4-phenylenediamine (CID 7814) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(14)
 
 
Inactive(85)
 
 
Inconclusive(59)
 
 
Unspecified(3)
 
 
Top Targets:
RIP(4)
 
 
NR LBD TR(4)
 
 
HELICc(4)
 
 
NR LBD ROR li..(4)
 
 
Menin(4)
 
 
 
BioAssay Types:
Confirmatory(76)
 
 
 
 
Literature(64)
 
 
 
 
 
Screening(8)
 
 
 
BioActivity Types:
Potency(74)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 77    Data Row: 161   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID29215299]
Potency 12.5893qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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2
[SID29215299]
Potency 14.1254qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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3
[SID29215299]
Potency 14.1254qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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4
[SID29215299]
 Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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5
[SID29215299]
 A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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6
[SID29215300]
 Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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7
[SID29215300]
 A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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8
[SID29215299]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_3, Type: Literature]
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9
[SID29215299]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_11, Type: Literature]
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10
[SID29215299]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_18, Type: Literature]
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11
[SID29215299]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_23, Type: Literature]
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12
[SID29215299]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_44, Type: Literature]
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13
[SID29215299]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_53, Type: Literature]
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14
[SID29215299]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_55, Type: Literature]
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15
[SID48414316]
 DSSTox (CPDBAS) Carcinogenic Potency Database Salmonella Mutagenicity [AID1194, Type: other]
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16
[SID103558906]
 Permeability coefficient in human skin [AID311367, Type: Literature]
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17
[SID103558906]
 Induction of rhabdomyolysis in ICR mouse assessed as serum creatine phosphokinase level at 70 mg/kg, po after 4 hrs by spectrophotometry (Rvb = 240 +/- 34 U/L) [AID498990, Type: Literature]
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18
[SID29215299]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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19
[SID29215299]
Potency Quantitative High-Throughput Screen for Regulators of Epigenetic Control [AID1865, Type: confirmatory]
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20
[SID29215299]
Potency qHTS Assay for Compounds that Induce Erasure of Genomic Imprints [AID1948, Type: confirmatory]
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21
[SID71006]
 NCI Yeast Anticancer Drug Screen. Data for the cln2 rad14 strain [AID165, Type: other]
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22
[SID71006]
 NCI Yeast Anticancer Drug Screen. Data for the bub3 strain [AID167, Type: other]
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23
[SID71006]
 NCI Yeast Anticancer Drug Screen. Data for the mlh1 rad18 strain [AID175, Type: other]
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24
[SID71006]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model L1210 Leukemia (intraperitoneal) in B6D2F1 (BDF1) mice [AID248, Type: other]
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25
[SID71006]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model L1210 Leukemia (intraperitoneal) in CD2F1 (CDF1) mice [AID256, Type: other]
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26
[SID71006]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia (intraperitoneal) in CD2F1 (CDF1) mice [AID330, Type: other]
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27
[SID71006]
 NCI Yeast Anticancer Drug Screen. Data for the sgs1 mgt1 strain [AID161, Type: other]
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28
[SID71006]
 NCI Yeast Anticancer Drug Screen. Data for the mec2-1 strain [AID157, Type: other]
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29
[SID71006]
 NCI Yeast Anticancer Drug Screen. Data for the rad50 strain [AID155, Type: other]
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30
[SID29215299]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_24, Type: Literature]
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31
[SID29215299]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_21, Type: Literature]
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32
[SID29215299]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_26, Type: Literature]
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33
[SID29215299]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_9, Type: Literature]
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34
[SID29215299]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_10, Type: Literature]
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35
[SID48414316]
 DSSTox (CPDBAS) Carcinogenic Potency Database Summary MultiCellCall Results [AID1205, Type: other]
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36
[SID48414316]
 DSSTox (CPDBAS) Carcinogenic Potency Database Summary Rat Bioassay Results [AID1208, Type: other]
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37
[SID29215299]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_61, Type: Literature]
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38
[SID29215299]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_58, Type: Literature]
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39
[SID29215299]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_59, Type: Literature]
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40
[SID29215299]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_41, Type: Literature]
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41
[SID29215299]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_17, Type: Literature]
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42
[SID29215299]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_30, Type: Literature]
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43
[SID29215299]
Potency qHTS of Trypanosoma Brucei Inhibitors [AID624173, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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44
[SID29215299]
Potency qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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45
[SID29215300]
Potency qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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46
[SID29215299]
Potency qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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47
[SID29215300]
Potency qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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48
[SID29215299]
Potency qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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49
[SID29215299]
Potency Counterscreen for Luciferase (Kinase-Glo TM) Inhibition [AID1379, Type: confirmatory]luciferase [Photuris pennsylvanica] [gi:1669525]
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50
[SID29215299]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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