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BioActivity Data for Compound Acrolein (CID 7847)

BioActivity Outcomes:
Active(9)
 
 
Inactive(258)
 
 
Inconclusive(12)
 
 
Unspecified(186)
 
 
Top Targets:
NR LBD PPAR(13)
 
 
 
NR LBD ER(9)
 
 
NR LBD AR(9)
 
 
 
NR LBD TR(7)
 
 
 
NR LBD VDR(6)
 
 
 
BioAssay Types:
Confirmatory(222)
 
 
 
 
Summary(29)
 
 
 
 
Literature(13)
 
 
 
 
BioAssay Categories:
In vitro(2)
 
 
In vivo(185)
 
 
 
Biochemical(8)
 
 
 
 
Toxicity(217)
 
 
 
 
ADME(1)
 
 
Cell-based(3)
 
 
 
BioActivity Types:
Potency(209)
 
 
 
 
IC50(3)
 
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 453    Data Row: 465   Total Pages: 24   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17390064]
Potency 0.0224qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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2
[SID103196772]
EC50 0.8Activation of TRPA1 channel [AID482142, Type: Literature]
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3
[SID103196772]
EC50 5Activation of TRPA1 [AID329099, Type: Literature]
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4
[SID144208182]
Ratio Potency (uM) 24.882qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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5
[SID17390064]
Potency 47.3079qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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6
[SID103196772]
IC50 48Concentration required to reduce the viability of L1210 cells by 50% after 1-h incubation at 37 degrees C [AID93938, Type: Literature]
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7
[SID48415067]
DSSTox (EPAFHM) EPA Fathead Minnow Acute Toxicity [AID1188, Type: other]
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8
[SID48413150]
DSSTox (CPDBAS) Carcinogenic Potency Database Salmonella Mutagenicity [AID1194, Type: other]
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9
[SID17390064]
Cell Viability - SH-SY5Y [AID544, Type: confirmatory]
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10
[SID103196772]
IC50 50Growth inhibitory activity against CHO cells in culture. [AID44892, Type: Literature]
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11
[SID103196772]
IC50 50Growth inhibitory activity against CHO/FU cells in culture. [AID45594, Type: Literature]
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12
[SID103196772]
Evaluated in vitro for inhibition of mitochondrial aldehyde dehydrogenase (AIDH) activity in disrupted rat liver mitochondria (0.2 mM) [AID34049, Type: Literature]
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13
[SID103196772]
Evaluated in vitro for inhibition of mitochondrial aldehyde dehydrogenase (AIDH) activity in intact rat liver mitochondria (0.2 mM) [AID34050, Type: Literature]
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14
[SID103196772]
DrugMatrix: Regimen: Daily Repeat; Time: 5 day; Dose: High; Vehicle: 100 % water; Route: oral gavage | Dataset: Hematology; Assay: MONOLE (Monocytes/Leukocytes); Study_ID: R040818 [AID923602, Type: other]
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15
[SID103196772]
DrugMatrix: Regimen: Daily Repeat; Time: 3 day; Dose: High; Vehicle: 100 % water; Route: oral gavage | Dataset: Hematology; Assay: LYMLE (Lymphocytes/Leukocytes); Study_ID: R040818 [AID923607, Type: other]
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16
[SID103196772]
DrugMatrix: Regimen: Daily Repeat; Time: 3 day; Dose: High; Vehicle: 100 % water; Route: oral gavage | Dataset: Hematology; Assay: MONOLE (Monocytes/Leukocytes); Study_ID: R040818 [AID923608, Type: other]
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17
[SID103196772]
DrugMatrix: Regimen: Daily Repeat; Time: 3 day; Dose: High; Vehicle: 100 % water; Route: oral gavage | Dataset: Hematology; Assay: MCHC (Ery. Mean Corpuscular HGB Concentration); Study_ID: R040818 [AID923609, Type: other]
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18
[SID103196772]
DrugMatrix: Regimen: Daily Repeat; Time: 3 day; Dose: High; Vehicle: 100 % water; Route: oral gavage | Dataset: Hematology; Assay: PLAT (Platelets); Study_ID: R040818 [AID923610, Type: other]
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19
[SID103196772]
DrugMatrix: Regimen: Daily Repeat; Time: 3 day; Dose: High; Vehicle: 100 % water; Route: oral gavage | Dataset: Hematology; Assay: BASOLE (Basophils/Leukocytes); Study_ID: R040818 [AID923611, Type: other]
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20
[SID103196772]
DrugMatrix: Regimen: Daily Repeat; Time: 3 day; Dose: High; Vehicle: 100 % water; Route: oral gavage | Dataset: Hematology; Assay: EOSLE (Eosinophils/Leukocytes); Study_ID: R040818 [AID923612, Type: other]
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