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BioActivity Data for Compound Caprolactam (CID 7768)

BioActivity Outcomes:
Inactive(197)
 
 
Inconclusive(4)
 
 
Unspecified(13)
 
 
Top Targets:
NR LBD PPAR(16)
 
 
 
NR LBD AR(14)
 
 
 
NR LBD ER(14)
 
 
NR LBD Fxr(8)
 
 
NR LBD GR(8)
 
 
BioAssay Types:
Confirmatory(136)
 
 
 
Summary(52)
 
 
 
Literature(12)
 
 
BioAssay Categories:
In vivo(2)
 
 
Biochemical(1)
 
 
Toxicity(14)
 
 
 
ADME(4)
 
 
Cell-based(4)
 
 
BioActivity Types:
Potency(176)
 
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 119    Data Row: 214   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103172909]
IC50 17400Ability to displace radioligand [35S]TBPS from Gamma-aminobutyric acid A receptor binding site in rat brain membranes [AID71833, Type: Literature]
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2
[SID103172909]
Concentration producing the maximum percentage of benzidine-positive cells after 6-days of continuous exposure in murine leukemia cells. [AID70691, Type: Literature]
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3
[SID103172909]
Cell growth was measured on day 6 after murine erythroleukemia cells were exposed at a cell concentration of 1*10e5 cells/mL. [AID70690, Type: Literature]
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4
[SID103172909]
Cell growth was measured on day 3, after murine erythroleukemia cells were exposed at a cell concentration of 1*10e5 cells/mL. [AID70689, Type: Literature]
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5
[SID103172909]
Percentage of benzidine-positive murine erythroleukemia cells on day 6. [AID70688, Type: Literature]
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6
[SID103172909]
Compound was evaluated for the second order hydrolysis rate constant [AID25749, Type: Literature]
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7
[SID103172909]
Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake flask method described in J. Biomol. Screen. 2011, 16, 348-355. Experimental range -1.5 to 4.5 [AID1159387, Type: other]
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8
[SID103172909]
Virtual screen for compounds with anticonvulsant activity [AID227699, Type: Literature]
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9
[SID103172909]
Protective Index (PI) determined as the ratio of toxic dose (TD50) and effective dose (ED50 (PTZ)) [AID226512, Type: Literature]
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10
[SID103172909]
Protective Index (PI) determined as the ratio of toxic dose (TD50) and effective dose (ED50 (MES)) [AID226511, Type: Literature]
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11
[SID103172909]
Neurotoxicity was evaluated by a rotarod test [AID212342, Type: Literature]
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12
[SID103172909]
Anticonvulsant activity expressed as dose at which 50% of the mice were protected from tonic hindlimb seizures induced by maximal electroshock (MES) [AID113779, Type: Literature]
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13
[SID103172909]
Anticonvulsant activity expressed as dose at which 50% of the mice were protected from clonic seizures induced by pentylenetetrazole (85 mg/Kg); cytotoxicity observed at 300 mg/kg [AID113778, Type: Literature]
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14
[SID144209400]
Potency-Replicate_1 21.934qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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15
[SID144209400]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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16
[SID144209400]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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17
[SID144209400]
Ratio Potency (uM) qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743078, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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18
[SID144209400]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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19
[SID144209400]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743080, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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20
[SID144209400]
ER Potency (uM) qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line: Summary [AID743091, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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