400 nM N-[4-[(2-amino-6-methyl-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)thio]-2chlorobenzoyl]-L-glutamic acid-induced growth inhibition of human CCRF-CEM cells at 10 uM relative to control [AID282402, Type: Literature]
View
14
[SID103503976]
 Growth inhibition of human CCRF-CEM cells at 10 uM relative to leucovorin [AID282410, Type: Literature]
View
15
[SID103503976]
 Protection against 4000 nM N-{4-[(2,4-diamino-5-methyl-4, 7-dihydro-3H-pyrrolo[2,3-d]pyr imidin-6-yl)thio]benzoyl}-L-gl utamic acid-induced growth inhibition in human CCRF-CEM cells assessed as growth at 10 uM relative to control [AID282809, Type: Literature]
View
16
[SID103503976]
 Protection against 40 nM methotrexate-induced growth inhibition in human CCRF-CEM cells assessed as growth at 10 uM relative to control [AID282810, Type: Literature]
View
17
[SID103503976]
 Inhibition of phosphatidylinositol 4-kinase in human A431 cell membrane by liquid scintillation counting [AID338748, Type: other]
View
18
[SID26749634]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
View
19
[SID103503976]
 The concentration required to inhibit the growth of L-1210 leukemic cells was evaluated [AID97843, Type: Literature]
View
20
[SID103503976]
 The concentration required (hypoxanthine+uridine) to inhibit the growth of L-1210 leukemic cells was evaluated [AID97848, Type: Literature]
View
21
[SID103503976]
 Ratio of Ki values for guanine and related hypoxanthines in PNP inhibition assay [AID230017, Type: Literature]Purine nucleoside phosphorylase [gi:205829287]
View
22
[SID26749634]
Potency qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase: hit validation [AID492961, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei] [gi:72386991]
View
23
[SID26749634]
Potency qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Green Fluorophore) [AID875, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
View
24
[SID26749634]
Potency qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore) [AID892, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
View
25
[SID11536560]
 NMR Based Screening Assay For Novel Chemical Probes Targeting The FRB Domain of mTOR [AID1648, Type: other]Chain A, Nmr Solution Structure Of The Frb Domain Of Mtor [gi:159164579]
View
26
[SID11538005]
 NMR Based Screening Assay For Novel Chemical Probes Targeting The FRB Domain of mTOR [AID1648, Type: other]Chain A, Nmr Solution Structure Of The Frb Domain Of Mtor [gi:159164579]
View
27
[SID26749634]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
View
28
[SID26749634]
Potency qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
View
29
[SID26749634]
Potency qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
View
30
[SID26749634]
Potency qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
View
31
[SID26749634]
Potency qHTS Assay for Identification of Novel General Anesthetics [AID485281, Type: confirmatory]Chain A, Horse Spleen Apoferritin [gi:254220970]
View
32
[SID26749634]
Potency qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent) [AID1476, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
View
33
[SID26749634]
Potency qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent) [AID1478, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
View
34
[SID26749634]
Potency qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
View
35
[SID26749634]
Potency qHTS Assay for Modulators of Lamin A Splicing [AID1487, Type: confirmatory]prelamin-A/C isoform 3 [Homo sapiens] [gi:27436948]
View
36
[SID26749634]
Potency qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1468, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
View
37
[SID26749634]
Potency qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1468, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
View
38
[SID26749634]
Potency qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
View
39
[SID26749634]
Potency qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
View
40
[SID26749634]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide [AID1766, Type: confirmatory]MEN1 gene product [Homo sapiens] [gi:18860839]
View
41
[SID26749634]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]MEN1 gene product [Homo sapiens] [gi:18860839]
View
42
[SID26749634]
Potency qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction [AID2662, Type: confirmatory]MLL gene product [Homo sapiens] [gi:56550039]
View
43
[SID26749634]
Potency A Quantitative High throughput Screen to Identify Chemical Modulators of PINK1 Expression [AID624263, Type: confirmatory]Parkin [Homo sapiens] [gi:3063388]
View
44
[SID26749634]
Potency qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF [AID1454, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
View
45
[SID26749634]
Potency qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF [AID1454, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
View
46
[SID26749634]
Potency qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF [AID1454, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
View
47
[SID26749634]
Potency qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay [AID995, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
View
48
[SID26749634]
Potency qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay [AID995, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
View
49
[SID26749634]
Potency qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay [AID995, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
View
50
[SID26613338]
 Modulators of the EP2 prostaglandin E2 receptor - Primary Screening [AID940, Type: screening]prostaglandin E receptor 2 (subtype EP2), 53kDa [Homo sapiens] [gi:31881630]
View