Caprolactam (CID 7768) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Inactive(13)
 
 
Unspecified(12)
 
 
BioAssay Types:
Literature(12)
 
 
BioActivity Types:
IC50(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 24    Data Row: 25   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103172909]
IC50 17400Ability to displace radioligand [35S]TBPS from Gamma-aminobutyric acid A receptor binding site in rat brain membranes [AID71833, Type: Literature]
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2
[SID103172909]
 Anticonvulsant activity expressed as dose at which 50% of the mice were protected from clonic seizures induced by pentylenetetrazole (85 mg/Kg); cytotoxicity observed at 300 mg/kg [AID113778, Type: Literature]
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3
[SID103172909]
 Anticonvulsant activity expressed as dose at which 50% of the mice were protected from tonic hindlimb seizures induced by maximal electroshock (MES) [AID113779, Type: Literature]
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4
[SID103172909]
 Neurotoxicity was evaluated by a rotarod test [AID212342, Type: Literature]
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5
[SID103172909]
 Protective Index (PI) determined as the ratio of toxic dose (TD50) and effective dose (ED50 (MES)) [AID226511, Type: Literature]
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6
[SID103172909]
 Protective Index (PI) determined as the ratio of toxic dose (TD50) and effective dose (ED50 (PTZ)) [AID226512, Type: Literature]
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7
[SID103172909]
 Virtual screen for compounds with anticonvulsant activity [AID227699, Type: Literature]
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8
[SID103172909]
 Compound was evaluated for the second order hydrolysis rate constant [AID25749, Type: Literature]
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9
[SID103172909]
 Percentage of benzidine-positive murine erythroleukemia cells on day 6. [AID70688, Type: Literature]
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10
[SID103172909]
 Cell growth was measured on day 3, after murine erythroleukemia cells were exposed at a cell concentration of 1*10e5 cells/mL. [AID70689, Type: Literature]
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11
[SID103172909]
 Cell growth was measured on day 6 after murine erythroleukemia cells were exposed at a cell concentration of 1*10e5 cells/mL. [AID70690, Type: Literature]
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12
[SID103172909]
 Concentration producing the maximum percentage of benzidine-positive cells after 6-days of continuous exposure in murine leukemia cells. [AID70691, Type: Literature]
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13
[SID71169]
 NCI Yeast Anticancer Drug Screen. Data for the mec2-1 strain [AID157, Type: other]
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14
[SID71169]
 NCI Yeast Anticancer Drug Screen. Data for the rad50 strain [AID155, Type: other]
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15
[SID412917]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model L1210 Leukemia (intraperitoneal) in B6D2F1 (BDF1) mice [AID248, Type: other]
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16
[SID71169]
 NCI Yeast Anticancer Drug Screen. Data for the cln2 rad14 strain [AID165, Type: other]
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17
[SID71169]
 NCI Yeast Anticancer Drug Screen. Data for the bub3 strain [AID167, Type: other]
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18
[SID71169]
 NCI Yeast Anticancer Drug Screen. Data for the mlh1 rad18 strain [AID175, Type: other]
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19
[SID71169]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model L1210 Leukemia (intraperitoneal) in B6D2F1 (BDF1) mice [AID248, Type: other]
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20
[SID71169]
 NCI Yeast Anticancer Drug Screen. Data for the sgs1 mgt1 strain [AID161, Type: other]
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21
[SID48413372]
 DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results [AID1189, Type: other]
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22
[SID48413372]
 DSSTox (CPDBAS) Carcinogenic Potency Database Salmonella Mutagenicity [AID1194, Type: other]
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23
[SID48413372]
 DSSTox (CPDBAS) Carcinogenic Potency Database Summary Mouse Bioassay Results [AID1199, Type: other]
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24
[SID48413372]
 DSSTox (CPDBAS) Carcinogenic Potency Database Summary MultiCellCall Results [AID1205, Type: other]
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25
[SID48413372]
 DSSTox (CPDBAS) Carcinogenic Potency Database Summary Rat Bioassay Results [AID1208, Type: other]
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